Abstract:
Background:Melanoma as a type of skin cancer, is associated with a high mortality rate. Therefore, early diagnosis and efficient surgical treatment of this disease is very important. Photodynamic therapy (PDT) involves the activation of a photosensitizer by light at specific wavelength that interacts with oxygen and creates singlet oxygen molecules or reactive oxygen species (ROS), which can lead to tumor cell death. Furthermore, one of the main approches in the prevention and treatment of various cancers is plant compounds application. Phenolic compounds are essential class of natural antioxidants, which play crucial biological roles such as anticancer effects. It was previously suggested that flavonoid such as rutoside could acts as pro-oxidant or antioxidant. Hence, in this study, we aimed to investigate the effect of rutoside on the combination therapy with methylene blue (MB) assisted by photodynamic treatment (PDT) using red light source (660 nm; power density: 30 mW/cm2) on A375 human melanoma cancer cells. Methods:For this purpose, the A375 human melanoma cancer cell lines were treated by MB-PDT and rutoside. Clonogenic cell survival, MTT assay, and cell death mechanisms were also determined after performing the treatment. Subsequently, after the rutoside treatment and photodynamic therapy (PDT), cell cycle and intracellular reactive oxygen species (ROS) generation were measured. Results:The obtained results showed that, MB-PDT and rutoside had better cytotoxic and antiprolifrative effects on A375 melanoma cancer cells compared to each free drug, whereas the cytotoxic effect on HDF human dermal fibroblast cell was not significant. MB-PDT and rutoside combination induced apoptosis and cell cycle arrest in the human melanoma cancer cell line. Intracellular ROS increased in A375 cancer cell line after the treatment with MB-PDT and rutoside. Conclusion:The results suggest that, MB-PDT and rutoside could be considered as novel approaches as the combination treatment of melanoma cancer.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Khorsandi K,Hosseinzadeh R,Chamani Edoi
10.1186/s12935-020-01616-xsubject
Has Abstractpub_date
2020-10-29 00:00:00pages
525issn
1475-2867pii
1616journal_volume
20pub_type
杂志文章abstract:BACKGROUND:The aim of this study is to explore the expression of alpha-synuclein (α-synuclein) in benign, atypical, and anaplastic meningiomas and determine its role in the malignant progression of meningiomas. METHODS:Expression of α-synuclein was measured in 44 meningioma samples by real-time PCR analysis. The effec...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-016-0361-y
更新日期:2016-11-15 00:00:00
abstract:: Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently, a number of studies have shown that the deletion or mutation of A20, a negative regulator of NF-κB, is frequ...
journal_title:Cancer cell international
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journal_title:Cancer cell international
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更新日期:2017-01-25 00:00:00
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journal_title:Cancer cell international
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journal_title:Cancer cell international
pub_type: 杂志文章
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journal_title:Cancer cell international
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-1028-2
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journal_title:Cancer cell international
pub_type: 杂志文章
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更新日期:2003-08-20 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
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journal_title:Cancer cell international
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更新日期:2019-01-14 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章,评审
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0236-7
更新日期:2015-09-17 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-014-0093-9
更新日期:2014-09-24 00:00:00
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pub_type: 杂志文章
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1099-0
更新日期:2020-01-23 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01325-5
更新日期:2020-06-11 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0453-3
更新日期:2017-09-26 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0754-9
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journal_title:Cancer cell international
pub_type: 杂志文章,评审
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journal_title:Cancer cell international
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pub_type: 杂志文章,评审
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journal_title:Cancer cell international
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更新日期:2020-10-31 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
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更新日期:2020-03-04 00:00:00
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journal_title:Cancer cell international
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doi:10.1186/1475-2867-14-30
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1132-3
更新日期:2020-02-22 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0759-4
更新日期:2019-02-18 00:00:00
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journal_title:Cancer cell international
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更新日期:2019-05-16 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-20
更新日期:2014-03-03 00:00:00
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