LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma cell proliferation and resistance to apoptosis by targeting miR-4656/HDAC11 axis.

abstract：Background:Although major driver gene have been identified, the complex molecular heterogeneity of renal cell cancer (RCC) remains unclear. Therefore, more relevant genes need to be identified to explain the pathogenesis of renal cancer. Methods:Microarray datasets GSE781, GSE6344, GSE53000 and GSE68417 were downloade...

journal_title：Cancer cell international

authors： Chen Y,Gu D,Wen Y,Yang S,Duan X,Lai Y,Yang J,Yuan D,Khan A,Wu W,Zeng G

更新日期：2020-07-21 00:00:00

abstract：Background:Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, the present study was performed to determine whether lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAF...

journal_title：Cancer cell international

authors： Ruan Z,Deng H,Liang M,Xu Z,Lai M,Ren H,Deng X,Su X

更新日期：2020-10-19 00:00:00

abstract：Background:Pancreatic cancer is a common malignant tumor of the digestive tract. It has a high degree of malignancy and poor prognosis. Finding effective molecular markers has great significance for pancreatic cancer diagnosis and treatment. This study aimed to investigate DLGAP5 expression in pancreatic cancer and exp...

journal_title：Cancer cell international

authors： Ke MJ,Ji LD,Li YX

更新日期：2020-08-08 00:00:00

abstract：Background:Schwannoma arising from peripheral nervous sheaths is a benign tumor. Methods:To evaluate cell cytotoxicity, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction and terminal deoxynucleotidyltransferase UTP nick-end labeling (TUNEL) assays were used. A microRNA (miRNA) array ...

journal_title：Cancer cell international

authors： Sohn EJ,Bak KM,Nam YK,Park HT

更新日期：2018-12-04 00:00:00

abstract：Background:Long noncoding RNAs (lncRNAs) play essential roles in tumor progression. However, the functions and targets of lncRNAs in neuroblastoma (NB) progression still remain to be determined. In this study, we aimed to investigate the effect of lncRNA DLX6 antisense RNA 1 (DLX6-AS1) on NB and the underlying mechanis...

journal_title：Cancer cell international

authors： Zhang HY,Xing MQ,Guo J,Zhao JC,Chen X,Jiang Z,Zhang H,Dong Q

更新日期：2019-11-27 00:00:00

abstract：:Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternally expressed gene 10 (PEG10), located on human chromosome 7q21.3, has turned out to be an oncogene implicat...

journal_title：Cancer cell international

authors： Xie T,Pan S,Zheng H,Luo Z,Tembo KM,Jamal M,Yu Z,Yu Y,Xia J,Yin Q,Wang M,Yuan W,Zhang Q,Xiong J

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:Although recent studies have shown the utility of miR-203 as a cancer-relevant biomarker, the validated clinical significance of miR-203 in HCC remains obscure. The aim of the present study was to evaluate the relationship between miR-203 expression and clinicopathological features in HCC patients. METHODS:...

journal_title：Cancer cell international

authors： Liu Y,Ren F,Rong M,Luo Y,Dang Y,Chen G

更新日期：2015-06-18 00:00:00

abstract：BACKGROUND:In this report the phytochemical profile of Nitraria. Retusa (N. Retusa) leaf extracts were identified and their ability to induce apoptosis in human chronic myelogenous erythroleukaemia (K562) was evaluated. METHODS:Apoptosis of the human chronic myelogenous erythroleukaemia (K562) was evidenced by investi...

journal_title：Cancer cell international

authors： Boubaker J,Bhouri W,Sghaier MB,Bouhlel I,Skandrani I,Ghedira K,Chekir-Ghedira L

更新日期：2011-10-31 00:00:00

abstract：:Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences show that overexpression of Six1 plays a key role in tumorigenesis. However, the Six1 expression status and its relationship with the clinicopatholo...

journal_title：Cancer cell international

authors： Zeng J,Shi R,Cai CX,Liu XR,Song YB,Wei M,Ma WL

更新日期：2015-06-20 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the anti-tumor effects of Ad/gTRAIL (an adenoviral vector in which expression of GFP and TRAIL is driven by a human telomerase reverse transcriptase promoter, hTERT) on malignant meningiomas and gliomas. BACKGROUND:Gliomas and meningiomas are the two most common ty...

journal_title：Cancer cell international

authors： Li JT,Bian K,Zhang AL,Kim DH,Ashley WW,Nath R,McCutcheon I,Fang B,Murad F

更新日期：2011-10-28 00:00:00

abstract：Background:Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it's essential to elicit the PD-1 related immune process in different types of cancer. Methods:The Cancer Genome Atl...

journal_title：Cancer cell international

authors： Shang J,Song Q,Yang Z,Sun X,Xue M,Chen W,Yang J,Wang S

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:Recent studies have reported the involvement of microRNA-29 (miR-29) family members in human cancers through their ability to regulate cellular functions. The present study investigated biological function of miR-29b in colorectal cancer (CRC). METHODS:CRC tissues and adjacent normal tissues were collected ...

journal_title：Cancer cell international

authors： Leng Y,Chen Z,Ding H,Zhao X,Qin L,Pan Y

更新日期：2021-01-06 00:00:00

abstract：Background:Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen fails to bind estrogen-receptor (ER). High estrogen is a known carcinogen in postmenopausal women. Re...

journal_title：Cancer cell international

authors： Nazmeen A,Chen G,Ghosh TK,Maiti S

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Tumor tissue resembles chronically inflamed tissue. Since chronic inflammatory conditions are a strong stimulus for bone marrow-derived cells (BMDCs) it can be assumed that recruitment of BMDCs into cancer tissue should be a common phenomenon. Several data have outlined that BMDC can influence tumor growth a...

journal_title：Cancer cell international

authors： Nagler C,Hardt C,Zänker KS,Dittmar T

更新日期：2011-06-28 00:00:00

abstract：Background:Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Siah E3 ubiquitin protein ligase 1 (Siah1) has been identified as a tumor suppressor gene and plays an important role in the development of malignant tumors. However, the potential role and molecular mechanism of Siah1 in the de...

journal_title：Cancer cell international

authors： Xiao Z,Wei Z,Deng D,Zheng Z,Zhao Y,Jiang S,Zhang D,Zhang LJ,Fan M,Chen S,Wang S,Ding Y,Ye Y,Jiao H

更新日期：2020-02-13 00:00:00

abstract：BACKGROUND:Advanced cancer and chemotherapy are both associated with immune system suppression. We initiated a clinical trial in patients receiving chemotherapy for metastatic colorectal cancer to determine if administration of GM-CSF in this setting was immunostimulatory. METHODS:Between June, 2003 and January, 2007,...

journal_title：Cancer cell international

authors： Martinez M,Ono N,Planutiene M,Planutis K,Nelson EL,Holcombe RF

更新日期：2012-01-23 00:00:00

abstract：Background:Tumor necrosis factor-α (TNF-α) immunotherapy controls the progression of human cervical cancer. Here, we explored the detailed molecular mechanisms played by melatonin in human cervical cancer (HeLa cells) death in the presence of TNF-α injury, with a particular attention to the mitochondrial homeostasis. ...

journal_title：Cancer cell international

authors： Zhao Q,Wang W,Cui J

更新日期：2019-03-14 00:00:00

abstract：BACKGROUND:Despite the modern therapies available for treating glioblastoma multiforme (GBM), it is still a deadly disease. The development of new therapeutic strategies for the management of gliomas is therefore crucial. The present study is designed to analyze the therapeutic potentials of synthetic compound N-(2-hyd...

journal_title：Cancer cell international

authors： Hanif F,Perveen K,Jawed H,Ahmed A,Malhi SM,Jamall S,Simjee SU

更新日期：2014-11-30 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is the largest histological subgroup of lung cancer and has increased in prevalence in China over the past 5 years. The 5-year survival rate has remained at 15-20 %, with a median survival of 8-12 months. The tumorigenesis and progression of NSCLC is orchestrated by numerou...

journal_title：Cancer cell international

authors： Chen S,Li P,Yang R,Cheng R,Zhang F,Wang Y,Chen X,Sun Q,Zang W,Du Y,Zhao G,Zhang G

更新日期：2015-09-17 00:00:00

abstract：BACKGROUND:While some risk factors for breast cancer are well-known, the influence of other factors, particularly virus infection, remains unclear. Human cytomegalovirus (HCMV) is widespread in the general population, and both molecular and epidemiological evidence has indicated links between HCMV and breast cancer. Th...

journal_title：Cancer cell international

authors： Valle Oseguera CA,Spencer JV

更新日期：2017-02-13 00:00:00

abstract：BACKGROUND:Breast cancer (BrCa) is the most common female malignancy worldwide and has the highest morbidity among all cancers in females. Unfortunately, the mechanisms of BrCa growth and metastasis, which lead to a poor prognosis in BrCa patients, have not been well characterized. METHODS:Immunohistochemistry (IHC) w...

journal_title：Cancer cell international

authors： Hang C,Zhao S,Wang T,Zhang Y

更新日期：2021-01-06 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s12935-020-01426-1.]. ...

journal_title：Cancer cell international

authors： Li T,Liu Q,Zhang R,Liao Q,Zhao Y

更新日期：2020-08-18 00:00:00

abstract：:BACKGROUND: The aim of this work was to investigate in vitro the putative role of EGR-1 in the growth of glioma cells. EGR-1 expression was examined during the early passages in vitro of 17 primary cell lines grown from 3 grade III and from 14 grade IV malignant astrocytoma explants. The explanted tumors were genetica...

journal_title：Cancer cell international

authors： Calogero A,Lombari V,De Gregorio G,Porcellini A,Ucci S,Arcella A,Caruso R,Gagliardi FM,Gulino A,Lanzetta G,Frati L,Mercola D,Ragona G

更新日期：2004-01-07 00:00:00

abstract：:BACKGROUND: Mast cells are known to accumulate at sites of inflammation and upon activation to release their granule content, e.g. histamine, cytokines and proteases. The secretory leukocyte protease inhibitor (SLPI) is produced in the respiratory mucous and plays a role in regulating the activity of the proteases. RE...

journal_title：Cancer cell international

authors： Hollander C,Nyström M,Janciauskiene S,Westin U

更新日期：2003-08-20 00:00:00

abstract：Background:Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on...

journal_title：Cancer cell international

authors： Liu T,Jiang L,Yu L,Ge T,Wang J,Gao H

更新日期：2019-04-23 00:00:00

abstract：:An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiation, growth, invasion and metastasis are promoted by CSCs. An important reason for the widespread interest in th...

journal_title：Cancer cell international

authors： Garza-Treviño EN,Said-Fernández SL,Martínez-Rodríguez HG

更新日期：2015-01-28 00:00:00

abstract：Background:Accumulating studies showed that long noncoding RNAs (lncRNAs) played vital roles in cancer progression. LncRNA MIR4435-2HG was proved to act as an oncogene in various tumors. However, the underlying function of MIR4435-2HG in ovarian cancer (OC) remains unclear. Methods:The expression levels of MIR4435-2HG...

journal_title：Cancer cell international

authors： Zhu L,Wang A,Gao M,Duan X,Li Z

更新日期：2020-05-01 00:00:00

abstract：Background:Casticin, an isoflavone compound extracted from the herb Fructus Viticis, has demonstrated anti-inflammatory and anticancer activities and properties. The aim of this study was to investigate the effects and mechanisms of casticin in nasopharyngeal carcinoma (NPC) cells and to determine its potential for tar...

journal_title：Cancer cell international

authors： Liu J,Yang J,Hou Y,Zhu Z,He J,Zhao H,Ye X,Li D,Wu Z,Huang Z,Hao B,Yao K

更新日期：2019-12-21 00:00:00

abstract：BACKGROUND:Epithelial mesenchymal transition (EMT) mediated by TGF-β pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract of Stellera chamaejasme L. (ESC) was against proliferation of a variety of tumor cells, but there were no studies in the...

journal_title：Cancer cell international

authors： Liu XN,Wang S,Yang Q,Wang YJ,Chen DX,Zhu XX

更新日期：2015-12-10 00:00:00

abstract：Background:Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a novel lncRNA-NEAT has not been thoroughly investigated in melanoma cancer. The purposes of this study ...

journal_title：Cancer cell international

authors： Ding F,Lai J,Gao Y,Wang G,Shang J,Zhang D,Zheng S

更新日期：2019-08-22 00:00:00