ESC reverses epithelial mesenchymal transition induced by transforming growth factor-β via inhibition of Smad signal pathway in HepG2 liver cancer cells.

abstract：BACKGROUND:Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene (e.g. PTEN) or microRNAs (e.g. miR-23a and miR-29b). Metapristone is a hormone-related drug, which i...

journal_title：Cancer cell international

authors： Chang Y,Hao M,Jia R,Zhao Y,Cai Y,Liu Y

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:CircRNAs play crucial roles in multiple tumours. However, the functions of most circRNAs in cervical cancer remain unclear. METHODS:This study collected GSE113696 data from the GEO database to search for differentially expressed circRNAs in cervical cancer. Quantitative reverse transcription PCR was used to...

journal_title：Cancer cell international

authors： Chen Y,Geng Y,Huang J,Xi D,Xu G,Gu W,Shao Y

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation. However prolonged androgen deprivation often results in relapse and androgen-independent prostate cancer that is inevita...

journal_title：Cancer cell international

authors： Shaw G,Prowse DM

更新日期：2008-03-18 00:00:00

abstract：Background:Growing evidence suggests that MiRNAs play essential roles in the initiation and progression of colorectal cancer (CRC). The aberrant expression of miR-384 has been reported in some cancers. However, the role and mechanism of miR-384 in CRC proliferation remains unknown. Methods:The expression of miR-384 wa...

journal_title：Cancer cell international

authors： Wang YX,Zhu HF,Zhang ZY,Ren F,Hu YH

更新日期：2018-09-03 00:00:00

abstract：Background:Kinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of breast cancer. However, the prognostic value of whole family members was poorly done. Our study intends to demonstrate the value of kinesin superfamily members as prognostic biomarkers as well...

journal_title：Cancer cell international

authors： Li TF,Zeng HJ,Shan Z,Ye RY,Cheang TY,Zhang YJ,Lu SH,Zhang Q,Shao N,Lin Y

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:CD44 has recently been reported as a cancer stem cell marker in ovarian cancer. However, the clinicopathological and prognostic value of this marker in ovarian cancer remains controversial; Here, we aimed to investigate the correlation between CD44 expression and the clinicopathological features or survival ...

journal_title：Cancer cell international

authors： Lin J,Ding D

更新日期：2017-01-05 00:00:00

abstract：BACKGROUND:We have previously shown that ultraviolet-A (UVA) radiation enhances metastatic lung colonization capacity of B16-F1 melanoma cells. The aim of this study was to examine changes in expression profile of genes in mouse melanoma B16-F1 cells exposed to UVA radiation. RESULTS:B16-F1 melanoma cells were exposed...

journal_title：Cancer cell international

authors： Pastila R,Leszczynski D

更新日期：2007-05-02 00:00:00

abstract：BACKGROUND:Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize these cancers and try to identify potential biomarkers and novel therapeutic targets. MATERIALS AND M...

journal_title：Cancer cell international

authors： Rajkumar T,Vijayalakshmi N,Gopal G,Sabitha K,Shirley S,Raja UM,Ramakrishnan SA

更新日期：2010-11-24 00:00:00

abstract：Background:Avoiding the phagocytosis by tumor-associated macrophages (TAMs) is necessary for the growth and metastasis of solid tumors. CD47 binds to the receptor signal-regulatory protein-α (SIRP-α) on the macrophages to avoid normal phagocytosis. In this study, we evaluated the expression and prognostic significance ...

journal_title：Cancer cell international

authors： Yuan J,He H,Chen C,Wu J,Rao J,Yan H

更新日期：2019-09-11 00:00:00

abstract：Background:Transgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that transgelin was up-regulated in node-positive colorectal cancer (CRC) versus node-negative disease. Over-expression of TAGLN affected the expression of 256 downstream transcri...

journal_title：Cancer cell international

authors： Lew ZX,Zhou HM,Fang YY,Ye Z,Zhong W,Yang XY,Yu Z,Chen DY,Luo SM,Chen LF,Lin Y

更新日期：2020-08-03 00:00:00

abstract：:RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression, particularly in gastrointestinal cancers. RNA methylation has a variety of b...

journal_title：Cancer cell international

authors： Xie S,Chen W,Chen K,Chang Y,Yang F,Lin A,Shu Q,Zhou T,Yan X

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. The purposes of this study were to e...

journal_title：Cancer cell international

authors： Yu X,Zhang X,Wang G,Wang B,Ding Y,Zhao J,Liu H,Cui S

更新日期：2020-11-03 00:00:00

abstract：BACKGROUND:Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper gene expression and that aberrant DNA methylation of genes and histone methylation plays important ...

journal_title：Cancer cell international

authors： Watanabe H,Soejima K,Yasuda H,Kawada I,Nakachi I,Yoda S,Naoki K,Ishizaka A

更新日期：2008-11-03 00:00:00

abstract：Background:Endometrial carcinoma (EC) is one of the three major malignant tumors of the female reproductive system. In recent years, the incidence and mortality rate of EC have increased. B-cell translocation gene 1 (BTG1) is an anti-proliferation gene that regulates the occurrence and development of a variety of tumor...

journal_title：Cancer cell international

authors： Li Y,Huo J,He J,Zhang Y,Ma X

更新日期：2020-10-07 00:00:00

abstract：Background:Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on...

journal_title：Cancer cell international

authors： Liu T,Jiang L,Yu L,Ge T,Wang J,Gao H

更新日期：2019-04-23 00:00:00

abstract：Background:Long non-coding RNAs (lncRNAs) play significant roles in tumorigenesis and can contribute to identification of novel therapeutic targets for cancers. This paper was aimed at exploring the role of CTBP1 divergent transcript (CTBP1-AS2) in cervical cancer (CC) progression. Methods:qRT-PCR and western blot ass...

journal_title：Cancer cell international

authors： Yang S,Shi F,Du Y,Wang Z,Feng Y,Song J,Liu Y,Xiao M

更新日期：2020-07-28 00:00:00

abstract：BACKGROUND:Human umbilical cord blood derived-mesenchymal stem cells (hUCMSCs) offer an attractive alternative to bone marrow-derived MSCs (BMMSCs) for cell-based therapy as it is a less invasive source of biological material. However, limited studies have been conducted with hUCMSCs as compared to BMMSCs. The present ...

journal_title：Cancer cell international

authors： Yang X,Li Z,Ma Y,Gao J,Liu S,Gao Y,Wang G

更新日期：2014-09-24 00:00:00

abstract：:[This retracts the article DOI: 10.1186/s12935-015-0237-6.]. ...

journal_title：Cancer cell international

authors： Mirghasemi A,Taheriazam A,Karbasy SH,Torkaman A,Shakeri M,Yahaghi E,Mokarizadeh A

更新日期：2016-11-04 00:00:00

abstract：OBJECTIVES:Bladder transitional cell carcinoma (TCC) is one of the most common solid malignancies in China. This study examined the antitumor effect and underlying mechanism of action of sunitinib malate in human bladder TCC in vitro. METHODS:Bladder TCC cell lines 5637 and BIU87 were maintained in 1640 medium and T24...

journal_title：Cancer cell international

authors： Wen J,Li HZ,Ji ZG,Jin J

更新日期：2015-02-28 00:00:00

abstract：Background:Alternative splicing (AS) is a key factor in protein-coding gene diversity, and is associated with the development and progression of malignant tumours. However, the role of AS in cervical cancer is unclear. Methods:The AS data for cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) were...

journal_title：Cancer cell international

authors： Ouyang D,Yang P,Cai J,Sun S,Wang Z

更新日期：2020-06-08 00:00:00

abstract：Background:Neuroblastoma (NB) is the most common malignant tumor originating from the extracranial sympathetic nervous system in children. The molecular mechanisms underlying this disease are complex, and not completely understood. Methods:Quantitative real-time PCR (qRT-PCR) was applied to quantify the expression of ...

journal_title：Cancer cell international

authors： Yu Y,Zhang J,Jin Y,Yang Y,Shi J,Chen F,Han S,Chu P,Lu J,Wang H,Guo Y,Ni X

更新日期：2018-01-04 00:00:00

abstract：BACKGROUND:Gastric carcinoma (GC) is currently one of the most common malignant tumors of the digestive system, and gastric precancerous lesions play a vital role in studying the mechanism of GC. Multiple microRNAs (miRNAs) have been documented to be potential biomarkers to indicate progression of gastric precancerous ...

journal_title：Cancer cell international

authors： Zhang T,Zhang K,Ji K,Zhang C,Jiang Y,Zhang Q,Tian Z,Wang X,Zhang M,Li X

更新日期：2020-11-13 00:00:00

abstract：Background:A number of JmjC domain-containing histone demethylases have been identified and biochemically characterized in mammalian models and humans. JMJD2A is a transcriptional co-factor and enzyme that catalyzes the demethylation of histone H3 lysine 9 and 36 (H3K9 and H3K36). Here in this study, we reported the ro...

journal_title：Cancer cell international

authors： Li M,Cheng J,Ma Y,Guo H,Shu H,Huang H,Kuang Y,Yang T

更新日期：2020-03-30 00:00:00

abstract：Background:Acute lymphoblastic leukemia (ALL) is an aggressive hematopoietic malignancy that is most commonly observed in children. Alantolactone (ALT) has been reported to exhibit anti-tumor activity in different types of cancer. The aim of the present study was to investigate the anti-tumor activity and molecular mec...

journal_title：Cancer cell international

authors： Shi C,Lan W,Wang Z,Yang D,Wei J,Liu Z,Teng Y,Gu M,Yuan T,Cao F,Zhou J,Li Y

更新日期：2020-09-09 00:00:00

abstract：: Cancer-initiating cells display aberrant functional and phenotypic characteristics of normal stem cells from which they evolved by accumulation of multiple cytogenetic and/or epigenetic alterations. Signal transduction pathways which are essential for normal stem cell function are abnormally expressed by cancer cells...

journal_title：Cancer cell international

authors： Feller L,Kramer B,Lemmer J

更新日期：2012-06-07 00:00:00

abstract：BACKGROUND:Although recent studies have shown the utility of miR-203 as a cancer-relevant biomarker, the validated clinical significance of miR-203 in HCC remains obscure. The aim of the present study was to evaluate the relationship between miR-203 expression and clinicopathological features in HCC patients. METHODS:...

journal_title：Cancer cell international

authors： Liu Y,Ren F,Rong M,Luo Y,Dang Y,Chen G

更新日期：2015-06-18 00:00:00

abstract：BACKGROUND:MicroRNAs are a class of small non-coding RNAs that are involved in many important physiological and pathological processes by regulating gene expression negatively. The purpose of this study was to investigate the effect of miR-32 on cell proliferation, migration and apoptosis and to determine the functiona...

journal_title：Cancer cell international

authors： Xia W,Zhou J,Luo H,Liu Y,Peng C,Zheng W,Ma W

更新日期：2017-01-25 00:00:00

abstract：BACKGROUND:Despite the modern therapies available for treating glioblastoma multiforme (GBM), it is still a deadly disease. The development of new therapeutic strategies for the management of gliomas is therefore crucial. The present study is designed to analyze the therapeutic potentials of synthetic compound N-(2-hyd...

journal_title：Cancer cell international

authors： Hanif F,Perveen K,Jawed H,Ahmed A,Malhi SM,Jamall S,Simjee SU

更新日期：2014-11-30 00:00:00

abstract：BACKGROUND:Recent studies have reported the involvement of microRNA-29 (miR-29) family members in human cancers through their ability to regulate cellular functions. The present study investigated biological function of miR-29b in colorectal cancer (CRC). METHODS:CRC tissues and adjacent normal tissues were collected ...

journal_title：Cancer cell international

authors： Leng Y,Chen Z,Ding H,Zhao X,Qin L,Pan Y

更新日期：2021-01-06 00:00:00

abstract：:BACKGROUND: Mast cells are known to accumulate at sites of inflammation and upon activation to release their granule content, e.g. histamine, cytokines and proteases. The secretory leukocyte protease inhibitor (SLPI) is produced in the respiratory mucous and plays a role in regulating the activity of the proteases. RE...

journal_title：Cancer cell international

authors： Hollander C,Nyström M,Janciauskiene S,Westin U

更新日期：2003-08-20 00:00:00