Abstract:
BACKGROUND:Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper gene expression and that aberrant DNA methylation of genes and histone methylation plays important roles in tumor progression. To date, several histone lysine methyltransferases (HKMTs) have been identified and histone lysine methylation is now considered to be a critical regulator of transcription. However, still relatively little is known about the role of HKMTs in tumorigenesis. RESULTS:We observed differential HKMT expression in a lung cancer model in which normal human bronchial epithelial (NHBE) cells expressing telomerase, SV40 large T antigen, and Ras were immortal, formed colonies in soft agar, and expressed specific HKMTs for H3 lysine 9 and 27 residues but not for H3 lysine 4 residue. Modifications in the H3 tails affect the binding of proteins to the histone tails and regulate protein function and the position of lysine methylation marks a gene to be either activated or repressed. In the present study, suppression by siRNA of HKMTs (EZH2, G9A, SETDB1 and SUV39H1) that are over-expressed in immortalized and transformed cells lead to reduced cell proliferation and much less anchorage-independent colony growth. We also found that the suppression of H3-K9, G9A and SUV39H1 induced apoptosis and the suppression of H3-K27, EZH2 caused G1 arrest. CONCLUSION:Our results indicate the potential of these HKMTs in addition to the other targets for epigenetics such as DNMTs and HDACs to be interesting therapeutic targets.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Watanabe H,Soejima K,Yasuda H,Kawada I,Nakachi I,Yoda S,Naoki K,Ishizaka Adoi
10.1186/1475-2867-8-15subject
Has Abstractpub_date
2008-11-03 00:00:00pages
15issn
1475-2867pii
1475-2867-8-15journal_volume
8pub_type
杂志文章abstract:Background:It is well known that hepatocellular carcinoma (HCC) has been one of the most life-threatening diseases all over the world. Plenty of internal and extrinsic factors have been proven to be related to HCC, such as gene mutation, viral hepatitis, and Nitrosamines. Though previous studies demonstrated that gluta...
journal_title:Cancer cell international
pub_type: 杂志文章
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更新日期:2019-03-29 00:00:00
abstract:Background:Alternative splicing (AS) is a key factor in protein-coding gene diversity, and is associated with the development and progression of malignant tumours. However, the role of AS in cervical cancer is unclear. Methods:The AS data for cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) were...
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pub_type: 杂志文章
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abstract::N6-methyl-adenosine(m6A) modification emerges as an abundant and dynamic regulation throughout the Eukaryotic transcriptome. Dysregulation of the m6A regulators has increasingly been found in many neoplasms. It is reasonable to believe that m6A changes the fate of cancer cells and subsequently affected all aspects of ...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
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abstract:Background:Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high morbidity and mortality worldwide. MicroRNAs are key regulators of HCC genesis. However, the regulatory role and underlying mechanisms of microRNA in HCC is still limited. Methods:Cyclin B1 (CCNB1) mRNA levels were examined in...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0729-x
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abstract:Background:Extracellular ATP (eATP) was shown to induce epithelial-mesenchymal transition (EMT), a very important early process in metastasis, in cancer cells via purinergic receptor signaling. However, the exact induction mechanisms are far from fully known. We previously described that eATP is internalized by cancer ...
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pub_type: 杂志文章
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abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) are increasingly implicated in the regulation of the progression of malignancy. AIM:To clarify the relations among BCYRN1 (brain cytoplasmic RNA 1, a long non-coding RNA), c-MYC and cell metastasis of non-small-cell lung cancer (NSCLC). METHODS:Real-time PCR was used to measu...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0183-3
更新日期:2015-04-01 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01659-0
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pub_type: 杂志文章,评审
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0179-z
更新日期:2015-02-28 00:00:00
abstract::Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved in disease pathogenesis and progression may potentially lead to new therapeutic targ...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
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更新日期:2018-10-16 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章,评审
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更新日期:2018-11-14 00:00:00
abstract:BACKGROUND:Breast cancer (BrCa) is the most common female malignancy worldwide and has the highest morbidity among all cancers in females. Unfortunately, the mechanisms of BrCa growth and metastasis, which lead to a poor prognosis in BrCa patients, have not been well characterized. METHODS:Immunohistochemistry (IHC) w...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01733-7
更新日期:2021-01-06 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-014-0133-5
更新日期:2014-11-30 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-016-0361-y
更新日期:2016-11-15 00:00:00
abstract:Background:Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, the present study was performed to determine whether lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAF...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01485-4
更新日期:2020-10-19 00:00:00
abstract:BACKGROUND:LncRNA HOXA-AS2 has been found in the literature to deteriorate glioblastoma. However, its regulatory mechanism is yet to be fully investigated. Our study focused chiefly on the interaction and role of the HOXA-AS2/miR-885-5p/RBBP4 axis in the development of glioblastoma. METHODS:qRT-PCR analysis was perfor...
journal_title:Cancer cell international
pub_type: 杂志文章
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-1026-4
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0900-4
更新日期:2019-07-16 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1124-3
更新日期:2020-02-13 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0265-2
更新日期:2015-12-10 00:00:00
abstract:BACKGROUND:Gastric carcinoma (GC) is currently one of the most common malignant tumors of the digestive system, and gastric precancerous lesions play a vital role in studying the mechanism of GC. Multiple microRNAs (miRNAs) have been documented to be potential biomarkers to indicate progression of gastric precancerous ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01578-0
更新日期:2020-11-13 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01591-3
更新日期:2020-10-07 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-19
更新日期:2014-03-01 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1119-0
更新日期:2020-02-19 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0710-0
更新日期:2018-12-19 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:CD44 has been reported to be involved with tumor growth and metastasis and has also been implicated as a CSC marker in hepatocellular carcinoma (HCC). However, the prognostic value of CD44 still remains controversial; hence, we investigated the correlation between CD44 and the clinicopathological features of...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-016-0325-2
更新日期:2016-06-17 00:00:00
abstract:BACKGROUND:In vivo, the transforming growth factor-beta1 (TGF-β1)-induced epithelial to mesenchymal transition (EMT) occurs in seconds during cancer cells intravasation and extravasation. Although it has been established that cellular stiffness can change as a cancer cell transformed, the precise relationship between T...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-20
更新日期:2014-03-03 00:00:00