Abstract:
BACKGROUND:Breast cancer (BrCa) is the most common female malignancy worldwide and has the highest morbidity among all cancers in females. Unfortunately, the mechanisms of BrCa growth and metastasis, which lead to a poor prognosis in BrCa patients, have not been well characterized. METHODS:Immunohistochemistry (IHC) was performed on a BrCa tissue microarray (TMA) containing 80 samples to evaluate ubiquitin protein ligase E3C (UBE3C) expression. In addition, a series of cellular experiments were conducted to reveal the role of UBE3C in BrCa. RESULTS:In this research, we identified UBE3C as an oncogenic factor in BrCa growth and metastasis for the first time. UBE3C expression was upregulated in BrCa tissues compared with adjacent breast tissues. BrCa patients with high nuclear UBE3C expression in tumors showed remarkably worse overall survival (OS) than those with low nuclear expression. Knockdown of UBE3C expression in MCF-7 and MDA-MB-453 BrCa cells inhibited cell proliferation, migration and invasion in vitro, while overexpression of UBE3C in these cells exerted the opposite effects. Moreover, UBE3C promoted β-catenin nuclear accumulation, leading to the activation of the Wnt/β-catenin signaling pathway in BrCa cells. CONCLUSION:Collectively, these results imply that UBE3C plays crucial roles in BrCa development and progression and that UBE3C may be a novel target for the prevention and treatment of BrCa.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Hang C,Zhao S,Wang T,Zhang Ydoi
10.1186/s12935-020-01733-7subject
Has Abstractpub_date
2021-01-06 00:00:00pages
25issue
1issn
1475-2867pii
10.1186/s12935-020-01733-7journal_volume
21pub_type
杂志文章abstract:Background:Newly identified lncRNA zinc finger protein, FOG family member 2 antisense RNA 1 (ZFPM2-AS1) is identified as an oncogenic gene. However, the role of ZFPM2-AS1 in small cell lung cancer (SCLC) is poorly comprehended. Methods:The expression of genes in SCLC tissues and cells was measured by qRT-PCR. Colony f...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1157-7
更新日期:2020-04-03 00:00:00
abstract:: Cancer-initiating cells display aberrant functional and phenotypic characteristics of normal stem cells from which they evolved by accumulation of multiple cytogenetic and/or epigenetic alterations. Signal transduction pathways which are essential for normal stem cell function are abnormally expressed by cancer cells...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-12-24
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abstract:Background:Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property. Cytosine deaminase (CD), which is derived from bacteria or yeast, can convert a relatively nontoxic prodrug 5-fluorocytosine (5-FC) into the active an...
journal_title:Cancer cell international
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abstract:BACKGROUND:miR-222 has been reported to be overexpressed in colorectal cancer and it influences cancer cell proliferation, drug resistance and metastasis. However, the underlying molecular mechanism of miR-222 in colorectal cancer cell invasion and migration has not been thoroughly elucidated to date. METHODS:The cell...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0447-1
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01177-z
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abstract:Background:Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a novel lncRNA-NEAT has not been thoroughly investigated in melanoma cancer. The purposes of this study ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0927-6
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journal_title:Cancer cell international
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abstract:Background:Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with targeted agents. Methods:In the current study, TP53 wild-type cell lines with druggable MAPK pathway muta...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0768-3
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0712-y
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abstract:BACKGROUND:Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-α), which induce apoptosis in target cells. Many tumors express Heme oxygenase 1 (HO-1), and this expression has b...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-014-0100-1
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-9-18
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0693-x
更新日期:2018-12-04 00:00:00
abstract:BACKGROUND:The aim of this study is to explore the expression of alpha-synuclein (α-synuclein) in benign, atypical, and anaplastic meningiomas and determine its role in the malignant progression of meningiomas. METHODS:Expression of α-synuclein was measured in 44 meningioma samples by real-time PCR analysis. The effec...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-016-0361-y
更新日期:2016-11-15 00:00:00
abstract:Background:Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high morbidity and mortality worldwide. MicroRNAs are key regulators of HCC genesis. However, the regulatory role and underlying mechanisms of microRNA in HCC is still limited. Methods:Cyclin B1 (CCNB1) mRNA levels were examined in...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0729-x
更新日期:2019-01-14 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0618-8
更新日期:2018-09-05 00:00:00
abstract:Background:The aim of the study was to explore the association between the SIRT1 single nucleotide polymorphism (SNP) rs3758391 and diffuse large B cell lymphoma (DLBCL) in a Chinese Han population. Methods:206 patients diagnosed with DLBCL and 219 healthy individuals were recruited in the present study. The genotypin...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0659-z
更新日期:2018-10-22 00:00:00
abstract:BACKGROUND:Bladder cancer (BCa) is a malignant tumor that occurs on the mucosa of the bladder, in which dysregulated long non-coding RNAs (lncRNAs) are involved. This study investigated the effect of lncRNA small nucleolar RNA host gene 1 (SNHG14) on the biological characteristics of BCa cells from microRNA (miR)-211-3...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01717-7
更新日期:2021-01-22 00:00:00
abstract:Background:Oxidative stress is responsible for some alterations in the chemical structure and, consequently, in the function of proteins, lipids, and DNA. Recent studies have linked oxidative stress to cancers, particularly thyroid cancer, but the mechanisms remain unclear. Here, we further characterize the role of oxi...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0504-4
更新日期:2018-01-15 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0957-0
更新日期:2019-09-11 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-19
更新日期:2014-03-01 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01518-y
更新日期:2020-09-29 00:00:00
abstract::Colorectal cancer (CRC) is a complex and molecularly heterogeneous disease representing one of the most frequent causes of cancer-related death worldwide. About 8-15% of CRCs harbor a mutation in BRAF gene, a proto-oncogene involved in cell proliferation, differentiation and survival through the MAPK signaling cascade...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-1117-2
更新日期:2020-01-29 00:00:00
abstract:Background:Some studies have investigated the prognostic value exhibited by the Prognostic Nutritional Index (PNI) in patients suffering diffuse large B-cell lymphoma (DLBCL), but varying results were obtained. In order to determine the specific prognostic value more accurately, a meta-analysis was conducted in this st...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01535-x
更新日期:2020-09-15 00:00:00
abstract:Background:Increasing evidences have underlined the importance of long non-coding RNAs (lncRNAs) in human malignancies. LINC00958 has been found involved in some cancers. However, the underlying mechanical performance of LINC00958 in lung adenocarcinoma (LAD) has not been explored yet. Methods:The expression of releva...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1099-0
更新日期:2020-01-23 00:00:00
abstract:Background:T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods:In this study, we collected the bone marrow samples from 17 T-A...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0714-9
更新日期:2019-01-08 00:00:00
abstract:BACKGROUND:Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene predispose individuals to clear cell renal carcinomas, hemangioblastomas, and pheochromocytomas. The VHL gene product forms an ubiquitin E3 ligase complex, with regulation of hypoxia-inducible factor alpha (HIF-α) as its best known funct...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0175-3
更新日期:2015-02-22 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-13-42
更新日期:2013-05-15 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-12-2
更新日期:2012-01-23 00:00:00
abstract:BACKGROUND:Cancer cells, even in the presence of available oxygen, have a glycolysis enhancement. The "aerobic glycolysis" is known as the Warburg effect and it is considered one of the fundamental hallmarks of metabolic alteration during malignant transformation. A feature of many tumors is also a change into ions equ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-014-0077-9
更新日期:2014-08-12 00:00:00
abstract:Background:Melanoma as a type of skin cancer, is associated with a high mortality rate. Therefore, early diagnosis and efficient surgical treatment of this disease is very important. Photodynamic therapy (PDT) involves the activation of a photosensitizer by light at specific wavelength that interacts with oxygen and cr...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01616-x
更新日期:2020-10-29 00:00:00