Prognostic value of CD44 expression in patients with hepatocellular carcinoma: meta-analysis.


BACKGROUND:CD44 has been reported to be involved with tumor growth and metastasis and has also been implicated as a CSC marker in hepatocellular carcinoma (HCC). However, the prognostic value of CD44 still remains controversial; hence, we investigated the correlation between CD44 and the clinicopathological features of HCC by meta-analysis. METHODS:Identification and review of publications assessing clinical or prognostic significance of CD44 expression in HCC until November 1, 2015. A meta-analysis was performed to clarify the association between CD44 expression and clinical outcomes. RESULTS:A total of 14 publications met the criteria and comprised 2235 cases. Analysis of these data showed that CD44 expression was not significantly associated with the tumor differentiation (OR 1.48, 95 % confidence interval [CI] 0.85-2.60, P = 0.17), AFP level of HCC patients (OR 0.83, 95 % CI 0.52-1.33, P = 0.45), or disease-free survival (relative risk [RR] 1.15, 95 % CI, 0.85-1.54; P = 0.36). However, in the identified studies, CD44 expression was highly correlated with tumor TNM classification (OR 2.38, 95 % CI 1.23-4.60; P = 0.01) and decreased overall survival (RR 1.49, 95 % CI, 1.26-1.76; P < 0.00001). CONCLUSIONS:This meta-analysis shows CD44 expression in HCC is connected with decreased overall and thus marks a worse prognosis.


Cancer Cell Int


Luo Y,Tan Y




Has Abstract


2016-06-17 00:00:00










  • Investigation of the apoptotic way induced by digallic acid in human lymphoblastoid TK6 cells.

    abstract:BACKGROUND:The digallic acid (DGA) purified from Pistacia lentiscus. L fruits was investigated for its antiproliferative and apoptotic activities on human lymphoblastoid TK6 cells. METHODS:We attempt to characterize the apoptotic pathway activated by DGA. Apoptosis was detected by DNA fragmentation, PARP cleavage and ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Bhouri W,Boubaker J,Skandrani I,Ghedira K,Chekir Ghedira L

    更新日期:2012-06-11 00:00:00

  • CDK5RAP3 inhibits angiogenesis in gastric neuroendocrine carcinoma by modulating AKT/HIF-1α/VEGFA signaling.

    abstract:Background:Angiogenesis plays critical roles in the progression and metastasis of malignant tumors. Gastric neuroendocrine carcinoma is an uncommon stomach cancer that is rich in blood vessels and exhibits highly malignant biological behavior with a poor prognosis. The role of CDK5RAP3 in GNEC has not been reported to ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Lin JX,Weng XF,Xie XS,Lian NZ,Qiu SL,Wang JB,Lu J,Chen QY,Cao LL,Lin M,Tu RH,Yang YH,Liu SJ,Hu M,Lin YK,Huang CM,Zheng CH,Li P,Xie JW

    更新日期:2019-11-07 00:00:00

  • HMGB1 mediates lipopolysaccharide-induced inflammation via interacting with GPX4 in colon cancer cells.

    abstract:Background:Inflammation is one of a main reason for colon cancer progression and poor prognosis. The high-mobility group box-1 (HMGB1) and glutathione peroxidase 4 (GPX4) are responsible for inflammation, but the relationship between HMGB1 and GPX4 remains unknown about inflammation in colon cancer. Methods:RT-qPCR wa...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Yang Y,Yang L,Jiang S,Yang T,Lan J,Lei Y,Tan H,Pan K

    更新日期:2020-05-29 00:00:00

  • Functional promoter -765 G > C variant in COX-2 gene is associated with the susceptibility of breast cancer in Chinese Han women.

    abstract:BACKGROUND:Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandins synthesis which exists in two isoforms, COX-1 and COX-2. Over-expression of COX-2 was considered to increase the proliferation and enhance the invasiveness of breast cancer cells. It was suggested that genetic variations in COX-2 could influenc...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Gao J,Kang HF,Ma XB,Tang W,Liu D,Zhao Y,Zhang SQ,Guan HT,Lin S,Ren HT,Wang XJ,Dai ZJ

    更新日期:2014-05-06 00:00:00

  • Caspase-2 is involved in cell death induction by taxanes in breast cancer cells.

    abstract:BACKGROUND:We studied the role of caspase-2 in apoptosis induction by taxanes (paclitaxel, novel taxane SB-T-1216) in breast cancer cells using SK-BR-3 (nonfunctional p53, functional caspase-3) and MCF-7 (functional p53, nonfunctional caspase-3) cell lines. RESULTS:Both taxanes induced apoptosis in SK-BR-3 as well as ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Jelínek M,Balušíková K,Kopperová D,Nĕmcová-Fürstová V,Šrámek J,Fidlerová J,Zanardi I,Ojima I,Kovář J

    更新日期:2013-05-15 00:00:00

  • Par6 is an essential mediator of apoptotic response to transforming growth factor beta in NMuMG immortalized mammary cells.

    abstract:BACKGROUND:We previously observed that the TGFbeta-Par6 pathway mediates loss of polarity and apoptosis in NMuMG cells. Here we investigate the contribution of Par6 versus TGFbeta receptor I activation to TGFbeta-induced apoptosis in association with changes in apico-basal polarity. We focus on the effect of Par6 activ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Avery-Cooper G,Doerr M,Gilbert RW,Youssef M,Richard A,Huether P,Viloria-Petit AM

    更新日期:2014-03-01 00:00:00

  • Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF.

    abstract:Background:Carcinoma-associated fibroblasts (CAFs) are dominant components of tumor microenvironment, which has been reported to promote development, progression, and metastasis of cancer. However, the role of CAFs during adhesion process remains unknown. It has been hypothesized that CAFs contribute to adhesion to end...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zhang R,Qi F,Shao S,Li G,Feng Y

    更新日期:2019-07-24 00:00:00

  • Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative.

    abstract:BACKGROUND:The thieno[2,3-b]pyridines were discovered by virtual high throughput screening as potential inhibitors of phospholipase C (PLC) isoforms and showed potent growth inhibitory effects in National Cancer Institute's human tumour cell line panel (NCI60). The mechanism of the anti-proliferative activity of thieno...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Reynisson J,Jaiswal JK,Barker D,D'mello SA,Denny WA,Baguley BC,Leung EY

    更新日期:2016-03-10 00:00:00

  • Polymorphisms of TGFBR1, TLR4 are associated with prognosis of gastric cancer in a Chinese population.

    abstract:Background:Helicobacter pylori (H. pylori)-induced gastric cancer is an intricate progression of immune response against H. pylori infection. IL-16, TGF-β1 and TLR4 pathways were the mediators involved in the immune response. We hypothesized that genetic variations in genes of these pathways have potential susceptibili...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: He B,Xu T,Pan B,Pan Y,Wang X,Dong J,Sun H,Xu X,Liu X,Wang S

    更新日期:2018-11-20 00:00:00

  • Breast cancer pathogenesis is linked to the intra-tumoral estrogen sulfotransferase (hSULT1E1) expressions regulated by cellular redox dependent Nrf-2/NFκβ interplay.

    abstract:Background:Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen fails to bind estrogen-receptor (ER). High estrogen is a known carcinogen in postmenopausal women. Re...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Nazmeen A,Chen G,Ghosh TK,Maiti S

    更新日期:2020-03-04 00:00:00

  • Overexpression of microRNA-29b inhibits epithelial-mesenchymal transition and angiogenesis of colorectal cancer through the ETV4/ERK/EGFR axis.

    abstract:BACKGROUND:Recent studies have reported the involvement of microRNA-29 (miR-29) family members in human cancers through their ability to regulate cellular functions. The present study investigated biological function of miR-29b in colorectal cancer (CRC). METHODS:CRC tissues and adjacent normal tissues were collected ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Leng Y,Chen Z,Ding H,Zhao X,Qin L,Pan Y

    更新日期:2021-01-06 00:00:00

  • Long noncoding RNA ROR promotes breast cancer by regulating the TGF-β pathway.

    abstract:Background:Breast cancer is the leading cause of oncological mortality among women. Efficient detection of cancer cells in an early stage and potent therapeutic agents targeting metastatic tumors are highly needed to improve survival rates. Emerging evidence indicates that lncRNAs (long noncoding RNAs) are critical reg...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Hou L,Tu J,Cheng F,Yang H,Yu F,Wang M,Liu J,Fan J,Zhou G

    更新日期:2018-09-18 00:00:00

  • Pepsin promotes IL-8 signaling-induced epithelial-mesenchymal transition in laryngeal carcinoma.

    abstract:Background:Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting considerable attention. In recent years, the causal role between LPR and laryngeal carcinoma has been debated. The main harmful component of LPR is pepsin, which has been shown to induce mucosal inflammation by damaging the mucous m...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Tan JJ,Wang L,Mo TT,Wang J,Wang MG,Li XP

    更新日期:2019-03-20 00:00:00

  • Eukaryotic translation initiation factor 5A2 (eIF5A2) regulates chemoresistance in colorectal cancer through epithelial mesenchymal transition.

    abstract:BACKGROUND:Chemoresistance is a major obstacle to successful chemotherapy for colorectal cancer. Eukaryotic translation initiation factor 5A2 (eIF5A2), one of the two isoforms in the eIF5A family, has been reported to be a new oncogene in many types of human cancer. In the present study, we aimed to investigate whether...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Bao Y,Lu Y,Wang X,Feng W,Sun X,Guo H,Tang C,Zhang X,Shi Q,Yu H

    更新日期:2015-11-17 00:00:00

  • New insights into the association between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G variants and cancer risk.

    abstract:Background:Many epidemiological studies have investigated association of AXIN2 variants on overall cancer risks; however, the available results remain inconsistent. Methods:An updated analysis was conducted to ascertain a more accurate estimation of the correlation between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G po...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Xu B,Yuan W,Shi L,Zuo L,Wu XY,Zhang W,Wen Q

    更新日期:2019-05-06 00:00:00

  • Metabolic characteristics revealing cell differentiation of nasopharyngeal carcinoma by combining NMR spectroscopy with Raman spectroscopy.

    abstract:Background:The staging system of nasopharyngeal carcinoma (NPC) has close relationship with the degree of cell differentiation, but most NPC patients remain undiagnosed until advanced phases. Novel metabolic markers need to be characterized to support diagnose at an early stage. Methods:Metabolic characteristics of na...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Chen Y,Chen Z,Su Y,Lin D,Chen M,Feng S,Zou C

    更新日期:2019-02-18 00:00:00

  • MicroRNA-222 influences migration and invasion through MIA3 in colorectal cancer.

    abstract:BACKGROUND:miR-222 has been reported to be overexpressed in colorectal cancer and it influences cancer cell proliferation, drug resistance and metastasis. However, the underlying molecular mechanism of miR-222 in colorectal cancer cell invasion and migration has not been thoroughly elucidated to date. METHODS:The cell...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Gao H,Cong X,Zhou J,Guan M

    更新日期:2017-08-29 00:00:00

  • Correction to: miR-484 suppresses proliferation and epithelial-mesenchymal transition by targeting ZEB1 and SMAD2 in cervical cancer cells.

    abstract::[This corrects the article DOI: 10.1186/s12935-017-0407-9.]. ...

    journal_title:Cancer cell international

    pub_type: 已发布勘误


    authors: Hu Y,Xie H,Liu Y,Liu W,Liu M,Tang H

    更新日期:2020-07-17 00:00:00

  • Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer.

    abstract:Background:Kinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of breast cancer. However, the prognostic value of whole family members was poorly done. Our study intends to demonstrate the value of kinesin superfamily members as prognostic biomarkers as well...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Li TF,Zeng HJ,Shan Z,Ye RY,Cheang TY,Zhang YJ,Lu SH,Zhang Q,Shao N,Lin Y

    更新日期:2020-04-15 00:00:00

  • Antibiotics inhibit sphere-forming ability in suspension culture.

    abstract:BACKGROUND:This last decade, a lot of emphasis has been placed on developing new cancer cell culture models, closer to in vivo condition, in order to test new drugs and therapies. In the case of colorectal cancer, the use of patient biopsies to seed 3D primary cultures and mimic tumor initiation necessitates the use of...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Relier S,Yazdani L,Ayad O,Choquet A,Bourgaux JF,Prudhomme M,Pannequin J,Macari F,David A

    更新日期:2016-02-12 00:00:00

  • Granulocyte-macrophage stimulating factor (GM-CSF) increases circulating dendritic cells but does not abrogate suppression of adaptive cellular immunity in patients with metastatic colorectal cancer receiving chemotherapy.

    abstract:BACKGROUND:Advanced cancer and chemotherapy are both associated with immune system suppression. We initiated a clinical trial in patients receiving chemotherapy for metastatic colorectal cancer to determine if administration of GM-CSF in this setting was immunostimulatory. METHODS:Between June, 2003 and January, 2007,...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Martinez M,Ono N,Planutiene M,Planutis K,Nelson EL,Holcombe RF

    更新日期:2012-01-23 00:00:00

  • Increase of IFN-γ and TNF-α production in CD107a + NK-92 cells co-cultured with cervical cancer cell lines pre-treated with the HO-1 inhibitor.

    abstract:BACKGROUND:Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-α), which induce apoptosis in target cells. Many tumors express Heme oxygenase 1 (HO-1), and this expression has b...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Gómez-Lomelí P,Bravo-Cuellar A,Hernández-Flores G,Jave-Suárez LF,Aguilar-Lemarroy A,Lerma-Díaz JM,Domínguez-Rodríguez JR,Sánchez-Reyes K,Ortiz-Lazareno PC

    更新日期:2014-10-01 00:00:00

  • High brain acid soluble protein 1(BASP1) is a poor prognostic factor for cervical cancer and promotes tumor growth.

    abstract:BACKGROUND:The aim of this study was to determine whether brain abundant membrane attached signal protein 1 (BASP1) is a valuable prognostic biomarker for cervical cancer and whether BASP1 regulates the progression of cervical cancer. METHODS:Quantitative real-time PCR, western blotting, and immunohistochemistry were ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Tang H,Wang Y,Zhang B,Xiong S,Liu L,Chen W,Tan G,Li H

    更新日期:2017-10-24 00:00:00

  • Long non-coding RNA CTBP1-AS2 enhances cervical cancer progression via up-regulation of ZNF217 through sponging miR-3163.

    abstract:Background:Long non-coding RNAs (lncRNAs) play significant roles in tumorigenesis and can contribute to identification of novel therapeutic targets for cancers. This paper was aimed at exploring the role of CTBP1 divergent transcript (CTBP1-AS2) in cervical cancer (CC) progression. Methods:qRT-PCR and western blot ass...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Yang S,Shi F,Du Y,Wang Z,Feng Y,Song J,Liu Y,Xiao M

    更新日期:2020-07-28 00:00:00

  • Melatonin and non-small cell lung cancer: new insights into signaling pathways.

    abstract::Non-small-cell lung cancer (NSCLC) is a type of malignancy with progressive metastasis having poor prognosis and lowered survival resulting from late diagnosis. The therapeutic approaches for the treatment of this incurable cancer are chemo- and radiotherapy. Since current treatments are insufficient and because of dr...

    journal_title:Cancer cell international

    pub_type: 杂志文章,评审


    authors: Pourhanifeh MH,Sharifi M,Reiter RJ,Davoodabadi A,Asemi Z

    更新日期:2019-05-16 00:00:00

  • Comprehensive analysis of prognostic alternative splicing signature in cervical cancer.

    abstract:Background:Alternative splicing (AS) is a key factor in protein-coding gene diversity, and is associated with the development and progression of malignant tumours. However, the role of AS in cervical cancer is unclear. Methods:The AS data for cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) were...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Ouyang D,Yang P,Cai J,Sun S,Wang Z

    更新日期:2020-06-08 00:00:00

  • Long noncoding RNA DLX6-AS1 promotes neuroblastoma progression by regulating miR-107/BDNF pathway.

    abstract:Background:Long noncoding RNAs (lncRNAs) play essential roles in tumor progression. However, the functions and targets of lncRNAs in neuroblastoma (NB) progression still remain to be determined. In this study, we aimed to investigate the effect of lncRNA DLX6 antisense RNA 1 (DLX6-AS1) on NB and the underlying mechanis...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zhang HY,Xing MQ,Guo J,Zhao JC,Chen X,Jiang Z,Zhang H,Dong Q

    更新日期:2019-11-27 00:00:00

  • Metapristone (RU486-derivative) inhibits endometrial cancer cell progress through regulating miR-492/Klf5/Nrf1 axis.

    abstract:BACKGROUND:Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene (e.g. PTEN) or microRNAs (e.g. miR-23a and miR-29b). Metapristone is a hormone-related drug, which i...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Chang Y,Hao M,Jia R,Zhao Y,Cai Y,Liu Y

    更新日期:2021-01-07 00:00:00

  • Long noncoding RNA SNHG4 promotes renal cell carcinoma tumorigenesis and invasion by acting as ceRNA to sponge miR-204-5p and upregulate RUNX2.

    abstract:Background:Long noncoding RNAs (lncRNAs) are involved in the tumorigenesis and progression of human cancers, including renal cell carcinoma (RCC). Small nucleolar RNA host gene 4 (SNHG4) is reported to play an essential role in tumor growth and progression. However, the molecular mechanisms and function of SNHG4 in RCC...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Wu J,Liu T,Sun L,Zhang S,Dong G

    更新日期:2020-10-19 00:00:00

  • Alginate-embedded HuH-7 cells increase MMP-9 and reduce OCLN expression in vitro.

    abstract:BACKGROUND:Hepatocellular carcinoma is a common cancer, ranking third in cancer-associated deaths. An important cause of cancer patients' mortality is metastasis. At the start of metastasis progression, there is an epithelial-mesenchymal transition, characterized by matrix degradation, junction reductions and vessels f...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Angiolini VA,Cruz CU,López ML,Simon L,Matte U

    更新日期:2017-01-04 00:00:00