Prognostic value of CD44 expression in patients with hepatocellular carcinoma: meta-analysis.

Abstract:

BACKGROUND:CD44 has been reported to be involved with tumor growth and metastasis and has also been implicated as a CSC marker in hepatocellular carcinoma (HCC). However, the prognostic value of CD44 still remains controversial; hence, we investigated the correlation between CD44 and the clinicopathological features of HCC by meta-analysis. METHODS:Identification and review of publications assessing clinical or prognostic significance of CD44 expression in HCC until November 1, 2015. A meta-analysis was performed to clarify the association between CD44 expression and clinical outcomes. RESULTS:A total of 14 publications met the criteria and comprised 2235 cases. Analysis of these data showed that CD44 expression was not significantly associated with the tumor differentiation (OR 1.48, 95 % confidence interval [CI] 0.85-2.60, P = 0.17), AFP level of HCC patients (OR 0.83, 95 % CI 0.52-1.33, P = 0.45), or disease-free survival (relative risk [RR] 1.15, 95 % CI, 0.85-1.54; P = 0.36). However, in the identified studies, CD44 expression was highly correlated with tumor TNM classification (OR 2.38, 95 % CI 1.23-4.60; P = 0.01) and decreased overall survival (RR 1.49, 95 % CI, 1.26-1.76; P < 0.00001). CONCLUSIONS:This meta-analysis shows CD44 expression in HCC is connected with decreased overall and thus marks a worse prognosis.

journal_name

Cancer Cell Int

authors

Luo Y,Tan Y

doi

10.1186/s12935-016-0325-2

subject

Has Abstract

pub_date

2016-06-17 00:00:00

pages

47

issn

1475-2867

pii

325

journal_volume

16

pub_type

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