当前位置： SCI文献检索 > Cancer Cell International期刊下所有文献 > Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF.

Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF.

Abstract：

Background:Carcinoma-associated fibroblasts (CAFs) are dominant components of tumor microenvironment, which has been reported to promote development, progression, and metastasis of cancer. However, the role of CAFs during adhesion process remains unknown. It has been hypothesized that CAFs contribute to adhesion to endothelial cells of colorectal cancer (CRC) via HGF/c-Met pathway. Methods:Clinical specimen and orthotopic liver metastasis model was used to investigate association between CD44 expression and propensity of metastasis in CRC. Human CRC derived cancer associated fibroblasts was isolated and its effect on migration and adhesion of CRC cells was investigated. We also confirm the conclusion on animal metastasis model. Results:In this study, clinical specimen and orthotopic liver metastatic model indicated that overexpression of CD44 is associated with CRC metastasis, and we found that colorectal cancer-derived CAFs (CC-CAFs) increased the adhesion and migration of CRC cells in vitro through up-regulation of CD44, we also found that CC-CAFs promoted adhesion and liver or lung metastasis in vivo. Mechanistically, we found that the expression of HGF increased tenfolds compared CC-CAFs with adjacent normal fibroblasts, and HGF promoted adhesion through up-regulation of CD44 via HGF/c-MET signal pathway. Conclusions:These results indicated that CC-CAFs-derived HGF induced up-regulation of CD44 which mediated adhesion of CRC cells to endothelial cells, and subsequently resulted in enhancement of metastasis of CRC cells, it could provide a novel therapeutic or preventive target.

journal_name

Cancer Cell Int

journal_title

Cancer cell international

authors

Zhang R,Qi F,Shao S,Li G,Feng Y

doi

10.1186/s12935-019-0914-y

subject

Has Abstract

pub_date

2019-07-24 00:00:00

pages

192

issn

1475-2867

pii

914

journal_volume

19

pub_type

杂志文章

相关文献

Cancer Cell International文献大全
  • Association of TNFAIP8 gene polymorphisms with endometrial cancer in northern Chinese women.

    abstract：Background:Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0827-9

    authors： Liu T,Jiang L,Yu L,Ge T,Wang J,Gao H

    更新日期：2019-04-23 00:00:00

  • LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma cell proliferation and resistance to apoptosis by targeting miR-4656/HDAC11 axis.

    abstract：Background:Dysregulation of long non-coding RNAs (lncRNAs) results in development of human diseases including hepatocellular carcinoma (HCC). Although several HCC related lncRNAs have been reported, the biological functions of many lncRNAs during the development of HCC remains unknown. Methods:The expression of ST8SIA...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01325-5

    authors： Fei Q,Song F,Jiang X,Hong H,Xu X,Jin Z,Zhu X,Dai B,Yang J,Sui C,Xu M

    更新日期：2020-06-11 00:00:00

  • Mitochondrial structure alteration in human prostate cancer cells upon initial interaction with a chemopreventive agent phenethyl isothiocyanate.

    abstract：BACKGROUND:Phenethyl isothiocyanate (PEITC), present naturally in cruciferous vegetables, is a chemopreventive agent. It blocks initiation and post-initiation progression of carcinogenesis. Mechanism study in human prostate cancer cells revealed that PEITC is a dual inhibitor of aberrant DNA hypermethylation and histon...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-14-30

    authors： Xue C,Pasolli HA,Piscopo I,Gros DJ,Liu C,Chen Y,Chiao JW

    更新日期：2014-03-31 00:00:00

  • Expression profile of circular RNA and construction of circular RNA-Micro RNA network in salivary adenoid cystic carcinoma.

    abstract：BACKGROUND:Circular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types of human tumors. So they have been considered as promising candidates as diagnostic and therapeutic targets in cancer. This research aimed to screen the profile of circR...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01681-2

    authors： Han J,Han N,Xu Z,Zhang C,Liu J,Ruan M

    更新日期：2021-01-07 00:00:00

  • Emerging roles of RNA methylation in gastrointestinal cancers.

    abstract：:RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression, particularly in gastrointestinal cancers. RNA methylation has a variety of b...

    journal_title：Cancer cell international

    pub_type： 杂志文章,评审

    doi：10.1186/s12935-020-01679-w

    authors： Xie S,Chen W,Chen K,Chang Y,Yang F,Lin A,Shu Q,Zhou T,Yan X

    更新日期：2020-12-07 00:00:00

  • Melatonin enhances TNF-α-mediated cervical cancer HeLa cells death via suppressing CaMKII/Parkin/mitophagy axis.

    abstract：Background:Tumor necrosis factor-α (TNF-α) immunotherapy controls the progression of human cervical cancer. Here, we explored the detailed molecular mechanisms played by melatonin in human cervical cancer (HeLa cells) death in the presence of TNF-α injury, with a particular attention to the mitochondrial homeostasis. ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0777-2

    authors： Zhao Q,Wang W,Cui J

    更新日期：2019-03-14 00:00:00

  • Repression of GPRC5A is associated with activated STAT3, which contributes to tumor progression of head and neck squamous cell carcinoma.

    abstract：BACKGROUND:G protein-coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with pathologic differentiation grade of oral squamous cell carcinomas (OSCC) and overexpression of GPRC5A gene ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-017-0406-x

    authors： Liu S,Ye D,Wang T,Guo W,Song H,Liao Y,Xu D,Zhu H,Zhang Z,Deng J

    更新日期：2017-03-02 00:00:00

  • New insights into the association between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G variants and cancer risk.

    abstract：Background:Many epidemiological studies have investigated association of AXIN2 variants on overall cancer risks; however, the available results remain inconsistent. Methods:An updated analysis was conducted to ascertain a more accurate estimation of the correlation between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G po...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0840-z

    authors： Xu B,Yuan W,Shi L,Zuo L,Wu XY,Zhang W,Wen Q

    更新日期：2019-05-06 00:00:00

  • LncRNA MEG3 promotes melanoma growth, metastasis and formation through modulating miR-21/E-cadherin axis.

    abstract：Background:Melanoma is the most aggressive type of skin cancer with high mortality rate and poor prognosis. lncRNA MEG3, a tumor suppressor, is closely related to the development of various cancers. However, the role of lncRNA MEG3 in melanoma has seldom been studied. Methods:RT-PCR was used to examine the expressions...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-1087-4

    authors： Wu L,Zhu L,Li Y,Zheng Z,Lin X,Yang C

    更新日期：2020-01-10 00:00:00

  • SMAD6, positively regulated by the DNM3OS-miR-134-5p axis, confers promoting effects to cell proliferation, migration and EMT process in retinoblastoma.

    abstract：Background:Retinoblastoma (RB) is acknowledged to be the commonest intraocular malignancy in infants and children and the outcome of RB patients is unfavorable due to limited early diagnosis and effective therapy. SMAD family member 6 (SMAD6) has been reported in the initiation and progression of human cancers by actin...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-1103-8

    authors： Wang H,Ji X

    更新日期：2020-01-22 00:00:00

  • Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway.

    abstract：Background:Thyroid cancer is the most common type of endocrine malignancy and the incidence rate is rapidly increasing worldwide. Epigallocatechin-3-gallate (EGCG) could suppress cancer growth and induce apoptosis in many types of cancer cells. However, the mechanism of action of EGCG on the growth of human thyroid car...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0762-9

    authors： Wu D,Liu Z,Li J,Zhang Q,Zhong P,Teng T,Chen M,Xie Z,Ji A,Li Y

    更新日期：2019-02-28 00:00:00

  • Autophagy regulation using luteolin: new insight into its anti-tumor activity.

    abstract：:Application of novel methods in cancer therapy is important in terms of management and treatment of the life-threatening disorder. It appears that autophagy is a potential target in cancer therapy, as a variety of drugs targeting autophagy have shown great potential in reducing the viability and proliferation of cance...

    journal_title：Cancer cell international

    pub_type： 杂志文章,评审

    doi：10.1186/s12935-020-01634-9

    authors： Ashrafizadeh M,Ahmadi Z,Farkhondeh T,Samarghandian S

    更新日期：2020-11-04 00:00:00

  • Alginate-embedded HuH-7 cells increase MMP-9 and reduce OCLN expression in vitro.

    abstract：BACKGROUND:Hepatocellular carcinoma is a common cancer, ranking third in cancer-associated deaths. An important cause of cancer patients' mortality is metastasis. At the start of metastasis progression, there is an epithelial-mesenchymal transition, characterized by matrix degradation, junction reductions and vessels f...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-016-0370-x

    authors： Angiolini VA,Cruz CU,López ML,Simon L,Matte U

    更新日期：2017-01-04 00:00:00

  • miR-429 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by downregulation of TLN1.

    abstract：Background:miR-429 and TLN1 have been shown to affect the biological behaviours of many carcinomas. However, their effects in nasopharyngeal carcinoma (NPC) are not yet clear. Here, we investigated their regulatory relationships and effects on NPC cells. Methods:TargetScan was used to predict the regulatory relationsh...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0831-0

    authors： Wang Z,Zhu Z,Lin Z,Luo Y,Liang Z,Zhang C,Chen J,Peng P

    更新日期：2019-04-30 00:00:00

  • Alpha-synuclein contributes to malignant progression of human meningioma via the Akt/mTOR pathway.

    abstract：BACKGROUND:The aim of this study is to explore the expression of alpha-synuclein (α-synuclein) in benign, atypical, and anaplastic meningiomas and determine its role in the malignant progression of meningiomas. METHODS:Expression of α-synuclein was measured in 44 meningioma samples by real-time PCR analysis. The effec...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-016-0361-y

    authors： Ge Y,Xu K

    更新日期：2016-11-15 00:00:00

  • The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling.

    abstract：Background:A number of JmjC domain-containing histone demethylases have been identified and biochemically characterized in mammalian models and humans. JMJD2A is a transcriptional co-factor and enzyme that catalyzes the demethylation of histone H3 lysine 9 and 36 (H3K9 and H3K36). Here in this study, we reported the ro...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01177-z

    authors： Li M,Cheng J,Ma Y,Guo H,Shu H,Huang H,Kuang Y,Yang T

    更新日期：2020-03-30 00:00:00

  • Retraction Note: Down-regulation of miR-133a and miR-539 are associated with unfavorable prognosis in patients suffering from osteosarcoma.

    abstract：:[This retracts the article DOI: 10.1186/s12935-015-0237-6.]. ...

    journal_title：Cancer cell international

    pub_type： 撤回出版物

    doi：10.1186/s12935-016-0359-5

    authors： Mirghasemi A,Taheriazam A,Karbasy SH,Torkaman A,Shakeri M,Yahaghi E,Mokarizadeh A

    更新日期：2016-11-04 00:00:00

  • The prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis.

    abstract：BACKGROUND:CD44 has recently been reported as a cancer stem cell marker in ovarian cancer. However, the clinicopathological and prognostic value of this marker in ovarian cancer remains controversial; Here, we aimed to investigate the correlation between CD44 expression and the clinicopathological features or survival ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-016-0376-4

    authors： Lin J,Ding D

    更新日期：2017-01-05 00:00:00

  • SP1 induced long non-coding RNA LINC00958 overexpression facilitate cell proliferation, migration and invasion in lung adenocarcinoma via mediating miR-625-5p/CPSF7 axis.

    abstract：Background:Increasing evidences have underlined the importance of long non-coding RNAs (lncRNAs) in human malignancies. LINC00958 has been found involved in some cancers. However, the underlying mechanical performance of LINC00958 in lung adenocarcinoma (LAD) has not been explored yet. Methods:The expression of releva...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-1099-0

    authors： Yang L,Li L,Zhou Z,Liu Y,Sun J,Zhang X,Pan H,Liu S

    更新日期：2020-01-23 00:00:00

  • Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma.

    abstract：:BACKGROUND: The aim of this work was to investigate in vitro the putative role of EGR-1 in the growth of glioma cells. EGR-1 expression was examined during the early passages in vitro of 17 primary cell lines grown from 3 grade III and from 14 grade IV malignant astrocytoma explants. The explanted tumors were genetica...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-4-1

    authors： Calogero A,Lombari V,De Gregorio G,Porcellini A,Ucci S,Arcella A,Caruso R,Gagliardi FM,Gulino A,Lanzetta G,Frati L,Mercola D,Ragona G

    更新日期：2004-01-07 00:00:00

  • Activated gastric cancer-associated fibroblasts contribute to the malignant phenotype and 5-FU resistance via paracrine action in gastric cancer.

    abstract：Background:Cancer-associated fibroblasts (CAFs) play important roles in tumor progression. However, the behaviors of activated CAFs in gastric cancer remain to be determined. The aim of the present study was to investigate the correlations between activated gastric CAFs and the prognosis of patients with gastric cancer...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-018-0599-7

    authors： Ma Y,Zhu J,Chen S,Li T,Ma J,Guo S,Hu J,Yue T,Zhang J,Wang P,Wang X,Chen G,Liu Y

    更新日期：2018-07-20 00:00:00

  • A novel chalcone derivative suppresses melanoma cell growth through targeting Fyn/Stat3 pathway.

    abstract：Background:Fyn has been documented to have oncogenic features in multiple tumors, which might be a potential therapeutic target, however, few studies on the function role of Fyn and its specific inhibitors in melanoma. Methods:We investigated the impacts of Fyn and its inhibitor Lj-1-60 on melanoma through bioinformat...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01336-2

    authors： Tang L,Long J,Li K,Zhang X,Chen X,Peng C

    更新日期：2020-06-18 00:00:00

  • LncRNA MIR4435-2HG triggers ovarian cancer progression by regulating miR-128-3p/CKD14 axis.

    abstract：Background:Accumulating studies showed that long noncoding RNAs (lncRNAs) played vital roles in cancer progression. LncRNA MIR4435-2HG was proved to act as an oncogene in various tumors. However, the underlying function of MIR4435-2HG in ovarian cancer (OC) remains unclear. Methods:The expression levels of MIR4435-2HG...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01227-6

    authors： Zhu L,Wang A,Gao M,Duan X,Li Z

    更新日期：2020-05-01 00:00:00

  • MiR-7 inhibits progression of hepatocarcinoma by targeting KLF-4 and promises a novel diagnostic biomarker.

    abstract：BACKGROUND:MicroRNAs are 22-24 nt non-coding RNAs that bind to the 3' UTR of target mRNAs, thereby inducing mRNA degradation or inhibiting mRNA translation. Due to their implication in the regulation of post-transcriptional processes, the role of miRNAs in hepatocellular carcinoma (HCC) has been extensively studied. Ho...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-017-0386-x

    authors： Wu W,Liu S,Liang Y,Zhou Z,Liu X

    更新日期：2017-02-21 00:00:00

  • An overview of the role of platelets in angiogenesis, apoptosis and autophagy in chronic myeloid leukaemia.

    abstract：:Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-related death. Chronic myeloid leukaemia (CML) is a chronic leukaemia of the haematopoietic stem cells affecting...

    journal_title：Cancer cell international

    pub_type： 杂志文章,评审

    doi：10.1186/s12935-017-0460-4

    authors： Repsold L,Pool R,Karodia M,Tintinger G,Joubert AM

    更新日期：2017-10-30 00:00:00

  • Pathobiology of cancer metastasis: a short account.

    abstract：: Cancer-initiating cells display aberrant functional and phenotypic characteristics of normal stem cells from which they evolved by accumulation of multiple cytogenetic and/or epigenetic alterations. Signal transduction pathways which are essential for normal stem cell function are abnormally expressed by cancer cells...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-12-24

    authors： Feller L,Kramer B,Lemmer J

    更新日期：2012-06-07 00:00:00

  • HMGB1 mediates lipopolysaccharide-induced inflammation via interacting with GPX4 in colon cancer cells.

    abstract：Background:Inflammation is one of a main reason for colon cancer progression and poor prognosis. The high-mobility group box-1 (HMGB1) and glutathione peroxidase 4 (GPX4) are responsible for inflammation, but the relationship between HMGB1 and GPX4 remains unknown about inflammation in colon cancer. Methods:RT-qPCR wa...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01289-6

    authors： Yang Y,Yang L,Jiang S,Yang T,Lan J,Lei Y,Tan H,Pan K

    更新日期：2020-05-29 00:00:00

  • Understanding the colon cancer stem cells and perspectives on treatment.

    abstract：:An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiation, growth, invasion and metastasis are promoted by CSCs. An important reason for the widespread interest in th...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-015-0163-7

    authors： Garza-Treviño EN,Said-Fernández SL,Martínez-Rodríguez HG

    更新日期：2015-01-28 00:00:00

  • Association between underexpression of microrna-203 and clinicopathological significance in hepatocellular carcinoma tissues.

    abstract：BACKGROUND:Although recent studies have shown the utility of miR-203 as a cancer-relevant biomarker, the validated clinical significance of miR-203 in HCC remains obscure. The aim of the present study was to evaluate the relationship between miR-203 expression and clinicopathological features in HCC patients. METHODS:...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-015-0214-0

    authors： Liu Y,Ren F,Rong M,Luo Y,Dang Y,Chen G

    更新日期：2015-06-18 00:00:00

  • Correction to: Identification of prognosis-related genes and construction of multi-regulatory networks in pancreatic cancer microenvironment by bioinformatics analysis.

    abstract：:[This corrects the article DOI: 10.1186/s12935-020-01426-1.]. ...

    journal_title：Cancer cell international

    pub_type： 已发布勘误

    doi：10.1186/s12935-020-01482-7

    authors： Li T,Liu Q,Zhang R,Liao Q,Zhao Y

    更新日期：2020-08-18 00:00:00