Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF.


Background:Carcinoma-associated fibroblasts (CAFs) are dominant components of tumor microenvironment, which has been reported to promote development, progression, and metastasis of cancer. However, the role of CAFs during adhesion process remains unknown. It has been hypothesized that CAFs contribute to adhesion to endothelial cells of colorectal cancer (CRC) via HGF/c-Met pathway. Methods:Clinical specimen and orthotopic liver metastasis model was used to investigate association between CD44 expression and propensity of metastasis in CRC. Human CRC derived cancer associated fibroblasts was isolated and its effect on migration and adhesion of CRC cells was investigated. We also confirm the conclusion on animal metastasis model. Results:In this study, clinical specimen and orthotopic liver metastatic model indicated that overexpression of CD44 is associated with CRC metastasis, and we found that colorectal cancer-derived CAFs (CC-CAFs) increased the adhesion and migration of CRC cells in vitro through up-regulation of CD44, we also found that CC-CAFs promoted adhesion and liver or lung metastasis in vivo. Mechanistically, we found that the expression of HGF increased tenfolds compared CC-CAFs with adjacent normal fibroblasts, and HGF promoted adhesion through up-regulation of CD44 via HGF/c-MET signal pathway. Conclusions:These results indicated that CC-CAFs-derived HGF induced up-regulation of CD44 which mediated adhesion of CRC cells to endothelial cells, and subsequently resulted in enhancement of metastasis of CRC cells, it could provide a novel therapeutic or preventive target.


Cancer Cell Int


Zhang R,Qi F,Shao S,Li G,Feng Y




Has Abstract


2019-07-24 00:00:00










  • LncRNA HOXA-AS2 promotes glioblastoma carcinogenesis by targeting miR-885-5p/RBBP4 axis.

    abstract:BACKGROUND:LncRNA HOXA-AS2 has been found in the literature to deteriorate glioblastoma. However, its regulatory mechanism is yet to be fully investigated. Our study focused chiefly on the interaction and role of the HOXA-AS2/miR-885-5p/RBBP4 axis in the development of glioblastoma. METHODS:qRT-PCR analysis was perfor...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Shou J,Gao H,Cheng S,Wang B,Guan H

    更新日期:2021-01-11 00:00:00

  • Phorbol myristate acetate and Bryostatin 1 rescue IFN-gamma inducibility of MHC class II molecules in LS1034 colorectal carcinoma cell line.

    abstract:BACKGROUND:The expression of major histocompatibility complex class II (MHCII) antigens in both mouse and human tumors is rare, and these antigens are not easily inducible by IFN-gamma (IFNg). Since MHCII may play an important role in the development of host antitumor immune response, we explored the possibility of res...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Kudinov Y,Wiseman CL,Kharazi AI

    更新日期:2003-03-25 00:00:00

  • Bioinformatics analysis combined with experiments to explore potential prognostic factors for pancreatic cancer.

    abstract:Background:Pancreatic cancer is a common malignant tumor of the digestive tract. It has a high degree of malignancy and poor prognosis. Finding effective molecular markers has great significance for pancreatic cancer diagnosis and treatment. This study aimed to investigate DLGAP5 expression in pancreatic cancer and exp...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Ke MJ,Ji LD,Li YX

    更新日期:2020-08-08 00:00:00

  • Oncogenic UBE3C promotes breast cancer progression by activating Wnt/β-catenin signaling.

    abstract:BACKGROUND:Breast cancer (BrCa) is the most common female malignancy worldwide and has the highest morbidity among all cancers in females. Unfortunately, the mechanisms of BrCa growth and metastasis, which lead to a poor prognosis in BrCa patients, have not been well characterized. METHODS:Immunohistochemistry (IHC) w...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Hang C,Zhao S,Wang T,Zhang Y

    更新日期:2021-01-06 00:00:00

  • Mammaglobin as a potential molecular target for breast cancer drug delivery.

    abstract:BACKGROUND:Mammaglobin (MAM) has been used as a specific molecular marker for breast cancer diagnosis. Recently, several groups of researchers proposed a number of therapeutic strategies targeting this molecule. Some of the strategies are based upon an essential but not demonstrated hypothesis - mammaglobin is associat...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zuo L,Li L,Wang Q,Fleming TP,You S

    更新日期:2009-03-23 00:00:00

  • The histone demethylase JMJD2A promotes glioma cell growth via targeting Akt-mTOR signaling.

    abstract:Background:A number of JmjC domain-containing histone demethylases have been identified and biochemically characterized in mammalian models and humans. JMJD2A is a transcriptional co-factor and enzyme that catalyzes the demethylation of histone H3 lysine 9 and 36 (H3K9 and H3K36). Here in this study, we reported the ro...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Li M,Cheng J,Ma Y,Guo H,Shu H,Huang H,Kuang Y,Yang T

    更新日期:2020-03-30 00:00:00

  • Overexpression of CD59 inhibits apoptosis of T-acute lymphoblastic leukemia via AKT/Notch1 signaling pathway.

    abstract:Background:T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods:In this study, we collected the bone marrow samples from 17 T-A...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Jia Y,Qi Y,Wang Y,Ma X,Xu Y,Wang J,Zhang X,Gao M,Cong B,Han S

    更新日期:2019-01-08 00:00:00

  • Epigallocatechin-3-gallate inhibits the growth and increases the apoptosis of human thyroid carcinoma cells through suppression of EGFR/RAS/RAF/MEK/ERK signaling pathway.

    abstract:Background:Thyroid cancer is the most common type of endocrine malignancy and the incidence rate is rapidly increasing worldwide. Epigallocatechin-3-gallate (EGCG) could suppress cancer growth and induce apoptosis in many types of cancer cells. However, the mechanism of action of EGCG on the growth of human thyroid car...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Wu D,Liu Z,Li J,Zhang Q,Zhong P,Teng T,Chen M,Xie Z,Ji A,Li Y

    更新日期:2019-02-28 00:00:00

  • Antibiotics inhibit sphere-forming ability in suspension culture.

    abstract:BACKGROUND:This last decade, a lot of emphasis has been placed on developing new cancer cell culture models, closer to in vivo condition, in order to test new drugs and therapies. In the case of colorectal cancer, the use of patient biopsies to seed 3D primary cultures and mimic tumor initiation necessitates the use of...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Relier S,Yazdani L,Ayad O,Choquet A,Bourgaux JF,Prudhomme M,Pannequin J,Macari F,David A

    更新日期:2016-02-12 00:00:00

  • Potential Role of circPVT1 as a proliferative factor and treatment target in esophageal carcinoma.

    abstract:Background:Many circRNAs have been reported to play important roles in cancer development and have the potential to serve as a novel class of biomarkers for clinical diagnosis. However, the role of circRNAs in esophageal carcinoma (EC) remains unclear. In the current study, we investigated the potential role of circPVT...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zhong R,Chen Z,Mo T,Li Z,Zhang P

    更新日期:2019-10-15 00:00:00

  • Expression profile analysis identifies IER3 to predict overall survival and promote lymph node metastasis in tongue cancer.

    abstract:Background:Lymph node metastasis is one of the most important factors affecting the prognosis of tongue cancer, and the molecular mechanism regulating lymph node metastasis of tongue cancer is poorly known. Methods:The gene expression dataset GSE2280 and The Cancer Genome Atlas (TCGA) tongue cancer dataset were downlo...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Xiao F,Dai Y,Hu Y,Lu M,Dai Q

    更新日期:2019-11-21 00:00:00

  • Survivin: a unique target for tumor therapy.

    abstract::Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved in inhibition of apoptosis and regulation of cell cycle. These functional attributes make Survivin a unique protein exhibiting divergent functions i.e. regulating cell proliferation and cell death. Expression pattern of Su...

    journal_title:Cancer cell international

    pub_type: 杂志文章,评审


    authors: Garg H,Suri P,Gupta JC,Talwar GP,Dubey S

    更新日期:2016-06-23 00:00:00

  • A nomogram based on 9-lncRNAs signature for improving prognostic prediction of clear cell renal cell carcinoma.

    abstract:Background:Abnormal expressions of long noncoding RNAs (lncRNAs) are very common in clear cell renal cell carcinoma (ccRCC), and some of these have been reported to be highly correlated with prognosis of ccRCC patients. Methods:"edgeR" AND "DEseq" R packages were used to explore differentially expressed genes (DEGs) b...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Jiang W,Guo Q,Wang C,Zhu Y

    更新日期:2019-08-05 00:00:00

  • Expression profile of circular RNA and construction of circular RNA-Micro RNA network in salivary adenoid cystic carcinoma.

    abstract:BACKGROUND:Circular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types of human tumors. So they have been considered as promising candidates as diagnostic and therapeutic targets in cancer. This research aimed to screen the profile of circR...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Han J,Han N,Xu Z,Zhang C,Liu J,Ruan M

    更新日期:2021-01-07 00:00:00

  • Mst1 overexpression combined with Yap knockdown augments thyroid carcinoma apoptosis via promoting MIEF1-related mitochondrial fission and activating the JNK pathway.

    abstract:Background:Cancer cell viability is strongly modulated by the Hippo pathway, which includes mammalian STE20-like protein kinase 1 (Mst1) and yes-associated protein (Yap). Although the roles of Mst1 and Yap in thyroid carcinoma cell death have been fully addressed, no study has determined whether differential modificati...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zhang X,Li F,Cui Y,Liu S,Sun H

    更新日期:2019-05-22 00:00:00

  • Long noncoding RNA ROR promotes breast cancer by regulating the TGF-β pathway.

    abstract:Background:Breast cancer is the leading cause of oncological mortality among women. Efficient detection of cancer cells in an early stage and potent therapeutic agents targeting metastatic tumors are highly needed to improve survival rates. Emerging evidence indicates that lncRNAs (long noncoding RNAs) are critical reg...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Hou L,Tu J,Cheng F,Yang H,Yu F,Wang M,Liu J,Fan J,Zhou G

    更新日期:2018-09-18 00:00:00

  • Is systems biology a promising approach to resolve controversies in cancer research?

    abstract:: At the beginning of the 21st century cancer research has reached an impasse similar to that experienced in developmental biology in the first decades of the 20th century when conflicting results and interpretations co-existed for a long time until these differences were resolved and contradictions were eliminated. In...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Soto AM,Sonnenschein C

    更新日期:2012-03-26 00:00:00

  • Long non-coding RNA LBX2-AS1 enhances glioma proliferation through downregulating microRNA-491-5p.

    abstract:Background:Dysregulation of lncRNAs is frequent in glioma and has emerged as an important mechanism involved in tumorigenesis. Previous analysis of Chinese Glioma Genome Atlas (CGGA) database indicated that LBX2-AS1 expression is one of differentially expression lncRNA between lower grade glioma (LGG) (grade II and III...

    journal_title:Cancer cell international

    pub_type: 杂志文章,收录出版


    authors: Chen Q,Gao J,Zhao Y,Hou R

    更新日期:2020-08-26 00:00:00

  • Extracellular and macropinocytosis internalized ATP work together to induce epithelial-mesenchymal transition and other early metastatic activities in lung cancer.

    abstract:Background:Extracellular ATP (eATP) was shown to induce epithelial-mesenchymal transition (EMT), a very important early process in metastasis, in cancer cells via purinergic receptor signaling. However, the exact induction mechanisms are far from fully known. We previously described that eATP is internalized by cancer ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Cao Y,Wang X,Li Y,Evers M,Zhang H,Chen X

    更新日期:2019-10-01 00:00:00

  • Ultraviolet-A radiation induces changes in cyclin G gene expression in mouse melanoma B16-F1 cells.

    abstract:BACKGROUND:We have previously shown that ultraviolet-A (UVA) radiation enhances metastatic lung colonization capacity of B16-F1 melanoma cells. The aim of this study was to examine changes in expression profile of genes in mouse melanoma B16-F1 cells exposed to UVA radiation. RESULTS:B16-F1 melanoma cells were exposed...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Pastila R,Leszczynski D

    更新日期:2007-05-02 00:00:00

  • PD-1 and PD-L1 correlated gene expression profiles and their association with clinical outcomes of breast cancer.

    abstract:Background:Immunotherapies that targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have obtained prominent success in breast cancer (BC). However, not all the patients benefit from the antibody therapy. This study aimed to identify PD-1/PD-L1 correlated genes and pathways as well as investig...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Jiang C,Cao S,Li N,Jiang L,Sun T

    更新日期:2019-09-09 00:00:00

  • The mRNA expression of SATB1 and SATB2 in human breast cancer.

    abstract:BACKGROUND:SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. In this study, the level of mRNA expression of SATB1 a...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Patani N,Jiang W,Mansel R,Newbold R,Mokbel K

    更新日期:2009-07-30 00:00:00

  • MiR-591 functions as tumor suppressor in breast cancer by targeting TCF4 and inhibits Hippo-YAP/TAZ signaling pathway.

    abstract:Background:MicroRNAs have been involved in regulating crucial biological function in some tumors. However, the clinical role and functional effects of miR-591 in breast cancer remain unknown. Methods:The expression of miR-591 was detected in breast cancer tissues and their paired normal tissues by qRT-PCR. Functional ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Huang X,Tang F,Weng Z,Zhou M,Zhang Q

    更新日期:2019-04-24 00:00:00

  • SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response.

    abstract:Background:The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. USP28 controls hypoxia-dependent angiogenesis and metastasis by preventi...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Du SC,Zhu L,Wang YX,Liu J,Zhang D,Chen YL,Peng Q,Liu W,Liu B

    更新日期:2019-01-03 00:00:00

  • Curcumin reduces mitomycin C resistance in breast cancer stem cells by regulating Bcl-2 family-mediated apoptosis.

    abstract:BACKGROUND:Curcumin, a natural compound derived from the turmeric rhizome Curcuma longa Linn, has anticancer and chemoresistance reduction biological activities. We evaluated the efficacy of curcumin in sensitizing chemotherapy drugs through regulation of Bcl-2-mediated apoptosis in breast cancer stem-like cells (BCSCs...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zhou QM,Sun Y,Lu YY,Zhang H,Chen QL,Su SB

    更新日期:2017-09-26 00:00:00

  • Role of IGF-1/IGF-1R in regulation of invasion in DU145 prostate cancer cells.

    abstract:BACKGROUND:Prostate cancer progression to androgen independence is the primary cause of mortality by this tumor type. The IGF-1/IGF-1R axis is well known to contribute to prostate cancer initiation, but its contribution to invasiveness and the downstream signalling mechanisms that are involved are unclear at present. ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Saikali Z,Setya H,Singh G,Persad S

    更新日期:2008-07-03 00:00:00

  • Prognostic values, ceRNA network, and immune regulation function of SDPR in KRAS-mutant lung cancer.

    abstract:BACKGROUND:Serum Deprivation Protein Response (SDPR) plays an important role in formation of pulmonary alveoli. However, the functions and values of SDPR in lung cancer remain unknown. We explored prognostic value, expression pattern, and biological function of SDPR in non-small cell lung cancer (NSCLC) and KRAS-mutant...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Luo X,Peng S,Ding S,Zeng Q,Wang R,Ma Y,Chen S,Wang Y,Wang W

    更新日期:2021-01-12 00:00:00

  • Long noncoding RNA DLX6-AS1 promotes neuroblastoma progression by regulating miR-107/BDNF pathway.

    abstract:Background:Long noncoding RNAs (lncRNAs) play essential roles in tumor progression. However, the functions and targets of lncRNAs in neuroblastoma (NB) progression still remain to be determined. In this study, we aimed to investigate the effect of lncRNA DLX6 antisense RNA 1 (DLX6-AS1) on NB and the underlying mechanis...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zhang HY,Xing MQ,Guo J,Zhao JC,Chen X,Jiang Z,Zhang H,Dong Q

    更新日期:2019-11-27 00:00:00

  • ITK inhibition induced in vitro and in vivo anti-tumor activity through downregulating TCR signaling pathway in malignant T cell lymphoma.

    abstract:Background:Angioimmunoblastic T cell lymphoma (AITL) is a distinct subtype of peripheral T cell lymphoma and associated with poor outcomes. The activation status of T cell receptor (TCR) signaling has recently become a focus of attention in terms of the therapeutic targets. However, the molecular pathogenesis mechanism...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Liu Y,Wang X,Deng L,Ping L,Shi Y,Zheng W,Lin N,Wang X,Tu M,Xie Y,Liu W,Ying Z,Zhang C,Pan Z,Wang X,Ding N,Song Y,Zhu J

    更新日期:2019-02-14 00:00:00

  • miR-206 as a prognostic and sensitivity biomarker for platinum chemotherapy in epithelial ovarian cancer.

    abstract:BACKGROUND:Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. The purposes of this study were to e...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Yu X,Zhang X,Wang G,Wang B,Ding Y,Zhao J,Liu H,Cui S

    更新日期:2020-11-03 00:00:00