The prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis.

abstract：Background:Breast cancer is the leading cause of oncological mortality among women. Efficient detection of cancer cells in an early stage and potent therapeutic agents targeting metastatic tumors are highly needed to improve survival rates. Emerging evidence indicates that lncRNAs (long noncoding RNAs) are critical reg...

journal_title：Cancer cell international

authors： Hou L,Tu J,Cheng F,Yang H,Yu F,Wang M,Liu J,Fan J,Zhou G

更新日期：2018-09-18 00:00:00

abstract：Background:Helicobacter pylori (H. pylori)-induced gastric cancer is an intricate progression of immune response against H. pylori infection. IL-16, TGF-β1 and TLR4 pathways were the mediators involved in the immune response. We hypothesized that genetic variations in genes of these pathways have potential susceptibili...

journal_title：Cancer cell international

authors： He B,Xu T,Pan B,Pan Y,Wang X,Dong J,Sun H,Xu X,Liu X,Wang S

更新日期：2018-11-20 00:00:00

abstract：Background:To investigate the expression of RASSF-1A in oral squamous cell carcinoma (OSCC) and adjacent tissues, and to explore its mechanism of action in the development of OSCC. Methods:RASSF-1A and proliferation-related protein expression in clinical and OSCC mouse models were detected by qPCR and western blot. In...

journal_title：Cancer cell international

authors： Sun J

更新日期：2019-08-13 00:00:00

abstract：Background:Immunotherapies that targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have obtained prominent success in breast cancer (BC). However, not all the patients benefit from the antibody therapy. This study aimed to identify PD-1/PD-L1 correlated genes and pathways as well as investig...

journal_title：Cancer cell international

authors： Jiang C,Cao S,Li N,Jiang L,Sun T

更新日期：2019-09-09 00:00:00

abstract：Background:The hypoxic tumor microenvironment accelerates the invasion and migration of colorectal cancer (CRC) cells. The aim of this study was to develop and validate a hypoxia gene signature for predicting the outcome in stage I/II CRC patients that have limited therapeutic options. Methods:The hypoxic gene signatu...

journal_title：Cancer cell international

authors： Zou YF,Rong YM,Tan YX,Xiao J,Yu ZL,Chen YF,Ke J,Li CH,Chen X,Wu XJ,Lan P,Lin XT,Gao F

更新日期：2019-09-23 00:00:00

abstract：Background:Long noncoding RNAs (lncRNAs) are involved in the tumorigenesis and progression of human cancers, including renal cell carcinoma (RCC). Small nucleolar RNA host gene 4 (SNHG4) is reported to play an essential role in tumor growth and progression. However, the molecular mechanisms and function of SNHG4 in RCC...

journal_title：Cancer cell international

authors： Wu J,Liu T,Sun L,Zhang S,Dong G

更新日期：2020-10-19 00:00:00

abstract：Background:Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with targeted agents. Methods:In the current study, TP53 wild-type cell lines with druggable MAPK pathway muta...

journal_title：Cancer cell international

authors： Wu CE,Koay TS,Ho YH,Lovat P,Lunec J

更新日期：2019-03-07 00:00:00

abstract：OBJECTIVE:To explore the relationship between tumor necrosis factor receptor-associated factor 6 (TRAF6) and the clinicopathological features in HCC as well as its biological function. METHODS:Totally, 412 liver tissues were collected, including 171 hepatocellular carcinoma (HCC) and their corresponding non-tumor tiss...

journal_title：Cancer cell international

authors： Li JJ,Luo J,Lu JN,Liang XN,Luo YH,Liu YR,Yang J,Ding H,Qin GH,Yang LH,Dang YW,Yang H,Chen G

更新日期：2016-09-29 00:00:00

abstract：Background:Many epidemiological studies have investigated association of AXIN2 variants on overall cancer risks; however, the available results remain inconsistent. Methods:An updated analysis was conducted to ascertain a more accurate estimation of the correlation between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G po...

journal_title：Cancer cell international

authors： Xu B,Yuan W,Shi L,Zuo L,Wu XY,Zhang W,Wen Q

更新日期：2019-05-06 00:00:00

abstract：Background:LncRNAs are key regulators in cancer. The current study explored the role of lncRNA LINC00261 (LINC00261) in lung cancer (LC). Methods:Expression of LINC00261 in LC tissues and cells was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Pearson's Chi square test and Kaplan-Meier anal...

journal_title：Cancer cell international

authors： Guo C,Shi H,Shang Y,Zhang Y,Cui J,Yu H

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:MicroRNAs are 22-24 nt non-coding RNAs that bind to the 3' UTR of target mRNAs, thereby inducing mRNA degradation or inhibiting mRNA translation. Due to their implication in the regulation of post-transcriptional processes, the role of miRNAs in hepatocellular carcinoma (HCC) has been extensively studied. Ho...

journal_title：Cancer cell international

authors： Wu W,Liu S,Liang Y,Zhou Z,Liu X

更新日期：2017-02-21 00:00:00

abstract：BACKGROUND:We studied the role of caspase-2 in apoptosis induction by taxanes (paclitaxel, novel taxane SB-T-1216) in breast cancer cells using SK-BR-3 (nonfunctional p53, functional caspase-3) and MCF-7 (functional p53, nonfunctional caspase-3) cell lines. RESULTS:Both taxanes induced apoptosis in SK-BR-3 as well as ...

journal_title：Cancer cell international

authors： Jelínek M,Balušíková K,Kopperová D,Nĕmcová-Fürstová V,Šrámek J,Fidlerová J,Zanardi I,Ojima I,Kovář J

更新日期：2013-05-15 00:00:00

abstract：Background:Angioimmunoblastic T cell lymphoma (AITL) is a distinct subtype of peripheral T cell lymphoma and associated with poor outcomes. The activation status of T cell receptor (TCR) signaling has recently become a focus of attention in terms of the therapeutic targets. However, the molecular pathogenesis mechanism...

journal_title：Cancer cell international

authors： Liu Y,Wang X,Deng L,Ping L,Shi Y,Zheng W,Lin N,Wang X,Tu M,Xie Y,Liu W,Ying Z,Zhang C,Pan Z,Wang X,Ding N,Song Y,Zhu J

更新日期：2019-02-14 00:00:00

abstract：Background:Although major driver gene have been identified, the complex molecular heterogeneity of renal cell cancer (RCC) remains unclear. Therefore, more relevant genes need to be identified to explain the pathogenesis of renal cancer. Methods:Microarray datasets GSE781, GSE6344, GSE53000 and GSE68417 were downloade...

journal_title：Cancer cell international

authors： Chen Y,Gu D,Wen Y,Yang S,Duan X,Lai Y,Yang J,Yuan D,Khan A,Wu W,Zeng G

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is an aggressive cancer with high mortality and morbidity worldwide. The limited clinically relevant model has impeded the development of effective HCC treatment strategy. Patient-derived xenograft (PDX) models retain most of the characteristics of original tumors and were show...

journal_title：Cancer cell international

authors： Cheung PF,Yip CW,Ng LW,Lo KW,Chow C,Chan KF,Cheung TT,Cheung ST

更新日期：2016-06-08 00:00:00

abstract：Background:Retinoblastoma (RB) is acknowledged to be the commonest intraocular malignancy in infants and children and the outcome of RB patients is unfavorable due to limited early diagnosis and effective therapy. SMAD family member 6 (SMAD6) has been reported in the initiation and progression of human cancers by actin...

journal_title：Cancer cell international

authors： Wang H,Ji X

更新日期：2020-01-22 00:00:00

abstract：:BACKGROUND: We describe an alternative method to determine mRNA half-life (t1/2) based on the Real-Time RT-PCR procedure. This approach was evaluated by using the beta-actin gene as a reference molecule for measuring of mRNA stability. RESULTS: Human leukemia Nalm-6 and CCRF-CEM cells were treated with various concent...

journal_title：Cancer cell international

authors： Leclerc GJ,Leclerc GM,Barredo JC

更新日期：2002-03-07 00:00:00

abstract：Background:Cholangiocarcinoma (CCA) is an invasive malignancy arising from biliary epithelial cells; it is the most common primary tumour of the bile tract and has a poor prognosis. The aim of this study was to screen prognostic biomarkers for CCA by integrated multiomics analysis. Methods:The GSE32225 dataset was der...

journal_title：Cancer cell international

authors： Da Z,Gao L,Su G,Yao J,Fu W,Zhang J,Zhang X,Pei Z,Yue P,Bai B,Lin Y,Meng W,Li X

更新日期：2020-04-22 00:00:00

abstract：BACKGROUND:The expression of major histocompatibility complex class II (MHCII) antigens in both mouse and human tumors is rare, and these antigens are not easily inducible by IFN-gamma (IFNg). Since MHCII may play an important role in the development of host antitumor immune response, we explored the possibility of res...

journal_title：Cancer cell international

authors： Kudinov Y,Wiseman CL,Kharazi AI

更新日期：2003-03-25 00:00:00

abstract：Background:Transgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that transgelin was up-regulated in node-positive colorectal cancer (CRC) versus node-negative disease. Over-expression of TAGLN affected the expression of 256 downstream transcri...

journal_title：Cancer cell international

authors： Lew ZX,Zhou HM,Fang YY,Ye Z,Zhong W,Yang XY,Yu Z,Chen DY,Luo SM,Chen LF,Lin Y

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:We have previously shown that ultraviolet-A (UVA) radiation enhances metastatic lung colonization capacity of B16-F1 melanoma cells. The aim of this study was to examine changes in expression profile of genes in mouse melanoma B16-F1 cells exposed to UVA radiation. RESULTS:B16-F1 melanoma cells were exposed...

journal_title：Cancer cell international

authors： Pastila R,Leszczynski D

更新日期：2007-05-02 00:00:00

abstract：Background:Angiogenesis plays critical roles in the progression and metastasis of malignant tumors. Gastric neuroendocrine carcinoma is an uncommon stomach cancer that is rich in blood vessels and exhibits highly malignant biological behavior with a poor prognosis. The role of CDK5RAP3 in GNEC has not been reported to ...

journal_title：Cancer cell international

authors： Lin JX,Weng XF,Xie XS,Lian NZ,Qiu SL,Wang JB,Lu J,Chen QY,Cao LL,Lin M,Tu RH,Yang YH,Liu SJ,Hu M,Lin YK,Huang CM,Zheng CH,Li P,Xie JW

更新日期：2019-11-07 00:00:00

abstract：BACKGROUND:Mammaglobin (MAM) has been used as a specific molecular marker for breast cancer diagnosis. Recently, several groups of researchers proposed a number of therapeutic strategies targeting this molecule. Some of the strategies are based upon an essential but not demonstrated hypothesis - mammaglobin is associat...

journal_title：Cancer cell international

authors： Zuo L,Li L,Wang Q,Fleming TP,You S

更新日期：2009-03-23 00:00:00

abstract：BACKGROUND:BRAF inhibitors are effective anticancer agents in BRAF-mutated melanomas. By contrast, evidences about sensitivity of thyroid carcinomas to BRAF inhibition are conflicting and it has been proposed that BRAF V600E thyroid carcinoma cells are less sensitive to BRAF inhibitors due to activation of parallel sig...

journal_title：Cancer cell international

authors： Notarangelo T,Sisinni L,Condelli V,Landriscina M

更新日期：2017-10-04 00:00:00

abstract：Background:miR-429 and TLN1 have been shown to affect the biological behaviours of many carcinomas. However, their effects in nasopharyngeal carcinoma (NPC) are not yet clear. Here, we investigated their regulatory relationships and effects on NPC cells. Methods:TargetScan was used to predict the regulatory relationsh...

journal_title：Cancer cell international

authors： Wang Z,Zhu Z,Lin Z,Luo Y,Liang Z,Zhang C,Chen J,Peng P

更新日期：2019-04-30 00:00:00

abstract：Background:Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies and a major cause of cancer related death worldwide, especially in China. Cell lines are widely used disease models for basic medical research, however, well characterized ESCC cell models from China were seldom reported. Mis...

journal_title：Cancer cell international

authors： Li X,Tian D,Guo Y,Qiu S,Xu Z,Deng W,Su M

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:CircRNAs play crucial roles in multiple tumours. However, the functions of most circRNAs in cervical cancer remain unclear. METHODS:This study collected GSE113696 data from the GEO database to search for differentially expressed circRNAs in cervical cancer. Quantitative reverse transcription PCR was used to...

journal_title：Cancer cell international

authors： Chen Y,Geng Y,Huang J,Xi D,Xu G,Gu W,Shao Y

更新日期：2021-01-07 00:00:00

abstract：Background:In addition to morphological and cytogenetic features, acute myeloid leukemias are characterized by mutations that can be used for target-therapy; also the minimal/measurable residual disease (MRD) could be an important prognostic factor. The purpose of this retrospective study was to investigate if somatic ...

journal_title：Cancer cell international

authors： Salehzadeh S,Guerrini F,Pizzano U,Grassi S,Ciabatti E,Iovino L,Buda G,Caracciolo F,Benedetti E,Orciuolo E,Pelosini M,Consani G,Carulli G,Metelli MR,Martini F,Mazziotta F,Mazzantini E,Rossi P,Tavarozzi R,Ricci F,Pe

更新日期：2019-04-04 00:00:00

abstract：Background:Abnormal expressions of long noncoding RNAs (lncRNAs) are very common in clear cell renal cell carcinoma (ccRCC), and some of these have been reported to be highly correlated with prognosis of ccRCC patients. Methods:"edgeR" AND "DEseq" R packages were used to explore differentially expressed genes (DEGs) b...

journal_title：Cancer cell international

authors： Jiang W,Guo Q,Wang C,Zhu Y

更新日期：2019-08-05 00:00:00

abstract：Background:Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Siah E3 ubiquitin protein ligase 1 (Siah1) has been identified as a tumor suppressor gene and plays an important role in the development of malignant tumors. However, the potential role and molecular mechanism of Siah1 in the de...

journal_title：Cancer cell international

authors： Xiao Z,Wei Z,Deng D,Zheng Z,Zhao Y,Jiang S,Zhang D,Zhang LJ,Fan M,Chen S,Wang S,Ding Y,Ye Y,Jiao H

更新日期：2020-02-13 00:00:00