A signature of hypoxia-related factors reveals functional dysregulation and robustly predicts clinical outcomes in stage I/II colorectal cancer patients.

abstract：BACKGROUND:Castration-resistance in prostate cancer (PC) is a critical event hallmarking a switch to a more aggressive phenotype. Neuroendocrine differentiation and upregulation of NFκB transcriptional activity are two mechanisms that have been independently linked to this process. METHODS:We investigated these two pa...

journal_title：Cancer cell international

authors： Patrikidou A,Vlachostergios PJ,Voutsadakis IA,Hatzidaki E,Valeri RM,Destouni C,Apostolou E,Daliani D,Papandreou CN

更新日期：2011-05-15 00:00:00

abstract：Background:Inflammation is one of a main reason for colon cancer progression and poor prognosis. The high-mobility group box-1 (HMGB1) and glutathione peroxidase 4 (GPX4) are responsible for inflammation, but the relationship between HMGB1 and GPX4 remains unknown about inflammation in colon cancer. Methods:RT-qPCR wa...

journal_title：Cancer cell international

authors： Yang Y,Yang L,Jiang S,Yang T,Lan J,Lei Y,Tan H,Pan K

更新日期：2020-05-29 00:00:00

abstract：BACKGROUND:Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper gene expression and that aberrant DNA methylation of genes and histone methylation plays important ...

journal_title：Cancer cell international

authors： Watanabe H,Soejima K,Yasuda H,Kawada I,Nakachi I,Yoda S,Naoki K,Ishizaka A

更新日期：2008-11-03 00:00:00

abstract：:Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved in disease pathogenesis and progression may potentially lead to new therapeutic targ...

journal_title：Cancer cell international

authors： Otoukesh B,Boddouhi B,Moghtadaei M,Kaghazian P,Kaghazian M

更新日期：2018-10-16 00:00:00

abstract：BACKGROUND:The present study mainly aimed to investigate the direct effects of Endostar (ES) on the proliferation and radiosensitivity of human lung squamous cancer cell line H-520. RESULTS:ES significantly inhibited H-520 cell proliferation in a time- and dose-dependent manner. According to the colony-forming assays,...

journal_title：Cancer cell international

authors： You ZY,Zhao Y,Liu F,Zhang YD,Wang JJ

更新日期：2010-05-24 00:00:00

abstract：Background:Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on...

journal_title：Cancer cell international

authors： Liu T,Jiang L,Yu L,Ge T,Wang J,Gao H

更新日期：2019-04-23 00:00:00

abstract：:[This retracts the article DOI: 10.1186/s12935-015-0237-6.]. ...

journal_title：Cancer cell international

authors： Mirghasemi A,Taheriazam A,Karbasy SH,Torkaman A,Shakeri M,Yahaghi E,Mokarizadeh A

更新日期：2016-11-04 00:00:00

abstract：BACKGROUND:Mutational inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene has been linked to hereditary as well as sporadic clear cell renal carcinomas. The product of the VHL gene, pVHL, acts to target hypoxia-inducible factor alpha (HIF-alpha) subunits for ubiquitination and subsequent degradation. Usin...

journal_title：Cancer cell international

authors： Hughes MD,Kapllani E,Alexander AE,Burk RD,Schoenfeld AR

更新日期：2007-06-28 00:00:00

abstract：:Colorectal cancer (CRC) is a complex and molecularly heterogeneous disease representing one of the most frequent causes of cancer-related death worldwide. About 8-15% of CRCs harbor a mutation in BRAF gene, a proto-oncogene involved in cell proliferation, differentiation and survival through the MAPK signaling cascade...

journal_title：Cancer cell international

authors： Fanelli GN,Dal Pozzo CA,Depetris I,Schirripa M,Brignola S,Biason P,Balistreri M,Dal Santo L,Lonardi S,Munari G,Loupakis F,Fassan M

更新日期：2020-01-29 00:00:00

abstract：Background:Glioma is the most common highly aggressive, primary adult brain tumour. Clinical data show that therapeutic approaches cannot reach the expectations in patients, thus gliomas are mainly incurable diseases. Tumour cells can adapt rapidly to alterations during therapeutic treatments related to their metabolic...

journal_title：Cancer cell international

authors： Petővári G,Hujber Z,Krencz I,Dankó T,Nagy N,Tóth F,Raffay R,Mészáros K,Rajnai H,Vetlényi E,Takács-Vellai K,Jeney A,Sebestyén A

更新日期：2018-12-19 00:00:00

abstract：BACKGROUND:In vivo, the transforming growth factor-beta1 (TGF-β1)-induced epithelial to mesenchymal transition (EMT) occurs in seconds during cancer cells intravasation and extravasation. Although it has been established that cellular stiffness can change as a cancer cell transformed, the precise relationship between T...

journal_title：Cancer cell international

authors： Wu TH,Chou YW,Chiu PH,Tang MJ,Hu CW,Yeh ML

更新日期：2014-03-03 00:00:00

abstract：Background:Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen fails to bind estrogen-receptor (ER). High estrogen is a known carcinogen in postmenopausal women. Re...

journal_title：Cancer cell international

authors： Nazmeen A,Chen G,Ghosh TK,Maiti S

更新日期：2020-03-04 00:00:00

abstract：Background:Long noncoding RNAs (lncRNAs) are involved in the tumorigenesis and progression of human cancers, including renal cell carcinoma (RCC). Small nucleolar RNA host gene 4 (SNHG4) is reported to play an essential role in tumor growth and progression. However, the molecular mechanisms and function of SNHG4 in RCC...

journal_title：Cancer cell international

authors： Wu J,Liu T,Sun L,Zhang S,Dong G

更新日期：2020-10-19 00:00:00

abstract：Background:Carcinoma-associated fibroblasts (CAFs) are dominant components of tumor microenvironment, which has been reported to promote development, progression, and metastasis of cancer. However, the role of CAFs during adhesion process remains unknown. It has been hypothesized that CAFs contribute to adhesion to end...

journal_title：Cancer cell international

authors： Zhang R,Qi F,Shao S,Li G,Feng Y

更新日期：2019-07-24 00:00:00

abstract：Background:Thyroid cancer (TC) is the most frequent endocrine malignancy. Long noncoding RNAs (lncRNAs) have been confirmed to act as significant roles in tumor development. The role of lncRNA TMPO-AS1 in TC is still unclear, so it remains to be explored. The aim of the research is to investigate the role and regulator...

journal_title：Cancer cell international

authors： Li Z,Feng Y,Zhang Z,Cao X,Lu X

更新日期：2020-07-08 00:00:00

abstract：Background:The aim of the study was to explore the association between the SIRT1 single nucleotide polymorphism (SNP) rs3758391 and diffuse large B cell lymphoma (DLBCL) in a Chinese Han population. Methods:206 patients diagnosed with DLBCL and 219 healthy individuals were recruited in the present study. The genotypin...

journal_title：Cancer cell international

authors： Kan Y,Ge P,Wang X,Xiao G,Zhao H

更新日期：2018-10-22 00:00:00

abstract：Background:In recent years, the B cell receptor (BCR) signaling pathway has become a "hot point" because it plays a critical role in B-cell proliferation and function. Bruton's tyrosine kinase (BTK) is overexpressed in many subtypes of B-cell lymphoma as a downstream kinase in the BCR signaling pathway. Ibrutinib, the ...

journal_title：Cancer cell international

authors： Xue C,Wang X,Zhang L,Qu Q,Zhang Q,Jiang Y

更新日期：2020-09-29 00:00:00

abstract：BACKGROUND:Without doubt, natural products have been, and still are, the cornerstone of the health care armamentarium. Of all natural sources, the marine environment is clearly the last great frontier for pharmaceutical and medical research. METHODS:This work progresses in the direction of identifying component(s) fro...

journal_title：Cancer cell international

authors： Dellai A,Deghrigue M,Laroche-Clary A,Masour HB,Chouchane N,Robert J,Bouraoui A

更新日期：2012-05-15 00:00:00

abstract：Background:Acute myeloid leukemia (AML) is a clinically and biologically heterogeneous disease. The survival of older patients is generally poor. In the current study, we sought to investigate the differences in molecular gene mutations between younger and older AML patients, and to identify those newly diagnosed AML p...

journal_title：Cancer cell international

authors： Cao XX,Cai H,Mao YY,Wu Q,Zhang L,Zhou DB,Li J

更新日期：2018-12-22 00:00:00

abstract：Background:Abnormally expressed circular RNAs (circRNAs) are implicated in the development and treatment of gastric cancer (GC). Previous study has reported that hsa_circ_0003159 is expressed in GC. However, the role and mechanism of hsa_circ_0003159 in GC progression remain unclear. Methods:GC tissues and normal tiss...

journal_title：Cancer cell international

authors： Wang J,Lv W,Lin Z,Wang X,Bu J,Su Y

更新日期：2020-02-19 00:00:00

abstract：Background:Growing evidence suggests that MiRNAs play essential roles in the initiation and progression of colorectal cancer (CRC). The aberrant expression of miR-384 has been reported in some cancers. However, the role and mechanism of miR-384 in CRC proliferation remains unknown. Methods:The expression of miR-384 wa...

journal_title：Cancer cell international

authors： Wang YX,Zhu HF,Zhang ZY,Ren F,Hu YH

更新日期：2018-09-03 00:00:00

abstract：Background:Neuroblastoma (NB) is the most common malignant tumor originating from the extracranial sympathetic nervous system in children. The molecular mechanisms underlying this disease are complex, and not completely understood. Methods:Quantitative real-time PCR (qRT-PCR) was applied to quantify the expression of ...

journal_title：Cancer cell international

authors： Yu Y,Zhang J,Jin Y,Yang Y,Shi J,Chen F,Han S,Chu P,Lu J,Wang H,Guo Y,Ni X

更新日期：2018-01-04 00:00:00

abstract：Background:LncRNAs are key regulators in cancer. The current study explored the role of lncRNA LINC00261 (LINC00261) in lung cancer (LC). Methods:Expression of LINC00261 in LC tissues and cells was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Pearson's Chi square test and Kaplan-Meier anal...

journal_title：Cancer cell international

authors： Guo C,Shi H,Shang Y,Zhang Y,Cui J,Yu H

更新日期：2020-06-26 00:00:00

abstract：Background:Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting considerable attention. In recent years, the causal role between LPR and laryngeal carcinoma has been debated. The main harmful component of LPR is pepsin, which has been shown to induce mucosal inflammation by damaging the mucous m...

journal_title：Cancer cell international

authors： Tan JJ,Wang L,Mo TT,Wang J,Wang MG,Li XP

更新日期：2019-03-20 00:00:00

abstract：Background:Angiogenesis plays critical roles in the progression and metastasis of malignant tumors. Gastric neuroendocrine carcinoma is an uncommon stomach cancer that is rich in blood vessels and exhibits highly malignant biological behavior with a poor prognosis. The role of CDK5RAP3 in GNEC has not been reported to ...

journal_title：Cancer cell international

authors： Lin JX,Weng XF,Xie XS,Lian NZ,Qiu SL,Wang JB,Lu J,Chen QY,Cao LL,Lin M,Tu RH,Yang YH,Liu SJ,Hu M,Lin YK,Huang CM,Zheng CH,Li P,Xie JW

更新日期：2019-11-07 00:00:00

abstract：Background:Kinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of breast cancer. However, the prognostic value of whole family members was poorly done. Our study intends to demonstrate the value of kinesin superfamily members as prognostic biomarkers as well...

journal_title：Cancer cell international

authors： Li TF,Zeng HJ,Shan Z,Ye RY,Cheang TY,Zhang YJ,Lu SH,Zhang Q,Shao N,Lin Y

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor that has been reported to reduce the risk of breast cancer. In our previous study, celecoxib induced apoptosis and caused cell cycle arrest at the G0/G1 phase in the breast cancer cell line MDA-MB-231, and its effects were mediated by downregulation o...

journal_title：Cancer cell international

authors： Wang L,Kang F,Li J,Zhang J,Shan B

更新日期：2013-02-12 00:00:00

abstract：Background:Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high morbidity and mortality worldwide. MicroRNAs are key regulators of HCC genesis. However, the regulatory role and underlying mechanisms of microRNA in HCC is still limited. Methods:Cyclin B1 (CCNB1) mRNA levels were examined in...

journal_title：Cancer cell international

authors： Gu J,Liu X,Li J,He Y

更新日期：2019-01-14 00:00:00

abstract：Background:Increasing evidences have underlined the importance of long non-coding RNAs (lncRNAs) in human malignancies. LINC00958 has been found involved in some cancers. However, the underlying mechanical performance of LINC00958 in lung adenocarcinoma (LAD) has not been explored yet. Methods:The expression of releva...

journal_title：Cancer cell international

authors： Yang L,Li L,Zhou Z,Liu Y,Sun J,Zhang X,Pan H,Liu S

更新日期：2020-01-23 00:00:00

abstract：Background:To investigate the expression of RASSF-1A in oral squamous cell carcinoma (OSCC) and adjacent tissues, and to explore its mechanism of action in the development of OSCC. Methods:RASSF-1A and proliferation-related protein expression in clinical and OSCC mouse models were detected by qPCR and western blot. In...

journal_title：Cancer cell international

authors： Sun J

更新日期：2019-08-13 00:00:00