当前位置： SCI文献检索 > Cancer Cell International期刊下所有文献 > LncRNA LINC00261 overexpression suppresses the growth and metastasis of lung cancer via regulating miR-1269a/FOXO1 axis.

LncRNA LINC00261 overexpression suppresses the growth and metastasis of lung cancer via regulating miR-1269a/FOXO1 axis.

Abstract：

Background:LncRNAs are key regulators in cancer. The current study explored the role of lncRNA LINC00261 (LINC00261) in lung cancer (LC). Methods:Expression of LINC00261 in LC tissues and cells was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Pearson's Chi square test and Kaplan-Meier analysis were performed to evaluate the correlations between LINC00261 expression and clinical characteristics, and overall survival time. A549 and SPC-A1 cells were transfected with LINC00261 overexpression plasmid, cell viability, cell number, and apoptosis were detected by CCK-8 assay, colony formation, and flow cytometry. Moreover, wound-healing and transwell assay were performed to detect cell metastasis and invasion. Expressions of proteins related to cell proliferation and metastasis were determined by Western blot. Xenograft was constructed, and tumor size and weight were measured and the effects of LINC00261 overexpression on tumor growth were detected. Bioinformatics analysis, dual-luciferase reporter assay, qRT-PCR, correlation analysis, and functional rescue experiments were conducted on clinical cases and LC cells to explore the molecular mechanism of LINC00261 in LC. Results:In LC, LINC00261 expression was down-regulated, and was associated with more advanced TNM stage, metastasis and a shorter survival time. LINC00261 overexpression inhibited the growth and metastasis of LC cells in vitro and tumor growth in vivo. Furthermore, miR-1269a directly interacted with LINC00261 and FOXO1. The expressions of miR-1269a and FOXO1 were dysregulated by LINC00261 in LC. Additionally, miR-1269a promoted the progression of LC through targeting FOXO1. Conclusions:Down-regulation of LINC00261 expression has a prognostic value in LC, and overexpression LINC00261 inhibits LC progression via targeting miR-1269a/FOXO1 axis.

journal_name

Cancer Cell Int

journal_title

Cancer cell international

authors

Guo C,Shi H,Shang Y,Zhang Y,Cui J,Yu H

doi

10.1186/s12935-020-01332-6

subject

Has Abstract

pub_date

2020-06-26 00:00:00

pages

275

issn

1475-2867

pii

1332

journal_volume

20

pub_type

杂志文章

相关文献

Cancer Cell International文献大全
  • Overexpression of kinesin superfamily members as prognostic biomarkers of breast cancer.

    abstract：Background:Kinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of breast cancer. However, the prognostic value of whole family members was poorly done. Our study intends to demonstrate the value of kinesin superfamily members as prognostic biomarkers as well...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01191-1

    authors： Li TF,Zeng HJ,Shan Z,Ye RY,Cheang TY,Zhang YJ,Lu SH,Zhang Q,Shao N,Lin Y

    更新日期：2020-04-15 00:00:00

  • Role of microRNA-92a in metastasis of osteosarcoma cells in vivo and in vitro by inhibiting expression of TCF21 with the transmission of bone marrow derived mesenchymal stem cells.

    abstract：Background:This study aims to investigate the role of microRNA-92a (miR-92a) in metastasis of osteosarcoma (OS) cells in vivo and in vitro by regulatingTCF21 with the transmission of bone marrow derived mesenchymal stem cells (BMSCs). Methods:BMSCs were isolated, purified and cultured from healthy adult bone marrow ti...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0741-1

    authors： Cao S,Jiang L,Shen L,Xiong Z

    更新日期：2019-02-12 00:00:00

  • Caspase-2 is involved in cell death induction by taxanes in breast cancer cells.

    abstract：BACKGROUND:We studied the role of caspase-2 in apoptosis induction by taxanes (paclitaxel, novel taxane SB-T-1216) in breast cancer cells using SK-BR-3 (nonfunctional p53, functional caspase-3) and MCF-7 (functional p53, nonfunctional caspase-3) cell lines. RESULTS:Both taxanes induced apoptosis in SK-BR-3 as well as ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-13-42

    authors： Jelínek M,Balušíková K,Kopperová D,Nĕmcová-Fürstová V,Šrámek J,Fidlerová J,Zanardi I,Ojima I,Kovář J

    更新日期：2013-05-15 00:00:00

  • LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma cell proliferation and resistance to apoptosis by targeting miR-4656/HDAC11 axis.

    abstract：Background:Dysregulation of long non-coding RNAs (lncRNAs) results in development of human diseases including hepatocellular carcinoma (HCC). Although several HCC related lncRNAs have been reported, the biological functions of many lncRNAs during the development of HCC remains unknown. Methods:The expression of ST8SIA...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01325-5

    authors： Fei Q,Song F,Jiang X,Hong H,Xu X,Jin Z,Zhu X,Dai B,Yang J,Sui C,Xu M

    更新日期：2020-06-11 00:00:00

  • Overexpression of microRNA-29b inhibits epithelial-mesenchymal transition and angiogenesis of colorectal cancer through the ETV4/ERK/EGFR axis.

    abstract：BACKGROUND:Recent studies have reported the involvement of microRNA-29 (miR-29) family members in human cancers through their ability to regulate cellular functions. The present study investigated biological function of miR-29b in colorectal cancer (CRC). METHODS:CRC tissues and adjacent normal tissues were collected ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01700-2

    authors： Leng Y,Chen Z,Ding H,Zhao X,Qin L,Pan Y

    更新日期：2021-01-06 00:00:00

  • Ultraviolet-A radiation induces changes in cyclin G gene expression in mouse melanoma B16-F1 cells.

    abstract：BACKGROUND:We have previously shown that ultraviolet-A (UVA) radiation enhances metastatic lung colonization capacity of B16-F1 melanoma cells. The aim of this study was to examine changes in expression profile of genes in mouse melanoma B16-F1 cells exposed to UVA radiation. RESULTS:B16-F1 melanoma cells were exposed...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-7-7

    authors： Pastila R,Leszczynski D

    更新日期：2007-05-02 00:00:00

  • SOX2OT knockdown derived changes in mitotic regulatory gene network of cancer cells.

    abstract：Background:SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism explaining its function in cell proliferation regulation. Here we investigated cancer cell response t...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-018-0618-8

    authors： Saghaeian Jazi M,Samaei NM,Mowla SJ,Arefnezhad B,Kouhsar M

    更新日期：2018-09-05 00:00:00

  • MiR-145 functions as a tumor suppressor via regulating angiopoietin-2 in pancreatic cancer cells.

    abstract：BACKGROUND:Pancreatic cancer is currently one of the leading causes of cancer deaths without any effective therapies. Mir-145 has been found to be tumor-suppressive in various types of cancers. The aim of this study is to investigate the role of miR-145 in pancreatic cancer cells and explore its underlying mechanism. ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-016-0331-4

    authors： Wang H,Hang C,Ou XL,Nie JS,Ding YT,Xue SG,Gao H,Zhu JX

    更新日期：2016-08-25 00:00:00

  • High brain acid soluble protein 1(BASP1) is a poor prognostic factor for cervical cancer and promotes tumor growth.

    abstract：BACKGROUND:The aim of this study was to determine whether brain abundant membrane attached signal protein 1 (BASP1) is a valuable prognostic biomarker for cervical cancer and whether BASP1 regulates the progression of cervical cancer. METHODS:Quantitative real-time PCR, western blotting, and immunohistochemistry were ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-017-0452-4

    authors： Tang H,Wang Y,Zhang B,Xiong S,Liu L,Chen W,Tan G,Li H

    更新日期：2017-10-24 00:00:00

  • Downregulation of Siah1 promotes colorectal cancer cell proliferation and migration by regulating AKT and YAP ubiquitylation and proteasome degradation.

    abstract：Background:Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Siah E3 ubiquitin protein ligase 1 (Siah1) has been identified as a tumor suppressor gene and plays an important role in the development of malignant tumors. However, the potential role and molecular mechanism of Siah1 in the de...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-1124-3

    authors： Xiao Z,Wei Z,Deng D,Zheng Z,Zhao Y,Jiang S,Zhang D,Zhang LJ,Fan M,Chen S,Wang S,Ding Y,Ye Y,Jiao H

    更新日期：2020-02-13 00:00:00

  • The heterogeneous clinical and pathological landscapes of metastatic Braf-mutated colorectal cancer.

    abstract：:Colorectal cancer (CRC) is a complex and molecularly heterogeneous disease representing one of the most frequent causes of cancer-related death worldwide. About 8-15% of CRCs harbor a mutation in BRAF gene, a proto-oncogene involved in cell proliferation, differentiation and survival through the MAPK signaling cascade...

    journal_title：Cancer cell international

    pub_type： 杂志文章,评审

    doi：10.1186/s12935-020-1117-2

    authors： Fanelli GN,Dal Pozzo CA,Depetris I,Schirripa M,Brignola S,Biason P,Balistreri M,Dal Santo L,Lonardi S,Munari G,Loupakis F,Fassan M

    更新日期：2020-01-29 00:00:00

  • Hsa_circ_0003159 inhibits gastric cancer progression by regulating miR-223-3p/NDRG1 axis.

    abstract：Background:Abnormally expressed circular RNAs (circRNAs) are implicated in the development and treatment of gastric cancer (GC). Previous study has reported that hsa_circ_0003159 is expressed in GC. However, the role and mechanism of hsa_circ_0003159 in GC progression remain unclear. Methods:GC tissues and normal tiss...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-1119-0

    authors： Wang J,Lv W,Lin Z,Wang X,Bu J,Su Y

    更新日期：2020-02-19 00:00:00

  • Oncogenic UBE3C promotes breast cancer progression by activating Wnt/β-catenin signaling.

    abstract：BACKGROUND:Breast cancer (BrCa) is the most common female malignancy worldwide and has the highest morbidity among all cancers in females. Unfortunately, the mechanisms of BrCa growth and metastasis, which lead to a poor prognosis in BrCa patients, have not been well characterized. METHODS:Immunohistochemistry (IHC) w...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01733-7

    authors： Hang C,Zhao S,Wang T,Zhang Y

    更新日期：2021-01-06 00:00:00

  • Investigation of the apoptotic way induced by digallic acid in human lymphoblastoid TK6 cells.

    abstract：BACKGROUND:The digallic acid (DGA) purified from Pistacia lentiscus. L fruits was investigated for its antiproliferative and apoptotic activities on human lymphoblastoid TK6 cells. METHODS:We attempt to characterize the apoptotic pathway activated by DGA. Apoptosis was detected by DNA fragmentation, PARP cleavage and ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-12-26

    authors： Bhouri W,Boubaker J,Skandrani I,Ghedira K,Chekir Ghedira L

    更新日期：2012-06-11 00:00:00

  • MiR-20a-5p suppresses tumor proliferation by targeting autophagy-related gene 7 in neuroblastoma.

    abstract：Background:Neuroblastoma (NB) is the most common malignant tumor originating from the extracranial sympathetic nervous system in children. The molecular mechanisms underlying this disease are complex, and not completely understood. Methods:Quantitative real-time PCR (qRT-PCR) was applied to quantify the expression of ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-017-0499-2

    authors： Yu Y,Zhang J,Jin Y,Yang Y,Shi J,Chen F,Han S,Chu P,Lu J,Wang H,Guo Y,Ni X

    更新日期：2018-01-04 00:00:00

  • miR-206 as a prognostic and sensitivity biomarker for platinum chemotherapy in epithelial ovarian cancer.

    abstract：BACKGROUND:Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. The purposes of this study were to e...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01623-y

    authors： Yu X,Zhang X,Wang G,Wang B,Ding Y,Zhao J,Liu H,Cui S

    更新日期：2020-11-03 00:00:00

  • Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy.

    abstract：BACKGROUND:Ca2+ is known to be involved in a number of metastatic processes including motility and proliferation which can result in store-depletion of Ca2+. Up regulation of genes which contribute to store operated channel (SOC) activity may plausibly be necessary for these processes to take place efficiently. TRPC pr...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-9-23

    authors： Aydar E,Yeo S,Djamgoz M,Palmer C

    更新日期：2009-08-18 00:00:00

  • LncRNA MEG3 promotes melanoma growth, metastasis and formation through modulating miR-21/E-cadherin axis.

    abstract：Background:Melanoma is the most aggressive type of skin cancer with high mortality rate and poor prognosis. lncRNA MEG3, a tumor suppressor, is closely related to the development of various cancers. However, the role of lncRNA MEG3 in melanoma has seldom been studied. Methods:RT-PCR was used to examine the expressions...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-1087-4

    authors： Wu L,Zhu L,Li Y,Zheng Z,Lin X,Yang C

    更新日期：2020-01-10 00:00:00

  • Verteporfin disrupts multiple steps of autophagy and regulates p53 to sensitize osteosarcoma cells.

    abstract：BACKGROUND:Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also, the post-relapse survival of OS patients is as low as 20%. We the...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01720-y

    authors： Saini H,Sharma H,Mukherjee S,Chowdhury S,Chowdhury R

    更新日期：2021-01-14 00:00:00

  • Downregulation of long non-coding RNA MAFG-AS1 represses tumorigenesis of colorectal cancer cells through the microRNA-149-3p-dependent inhibition of HOXB8.

    abstract：Background:Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, the present study was performed to determine whether lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAF...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01485-4

    authors： Ruan Z,Deng H,Liang M,Xu Z,Lai M,Ren H,Deng X,Su X

    更新日期：2020-10-19 00:00:00

  • MiR-591 functions as tumor suppressor in breast cancer by targeting TCF4 and inhibits Hippo-YAP/TAZ signaling pathway.

    abstract：Background:MicroRNAs have been involved in regulating crucial biological function in some tumors. However, the clinical role and functional effects of miR-591 in breast cancer remain unknown. Methods:The expression of miR-591 was detected in breast cancer tissues and their paired normal tissues by qRT-PCR. Functional ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0818-x

    authors： Huang X,Tang F,Weng Z,Zhou M,Zhang Q

    更新日期：2019-04-24 00:00:00

  • Long noncoding RNA SNHG4 promotes renal cell carcinoma tumorigenesis and invasion by acting as ceRNA to sponge miR-204-5p and upregulate RUNX2.

    abstract：Background:Long noncoding RNAs (lncRNAs) are involved in the tumorigenesis and progression of human cancers, including renal cell carcinoma (RCC). Small nucleolar RNA host gene 4 (SNHG4) is reported to play an essential role in tumor growth and progression. However, the molecular mechanisms and function of SNHG4 in RCC...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01606-z

    authors： Wu J,Liu T,Sun L,Zhang S,Dong G

    更新日期：2020-10-19 00:00:00

  • RASSF-1A modulates proliferation-mediated oral squamous cell carcinoma progression.

    abstract：Background:To investigate the expression of RASSF-1A in oral squamous cell carcinoma (OSCC) and adjacent tissues, and to explore its mechanism of action in the development of OSCC. Methods:RASSF-1A and proliferation-related protein expression in clinical and OSCC mouse models were detected by qPCR and western blot. In...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0932-9

    authors： Sun J

    更新日期：2019-08-13 00:00:00

  • Real-time RT-PCR analysis of mRNA decay: half-life of Beta-actin mRNA in human leukemia CCRF-CEM and Nalm-6 cell lines.

    abstract：:BACKGROUND: We describe an alternative method to determine mRNA half-life (t1/2) based on the Real-Time RT-PCR procedure. This approach was evaluated by using the beta-actin gene as a reference molecule for measuring of mRNA stability. RESULTS: Human leukemia Nalm-6 and CCRF-CEM cells were treated with various concent...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-2-1

    authors： Leclerc GJ,Leclerc GM,Barredo JC

    更新日期：2002-03-07 00:00:00

  • Apigenin promotes apoptosis, inhibits invasion and induces cell cycle arrest of T24 human bladder cancer cells.

    abstract：BACKGROUND:Apigenin (4',5,7-trihydroxyflavone) was recently shown effective in inhibiting several cancers. The aim of this study was to investigate the effect and mechanism of apigenin in the human bladder cancer cell line T24 for the first time. METHODS:T24 cells were treated with varying concentrations and time of a...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-13-54

    authors： Zhu Y,Mao Y,Chen H,Lin Y,Hu Z,Wu J,Xu X,Xu X,Qin J,Xie L

    更新日期：2013-06-01 00:00:00

  • Increase of IFN-γ and TNF-α production in CD107a + NK-92 cells co-cultured with cervical cancer cell lines pre-treated with the HO-1 inhibitor.

    abstract：BACKGROUND:Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-α), which induce apoptosis in target cells. Many tumors express Heme oxygenase 1 (HO-1), and this expression has b...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-014-0100-1

    authors： Gómez-Lomelí P,Bravo-Cuellar A,Hernández-Flores G,Jave-Suárez LF,Aguilar-Lemarroy A,Lerma-Díaz JM,Domínguez-Rodríguez JR,Sánchez-Reyes K,Ortiz-Lazareno PC

    更新日期：2014-10-01 00:00:00

  • PD-1 and PD-L1 correlated gene expression profiles and their association with clinical outcomes of breast cancer.

    abstract：Background:Immunotherapies that targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have obtained prominent success in breast cancer (BC). However, not all the patients benefit from the antibody therapy. This study aimed to identify PD-1/PD-L1 correlated genes and pathways as well as investig...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0955-2

    authors： Jiang C,Cao S,Li N,Jiang L,Sun T

    更新日期：2019-09-09 00:00:00

  • MicroRNA-32 promotes cell proliferation, migration and suppresses apoptosis in breast cancer cells by targeting FBXW7.

    abstract：BACKGROUND:MicroRNAs are a class of small non-coding RNAs that are involved in many important physiological and pathological processes by regulating gene expression negatively. The purpose of this study was to investigate the effect of miR-32 on cell proliferation, migration and apoptosis and to determine the functiona...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-017-0383-0

    authors： Xia W,Zhou J,Luo H,Liu Y,Peng C,Zheng W,Ma W

    更新日期：2017-01-25 00:00:00

  • microRNA-30b inhibits cell invasion and migration through targeting collagen triple helix repeat containing 1 in non-small cell lung cancer.

    abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is the largest histological subgroup of lung cancer and has increased in prevalence in China over the past 5 years. The 5-year survival rate has remained at 15-20 %, with a median survival of 8-12 months. The tumorigenesis and progression of NSCLC is orchestrated by numerou...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-015-0236-7

    authors： Chen S,Li P,Yang R,Cheng R,Zhang F,Wang Y,Chen X,Sun Q,Zang W,Du Y,Zhao G,Zhang G

    更新日期：2015-09-17 00:00:00

  • Expression profile of circular RNA and construction of circular RNA-Micro RNA network in salivary adenoid cystic carcinoma.

    abstract：BACKGROUND:Circular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types of human tumors. So they have been considered as promising candidates as diagnostic and therapeutic targets in cancer. This research aimed to screen the profile of circR...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01681-2

    authors： Han J,Han N,Xu Z,Zhang C,Liu J,Ruan M

    更新日期：2021-01-07 00:00:00