High brain acid soluble protein 1(BASP1) is a poor prognostic factor for cervical cancer and promotes tumor growth.

abstract：BACKGROUND:Bladder cancer (BCa) is a malignant tumor that occurs on the mucosa of the bladder, in which dysregulated long non-coding RNAs (lncRNAs) are involved. This study investigated the effect of lncRNA small nucleolar RNA host gene 1 (SNHG14) on the biological characteristics of BCa cells from microRNA (miR)-211-3...

journal_title：Cancer cell international

authors： Feng R,Li Z,Wang X,Ge G,Jia Y,Wu D,Ji Y,Wang C

更新日期：2021-01-22 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) is a type of malignancy with progressive metastasis having poor prognosis and lowered survival resulting from late diagnosis. The therapeutic approaches for the treatment of this incurable cancer are chemo- and radiotherapy. Since current treatments are insufficient and because of dr...

journal_title：Cancer cell international

authors： Pourhanifeh MH,Sharifi M,Reiter RJ,Davoodabadi A,Asemi Z

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:MicroRNAs are a class of small non-coding RNAs that are involved in many important physiological and pathological processes by regulating gene expression negatively. The purpose of this study was to investigate the effect of miR-32 on cell proliferation, migration and apoptosis and to determine the functiona...

journal_title：Cancer cell international

authors： Xia W,Zhou J,Luo H,Liu Y,Peng C,Zheng W,Ma W

更新日期：2017-01-25 00:00:00

abstract：BACKGROUND:Castration-resistance in prostate cancer (PC) is a critical event hallmarking a switch to a more aggressive phenotype. Neuroendocrine differentiation and upregulation of NFκB transcriptional activity are two mechanisms that have been independently linked to this process. METHODS:We investigated these two pa...

journal_title：Cancer cell international

authors： Patrikidou A,Vlachostergios PJ,Voutsadakis IA,Hatzidaki E,Valeri RM,Destouni C,Apostolou E,Daliani D,Papandreou CN

更新日期：2011-05-15 00:00:00

abstract：:Prostate cancer is a gland tumor in the male reproductive system. It is a multifaceted and genomically complex disease. Transmembrane protease, serine 2 and v-ets erythroblastosis virus E26 homolog (TMPRSS2-ERG) gene fusions are the common molecular signature of prostate cancer. Although tremendous advances have been ...

journal_title：Cancer cell international

authors： Farooqi AA,Hou MF,Chen CC,Wang CL,Chang HW

更新日期：2014-04-17 00:00:00

abstract：Background:Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-MYC interaction and limits the tumor-suppressive effect of BIN1. Cyclin-dependent kinase 5 (CDK5), a ...

journal_title：Cancer cell international

authors： Zhang X,Wang J,Jia Y,Liu T,Wang M,Lv W,Zhang R,Shi J,Liu L

更新日期：2019-09-02 00:00:00

abstract：Background:MicroRNA (MiRNA) is a small non-coding RNA which is implicated in a cohort of biological function in cancer, including proliferation, metastasis, apoptosis and invasion. MiR-96 has been reported to be involved in many cancers, including papillary thyroid cancer. However, the role of miR-96-3p in papillary th...

journal_title：Cancer cell international

authors： Zhao X,Li Y,Zhou Y

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. The purposes of this study were to e...

journal_title：Cancer cell international

authors： Yu X,Zhang X,Wang G,Wang B,Ding Y,Zhao J,Liu H,Cui S

更新日期：2020-11-03 00:00:00

abstract：Background:Breast cancer has been the first death cause of cancer in women all over the world. Metastasis is believed to be the most important process for treating breast cancer. There is evidence that lncRNA MEG3 functions as a tumor suppressor in breast cancer metastasis. However, upstream regulation of MEG3 in breas...

journal_title：Cancer cell international

authors： Wang XX,Guo GC,Qian XK,Dou DW,Zhang Z,Xu XD,Duan X,Pei XH

更新日期：2018-10-25 00:00:00

abstract：BACKGROUND:Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper gene expression and that aberrant DNA methylation of genes and histone methylation plays important ...

journal_title：Cancer cell international

authors： Watanabe H,Soejima K,Yasuda H,Kawada I,Nakachi I,Yoda S,Naoki K,Ishizaka A

更新日期：2008-11-03 00:00:00

abstract：Background:Glioma is the most common central nervous system (CNS) tumour. p62, an important autophagy adaptor, plays a crucial role in cancer. However, the role of p62 in the progression of glioma is poorly characterized. Methods:We examined the expression of p62 in glioma tissues and cell lines. Then we investigated ...

journal_title：Cancer cell international

authors： Deng D,Luo K,Liu H,Nie X,Xue L,Wang R,Xu Y,Cui J,Shao N,Zhi F

更新日期：2019-11-06 00:00:00

abstract：Background:Breast cancer is the leading cause of oncological mortality among women. Efficient detection of cancer cells in an early stage and potent therapeutic agents targeting metastatic tumors are highly needed to improve survival rates. Emerging evidence indicates that lncRNAs (long noncoding RNAs) are critical reg...

journal_title：Cancer cell international

authors： Hou L,Tu J,Cheng F,Yang H,Yu F,Wang M,Liu J,Fan J,Zhou G

更新日期：2018-09-18 00:00:00

abstract：Background:Cancer cell viability is strongly modulated by the Hippo pathway, which includes mammalian STE20-like protein kinase 1 (Mst1) and yes-associated protein (Yap). Although the roles of Mst1 and Yap in thyroid carcinoma cell death have been fully addressed, no study has determined whether differential modificati...

journal_title：Cancer cell international

authors： Zhang X,Li F,Cui Y,Liu S,Sun H

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:Phenethyl isothiocyanate (PEITC), present naturally in cruciferous vegetables, is a chemopreventive agent. It blocks initiation and post-initiation progression of carcinogenesis. Mechanism study in human prostate cancer cells revealed that PEITC is a dual inhibitor of aberrant DNA hypermethylation and histon...

journal_title：Cancer cell international

authors： Xue C,Pasolli HA,Piscopo I,Gros DJ,Liu C,Chen Y,Chiao JW

更新日期：2014-03-31 00:00:00

abstract：BACKGROUND:Urokinase-type Plasminogen Activator (uPA), a serine protease, plays a pivotal role in human breast cancer metastasis by mediating the degradation of extracellular matrix proteins and promoting cell motility. In more advanced breast cancers, uPA activity is significantly up regulated and serves as a prognost...

journal_title：Cancer cell international

authors： Candia BJ,Hines WC,Heaphy CM,Griffith JK,Orlando RA

更新日期：2006-05-31 00:00:00

abstract：Background:Carcinoma-associated fibroblasts (CAFs) are dominant components of tumor microenvironment, which has been reported to promote development, progression, and metastasis of cancer. However, the role of CAFs during adhesion process remains unknown. It has been hypothesized that CAFs contribute to adhesion to end...

journal_title：Cancer cell international

authors： Zhang R,Qi F,Shao S,Li G,Feng Y

更新日期：2019-07-24 00:00:00

abstract：Background:This study aims to investigate the role of microRNA-92a (miR-92a) in metastasis of osteosarcoma (OS) cells in vivo and in vitro by regulatingTCF21 with the transmission of bone marrow derived mesenchymal stem cells (BMSCs). Methods:BMSCs were isolated, purified and cultured from healthy adult bone marrow ti...

journal_title：Cancer cell international

authors： Cao S,Jiang L,Shen L,Xiong Z

更新日期：2019-02-12 00:00:00

abstract：Background:T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods:In this study, we collected the bone marrow samples from 17 T-A...

journal_title：Cancer cell international

authors： Jia Y,Qi Y,Wang Y,Ma X,Xu Y,Wang J,Zhang X,Gao M,Cong B,Han S

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Several reports have revealed that cancer stem cells (CSCs) exist in many types of solid tumors. Some studies have demonstrated that side population (SP) cells isolated from diverse cancer lines harbor cancer stem-like properties, but there are few reports examining the characteristic of SP cells in human ce...

journal_title：Cancer cell international

authors： Qi W,Zhao C,Zhao L,Liu N,Li X,Yu W,Wei L

更新日期：2014-01-13 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s12935-020-01426-1.]. ...

journal_title：Cancer cell international

authors： Li T,Liu Q,Zhang R,Liao Q,Zhao Y

更新日期：2020-08-18 00:00:00

abstract：Background:Dysregulation of long non-coding RNAs (lncRNAs) results in development of human diseases including hepatocellular carcinoma (HCC). Although several HCC related lncRNAs have been reported, the biological functions of many lncRNAs during the development of HCC remains unknown. Methods:The expression of ST8SIA...

journal_title：Cancer cell international

authors： Fei Q,Song F,Jiang X,Hong H,Xu X,Jin Z,Zhu X,Dai B,Yang J,Sui C,Xu M

更新日期：2020-06-11 00:00:00

abstract：:Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1α) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in...

journal_title：Cancer cell international

authors： Jin X,Dai L,Ma Y,Wang J,Liu Z

更新日期：2020-06-24 00:00:00

abstract：BACKGROUND:Epithelial mesenchymal transition (EMT) mediated by TGF-β pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract of Stellera chamaejasme L. (ESC) was against proliferation of a variety of tumor cells, but there were no studies in the...

journal_title：Cancer cell international

authors： Liu XN,Wang S,Yang Q,Wang YJ,Chen DX,Zhu XX

更新日期：2015-12-10 00:00:00

abstract：Background:miR-429 and TLN1 have been shown to affect the biological behaviours of many carcinomas. However, their effects in nasopharyngeal carcinoma (NPC) are not yet clear. Here, we investigated their regulatory relationships and effects on NPC cells. Methods:TargetScan was used to predict the regulatory relationsh...

journal_title：Cancer cell international

authors： Wang Z,Zhu Z,Lin Z,Luo Y,Liang Z,Zhang C,Chen J,Peng P

更新日期：2019-04-30 00:00:00

abstract：BACKGROUND:Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other health benefits. The survival pathways of Akt and extracellular signal-regulated kinase (Erk), and t...

journal_title：Cancer cell international

authors： Barron CC,Moore J,Tsakiridis T,Pickering G,Tsiani E

更新日期：2014-01-23 00:00:00

abstract：BACKGROUND:Prostate cancer progression to androgen independence is the primary cause of mortality by this tumor type. The IGF-1/IGF-1R axis is well known to contribute to prostate cancer initiation, but its contribution to invasiveness and the downstream signalling mechanisms that are involved are unclear at present. ...

journal_title：Cancer cell international

authors： Saikali Z,Setya H,Singh G,Persad S

更新日期：2008-07-03 00:00:00

abstract：Background:Many circRNAs have been reported to play important roles in cancer development and have the potential to serve as a novel class of biomarkers for clinical diagnosis. However, the role of circRNAs in esophageal carcinoma (EC) remains unclear. In the current study, we investigated the potential role of circPVT...

journal_title：Cancer cell international

authors： Zhong R,Chen Z,Mo T,Li Z,Zhang P

更新日期：2019-10-15 00:00:00

abstract：:Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-related death. Chronic myeloid leukaemia (CML) is a chronic leukaemia of the haematopoietic stem cells affecting...

journal_title：Cancer cell international

authors： Repsold L,Pool R,Karodia M,Tintinger G,Joubert AM

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:The goal of this study was to identify the nature of the inclusion bodies that have been found in HeLa cells (cervical cancer immortal cell line) by electron microscope and to determine whether the major capsid protein (L1) of human papillomavirus (HPV) can be expressed in HPV-positive uterine cervix cancer ...

journal_title：Cancer cell international

authors： Xiao CY,Fu BB,Li ZY,Mushtaq G,Kamal MA,Li JH,Tang GC,Xiao SS

更新日期：2015-05-23 00:00:00

abstract：: Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently, a number of studies have shown that the deletion or mutation of A20, a negative regulator of NF-κB, is frequ...

journal_title：Cancer cell international

authors： Zhang F,Yang L,Li Y

更新日期：2012-11-07 00:00:00