Abstract:
:[This corrects the article DOI: 10.1186/s12935-020-01426-1.].
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Li T,Liu Q,Zhang R,Liao Q,Zhao Ydoi
10.1186/s12935-020-01482-7subject
Has Abstractpub_date
2020-08-18 00:00:00pages
397issn
1475-2867pii
1482journal_volume
20pub_type
已发布勘误abstract:Background:Long non-coding RNAs (lncRNAs) play significant roles in tumorigenesis and can contribute to identification of novel therapeutic targets for cancers. This paper was aimed at exploring the role of CTBP1 divergent transcript (CTBP1-AS2) in cervical cancer (CC) progression. Methods:qRT-PCR and western blot ass...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01430-5
更新日期:2020-07-28 00:00:00
abstract:Background:Cutaneous melanoma is one of the most aggressive and lethal skin cancers. It is greatly important to identify prognostic biomarkers to guide the clinical management. However, it is technically challenging for untrained researchers to process high dimensional profiling data and identify potential prognostic g...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01262-3
更新日期:2020-05-19 00:00:00
abstract:BACKGROUND:Ca2+ is known to be involved in a number of metastatic processes including motility and proliferation which can result in store-depletion of Ca2+. Up regulation of genes which contribute to store operated channel (SOC) activity may plausibly be necessary for these processes to take place efficiently. TRPC pr...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-9-23
更新日期:2009-08-18 00:00:00
abstract:Background:Inflammation is one of a main reason for colon cancer progression and poor prognosis. The high-mobility group box-1 (HMGB1) and glutathione peroxidase 4 (GPX4) are responsible for inflammation, but the relationship between HMGB1 and GPX4 remains unknown about inflammation in colon cancer. Methods:RT-qPCR wa...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01289-6
更新日期:2020-05-29 00:00:00
abstract:Background:Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with targeted agents. Methods:In the current study, TP53 wild-type cell lines with druggable MAPK pathway muta...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0768-3
更新日期:2019-03-07 00:00:00
abstract:OBJECTIVES:Bladder transitional cell carcinoma (TCC) is one of the most common solid malignancies in China. This study examined the antitumor effect and underlying mechanism of action of sunitinib malate in human bladder TCC in vitro. METHODS:Bladder TCC cell lines 5637 and BIU87 were maintained in 1640 medium and T24...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0179-z
更新日期:2015-02-28 00:00:00
abstract:Background:Newly identified lncRNA zinc finger protein, FOG family member 2 antisense RNA 1 (ZFPM2-AS1) is identified as an oncogenic gene. However, the role of ZFPM2-AS1 in small cell lung cancer (SCLC) is poorly comprehended. Methods:The expression of genes in SCLC tissues and cells was measured by qRT-PCR. Colony f...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1157-7
更新日期:2020-04-03 00:00:00
abstract:Background:Growing evidence suggests that MiRNAs play essential roles in the initiation and progression of colorectal cancer (CRC). The aberrant expression of miR-384 has been reported in some cancers. However, the role and mechanism of miR-384 in CRC proliferation remains unknown. Methods:The expression of miR-384 wa...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0628-6
更新日期:2018-09-03 00:00:00
abstract:BACKGROUND:Several reports have revealed that cancer stem cells (CSCs) exist in many types of solid tumors. Some studies have demonstrated that side population (SP) cells isolated from diverse cancer lines harbor cancer stem-like properties, but there are few reports examining the characteristic of SP cells in human ce...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-3
更新日期:2014-01-13 00:00:00
abstract::Prostate cancer is a gland tumor in the male reproductive system. It is a multifaceted and genomically complex disease. Transmembrane protease, serine 2 and v-ets erythroblastosis virus E26 homolog (TMPRSS2-ERG) gene fusions are the common molecular signature of prostate cancer. Although tremendous advances have been ...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/1475-2867-14-34
更新日期:2014-04-17 00:00:00
abstract:BACKGROUND:The goal of this study was to identify the nature of the inclusion bodies that have been found in HeLa cells (cervical cancer immortal cell line) by electron microscope and to determine whether the major capsid protein (L1) of human papillomavirus (HPV) can be expressed in HPV-positive uterine cervix cancer ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0206-0
更新日期:2015-05-23 00:00:00
abstract:Background:Drug resistance to 5-fluorouracil (5-FU) and recurrence after chemotherapy in colorectal cancer remain a challenge to be resolved for the improvement of patient outcomes. It is recognized that a variety of secretory proteins released from the tumor cells exposed to chemo-drugs into the tumor microenvironment...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01541-z
更新日期:2020-09-14 00:00:00
abstract:Background:Schwannoma arising from peripheral nervous sheaths is a benign tumor. Methods:To evaluate cell cytotoxicity, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction and terminal deoxynucleotidyltransferase UTP nick-end labeling (TUNEL) assays were used. A microRNA (miRNA) array ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0693-x
更新日期:2018-12-04 00:00:00
abstract:Background:Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property. Cytosine deaminase (CD), which is derived from bacteria or yeast, can convert a relatively nontoxic prodrug 5-fluorocytosine (5-FC) into the active an...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01340-6
更新日期:2020-06-15 00:00:00
abstract:Background:Sarcomas are malignant heterogeneous tumors of mesenchymal derivation. Dedifferentiated liposarcoma (DDLPS) is aggressive with recurrence in 80% and metastasis in 20% of patients. We previously found that miR-133a was significantly underexpressed in liposarcoma tissues. As this miRNA has recently been shown ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0583-2
更新日期:2018-06-26 00:00:00
abstract:Background and aims:microRNAs (miRNAs) have been reported to regulate proliferation and migration by down-regulating the expression of target genes. The aims of this study were to investigate whether miR-4316 inhibited proliferation and migration by downregulating vascular endothelial growth factor A (VEGF-A) and its c...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1132-3
更新日期:2020-02-22 00:00:00
abstract::[This retracts the article DOI: 10.1186/s12935-015-0237-6.]. ...
journal_title:Cancer cell international
pub_type: 撤回出版物
doi:10.1186/s12935-016-0359-5
更新日期:2016-11-04 00:00:00
abstract:BACKGROUND:Epithelial mesenchymal transition (EMT) mediated by TGF-β pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract of Stellera chamaejasme L. (ESC) was against proliferation of a variety of tumor cells, but there were no studies in the...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0265-2
更新日期:2015-12-10 00:00:00
abstract:BACKGROUND:Abnormal proliferation, metastasis and epithelial-mesenchymal transformation (EMT) of lens epithelial cells (LECs) are direct factors of posterior capsular opacification (PCO). Nuclear enriched abundant transcript 1 (NEAT1) has been shown to promote cell proliferation, metastasis and EMT, but whether it affe...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01619-8
更新日期:2020-10-31 00:00:00
abstract:BACKGROUND:Tumor tissue resembles chronically inflamed tissue. Since chronic inflammatory conditions are a strong stimulus for bone marrow-derived cells (BMDCs) it can be assumed that recruitment of BMDCs into cancer tissue should be a common phenomenon. Several data have outlined that BMDC can influence tumor growth a...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-11-21
更新日期:2011-06-28 00:00:00
abstract::Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences show that overexpression of Six1 plays a key role in tumorigenesis. However, the Six1 expression status and its relationship with the clinicopatholo...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0215-z
更新日期:2015-06-20 00:00:00
abstract:Background:Although major driver gene have been identified, the complex molecular heterogeneity of renal cell cancer (RCC) remains unclear. Therefore, more relevant genes need to be identified to explain the pathogenesis of renal cancer. Methods:Microarray datasets GSE781, GSE6344, GSE53000 and GSE68417 were downloade...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01405-6
更新日期:2020-07-21 00:00:00
abstract::Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternally expressed gene 10 (PEG10), located on human chromosome 7q21.3, has turned out to be an oncogene implicat...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-018-0610-3
更新日期:2018-08-13 00:00:00
abstract:BACKGROUND:Mutational inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene has been linked to hereditary as well as sporadic clear cell renal carcinomas. The product of the VHL gene, pVHL, acts to target hypoxia-inducible factor alpha (HIF-alpha) subunits for ubiquitination and subsequent degradation. Usin...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-7-13
更新日期:2007-06-28 00:00:00
abstract:Background:Melanoma as a type of skin cancer, is associated with a high mortality rate. Therefore, early diagnosis and efficient surgical treatment of this disease is very important. Photodynamic therapy (PDT) involves the activation of a photosensitizer by light at specific wavelength that interacts with oxygen and cr...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01616-x
更新日期:2020-10-29 00:00:00
abstract:Background:Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0827-9
更新日期:2019-04-23 00:00:00
abstract:BACKGROUND:Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene predispose individuals to clear cell renal carcinomas, hemangioblastomas, and pheochromocytomas. The VHL gene product forms an ubiquitin E3 ligase complex, with regulation of hypoxia-inducible factor alpha (HIF-α) as its best known funct...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0175-3
更新日期:2015-02-22 00:00:00
abstract:BACKGROUND:SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. In this study, the level of mRNA expression of SATB1 a...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-9-18
更新日期:2009-07-30 00:00:00
abstract:BACKGROUND:The digallic acid (DGA) purified from Pistacia lentiscus. L fruits was investigated for its antiproliferative and apoptotic activities on human lymphoblastoid TK6 cells. METHODS:We attempt to characterize the apoptotic pathway activated by DGA. Apoptosis was detected by DNA fragmentation, PARP cleavage and ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-12-26
更新日期:2012-06-11 00:00:00
abstract::Non-small-cell lung cancer (NSCLC) is a type of malignancy with progressive metastasis having poor prognosis and lowered survival resulting from late diagnosis. The therapeutic approaches for the treatment of this incurable cancer are chemo- and radiotherapy. Since current treatments are insufficient and because of dr...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-019-0853-7
更新日期:2019-05-16 00:00:00