Abstract:
BACKGROUND:The digallic acid (DGA) purified from Pistacia lentiscus. L fruits was investigated for its antiproliferative and apoptotic activities on human lymphoblastoid TK6 cells. METHODS:We attempt to characterize the apoptotic pathway activated by DGA. Apoptosis was detected by DNA fragmentation, PARP cleavage and by evaluating caspase activities. RESULTS:The inhibition of lymphoblastoid cell proliferation was noted from 8.5 μg/ml of DGA. The induction of apoptosis was confirmed by DNA fragmentation and PARP cleavage. We have demonstrated that DGA induces apoptosis by activating the caspase-8 extrinsic pathway. Caspase-3 was also activated in a dose dependent manner. CONCLUSION:In summary, DGA exhibited an apoptosis inductor effect in TK6 cells revealing thus its potential as a cancer-preventive agent.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Bhouri W,Boubaker J,Skandrani I,Ghedira K,Chekir Ghedira Ldoi
10.1186/1475-2867-12-26subject
Has Abstractpub_date
2012-06-11 00:00:00pages
26issue
1issn
1475-2867pii
1475-2867-12-26journal_volume
12pub_type
杂志文章abstract:Background:Transgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that transgelin was up-regulated in node-positive colorectal cancer (CRC) versus node-negative disease. Over-expression of TAGLN affected the expression of 256 downstream transcri...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01461-y
更新日期:2020-08-03 00:00:00
abstract:Background:Lymph node metastasis is one of the most important factors affecting the prognosis of tongue cancer, and the molecular mechanism regulating lymph node metastasis of tongue cancer is poorly known. Methods:The gene expression dataset GSE2280 and The Cancer Genome Atlas (TCGA) tongue cancer dataset were downlo...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-1028-2
更新日期:2019-11-21 00:00:00
abstract:BACKGROUND:Epithelial mesenchymal transition (EMT) mediated by TGF-β pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract of Stellera chamaejasme L. (ESC) was against proliferation of a variety of tumor cells, but there were no studies in the...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0265-2
更新日期:2015-12-10 00:00:00
abstract:OBJECTIVES:Bladder transitional cell carcinoma (TCC) is one of the most common solid malignancies in China. This study examined the antitumor effect and underlying mechanism of action of sunitinib malate in human bladder TCC in vitro. METHODS:Bladder TCC cell lines 5637 and BIU87 were maintained in 1640 medium and T24...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0179-z
更新日期:2015-02-28 00:00:00
abstract:Background:Some studies have investigated the prognostic value exhibited by the Prognostic Nutritional Index (PNI) in patients suffering diffuse large B-cell lymphoma (DLBCL), but varying results were obtained. In order to determine the specific prognostic value more accurately, a meta-analysis was conducted in this st...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01535-x
更新日期:2020-09-15 00:00:00
abstract:BACKGROUND:Mammaglobin (MAM) has been used as a specific molecular marker for breast cancer diagnosis. Recently, several groups of researchers proposed a number of therapeutic strategies targeting this molecule. Some of the strategies are based upon an essential but not demonstrated hypothesis - mammaglobin is associat...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-9-8
更新日期:2009-03-23 00:00:00
abstract:BACKGROUND:CD44 has recently been reported as a cancer stem cell marker in ovarian cancer. However, the clinicopathological and prognostic value of this marker in ovarian cancer remains controversial; Here, we aimed to investigate the correlation between CD44 expression and the clinicopathological features or survival ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-016-0376-4
更新日期:2017-01-05 00:00:00
abstract:BACKGROUND:Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other health benefits. The survival pathways of Akt and extracellular signal-regulated kinase (Erk), and t...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-6
更新日期:2014-01-23 00:00:00
abstract:Background:Kinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of breast cancer. However, the prognostic value of whole family members was poorly done. Our study intends to demonstrate the value of kinesin superfamily members as prognostic biomarkers as well...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01191-1
更新日期:2020-04-15 00:00:00
abstract:Background:Dysregulation of lncRNAs is frequent in glioma and has emerged as an important mechanism involved in tumorigenesis. Previous analysis of Chinese Glioma Genome Atlas (CGGA) database indicated that LBX2-AS1 expression is one of differentially expression lncRNA between lower grade glioma (LGG) (grade II and III...
journal_title:Cancer cell international
pub_type: 杂志文章,收录出版
doi:10.1186/s12935-020-01433-2
更新日期:2020-08-26 00:00:00
abstract::Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved in inhibition of apoptosis and regulation of cell cycle. These functional attributes make Survivin a unique protein exhibiting divergent functions i.e. regulating cell proliferation and cell death. Expression pattern of Su...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-016-0326-1
更新日期:2016-06-23 00:00:00
abstract::Prostate cancer is a gland tumor in the male reproductive system. It is a multifaceted and genomically complex disease. Transmembrane protease, serine 2 and v-ets erythroblastosis virus E26 homolog (TMPRSS2-ERG) gene fusions are the common molecular signature of prostate cancer. Although tremendous advances have been ...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/1475-2867-14-34
更新日期:2014-04-17 00:00:00
abstract:BACKGROUND:Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation. However prolonged androgen deprivation often results in relapse and androgen-independent prostate cancer that is inevita...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-8-3
更新日期:2008-03-18 00:00:00
abstract:BACKGROUND:Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. The purposes of this study were to e...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01623-y
更新日期:2020-11-03 00:00:00
abstract:BACKGROUND:Castration-resistance in prostate cancer (PC) is a critical event hallmarking a switch to a more aggressive phenotype. Neuroendocrine differentiation and upregulation of NFκB transcriptional activity are two mechanisms that have been independently linked to this process. METHODS:We investigated these two pa...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-11-13
更新日期:2011-05-15 00:00:00
abstract:Background:Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen fails to bind estrogen-receptor (ER). High estrogen is a known carcinogen in postmenopausal women. Re...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1153-y
更新日期:2020-03-04 00:00:00
abstract:Background:Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a novel lncRNA-NEAT has not been thoroughly investigated in melanoma cancer. The purposes of this study ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0927-6
更新日期:2019-08-22 00:00:00
abstract:Background:New drugs for adrenocortical carcinoma (ACC) are needed because most patients undergo rapid disease progression despite surgery and adjuvant therapy with mitotane. In this study, we aimed to investigate the in vitro effects of different chemotherapy drugs, alone or combined with mitotane, on the viability of...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0527-x
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:MicroRNAs are a class of small non-coding RNAs that are involved in many important physiological and pathological processes by regulating gene expression negatively. The purpose of this study was to investigate the effect of miR-32 on cell proliferation, migration and apoptosis and to determine the functiona...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0383-0
更新日期:2017-01-25 00:00:00
abstract:BACKGROUND:Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-α), which induce apoptosis in target cells. Many tumors express Heme oxygenase 1 (HO-1), and this expression has b...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-014-0100-1
更新日期:2014-10-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether brain abundant membrane attached signal protein 1 (BASP1) is a valuable prognostic biomarker for cervical cancer and whether BASP1 regulates the progression of cervical cancer. METHODS:Quantitative real-time PCR, western blotting, and immunohistochemistry were ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0452-4
更新日期:2017-10-24 00:00:00
abstract:Background:Newly identified lncRNA zinc finger protein, FOG family member 2 antisense RNA 1 (ZFPM2-AS1) is identified as an oncogenic gene. However, the role of ZFPM2-AS1 in small cell lung cancer (SCLC) is poorly comprehended. Methods:The expression of genes in SCLC tissues and cells was measured by qRT-PCR. Colony f...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1157-7
更新日期:2020-04-03 00:00:00
abstract:Background:Breast cancer is one of the most common malignancy among females from the worldwide cancer incidence statistics. Peroxisome gamma coactivator-1β (PGC-1β) has long been identified to be involved in this type of tumorigenesis. However, the mechanisms of PGC-1β in human breast cancer have not been fully underst...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0810-5
更新日期:2019-04-11 00:00:00
abstract::Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences show that overexpression of Six1 plays a key role in tumorigenesis. However, the Six1 expression status and its relationship with the clinicopatholo...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0215-z
更新日期:2015-06-20 00:00:00
abstract:Background:Acute myeloid leukemia (AML) is a clinically and biologically heterogeneous disease. The survival of older patients is generally poor. In the current study, we sought to investigate the differences in molecular gene mutations between younger and older AML patients, and to identify those newly diagnosed AML p...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0716-7
更新日期:2018-12-22 00:00:00
abstract:BACKGROUND:The aim of this study is to explore the expression of alpha-synuclein (α-synuclein) in benign, atypical, and anaplastic meningiomas and determine its role in the malignant progression of meningiomas. METHODS:Expression of α-synuclein was measured in 44 meningioma samples by real-time PCR analysis. The effec...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-016-0361-y
更新日期:2016-11-15 00:00:00
abstract:Background:Pancreatic cancer is a common malignant tumor of the digestive tract. It has a high degree of malignancy and poor prognosis. Finding effective molecular markers has great significance for pancreatic cancer diagnosis and treatment. This study aimed to investigate DLGAP5 expression in pancreatic cancer and exp...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01474-7
更新日期:2020-08-08 00:00:00
abstract:Background:A number of JmjC domain-containing histone demethylases have been identified and biochemically characterized in mammalian models and humans. JMJD2A is a transcriptional co-factor and enzyme that catalyzes the demethylation of histone H3 lysine 9 and 36 (H3K9 and H3K36). Here in this study, we reported the ro...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01177-z
更新日期:2020-03-30 00:00:00
abstract:Background:Many epidemiological studies have investigated association of AXIN2 variants on overall cancer risks; however, the available results remain inconsistent. Methods:An updated analysis was conducted to ascertain a more accurate estimation of the correlation between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G po...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0840-z
更新日期:2019-05-06 00:00:00
abstract:Background:Alternative splicing (AS) is a key factor in protein-coding gene diversity, and is associated with the development and progression of malignant tumours. However, the role of AS in cervical cancer is unclear. Methods:The AS data for cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) were...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01299-4
更新日期:2020-06-08 00:00:00