Abstract:
Background:Glioma is the most common central nervous system (CNS) tumour. p62, an important autophagy adaptor, plays a crucial role in cancer. However, the role of p62 in the progression of glioma is poorly characterized. Methods:We examined the expression of p62 in glioma tissues and cell lines. Then we investigated the function of p62 in vitro, and clarified the mechanism underlying the regulation of p62 expression. Results:We revealed that p62 was upregulated at both the mRNA and protein levels in human glioma tissues irrelevant to isocitrate dehydrogenase (IDH) status. Then, we found that overexpression of p62 promoted glioma progression by promoting proliferation, migration, glycolysis, temozolomide (TMZ) resistance and nuclear factor κB (NF-κB) signalling pathway, and repressing autophagic flux and reactive oxygen species (ROS) in vitro. In accordance with p62 overexpression, knockdown of p62 exerted anti-tumour effects in glioma cells. Subsequently, we demonstrated that miR-124-3p directly targeted the 3'-UTR of p62 mRNA, leading to the downregulation of p62. Finally, we found that p62 function could be partially reversed by miR-124-3p overexpression. Conclusions:Our results demonstrate that p62 can be targeted by miR-124-3p and acts as an oncogene in glioma, suggesting the potential value of p62 as a novel therapeutic target for glioma.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Deng D,Luo K,Liu H,Nie X,Xue L,Wang R,Xu Y,Cui J,Shao N,Zhi Fdoi
10.1186/s12935-019-1004-xsubject
Has Abstractpub_date
2019-11-06 00:00:00pages
280issn
1475-2867pii
1004journal_volume
19pub_type
杂志文章abstract:Background:Cutaneous melanoma is one of the most aggressive and lethal skin cancers. It is greatly important to identify prognostic biomarkers to guide the clinical management. However, it is technically challenging for untrained researchers to process high dimensional profiling data and identify potential prognostic g...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01262-3
更新日期:2020-05-19 00:00:00
abstract:BACKGROUND:We previously observed that the TGFbeta-Par6 pathway mediates loss of polarity and apoptosis in NMuMG cells. Here we investigate the contribution of Par6 versus TGFbeta receptor I activation to TGFbeta-induced apoptosis in association with changes in apico-basal polarity. We focus on the effect of Par6 activ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-19
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND:Several reports have revealed that cancer stem cells (CSCs) exist in many types of solid tumors. Some studies have demonstrated that side population (SP) cells isolated from diverse cancer lines harbor cancer stem-like properties, but there are few reports examining the characteristic of SP cells in human ce...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-3
更新日期:2014-01-13 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-4-1
更新日期:2004-01-07 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-016-0293-6
更新日期:2016-03-10 00:00:00
abstract:BACKGROUND:Phenethyl isothiocyanate (PEITC), present naturally in cruciferous vegetables, is a chemopreventive agent. It blocks initiation and post-initiation progression of carcinogenesis. Mechanism study in human prostate cancer cells revealed that PEITC is a dual inhibitor of aberrant DNA hypermethylation and histon...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-30
更新日期:2014-03-31 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0722-9
更新日期:2019-01-03 00:00:00
abstract:Background:Tumor necrosis factor-α (TNF-α) immunotherapy controls the progression of human cervical cancer. Here, we explored the detailed molecular mechanisms played by melatonin in human cervical cancer (HeLa cells) death in the presence of TNF-α injury, with a particular attention to the mitochondrial homeostasis. ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0777-2
更新日期:2019-03-14 00:00:00
abstract:BACKGROUND:Gastric carcinoma (GC) is currently one of the most common malignant tumors of the digestive system, and gastric precancerous lesions play a vital role in studying the mechanism of GC. Multiple microRNAs (miRNAs) have been documented to be potential biomarkers to indicate progression of gastric precancerous ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01578-0
更新日期:2020-11-13 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01720-y
更新日期:2021-01-14 00:00:00
abstract:BACKGROUND:Pancreatic cancer is currently one of the leading causes of cancer deaths without any effective therapies. Mir-145 has been found to be tumor-suppressive in various types of cancers. The aim of this study is to investigate the role of miR-145 in pancreatic cancer cells and explore its underlying mechanism. ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-016-0331-4
更新日期:2016-08-25 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01350-4
更新日期:2020-06-22 00:00:00
abstract:BACKGROUND:The goal of this study was to identify the nature of the inclusion bodies that have been found in HeLa cells (cervical cancer immortal cell line) by electron microscope and to determine whether the major capsid protein (L1) of human papillomavirus (HPV) can be expressed in HPV-positive uterine cervix cancer ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0206-0
更新日期:2015-05-23 00:00:00
abstract::Application of novel methods in cancer therapy is important in terms of management and treatment of the life-threatening disorder. It appears that autophagy is a potential target in cancer therapy, as a variety of drugs targeting autophagy have shown great potential in reducing the viability and proliferation of cance...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01634-9
更新日期:2020-11-04 00:00:00
abstract:Background:Increasing evidences have underlined the importance of long non-coding RNAs (lncRNAs) in human malignancies. LINC00958 has been found involved in some cancers. However, the underlying mechanical performance of LINC00958 in lung adenocarcinoma (LAD) has not been explored yet. Methods:The expression of releva...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1099-0
更新日期:2020-01-23 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-014-0093-9
更新日期:2014-09-24 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0677-x
更新日期:2018-11-13 00:00:00
abstract:BACKGROUND:MicroRNAs are a class of small non-coding RNAs that are involved in many important physiological and pathological processes by regulating gene expression negatively. The purpose of this study was to investigate the effect of miR-32 on cell proliferation, migration and apoptosis and to determine the functiona...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0383-0
更新日期:2017-01-25 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01289-6
更新日期:2020-05-29 00:00:00
abstract:BACKGROUND:Circular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types of human tumors. So they have been considered as promising candidates as diagnostic and therapeutic targets in cancer. This research aimed to screen the profile of circR...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01681-2
更新日期:2021-01-07 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0710-0
更新日期:2018-12-19 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0754-9
更新日期:2019-02-14 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1124-3
更新日期:2020-02-13 00:00:00
abstract:Background:Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting considerable attention. In recent years, the causal role between LPR and laryngeal carcinoma has been debated. The main harmful component of LPR is pepsin, which has been shown to induce mucosal inflammation by damaging the mucous m...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0772-7
更新日期:2019-03-20 00:00:00
abstract:BACKGROUND:MicroRNAs are 22-24 nt non-coding RNAs that bind to the 3' UTR of target mRNAs, thereby inducing mRNA degradation or inhibiting mRNA translation. Due to their implication in the regulation of post-transcriptional processes, the role of miRNAs in hepatocellular carcinoma (HCC) has been extensively studied. Ho...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0386-x
更新日期:2017-02-21 00:00:00
abstract:Objective:This study aimed to investigate the relationship among miR-145-5p, ANGPT2 and the NOD_LIKE_RECEPTOR pathway, thereby revealing the molecular mechanism of these three factors underlying the proliferation, migration and invasion of gastric cancer (GC) epithelial cells. Methods:qRT-PCR was carried out to detect...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01483-6
更新日期:2020-08-28 00:00:00
abstract:Background:Chimeric antigen receptors (CARs) represent a novel facet of modern day synthetic biology that exemplifies personalized medicine at work through their ability to harness and redirect a patient's immune system to fight cancer. Body:By combining the target-specificity of antibodies to the effector capabilitie...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-018-0685-x
更新日期:2018-11-14 00:00:00
abstract:: At the beginning of the 21st century cancer research has reached an impasse similar to that experienced in developmental biology in the first decades of the 20th century when conflicting results and interpretations co-existed for a long time until these differences were resolved and contradictions were eliminated. In...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-12-12
更新日期:2012-03-26 00:00:00
abstract:Background and aims:microRNAs (miRNAs) have been reported to regulate proliferation and migration by down-regulating the expression of target genes. The aims of this study were to investigate whether miR-4316 inhibited proliferation and migration by downregulating vascular endothelial growth factor A (VEGF-A) and its c...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1132-3
更新日期:2020-02-22 00:00:00
abstract:BACKGROUND:Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandins synthesis which exists in two isoforms, COX-1 and COX-2. Over-expression of COX-2 was considered to increase the proliferation and enhance the invasiveness of breast cancer cells. It was suggested that genetic variations in COX-2 could influenc...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-38
更新日期:2014-05-06 00:00:00