Abstract：
: At the beginning of the 21st century cancer research has reached an impasse similar to that experienced in developmental biology in the first decades of the 20th century when conflicting results and interpretations co-existed for a long time until these differences were resolved and contradictions were eliminated. In cancer research, instead of this healthy "weeding-out" process, there have been attempts to reach a premature synthesis, while no hypothesis is being rejected. Systems Biology could help cancer research to overcome this stalemate by resolving contradictions and identifying spurious data. First, in silico experiments should allow cancer researchers to be bold and a priori reject sets of data and hypotheses in order to gain a deeper understanding of how each dataset and each hypothesis contributes to the overall picture. In turn, this process should generate novel hypotheses and rules, which could be explored using these in silico approaches. These activities are significantly less costly and much faster than "wet-experiments". Consequently, Systems Biology could be advantageously used both as a heuristic tool to guide "wet-experiments" and to refine hypotheses and test predictions.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Soto AM,Sonnenschein Cdoi
10.1186/1475-2867-12-12subject
Has Abstractpub_date
2012-03-26 00:00:00pages
12issue
1issn
1475-2867pii
1475-2867-12-12journal_volume
12pub_type
杂志文章abstract：OBJECTIVE:To explore the relationship between tumor necrosis factor receptor-associated factor 6 (TRAF6) and the clinicopathological features in HCC as well as its biological function. METHODS:Totally, 412 liver tissues were collected, including 171 hepatocellular carcinoma (HCC) and their corresponding non-tumor tiss...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-016-0352-z
更新日期：2016-09-29 00:00:00
abstract：Background:Abnormal expressions of long noncoding RNAs (lncRNAs) are very common in clear cell renal cell carcinoma (ccRCC), and some of these have been reported to be highly correlated with prognosis of ccRCC patients. Methods:"edgeR" AND "DEseq" R packages were used to explore differentially expressed genes (DEGs) b...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0928-5
更新日期：2019-08-05 00:00:00
abstract：:Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences show that overexpression of Six1 plays a key role in tumorigenesis. However, the Six1 expression status and its relationship with the clinicopatholo...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-015-0215-z
更新日期：2015-06-20 00:00:00
abstract：:RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression, particularly in gastrointestinal cancers. RNA methylation has a variety of b...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-020-01679-w
更新日期：2020-12-07 00:00:00
abstract：Background:Pancreatic cancer (PC) remains one of the most aggressive cancers worldwide. However, genetic factors underlying PC susceptibility remain largely unclear. Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an oncogene and its genetic variation has been linked to many cancers. However, ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0761-x
更新日期：2019-02-28 00:00:00
abstract：BACKGROUND:Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other health benefits. The survival pathways of Akt and extracellular signal-regulated kinase (Erk), and t...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-14-6
更新日期：2014-01-23 00:00:00
abstract：Background:Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a novel lncRNA-NEAT has not been thoroughly investigated in melanoma cancer. The purposes of this study ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0927-6
更新日期：2019-08-22 00:00:00
abstract：BACKGROUND:CircRNAs play crucial roles in multiple tumours. However, the functions of most circRNAs in cervical cancer remain unclear. METHODS:This study collected GSE113696 data from the GEO database to search for differentially expressed circRNAs in cervical cancer. Quantitative reverse transcription PCR was used to...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01736-4
更新日期：2021-01-07 00:00:00
abstract：Background:The crucial role of long non-coding RNAs (lncRNAs) has been certified in human cancers. The lncRNAs with abnormal expressions could act as tumor inhibitors or oncogenes in the advancement of tumors. LBX2-AS1 was once reported to accelerate esophageal squamous cell carcinoma. Nonetheless, its function in gast...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01207-w
更新日期：2020-04-26 00:00:00
abstract：UNLABELLED: BACKGROUND:Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitotic activity. Investigating the anticancer potential of 2-methoxyestradiol-bis-sulphamat...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-12-37
更新日期：2012-08-20 00:00:00
abstract：BACKGROUND:Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. The purposes of this study were to e...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01623-y
更新日期：2020-11-03 00:00:00
abstract：Background:Cancer-associated fibroblasts (CAFs) play important roles in tumor progression. However, the behaviors of activated CAFs in gastric cancer remain to be determined. The aim of the present study was to investigate the correlations between activated gastric CAFs and the prognosis of patients with gastric cancer...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0599-7
更新日期：2018-07-20 00:00:00
abstract：BACKGROUND:Expression of P-glycoprotein (P-gp), the multidrug resistance (MDR) 1 gene product, can lead to multidrug resistance in tumours. However, the physiological role of P-gp in tumours growing as multicellular spheroids is not well understood. Recent evidence suggests that P-gp activity may be modulated by cellul...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-5-20
更新日期：2005-07-07 00:00:00
abstract：:[This retracts the article DOI: 10.1186/s12935-015-0237-6.]. ...
journal_title：Cancer cell international
pub_type： 撤回出版物
doi：10.1186/s12935-016-0359-5
更新日期：2016-11-04 00:00:00
abstract：BACKGROUND:Despite the modern therapies available for treating glioblastoma multiforme (GBM), it is still a deadly disease. The development of new therapeutic strategies for the management of gliomas is therefore crucial. The present study is designed to analyze the therapeutic potentials of synthetic compound N-(2-hyd...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-014-0133-5
更新日期：2014-11-30 00:00:00
abstract：Background:Breast cancer is one of the most common malignancy among females from the worldwide cancer incidence statistics. Peroxisome gamma coactivator-1β (PGC-1β) has long been identified to be involved in this type of tumorigenesis. However, the mechanisms of PGC-1β in human breast cancer have not been fully underst...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0810-5
更新日期：2019-04-11 00:00:00
abstract：BACKGROUND:Urokinase-type Plasminogen Activator (uPA), a serine protease, plays a pivotal role in human breast cancer metastasis by mediating the degradation of extracellular matrix proteins and promoting cell motility. In more advanced breast cancers, uPA activity is significantly up regulated and serves as a prognost...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-6-16
更新日期：2006-05-31 00:00:00
abstract：Background:The staging system of nasopharyngeal carcinoma (NPC) has close relationship with the degree of cell differentiation, but most NPC patients remain undiagnosed until advanced phases. Novel metabolic markers need to be characterized to support diagnose at an early stage. Methods:Metabolic characteristics of na...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0759-4
更新日期：2019-02-18 00:00:00
abstract：Background:Accumulating studies showed that long noncoding RNAs (lncRNAs) played vital roles in cancer progression. LncRNA MIR4435-2HG was proved to act as an oncogene in various tumors. However, the underlying function of MIR4435-2HG in ovarian cancer (OC) remains unclear. Methods:The expression levels of MIR4435-2HG...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01227-6
更新日期：2020-05-01 00:00:00
abstract：Background:Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies and a major cause of cancer related death worldwide, especially in China. Cell lines are widely used disease models for basic medical research, however, well characterized ESCC cell models from China were seldom reported. Mis...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01268-x
更新日期：2020-05-24 00:00:00
abstract：Background:The hypoxic tumor microenvironment accelerates the invasion and migration of colorectal cancer (CRC) cells. The aim of this study was to develop and validate a hypoxia gene signature for predicting the outcome in stage I/II CRC patients that have limited therapeutic options. Methods:The hypoxic gene signatu...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0964-1
更新日期：2019-09-23 00:00:00
abstract：BACKGROUND:The present study mainly aimed to investigate the direct effects of Endostar (ES) on the proliferation and radiosensitivity of human lung squamous cancer cell line H-520. RESULTS:ES significantly inhibited H-520 cell proliferation in a time- and dose-dependent manner. According to the colony-forming assays,...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-10-17
更新日期：2010-05-24 00:00:00
abstract：BACKGROUND:MicroRNAs are 22-24 nt non-coding RNAs that bind to the 3' UTR of target mRNAs, thereby inducing mRNA degradation or inhibiting mRNA translation. Due to their implication in the regulation of post-transcriptional processes, the role of miRNAs in hepatocellular carcinoma (HCC) has been extensively studied. Ho...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0386-x
更新日期：2017-02-21 00:00:00
abstract：:[This corrects the article DOI: 10.1186/s12935-020-01426-1.]. ...
journal_title：Cancer cell international
pub_type： 已发布勘误
doi：10.1186/s12935-020-01482-7
更新日期：2020-08-18 00:00:00
abstract：BACKGROUND:The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death. The role of these channels in the onset and progression of ovarian cancer is unknown. An understanding of mechanism by whi...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-11-6
更新日期：2011-03-10 00:00:00
abstract：:Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved in inhibition of apoptosis and regulation of cell cycle. These functional attributes make Survivin a unique protein exhibiting divergent functions i.e. regulating cell proliferation and cell death. Expression pattern of Su...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-016-0326-1
更新日期：2016-06-23 00:00:00
abstract：: Cancer-initiating cells display aberrant functional and phenotypic characteristics of normal stem cells from which they evolved by accumulation of multiple cytogenetic and/or epigenetic alterations. Signal transduction pathways which are essential for normal stem cell function are abnormally expressed by cancer cells...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-12-24
更新日期：2012-06-07 00:00:00
abstract：Background:MicroRNAs have been involved in regulating crucial biological function in some tumors. However, the clinical role and functional effects of miR-591 in breast cancer remain unknown. Methods:The expression of miR-591 was detected in breast cancer tissues and their paired normal tissues by qRT-PCR. Functional ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0818-x
更新日期：2019-04-24 00:00:00
abstract：BACKGROUND:Mammaglobin (MAM) has been used as a specific molecular marker for breast cancer diagnosis. Recently, several groups of researchers proposed a number of therapeutic strategies targeting this molecule. Some of the strategies are based upon an essential but not demonstrated hypothesis - mammaglobin is associat...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-9-8
更新日期：2009-03-23 00:00:00
abstract：BACKGROUND:Resistance to drug therapy is a major impediment for successful treatment of patients suffering from breast cancer (BC). Tamoxifen (TAM) is an extensively used therapeutic agent, which substantially reduces the risk of recurrence and associated mortality in BC. This study demonstrated that exosomal transfer ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01659-0
更新日期：2021-01-15 00:00:00
