Bioinformatics analysis combined with experiments to explore potential prognostic factors for pancreatic cancer.

abstract：Background:Osteosarcoma (OS) is still a disease with high mortality from malignant tumors in children and adolescents. Due to its poor treatment, this study explored the involvement of lncRNA ZFAS1/microRNA-135a (miR-135a)/apurinic/apyrimidinic exonuclease 1 (APEX1) axis in the regulation of OS growth and metastasis. ...

journal_title：Cancer cell international

authors： Zhao Z,Lin X,Tong Y,Li W

更新日期：2019-12-03 00:00:00

abstract：BACKGROUND:BRAF inhibitors are effective anticancer agents in BRAF-mutated melanomas. By contrast, evidences about sensitivity of thyroid carcinomas to BRAF inhibition are conflicting and it has been proposed that BRAF V600E thyroid carcinoma cells are less sensitive to BRAF inhibitors due to activation of parallel sig...

journal_title：Cancer cell international

authors： Notarangelo T,Sisinni L,Condelli V,Landriscina M

更新日期：2017-10-04 00:00:00

abstract：: Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently, a number of studies have shown that the deletion or mutation of A20, a negative regulator of NF-κB, is frequ...

journal_title：Cancer cell international

authors： Zhang F,Yang L,Li Y

更新日期：2012-11-07 00:00:00

abstract：BACKGROUND:Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene (e.g. PTEN) or microRNAs (e.g. miR-23a and miR-29b). Metapristone is a hormone-related drug, which i...

journal_title：Cancer cell international

authors： Chang Y,Hao M,Jia R,Zhao Y,Cai Y,Liu Y

更新日期：2021-01-07 00:00:00

abstract：Background:Glioma is the most common central nervous system (CNS) tumour. p62, an important autophagy adaptor, plays a crucial role in cancer. However, the role of p62 in the progression of glioma is poorly characterized. Methods:We examined the expression of p62 in glioma tissues and cell lines. Then we investigated ...

journal_title：Cancer cell international

authors： Deng D,Luo K,Liu H,Nie X,Xue L,Wang R,Xu Y,Cui J,Shao N,Zhi F

更新日期：2019-11-06 00:00:00

abstract：BACKGROUND:Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-α), which induce apoptosis in target cells. Many tumors express Heme oxygenase 1 (HO-1), and this expression has b...

journal_title：Cancer cell international

authors： Gómez-Lomelí P,Bravo-Cuellar A,Hernández-Flores G,Jave-Suárez LF,Aguilar-Lemarroy A,Lerma-Díaz JM,Domínguez-Rodríguez JR,Sánchez-Reyes K,Ortiz-Lazareno PC

更新日期：2014-10-01 00:00:00

abstract：Background:Pancreatic cancer (PC) remains one of the most aggressive cancers worldwide. However, genetic factors underlying PC susceptibility remain largely unclear. Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an oncogene and its genetic variation has been linked to many cancers. However, ...

journal_title：Cancer cell international

authors： Jiang D,Xu L,Ni J,Zhang J,Cai M,Shen L

更新日期：2019-02-28 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is an aggressive cancer with high mortality and morbidity worldwide. The limited clinically relevant model has impeded the development of effective HCC treatment strategy. Patient-derived xenograft (PDX) models retain most of the characteristics of original tumors and were show...

journal_title：Cancer cell international

authors： Cheung PF,Yip CW,Ng LW,Lo KW,Chow C,Chan KF,Cheung TT,Cheung ST

更新日期：2016-06-08 00:00:00

abstract：BACKGROUND:Pancreatic cancer is currently one of the leading causes of cancer deaths without any effective therapies. Mir-145 has been found to be tumor-suppressive in various types of cancers. The aim of this study is to investigate the role of miR-145 in pancreatic cancer cells and explore its underlying mechanism. ...

journal_title：Cancer cell international

authors： Wang H,Hang C,Ou XL,Nie JS,Ding YT,Xue SG,Gao H,Zhu JX

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:CircRNAs play crucial roles in multiple tumours. However, the functions of most circRNAs in cervical cancer remain unclear. METHODS:This study collected GSE113696 data from the GEO database to search for differentially expressed circRNAs in cervical cancer. Quantitative reverse transcription PCR was used to...

journal_title：Cancer cell international

authors： Chen Y,Geng Y,Huang J,Xi D,Xu G,Gu W,Shao Y

更新日期：2021-01-07 00:00:00

abstract：Background:Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, the present study was performed to determine whether lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAF...

journal_title：Cancer cell international

authors： Ruan Z,Deng H,Liang M,Xu Z,Lai M,Ren H,Deng X,Su X

更新日期：2020-10-19 00:00:00

abstract：BACKGROUND:G protein-coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with pathologic differentiation grade of oral squamous cell carcinomas (OSCC) and overexpression of GPRC5A gene ...

journal_title：Cancer cell international

authors： Liu S,Ye D,Wang T,Guo W,Song H,Liao Y,Xu D,Zhu H,Zhang Z,Deng J

更新日期：2017-03-02 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s12935-017-0407-9.]. ...

journal_title：Cancer cell international

authors： Hu Y,Xie H,Liu Y,Liu W,Liu M,Tang H

更新日期：2020-07-17 00:00:00

abstract：Background:Long non-coding RNAs (lncRNAs) play significant roles in tumorigenesis and can contribute to identification of novel therapeutic targets for cancers. This paper was aimed at exploring the role of CTBP1 divergent transcript (CTBP1-AS2) in cervical cancer (CC) progression. Methods:qRT-PCR and western blot ass...

journal_title：Cancer cell international

authors： Yang S,Shi F,Du Y,Wang Z,Feng Y,Song J,Liu Y,Xiao M

更新日期：2020-07-28 00:00:00

abstract：Background:Angiogenesis plays critical roles in the progression and metastasis of malignant tumors. Gastric neuroendocrine carcinoma is an uncommon stomach cancer that is rich in blood vessels and exhibits highly malignant biological behavior with a poor prognosis. The role of CDK5RAP3 in GNEC has not been reported to ...

journal_title：Cancer cell international

authors： Lin JX,Weng XF,Xie XS,Lian NZ,Qiu SL,Wang JB,Lu J,Chen QY,Cao LL,Lin M,Tu RH,Yang YH,Liu SJ,Hu M,Lin YK,Huang CM,Zheng CH,Li P,Xie JW

更新日期：2019-11-07 00:00:00

abstract：Background:Extracellular ATP (eATP) was shown to induce epithelial-mesenchymal transition (EMT), a very important early process in metastasis, in cancer cells via purinergic receptor signaling. However, the exact induction mechanisms are far from fully known. We previously described that eATP is internalized by cancer ...

journal_title：Cancer cell international

authors： Cao Y,Wang X,Li Y,Evers M,Zhang H,Chen X

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:We previously observed that the TGFbeta-Par6 pathway mediates loss of polarity and apoptosis in NMuMG cells. Here we investigate the contribution of Par6 versus TGFbeta receptor I activation to TGFbeta-induced apoptosis in association with changes in apico-basal polarity. We focus on the effect of Par6 activ...

journal_title：Cancer cell international

authors： Avery-Cooper G,Doerr M,Gilbert RW,Youssef M,Richard A,Huether P,Viloria-Petit AM

更新日期：2014-03-01 00:00:00

abstract：Background:Recent studies have demonstrated that the kallikrein and kallikrein-related peptidases (KLKs) exhibit aberrant expression in patients with colorectal cancer (CRC) and might be considered as potential prognostic biomarkers of CRC. However, inconsistent findings have been reported, which promote us to summariz...

journal_title：Cancer cell international

authors： Peng Q,Shen Y,Zhao P,Cheng M,Wu Y,Zhu Y

更新日期：2020-06-22 00:00:00

abstract：BACKGROUND:Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor that has been reported to reduce the risk of breast cancer. In our previous study, celecoxib induced apoptosis and caused cell cycle arrest at the G0/G1 phase in the breast cancer cell line MDA-MB-231, and its effects were mediated by downregulation o...

journal_title：Cancer cell international

authors： Wang L,Kang F,Li J,Zhang J,Shan B

更新日期：2013-02-12 00:00:00

abstract：BACKGROUND:Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper gene expression and that aberrant DNA methylation of genes and histone methylation plays important ...

journal_title：Cancer cell international

authors： Watanabe H,Soejima K,Yasuda H,Kawada I,Nakachi I,Yoda S,Naoki K,Ishizaka A

更新日期：2008-11-03 00:00:00

abstract：BACKGROUND:The aim of this study is to explore the expression of alpha-synuclein (α-synuclein) in benign, atypical, and anaplastic meningiomas and determine its role in the malignant progression of meningiomas. METHODS:Expression of α-synuclein was measured in 44 meningioma samples by real-time PCR analysis. The effec...

journal_title：Cancer cell international

authors： Ge Y,Xu K

更新日期：2016-11-15 00:00:00

abstract：BACKGROUND:Bladder cancer (BCa) is a malignant tumor that occurs on the mucosa of the bladder, in which dysregulated long non-coding RNAs (lncRNAs) are involved. This study investigated the effect of lncRNA small nucleolar RNA host gene 1 (SNHG14) on the biological characteristics of BCa cells from microRNA (miR)-211-3...

journal_title：Cancer cell international

authors： Feng R,Li Z,Wang X,Ge G,Jia Y,Wu D,Ji Y,Wang C

更新日期：2021-01-22 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s12935-019-0742-0.]. ...

journal_title：Cancer cell international

authors： Ma MH,An JX,Zhang C,Liu J,Liang Y,Zhang CD,Zhang Z,Dai DQ

更新日期：2019-04-11 00:00:00

abstract：Background:Nuclear transcription factor kappa B (NF-κB) subunits exhibit crucial roles in tumorigenesis and chemo-sensitivity. Recent studies suggest that RelB, the key subunit of the alternative NF-κB pathway, plays a critical role in the progression of diverse human malignancies. However, the significance of RelB in ...

journal_title：Cancer cell international

authors： Zhou X,Shan Z,Yang H,Xu J,Li W,Guo F

更新日期：2018-11-13 00:00:00

abstract：Background:Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies and a major cause of cancer related death worldwide, especially in China. Cell lines are widely used disease models for basic medical research, however, well characterized ESCC cell models from China were seldom reported. Mis...

journal_title：Cancer cell international

authors： Li X,Tian D,Guo Y,Qiu S,Xu Z,Deng W,Su M

更新日期：2020-05-24 00:00:00

abstract：:Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1α) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in...

journal_title：Cancer cell international

authors： Jin X,Dai L,Ma Y,Wang J,Liu Z

更新日期：2020-06-24 00:00:00

abstract：Background:Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on...

journal_title：Cancer cell international

authors： Liu T,Jiang L,Yu L,Ge T,Wang J,Gao H

更新日期：2019-04-23 00:00:00

abstract：BACKGROUND:Cancer cells, even in the presence of available oxygen, have a glycolysis enhancement. The "aerobic glycolysis" is known as the Warburg effect and it is considered one of the fundamental hallmarks of metabolic alteration during malignant transformation. A feature of many tumors is also a change into ions equ...

journal_title：Cancer cell international

authors： Bruni L,Babarinde AA,Ortalli I,Croci S

更新日期：2014-08-12 00:00:00

abstract：OBJECTIVE:To explore the relationship between tumor necrosis factor receptor-associated factor 6 (TRAF6) and the clinicopathological features in HCC as well as its biological function. METHODS:Totally, 412 liver tissues were collected, including 171 hepatocellular carcinoma (HCC) and their corresponding non-tumor tiss...

journal_title：Cancer cell international

authors： Li JJ,Luo J,Lu JN,Liang XN,Luo YH,Liu YR,Yang J,Ding H,Qin GH,Yang LH,Dang YW,Yang H,Chen G

更新日期：2016-09-29 00:00:00

abstract：:Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-related death. Chronic myeloid leukaemia (CML) is a chronic leukaemia of the haematopoietic stem cells affecting...

journal_title：Cancer cell international

authors： Repsold L,Pool R,Karodia M,Tintinger G,Joubert AM

更新日期：2017-10-30 00:00:00