Abstract:
BACKGROUND:Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation. However prolonged androgen deprivation often results in relapse and androgen-independent prostate cancer that is inevitably fatal despite optimal chemotherapy. The Hedgehog signalling pathway has recently been implicated in prostate cancer development and metastasis. EGFR or ErbB2 expression has been also correlated with androgen independence, shorter survival and metastasis. RESULTS:We determined that the Hedgehog and ErbB signalling pathways are active in circulating tumour cells isolated from androgen-independent prostate cancer patients and in the androgen-independent prostate cancer cell line LNCaP C4-2B. As a basis for synergistic chemotherapy protocols combinations of the Hedgehog specific inhibitor cyclopamine and the ErbB signalling inhibitors gefitinib or lapatinib were tested in this study. Androgen-independent prostate cancer cell growth was inhibited by a SMO inhibitor (cyclopamine) which blocks Hedgehog signalling and by ErbB inhibitors (gefitinib and lapatinib). The isobologram and combination index method of Chou and Talalay was used to evaluate drug interactions. Synergistic antiproliferation effects were observed when the Hedgehog and ErbB inhibitors were combined. CONCLUSION:Androgen-independent prostate cancer cell proliferation was associated with activity of the Hedgehog and ErbB signalling pathways. Cyclopamine, gefitinib or lapatinib treatment significantly decreased the proliferation of androgen-independent prostate cancer cells. The Hedgehog pathway therefore represents a promising new therapeutic target in androgen-independent prostate cancer. Synergistic effects were observed when Hedgehog and ErbB inhibitors were used together. This study may have clinical implications for improving the treatment of advanced prostate cancer.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Shaw G,Prowse DMdoi
10.1186/1475-2867-8-3subject
Has Abstractpub_date
2008-03-18 00:00:00pages
3issn
1475-2867pii
1475-2867-8-3journal_volume
8pub_type
杂志文章abstract:BACKGROUND:Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene (e.g. PTEN) or microRNAs (e.g. miR-23a and miR-29b). Metapristone is a hormone-related drug, which i...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01682-1
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Increased expression of voltage-gated sodium channels (VGSCs) have been implicated with strong metastatic potential of human breast cancer in vitro and in vivo where the main culprits are cardiac isoform Nav1.5 and its 'neonatal' splice variant, nNav1.5. Several factors have been associated with Nav1.5 and n...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0442-6
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:BRAF inhibitors are effective anticancer agents in BRAF-mutated melanomas. By contrast, evidences about sensitivity of thyroid carcinomas to BRAF inhibition are conflicting and it has been proposed that BRAF V600E thyroid carcinoma cells are less sensitive to BRAF inhibitors due to activation of parallel sig...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0457-z
更新日期:2017-10-04 00:00:00
abstract:BACKGROUND:Gastric carcinoma (GC) is currently one of the most common malignant tumors of the digestive system, and gastric precancerous lesions play a vital role in studying the mechanism of GC. Multiple microRNAs (miRNAs) have been documented to be potential biomarkers to indicate progression of gastric precancerous ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01578-0
更新日期:2020-11-13 00:00:00
abstract:Background:It is well known that hepatocellular carcinoma (HCC) has been one of the most life-threatening diseases all over the world. Plenty of internal and extrinsic factors have been proven to be related to HCC, such as gene mutation, viral hepatitis, and Nitrosamines. Though previous studies demonstrated that gluta...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0792-3
更新日期:2019-03-29 00:00:00
abstract:BACKGROUND:Liver cancer is one of the most frequent cancers in the world. Targeted therapy of cancer with specific inhibitors is developing and has shown promising antitumor efficacy. CCI-779 (temsirolimus), a specific inhibitor of mTOR (mammalian target of rapamycin), can block the mTOR signaling pathway. Here, we sys...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-13-30
更新日期:2013-03-28 00:00:00
abstract:Background:miR-429 and TLN1 have been shown to affect the biological behaviours of many carcinomas. However, their effects in nasopharyngeal carcinoma (NPC) are not yet clear. Here, we investigated their regulatory relationships and effects on NPC cells. Methods:TargetScan was used to predict the regulatory relationsh...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0831-0
更新日期:2019-04-30 00:00:00
abstract:BACKGROUND:Phenethyl isothiocyanate (PEITC), present naturally in cruciferous vegetables, is a chemopreventive agent. It blocks initiation and post-initiation progression of carcinogenesis. Mechanism study in human prostate cancer cells revealed that PEITC is a dual inhibitor of aberrant DNA hypermethylation and histon...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-30
更新日期:2014-03-31 00:00:00
abstract:BACKGROUND:Long non-coding RNAs (lncRNAs) are increasingly implicated in the regulation of the progression of malignancy. AIM:To clarify the relations among BCYRN1 (brain cytoplasmic RNA 1, a long non-coding RNA), c-MYC and cell metastasis of non-small-cell lung cancer (NSCLC). METHODS:Real-time PCR was used to measu...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0183-3
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:The incidence and mortalities from cancers remain on the rise worldwide. Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. As such, efforts to discover and develop new and more effective and less toxic agents against cancer remain a t...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0404-z
更新日期:2017-03-07 00:00:00
abstract:Background:Some studies have investigated the prognostic value exhibited by the Prognostic Nutritional Index (PNI) in patients suffering diffuse large B-cell lymphoma (DLBCL), but varying results were obtained. In order to determine the specific prognostic value more accurately, a meta-analysis was conducted in this st...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01535-x
更新日期:2020-09-15 00:00:00
abstract:Background:Transgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that transgelin was up-regulated in node-positive colorectal cancer (CRC) versus node-negative disease. Over-expression of TAGLN affected the expression of 256 downstream transcri...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01461-y
更新日期:2020-08-03 00:00:00
abstract:Background:Abnormally expressed circular RNAs (circRNAs) are implicated in the development and treatment of gastric cancer (GC). Previous study has reported that hsa_circ_0003159 is expressed in GC. However, the role and mechanism of hsa_circ_0003159 in GC progression remain unclear. Methods:GC tissues and normal tiss...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1119-0
更新日期:2020-02-19 00:00:00
abstract:Background:Cholangiocarcinoma (CCA) is an invasive malignancy arising from biliary epithelial cells; it is the most common primary tumour of the bile tract and has a poor prognosis. The aim of this study was to screen prognostic biomarkers for CCA by integrated multiomics analysis. Methods:The GSE32225 dataset was der...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01212-z
更新日期:2020-04-22 00:00:00
abstract::Circular RNAs (circRNAs) are small non-coding RNAs with a unique ring structure and play important roles as gene regulators. Disturbed expressions of circRNAs is closely related to varieties of pathological processes. The roles of circRNAs in cancers have gained increasing concerns. The communications between the canc...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01301-z
更新日期:2020-06-03 00:00:00
abstract:Background:In recent years, the B cell receptor (BCR) signaling pathway has become a "hot point" because it plays a critical role in B-cell proliferation and function. Bruton's tyrosine kinase (BTK) is overexpressed in many subtypes of B-cell lymphoma as a downstream kinase in the BCR signaling pathway. Ibrutinib, the ...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01518-y
更新日期:2020-09-29 00:00:00
abstract:BACKGROUND:Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other health benefits. The survival pathways of Akt and extracellular signal-regulated kinase (Erk), and t...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-6
更新日期:2014-01-23 00:00:00
abstract:Background:Schwannoma arising from peripheral nervous sheaths is a benign tumor. Methods:To evaluate cell cytotoxicity, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction and terminal deoxynucleotidyltransferase UTP nick-end labeling (TUNEL) assays were used. A microRNA (miRNA) array ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0693-x
更新日期:2018-12-04 00:00:00
abstract:Background:SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism explaining its function in cell proliferation regulation. Here we investigated cancer cell response t...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0618-8
更新日期:2018-09-05 00:00:00
abstract:Background and aims:microRNAs (miRNAs) have been reported to regulate proliferation and migration by down-regulating the expression of target genes. The aims of this study were to investigate whether miR-4316 inhibited proliferation and migration by downregulating vascular endothelial growth factor A (VEGF-A) and its c...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1132-3
更新日期:2020-02-22 00:00:00
abstract:BACKGROUND:ErbB3-binding protein 1 (Ebp1) is a member of the PA2G4 family of proliferation-regulated proteins that is expressed in multiple malignant and non-malignant cells. ErbB3 and other members of the EGFR family have been implicated in cancer progression, it however remains unknown whether Ebp1 participate in pro...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-8-18
更新日期:2008-11-24 00:00:00
abstract::BACKGROUND: We describe an alternative method to determine mRNA half-life (t1/2) based on the Real-Time RT-PCR procedure. This approach was evaluated by using the beta-actin gene as a reference molecule for measuring of mRNA stability. RESULTS: Human leukemia Nalm-6 and CCRF-CEM cells were treated with various concent...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-2-1
更新日期:2002-03-07 00:00:00
abstract:BACKGROUND:miR-222 has been reported to be overexpressed in colorectal cancer and it influences cancer cell proliferation, drug resistance and metastasis. However, the underlying molecular mechanism of miR-222 in colorectal cancer cell invasion and migration has not been thoroughly elucidated to date. METHODS:The cell...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0447-1
更新日期:2017-08-29 00:00:00
abstract:Background:To investigate the expression of RASSF-1A in oral squamous cell carcinoma (OSCC) and adjacent tissues, and to explore its mechanism of action in the development of OSCC. Methods:RASSF-1A and proliferation-related protein expression in clinical and OSCC mouse models were detected by qPCR and western blot. In...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0932-9
更新日期:2019-08-13 00:00:00
abstract::[This retracts the article DOI: 10.1186/s12935-015-0237-6.]. ...
journal_title:Cancer cell international
pub_type: 撤回出版物
doi:10.1186/s12935-016-0359-5
更新日期:2016-11-04 00:00:00
abstract:Background:Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a novel lncRNA-NEAT has not been thoroughly investigated in melanoma cancer. The purposes of this study ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0927-6
更新日期:2019-08-22 00:00:00
abstract:Background:Gastric cancer (GC) is a common cause of cancer-related mortality worldwide, and microRNAs (miRNAs) have been shown to play an important role in GC development. This study aims to explore the effect of microRNA-93-5p (miR-93-5p) on the epithelial-mesenchymal transition (EMT) in GC, via AHNAK and the Wnt sign...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-1092-7
更新日期:2020-03-12 00:00:00
abstract:Background:MicroRNA (MiRNA) is a small non-coding RNA which is implicated in a cohort of biological function in cancer, including proliferation, metastasis, apoptosis and invasion. MiR-96 has been reported to be involved in many cancers, including papillary thyroid cancer. However, the role of miR-96-3p in papillary th...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-1003-y
更新日期:2019-11-12 00:00:00
abstract:Background:Abnormal expressions of long noncoding RNAs (lncRNAs) are very common in clear cell renal cell carcinoma (ccRCC), and some of these have been reported to be highly correlated with prognosis of ccRCC patients. Methods:"edgeR" AND "DEseq" R packages were used to explore differentially expressed genes (DEGs) b...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0928-5
更新日期:2019-08-05 00:00:00
abstract:BACKGROUND:The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death. The role of these channels in the onset and progression of ovarian cancer is unknown. An understanding of mechanism by whi...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-11-6
更新日期:2011-03-10 00:00:00