Alantolactone inhibits cell autophagy and promotes apoptosis via AP2M1 in acute lymphoblastic leukemia.

abstract：BACKGROUND:Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. The purposes of this study were to e...

journal_title：Cancer cell international

authors： Yu X,Zhang X,Wang G,Wang B,Ding Y,Zhao J,Liu H,Cui S

更新日期：2020-11-03 00:00:00

abstract：Background:The staging system of nasopharyngeal carcinoma (NPC) has close relationship with the degree of cell differentiation, but most NPC patients remain undiagnosed until advanced phases. Novel metabolic markers need to be characterized to support diagnose at an early stage. Methods:Metabolic characteristics of na...

journal_title：Cancer cell international

authors： Chen Y,Chen Z,Su Y,Lin D,Chen M,Feng S,Zou C

更新日期：2019-02-18 00:00:00

abstract：Background:MicroRNA (MiRNA) is a small non-coding RNA which is implicated in a cohort of biological function in cancer, including proliferation, metastasis, apoptosis and invasion. MiR-96 has been reported to be involved in many cancers, including papillary thyroid cancer. However, the role of miR-96-3p in papillary th...

journal_title：Cancer cell international

authors： Zhao X,Li Y,Zhou Y

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:Serum Deprivation Protein Response (SDPR) plays an important role in formation of pulmonary alveoli. However, the functions and values of SDPR in lung cancer remain unknown. We explored prognostic value, expression pattern, and biological function of SDPR in non-small cell lung cancer (NSCLC) and KRAS-mutant...

journal_title：Cancer cell international

authors： Luo X,Peng S,Ding S,Zeng Q,Wang R,Ma Y,Chen S,Wang Y,Wang W

更新日期：2021-01-12 00:00:00

abstract：Background:Immunotherapies that targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have obtained prominent success in breast cancer (BC). However, not all the patients benefit from the antibody therapy. This study aimed to identify PD-1/PD-L1 correlated genes and pathways as well as investig...

journal_title：Cancer cell international

authors： Jiang C,Cao S,Li N,Jiang L,Sun T

更新日期：2019-09-09 00:00:00

abstract：BACKGROUND:Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct induction of apoptosis is a promising approach in these apoptosis-resistant tumor cells. The BH3 mimeti...

journal_title：Cancer cell international

authors： Broecker-Preuss M,Becher-Boveleth N,Müller S,Mann K

更新日期：2016-04-02 00:00:00

abstract：Background:The aim of the study was to explore the association between the SIRT1 single nucleotide polymorphism (SNP) rs3758391 and diffuse large B cell lymphoma (DLBCL) in a Chinese Han population. Methods:206 patients diagnosed with DLBCL and 219 healthy individuals were recruited in the present study. The genotypin...

journal_title：Cancer cell international

authors： Kan Y,Ge P,Wang X,Xiao G,Zhao H

更新日期：2018-10-22 00:00:00

abstract：BACKGROUND:CD44 has been reported to be involved with tumor growth and metastasis and has also been implicated as a CSC marker in hepatocellular carcinoma (HCC). However, the prognostic value of CD44 still remains controversial; hence, we investigated the correlation between CD44 and the clinicopathological features of...

journal_title：Cancer cell international

authors： Luo Y,Tan Y

更新日期：2016-06-17 00:00:00

abstract：BACKGROUND:BRAF inhibitors are effective anticancer agents in BRAF-mutated melanomas. By contrast, evidences about sensitivity of thyroid carcinomas to BRAF inhibition are conflicting and it has been proposed that BRAF V600E thyroid carcinoma cells are less sensitive to BRAF inhibitors due to activation of parallel sig...

journal_title：Cancer cell international

authors： Notarangelo T,Sisinni L,Condelli V,Landriscina M

更新日期：2017-10-04 00:00:00

abstract：BACKGROUND:The present study mainly aimed to investigate the direct effects of Endostar (ES) on the proliferation and radiosensitivity of human lung squamous cancer cell line H-520. RESULTS:ES significantly inhibited H-520 cell proliferation in a time- and dose-dependent manner. According to the colony-forming assays,...

journal_title：Cancer cell international

authors： You ZY,Zhao Y,Liu F,Zhang YD,Wang JJ

更新日期：2010-05-24 00:00:00

abstract：Background:Many circRNAs have been reported to play important roles in cancer development and have the potential to serve as a novel class of biomarkers for clinical diagnosis. However, the role of circRNAs in esophageal carcinoma (EC) remains unclear. In the current study, we investigated the potential role of circPVT...

journal_title：Cancer cell international

authors： Zhong R,Chen Z,Mo T,Li Z,Zhang P

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Liver cancer is one of the most frequent cancers in the world. Targeted therapy of cancer with specific inhibitors is developing and has shown promising antitumor efficacy. CCI-779 (temsirolimus), a specific inhibitor of mTOR (mammalian target of rapamycin), can block the mTOR signaling pathway. Here, we sys...

journal_title：Cancer cell international

authors： Li S,Liang Y,Wu M,Wang X,Fu H,Chen Y,Wang Z

更新日期：2013-03-28 00:00:00

abstract：BACKGROUND:The digallic acid (DGA) purified from Pistacia lentiscus. L fruits was investigated for its antiproliferative and apoptotic activities on human lymphoblastoid TK6 cells. METHODS:We attempt to characterize the apoptotic pathway activated by DGA. Apoptosis was detected by DNA fragmentation, PARP cleavage and ...

journal_title：Cancer cell international

authors： Bhouri W,Boubaker J,Skandrani I,Ghedira K,Chekir Ghedira L

更新日期：2012-06-11 00:00:00

abstract：Background:Recent studies have emphasized the important prognostic role of long noncoding RNAs (lncRNAs) in various types of cancers. Here we conducted a meta-analysis to investigate whether lncRNA HOXA11-AS can be served as a prognostic biomarker in human cancers. Patients/methods:We systematically searched PubMed, E...

journal_title：Cancer cell international

authors： Mu S,Ai L,Fan F,Sun C,Hu Y

更新日期：2018-01-03 00:00:00

abstract：BACKGROUND:CircRNAs play crucial roles in multiple tumours. However, the functions of most circRNAs in cervical cancer remain unclear. METHODS:This study collected GSE113696 data from the GEO database to search for differentially expressed circRNAs in cervical cancer. Quantitative reverse transcription PCR was used to...

journal_title：Cancer cell international

authors： Chen Y,Geng Y,Huang J,Xi D,Xu G,Gu W,Shao Y

更新日期：2021-01-07 00:00:00

abstract：:Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved in disease pathogenesis and progression may potentially lead to new therapeutic targ...

journal_title：Cancer cell international

authors： Otoukesh B,Boddouhi B,Moghtadaei M,Kaghazian P,Kaghazian M

更新日期：2018-10-16 00:00:00

abstract：Background:Long noncoding RNAs (lncRNAs) are involved in the tumorigenesis and progression of human cancers, including renal cell carcinoma (RCC). Small nucleolar RNA host gene 4 (SNHG4) is reported to play an essential role in tumor growth and progression. However, the molecular mechanisms and function of SNHG4 in RCC...

journal_title：Cancer cell international

authors： Wu J,Liu T,Sun L,Zhang S,Dong G

更新日期：2020-10-19 00:00:00

abstract：Background:Some studies have investigated the prognostic value exhibited by the Prognostic Nutritional Index (PNI) in patients suffering diffuse large B-cell lymphoma (DLBCL), but varying results were obtained. In order to determine the specific prognostic value more accurately, a meta-analysis was conducted in this st...

journal_title：Cancer cell international

authors： Luan C,Wang F,Wei N,Chen B

更新日期：2020-09-15 00:00:00

abstract：BACKGROUND:SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. In this study, the level of mRNA expression of SATB1 a...

journal_title：Cancer cell international

authors： Patani N,Jiang W,Mansel R,Newbold R,Mokbel K

更新日期：2009-07-30 00:00:00

abstract：Background:Renal cell carcinoma (RCC) is the most common kidney cancer and includes several molecular and histological subtypes with different clinical characteristics. The combination of DNA methylation and gene expression data can improve the classification of tumor heterogeneity, by incorporating differences at the ...

journal_title：Cancer cell international

authors： Chen W,Zhuang J,Wang PP,Jiang J,Lin C,Zeng P,Liang Y,Zhang X,Dai Y,Diao H

更新日期：2019-07-16 00:00:00

abstract：BACKGROUND:Recent studies have reported the involvement of microRNA-29 (miR-29) family members in human cancers through their ability to regulate cellular functions. The present study investigated biological function of miR-29b in colorectal cancer (CRC). METHODS:CRC tissues and adjacent normal tissues were collected ...

journal_title：Cancer cell international

authors： Leng Y,Chen Z,Ding H,Zhao X,Qin L,Pan Y

更新日期：2021-01-06 00:00:00

abstract：:miRNAs, a major class of small noncoding RNAs approximately 18-25 nucleotides in length, function by repressing the expression of target genes through binding to complementary sequences in the 3'-UTRs of target genes. Emerging evidence has highlighted their important roles in numerous diseases, including human cancers...

journal_title：Cancer cell international

authors： Yu Y,Cao XC

更新日期：2019-10-07 00:00:00

abstract：Background:Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property. Cytosine deaminase (CD), which is derived from bacteria or yeast, can convert a relatively nontoxic prodrug 5-fluorocytosine (5-FC) into the active an...

journal_title：Cancer cell international

authors： Ding Y,Fan J,Deng L,Huang B,Zhou B

更新日期：2020-06-15 00:00:00

abstract：BACKGROUND:Circular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types of human tumors. So they have been considered as promising candidates as diagnostic and therapeutic targets in cancer. This research aimed to screen the profile of circR...

journal_title：Cancer cell international

authors： Han J,Han N,Xu Z,Zhang C,Liu J,Ruan M

更新日期：2021-01-07 00:00:00

abstract：BACKGROUND:The goal of this study was to identify the nature of the inclusion bodies that have been found in HeLa cells (cervical cancer immortal cell line) by electron microscope and to determine whether the major capsid protein (L1) of human papillomavirus (HPV) can be expressed in HPV-positive uterine cervix cancer ...

journal_title：Cancer cell international

authors： Xiao CY,Fu BB,Li ZY,Mushtaq G,Kamal MA,Li JH,Tang GC,Xiao SS

更新日期：2015-05-23 00:00:00

abstract：Background:Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen fails to bind estrogen-receptor (ER). High estrogen is a known carcinogen in postmenopausal women. Re...

journal_title：Cancer cell international

authors： Nazmeen A,Chen G,Ghosh TK,Maiti S

更新日期：2020-03-04 00:00:00

abstract：Background:Gastric cancer (GC) is a common cause of cancer-related mortality worldwide, and microRNAs (miRNAs) have been shown to play an important role in GC development. This study aims to explore the effect of microRNA-93-5p (miR-93-5p) on the epithelial-mesenchymal transition (EMT) in GC, via AHNAK and the Wnt sign...

journal_title：Cancer cell international

authors： Shen E,Wang X,Liu X,Lv M,Zhang L,Zhu G,Sun Z

更新日期：2020-03-12 00:00:00

abstract：Background:Oxidative stress is responsible for some alterations in the chemical structure and, consequently, in the function of proteins, lipids, and DNA. Recent studies have linked oxidative stress to cancers, particularly thyroid cancer, but the mechanisms remain unclear. Here, we further characterize the role of oxi...

journal_title：Cancer cell international

authors： Metere A,Frezzotti F,Graves CE,Vergine M,De Luca A,Pietraforte D,Giacomelli L

更新日期：2018-01-15 00:00:00

abstract：Background:Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with targeted agents. Methods:In the current study, TP53 wild-type cell lines with druggable MAPK pathway muta...

journal_title：Cancer cell international

authors： Wu CE,Koay TS,Ho YH,Lovat P,Lunec J

更新日期：2019-03-07 00:00:00

abstract：Background:Pancreatic cancer (PC) remains one of the most aggressive cancers worldwide. However, genetic factors underlying PC susceptibility remain largely unclear. Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an oncogene and its genetic variation has been linked to many cancers. However, ...

journal_title：Cancer cell international

authors： Jiang D,Xu L,Ni J,Zhang J,Cai M,Shen L

更新日期：2019-02-28 00:00:00