Abstract:
BACKGROUND:Serum Deprivation Protein Response (SDPR) plays an important role in formation of pulmonary alveoli. However, the functions and values of SDPR in lung cancer remain unknown. We explored prognostic value, expression pattern, and biological function of SDPR in non-small cell lung cancer (NSCLC) and KRAS-mutant lung cancers. METHODS:SDPR expression was evaluated by quantitative real-time PCR (RT-qPCR), immunohistochemistry (IHC), and Western blot on human NSCLC cells, lung adenocarcinoma tissue array, KRAS-mutant transgenic mice, TCGA and GEO datasets. Prognostic values of SDPR were evaluated by Kaplan-Meier and Cox regression analysis. Bioinformatics implications of SDPR including SDPR-combined transcription factors (TFs) and microRNAs were predicted. In addition, correlations between SDPR, immune checkpoint molecules, and tumor infiltration models were illustrated. RESULTS:SDPR expression was downregulated in tumor cells and tissues. Low SDPR expression was an independent factor that correlated with shorter overall survival of patients both in lung cancer and KRAS-mutant subgroups. Meanwhile, ceRNA network was constructed to clarify the regulatory and biological functions of SDPR. Negative correlations were found between SDPR and immune checkpoint molecules (PD-L1, TNFRSF18, TNFRSF9, and TDO2). Moreover, diversity immune infiltration models were observed in NSCLC with different SDPR expression and copy number variation (CNV) patterns. CONCLUSIONS:This study elucidated regulation network of SDPR in KRAS-mutant NSCLC, and it illustrated correlations between low SDPR expression and suppressed immune system, unfolding a prognostic factor and potential target for the treatment of lung cancer, especially for KRAS-mutant NSCLC.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Luo X,Peng S,Ding S,Zeng Q,Wang R,Ma Y,Chen S,Wang Y,Wang Wdoi
10.1186/s12935-021-01756-8subject
Has Abstractpub_date
2021-01-12 00:00:00pages
49issue
1issn
1475-2867pii
10.1186/s12935-021-01756-8journal_volume
21pub_type
杂志文章abstract:BACKGROUND:Apigenin (4',5,7-trihydroxyflavone) was recently shown effective in inhibiting several cancers. The aim of this study was to investigate the effect and mechanism of apigenin in the human bladder cancer cell line T24 for the first time. METHODS:T24 cells were treated with varying concentrations and time of a...
journal_title:Cancer cell international
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journal_title:Cancer cell international
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journal_title:Cancer cell international
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0807-0
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journal_title:Cancer cell international
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journal_title:Cancer cell international
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doi:10.1186/s12935-020-01299-4
更新日期:2020-06-08 00:00:00
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journal_title:Cancer cell international
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journal_title:Cancer cell international
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journal_title:Cancer cell international
pub_type: 杂志文章
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journal_title:Cancer cell international
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journal_title:Cancer cell international
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journal_title:Cancer cell international
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