The heterogeneity of cancer stem-like cells at the invasive front.

abstract：Background:Acute myeloid leukemia (AML) is a clinically and biologically heterogeneous disease. The survival of older patients is generally poor. In the current study, we sought to investigate the differences in molecular gene mutations between younger and older AML patients, and to identify those newly diagnosed AML p...

journal_title：Cancer cell international

authors： Cao XX,Cai H,Mao YY,Wu Q,Zhang L,Zhou DB,Li J

更新日期：2018-12-22 00:00:00

abstract：BACKGROUND:Pancreatic cancer is currently one of the leading causes of cancer deaths without any effective therapies. Mir-145 has been found to be tumor-suppressive in various types of cancers. The aim of this study is to investigate the role of miR-145 in pancreatic cancer cells and explore its underlying mechanism. ...

journal_title：Cancer cell international

authors： Wang H,Hang C,Ou XL,Nie JS,Ding YT,Xue SG,Gao H,Zhu JX

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:ErbB3-binding protein 1 (Ebp1) is a member of the PA2G4 family of proliferation-regulated proteins that is expressed in multiple malignant and non-malignant cells. ErbB3 and other members of the EGFR family have been implicated in cancer progression, it however remains unknown whether Ebp1 participate in pro...

journal_title：Cancer cell international

authors： Gannon PO,Koumakpayi IH,Le Page C,Karakiewicz PI,Mes-Masson AM,Saad F

更新日期：2008-11-24 00:00:00

abstract：Background:Lung adenocarcinoma (LUAD) patients experiencing lymph node metastasis (LNM) always exhibit poor clinical outcomes. A biomarker or gene signature that could predict survival in these patients would have a substantial clinical impact, allowing for earlier detection of mortality risk and for individualized the...

journal_title：Cancer cell international

authors： Wang Y,Zhang Q,Gao Z,Xin S,Zhao Y,Zhang K,Shi R,Bao X

更新日期：2019-04-16 00:00:00

abstract：Background:Helicobacter pylori (H. pylori)-induced gastric cancer is an intricate progression of immune response against H. pylori infection. IL-16, TGF-β1 and TLR4 pathways were the mediators involved in the immune response. We hypothesized that genetic variations in genes of these pathways have potential susceptibili...

journal_title：Cancer cell international

authors： He B,Xu T,Pan B,Pan Y,Wang X,Dong J,Sun H,Xu X,Liu X,Wang S

更新日期：2018-11-20 00:00:00

abstract：BACKGROUND:Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene predispose individuals to clear cell renal carcinomas, hemangioblastomas, and pheochromocytomas. The VHL gene product forms an ubiquitin E3 ligase complex, with regulation of hypoxia-inducible factor alpha (HIF-α) as its best known funct...

journal_title：Cancer cell international

authors： Doonachar A,Gallo MD,Doukas D,Pasricha R,Lantsberg I,Schoenfeld AR

更新日期：2015-02-22 00:00:00

abstract：Background:Accumulating studies showed that long noncoding RNAs (lncRNAs) played vital roles in cancer progression. LncRNA MIR4435-2HG was proved to act as an oncogene in various tumors. However, the underlying function of MIR4435-2HG in ovarian cancer (OC) remains unclear. Methods:The expression levels of MIR4435-2HG...

journal_title：Cancer cell international

authors： Zhu L,Wang A,Gao M,Duan X,Li Z

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Chemoresistance is a major obstacle to successful chemotherapy for colorectal cancer. Eukaryotic translation initiation factor 5A2 (eIF5A2), one of the two isoforms in the eIF5A family, has been reported to be a new oncogene in many types of human cancer. In the present study, we aimed to investigate whether...

journal_title：Cancer cell international

authors： Bao Y,Lu Y,Wang X,Feng W,Sun X,Guo H,Tang C,Zhang X,Shi Q,Yu H

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) are increasingly implicated in the regulation of the progression of malignancy. AIM:To clarify the relations among BCYRN1 (brain cytoplasmic RNA 1, a long non-coding RNA), c-MYC and cell metastasis of non-small-cell lung cancer (NSCLC). METHODS:Real-time PCR was used to measu...

journal_title：Cancer cell international

authors： Hu T,Lu YR

更新日期：2015-04-01 00:00:00

abstract：Background and aims:microRNAs (miRNAs) have been reported to regulate proliferation and migration by down-regulating the expression of target genes. The aims of this study were to investigate whether miR-4316 inhibited proliferation and migration by downregulating vascular endothelial growth factor A (VEGF-A) and its c...

journal_title：Cancer cell international

authors： Mousa H,Yuan M,Zhang X,Li X,Shopit A,Almoiliqy M,Alshwmi M,Al-Dherasi A,Xu Y,Zuo Y

更新日期：2020-02-22 00:00:00

abstract：Background:MicroRNA (MiRNA) is a small non-coding RNA which is implicated in a cohort of biological function in cancer, including proliferation, metastasis, apoptosis and invasion. MiR-96 has been reported to be involved in many cancers, including papillary thyroid cancer. However, the role of miR-96-3p in papillary th...

journal_title：Cancer cell international

authors： Zhao X,Li Y,Zhou Y

更新日期：2019-11-12 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer comprises the majority of lung cancer cases and is insensitive to chemotherapy. Most patients develop drug resistance. Recently, tetrandrine (TET), a bis-benzylisoquinoline alkaloid, was identified as a novel anti-cancer agent. However, the effect of tetrandrine combined with cispl...

journal_title：Cancer cell international

authors： Ye LY,Hu S,Xu HE,Xu RR,Kong H,Zeng XN,Xie WP,Wang H

更新日期：2017-03-27 00:00:00

abstract：Background:Avoiding the phagocytosis by tumor-associated macrophages (TAMs) is necessary for the growth and metastasis of solid tumors. CD47 binds to the receptor signal-regulatory protein-α (SIRP-α) on the macrophages to avoid normal phagocytosis. In this study, we evaluated the expression and prognostic significance ...

journal_title：Cancer cell international

authors： Yuan J,He H,Chen C,Wu J,Rao J,Yan H

更新日期：2019-09-11 00:00:00

abstract：BACKGROUND:Without doubt, natural products have been, and still are, the cornerstone of the health care armamentarium. Of all natural sources, the marine environment is clearly the last great frontier for pharmaceutical and medical research. METHODS:This work progresses in the direction of identifying component(s) fro...

journal_title：Cancer cell international

authors： Dellai A,Deghrigue M,Laroche-Clary A,Masour HB,Chouchane N,Robert J,Bouraoui A

更新日期：2012-05-15 00:00:00

abstract：Background:Increasing evidences have underlined the importance of long non-coding RNAs (lncRNAs) in human malignancies. LINC00958 has been found involved in some cancers. However, the underlying mechanical performance of LINC00958 in lung adenocarcinoma (LAD) has not been explored yet. Methods:The expression of releva...

journal_title：Cancer cell international

authors： Yang L,Li L,Zhou Z,Liu Y,Sun J,Zhang X,Pan H,Liu S

更新日期：2020-01-23 00:00:00

abstract：Background:Cancer cell viability is strongly modulated by the Hippo pathway, which includes mammalian STE20-like protein kinase 1 (Mst1) and yes-associated protein (Yap). Although the roles of Mst1 and Yap in thyroid carcinoma cell death have been fully addressed, no study has determined whether differential modificati...

journal_title：Cancer cell international

authors： Zhang X,Li F,Cui Y,Liu S,Sun H

更新日期：2019-05-22 00:00:00

abstract：BACKGROUND:In past few years, long non-coding RNAs (lncRNAs) have been reported to play regulatory roles during cancer progression. LncRNA SNHG10 has been explored in several sorts of cancers. However, its detailed role and mechanism are still not well understood in glioma. METHODS:Expression levels of genes were eval...

journal_title：Cancer cell international

authors： Jin L,Huang S,Guan C,Chang S

更新日期：2020-12-09 00:00:00

abstract：Background:Many circRNAs have been reported to play important roles in cancer development and have the potential to serve as a novel class of biomarkers for clinical diagnosis. However, the role of circRNAs in esophageal carcinoma (EC) remains unclear. In the current study, we investigated the potential role of circPVT...

journal_title：Cancer cell international

authors： Zhong R,Chen Z,Mo T,Li Z,Zhang P

更新日期：2019-10-15 00:00:00

abstract：Background:Newly identified lncRNA zinc finger protein, FOG family member 2 antisense RNA 1 (ZFPM2-AS1) is identified as an oncogenic gene. However, the role of ZFPM2-AS1 in small cell lung cancer (SCLC) is poorly comprehended. Methods:The expression of genes in SCLC tissues and cells was measured by qRT-PCR. Colony f...

journal_title：Cancer cell international

authors： Yan Z,Yang Q,Xue M,Wang S,Hong W,Gao X

更新日期：2020-04-03 00:00:00

abstract：Background:SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism explaining its function in cell proliferation regulation. Here we investigated cancer cell response t...

journal_title：Cancer cell international

authors： Saghaeian Jazi M,Samaei NM,Mowla SJ,Arefnezhad B,Kouhsar M

更新日期：2018-09-05 00:00:00

abstract：BACKGROUND:The expression of major histocompatibility complex class II (MHCII) antigens in both mouse and human tumors is rare, and these antigens are not easily inducible by IFN-gamma (IFNg). Since MHCII may play an important role in the development of host antitumor immune response, we explored the possibility of res...

journal_title：Cancer cell international

authors： Kudinov Y,Wiseman CL,Kharazi AI

更新日期：2003-03-25 00:00:00

abstract：Background:Breast cancer is one of the most common malignancy among females from the worldwide cancer incidence statistics. Peroxisome gamma coactivator-1β (PGC-1β) has long been identified to be involved in this type of tumorigenesis. However, the mechanisms of PGC-1β in human breast cancer have not been fully underst...

journal_title：Cancer cell international

authors： Cao J,Wang X,Wang D,Ma R,Li X,Feng H,Wang J,Liu S,Wang L

更新日期：2019-04-11 00:00:00

abstract：BACKGROUND:Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize these cancers and try to identify potential biomarkers and novel therapeutic targets. MATERIALS AND M...

journal_title：Cancer cell international

authors： Rajkumar T,Vijayalakshmi N,Gopal G,Sabitha K,Shirley S,Raja UM,Ramakrishnan SA

更新日期：2010-11-24 00:00:00

abstract：:BACKGROUND: Mast cells are known to accumulate at sites of inflammation and upon activation to release their granule content, e.g. histamine, cytokines and proteases. The secretory leukocyte protease inhibitor (SLPI) is produced in the respiratory mucous and plays a role in regulating the activity of the proteases. RE...

journal_title：Cancer cell international

authors： Hollander C,Nyström M,Janciauskiene S,Westin U

更新日期：2003-08-20 00:00:00

abstract：Background:Drug resistance to 5-fluorouracil (5-FU) and recurrence after chemotherapy in colorectal cancer remain a challenge to be resolved for the improvement of patient outcomes. It is recognized that a variety of secretory proteins released from the tumor cells exposed to chemo-drugs into the tumor microenvironment...

journal_title：Cancer cell international

authors： Chang S,Huang J,Niu H,Wang J,Si Y,Bai Z,Cheng S,Ding W

更新日期：2020-09-14 00:00:00

abstract：:BACKGROUND: We describe an alternative method to determine mRNA half-life (t1/2) based on the Real-Time RT-PCR procedure. This approach was evaluated by using the beta-actin gene as a reference molecule for measuring of mRNA stability. RESULTS: Human leukemia Nalm-6 and CCRF-CEM cells were treated with various concent...

journal_title：Cancer cell international

authors： Leclerc GJ,Leclerc GM,Barredo JC

更新日期：2002-03-07 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) is a type of malignancy with progressive metastasis having poor prognosis and lowered survival resulting from late diagnosis. The therapeutic approaches for the treatment of this incurable cancer are chemo- and radiotherapy. Since current treatments are insufficient and because of dr...

journal_title：Cancer cell international

authors： Pourhanifeh MH,Sharifi M,Reiter RJ,Davoodabadi A,Asemi Z

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct induction of apoptosis is a promising approach in these apoptosis-resistant tumor cells. The BH3 mimeti...

journal_title：Cancer cell international

authors： Broecker-Preuss M,Becher-Boveleth N,Müller S,Mann K

更新日期：2016-04-02 00:00:00

abstract：Background:Melanoma is the most aggressive type of skin cancer with high mortality rate and poor prognosis. lncRNA MEG3, a tumor suppressor, is closely related to the development of various cancers. However, the role of lncRNA MEG3 in melanoma has seldom been studied. Methods:RT-PCR was used to examine the expressions...

journal_title：Cancer cell international

authors： Wu L,Zhu L,Li Y,Zheng Z,Lin X,Yang C

更新日期：2020-01-10 00:00:00

abstract：Background:The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. USP28 controls hypoxia-dependent angiogenesis and metastasis by preventi...

journal_title：Cancer cell international

authors： Du SC,Zhu L,Wang YX,Liu J,Zhang D,Chen YL,Peng Q,Liu W,Liu B

更新日期：2019-01-03 00:00:00