Abstract:
Background:Recent studies have emphasized the important prognostic role of long noncoding RNAs (lncRNAs) in various types of cancers. Here we conducted a meta-analysis to investigate whether lncRNA HOXA11-AS can be served as a prognostic biomarker in human cancers. Patients/methods:We systematically searched PubMed, Embase, ISI Web of Science, and SCOPUS for relevant studies, to investigate the prognostic significance of HOXA11-AS expression in cancer patients. Odds ratios (ORs) or hazards ratios (HRs) with corresponding 95% confidence intervals (CIs) are pooled to estimate the association between HOXA11-AS expression and clinicopathological parameters or survival of cancer patients. Results:A total of eight eligible studies with 1320 cancer patients were enrolled in our meta-analysis. The results revealed that increased expression level of HOXA11-AS was significantly associated with clinicopathological parameters including more lymph node metastasis (OR = 2.06, 95% CI 1.31-3.25), advanced tumor stage (OR = 4.22, 95% CI 2.60-6.85), as well as poor tumor differentiation (OR = 2.49, 95 CI 1.47-4.20), but not correlated with age (p = 0.101) or gender (p = 0.845). In addition, cancer patients with high HOXA11-AS are prognosed to have shorter OS (pooled HR = 1.86, 95% CI 1.39-2.48) and PFS (pooled HR = 2.47, 95% CI 1.29-4.75). Conclusions:HOXA11-AS overexpression might be a convinced unfavorable prognostic factor that helps the clinical decision-making process.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Mu S,Ai L,Fan F,Sun C,Hu Ydoi
10.1186/s12935-017-0498-3subject
Has Abstractpub_date
2018-01-03 00:00:00pages
1issn
1475-2867pii
498journal_volume
18pub_type
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journal_title:Cancer cell international
pub_type: 杂志文章
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-12-26
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journal_title:Cancer cell international
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journal_title:Cancer cell international
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journal_title:Cancer cell international
pub_type: 杂志文章
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journal_title:Cancer cell international
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journal_title:Cancer cell international
pub_type: 杂志文章
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journal_title:Cancer cell international
pub_type: 杂志文章
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journal_title:Cancer cell international
pub_type: 杂志文章,评审
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01681-2
更新日期:2021-01-07 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01405-6
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0714-9
更新日期:2019-01-08 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01682-1
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-11-21
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pub_type: 杂志文章
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journal_title:Cancer cell international
pub_type: 杂志文章
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journal_title:Cancer cell international
pub_type: 杂志文章,评审
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journal_title:Cancer cell international
pub_type: 杂志文章
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更新日期:2012-03-26 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
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更新日期:2013-05-15 00:00:00
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journal_title:Cancer cell international
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01736-4
更新日期:2021-01-07 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12935-020-01426-1.]. ...
journal_title:Cancer cell international
pub_type: 已发布勘误
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更新日期:2020-08-18 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
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更新日期:2019-09-23 00:00:00
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pub_type: 杂志文章
doi:10.1186/1475-2867-3-4
更新日期:2003-03-25 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01301-z
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