Abstract:
:Creatine monohydrate has been shown to increase strength in studies of young healthy subjects and in a few studies with patients. Creatine monohydrate (10 g daily for 5 days to 5 g daily for 5 days) was administered to patients with neuromuscular disease in a pilot study (Study 1; n = 81), followed by a single-blinded study (Study 2; n = 21). Body weight, handgrip, dorsiflexion, and knee extensor strength were measured before and after treatment. Creatine administration increased all measured indices in both studies. Short-term creatine monohydrate increased high-intensity strength significantly in patients with neuromuscular disease.
journal_name
Neurologyjournal_title
Neurologyauthors
Tarnopolsky M,Martin Jdoi
10.1212/wnl.52.4.854subject
Has Abstractpub_date
1999-03-10 00:00:00pages
854-7issue
4eissn
0028-3878issn
1526-632Xjournal_volume
52pub_type
临床试验,杂志文章相关文献
NEUROLOGY文献大全abstract::Photoparoxysmal response (PPR) is sometimes incidentally encountered in EEGs performed for evaluation of nonepileptic symptoms. We conducted the first long-term study of a cohort of nonepileptic patients to determine their risk of having seizures subsequent to incidental recording of PPR. After 6 to 12 years (mean, 9 ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.9.1719
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of age, sex, APOE4 genotype, and lifestyle enrichment (education/occupation, midlife cognitive activity, and midlife physical activity) on Alzheimer disease (AD) biomarker trajectories using longitudinal imaging data (brain β-amyloid load via Pittsburgh compound B PET and neurodegene...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002490
更新日期:2016-03-22 00:00:00
abstract::We investigated 185 families with ALS for evidence of anticipation and mitochondrial inheritance. Although initial analysis demonstrated significant anticipation of age at death between generations in patients with familial ALS, further analysis demonstrated features of regression to the mean, suggesting that the perc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000160395.43761.AC
更新日期:2005-05-10 00:00:00
abstract:OBJECTIVE:To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD). METHODS:Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI. RESUL...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000247052.18422.e5
更新日期:2006-12-12 00:00:00
abstract:OBJECTIVE:To test the hypothesis that patients with Alzheimer disease (AD) who have vascular risk factors have a worse prognosis over 18 months vs those without such risk factors. METHODS:A sample of 224 people with AD and their caregivers were recruited purposively to be representative of people with dementia in term...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000240129.46080.53
更新日期:2006-10-24 00:00:00
abstract::Current concepts suggest that avoidance of pulsatile stimulation of dopamine receptors in Parkinson's disease (PD) can prevent the onset of dyskinesia. In MPTP-treated primates, repeated administration of levodopa or other short-acting dopamine agonist drugs leads to the onset of marked involuntary movements. In contr...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.62.1_suppl_1.s47
更新日期:2004-01-13 00:00:00
abstract::Motor axons supplying lumbrical muscles are less severely affected than axons supplying thenar muscles in the carpal tunnel syndrome; sometimes lumbrical motor fibers are less affected than digit 2 sensory fibers. This pattern is consistent with compression of both the anterior and posterior aspects of the median nerv...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.9.1499
更新日期:1987-09-01 00:00:00
abstract:OBJECTIVE:To estimate the lifetime cumulative incidence of dementia and its subtypes from a community-dwelling elderly population in Japan. METHODS:A total of 1,193 community-dwelling Japanese individuals without dementia, aged 60 years or older, were followed up prospectively for 17 years. The cumulative incidence of...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000009917
更新日期:2020-08-04 00:00:00
abstract:OBJECTIVE:To evaluate the episodic migraine (EM)-obesity association and the influence of age, race, and sex on this relationship. METHODS:We examined the EM-obesity association and the influence of age, race, and sex in 3,862 adult participants of both black and white race interviewed in the National Comorbidity Surv...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a824f7
更新日期:2013-10-08 00:00:00
abstract:OBJECTIVE:To examine the relationship between the degree of handedness and hemispheric language dominance in patients with epilepsy. METHODS:The authors examined the relationship between degree of handedness and hemispheric language dominance in 174 epilepsy surgery candidates using the intracarotid amobarbital proced...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000219623.28769.74
更新日期:2006-06-27 00:00:00
abstract::In 17 patients with cough syncope, electroencephalograms showed normal interictal recordings in 12 patients, minimally abnormal recordings in 4, and a moderately abnormal recording in 1. Fourteen episodes of cough syncope (six patients) were recorded, with the EEGs showing diffuse theta and delta slowing during the ep...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.3.371
更新日期:1984-03-01 00:00:00
abstract:OBJECTIVES:To study the effects of head injury on disease progression and on neuropathologic outcomes in amyotrophic lateral sclerosis (ALS). METHODS:Patients with ALS were surveyed to obtain head injury history, and medical records were reviewed. Linear regression was performed to determine if head injury was a predi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001522
更新日期:2015-04-28 00:00:00
abstract:OBJECTIVE:To evaluate the occurrence, treatment, and outcome of subdural empyema complicating community-acquired bacterial meningitis in adults. METHODS:Case series from a prospective nationwide cohort study from Dutch hospitals from 2006 to 2011. RESULTS:Subdural empyema was diagnosed in 28 of 1,034 episodes (2.7%),...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182752d0e
更新日期:2012-11-20 00:00:00
abstract:BACKGROUND:Optimal treatment remains uncertain for patients with cognitive impairment that persists or returns after standard IV antibiotic therapy for Lyme disease. METHODS:Patients had well-documented Lyme disease, with at least 3 weeks of prior IV antibiotics, current positive IgG Western blot, and objective memory...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/01.WNL.0000284604.61160.2d
更新日期:2008-03-25 00:00:00
abstract::The mitochondrial genome has an underdeveloped "DNA repair repertoire" compared with the nuclear genome, making the mitochondrial DNA more susceptible to mutations by endogenous factors such as defects of the mitochondrial polymerase itself, and by exogenous factors such as radiation and UV light. Increased sensitivit...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.43.2.280
更新日期:1993-02-01 00:00:00
abstract::Pergolide, a long-acting central dopamine agonist, was used as monotherapy in 16 parkinsonian patients. A mean daily dose of 6.3 mg resulted in 73% improvement of parkinsonian disability. Clinical improvement after acute administration of one dose of pergolide was similar to that observed after levodopa plus a periphe...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.7.983
更新日期:1984-07-01 00:00:00
abstract::Although the ultimate diagnosis of multiple sclerosis (MS) still remains clinical, confirmatory laboratory aids can be of marked assistance, especially in early and atypical cases. Whereas numerous tests have been described, the only ones to withstand scrutiny in numerous laboratories have been various immunoglobulin ...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.30.7_part_2.106
更新日期:1980-07-01 00:00:00
abstract:OBJECTIVE:Migrainous infarction is considered a rare complication of migraine. Although several studies reported silent brain lesions on neuroimaging in patients with migraine with aura, knowledge about lesion patterns in acute migrainous infarction is scarce. We investigated clinical and MRI characteristics in a serie...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31821d74d5
更新日期:2011-05-31 00:00:00
abstract:OBJECTIVE:To estimate the prevalence and examine the course of mild cognitive impairment (MCI), amnestic type, using current criteria, within a representative community sample. METHODS:Retroactive application of MCI criteria to data collected during a prospective epidemiologic study was performed. The subjects were dr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000132523.27540.81
更新日期:2004-07-13 00:00:00
abstract::Many studies have demonstrated that dipyridamole is not purely an antiplatelet agent but also exerts its antithrombotic properties through the vessel wall. Using a laboratory model in which bovine endothelial cells are seeded to form a subendothelial matrix (SEM), investigators have shown that dipyridamole enhances th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.suppl_2.s20
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To investigate the relationship between markers of vitamin B(12) status and brain volume loss per year over a 5-year period in an elderly population. METHODS:A prospective study of 107 community-dwelling volunteers aged 61 to 87 years without cognitive impairment at enrollment. Volunteers were assessed year...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000325581.26991.f2
更新日期:2008-09-09 00:00:00
abstract::Two successive, 6-month, randomized, double-blind, controlled trials of prednisone showed that 0.75 mg/kg/d was the optimal dose to improve strength in boys with Duchenne muscular dystrophy (DMD). We attempted to maintain 93 boys on that dose for an additional 2 years. During the 3 years of observation, the decline in...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.41.12.1874
更新日期:1991-12-01 00:00:00
abstract::Cytokines such as interleukin-1 and tumor necrosis factor are involved in the triggering of the immune response, induction of acute inflammatory events, and transition to, or persistence of, chronic inflammation. The action of proinflammatory cytokines is regulated by their receptor expression, downregulation and shed...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.45.6_suppl_6.s39
更新日期:1995-06-01 00:00:00
abstract::We applied quantitative methods to measure extrapyramidal signs in 50 Alzheimer's disease (AD) patients and 40 age-matched control subjects. We measured tremor using accelerometers, bradykinesia using computer-detected reaction times (RTs) and movement times (MTs), and rigidity using a strain gauge linked to a movable...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.3_part_1.500
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Studies have suggested that mood status is associated with an increased risk of stroke, though mostly based on measures of depression defined by symptoms alone rather than diagnostic criteria representative of clinically important distress and impairment. We investigated this association based upon a large p...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000304109.18563.81
更新日期:2008-03-04 00:00:00
abstract::An allele (263bp) of the nonamyloid component of plaques (NACP)-Repl polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease (HD)...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.5.1195
更新日期:2000-03-14 00:00:00
abstract::In a retrospective study of 103 corticosteroid-treated MS patients, the average rate of fracture events was 3.2% of the patients per year over 7.1 (+/- 5.7 SD) years at risk. Fractures of the ribs, pelvis, hip, or vertebrae occurred in 11 patients and became most common 5 years after starting steroids. Relatively high...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.7.1389
更新日期:1992-07-01 00:00:00
abstract::Chronic daily headache (CDH) affects approximately 4 to 5% of the population and encompasses a number of different diagnoses, including transformed migraine, chronic tension-type headache (TTH), new-onset daily persistent headache, and hemicrania continua. Although the pathophysiology of CDH is still poorly understood...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.59.5_suppl_2.s8
更新日期:2002-09-10 00:00:00
abstract:OBJECTIVE:To visualize the sites involved in audiovestibular dysfunction during bacterial meningitis in adults and to relate these findings to the extent of hearing impairment and vestibular dysfunction. BACKGROUND:Hearing impairment is among the most frequent complications of bacterial meningitis. METHODS:High-resol...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.5.1003
更新日期:1999-03-23 00:00:00
abstract:OBJECTIVE:We aimed to analyze lesion patterns of lacunae-sized infarctions in the perforating arterial territory in terms of shape and to determine whether the particular pattern of conglomerated beads shape affected early neurologic deterioration. METHODS:We consecutively included acute ischemic stroke patients with ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318253d62f
更新日期:2012-05-01 00:00:00