Long-term benefit from prednisone therapy in Duchenne muscular dystrophy.

abstract：:We gave three adult rhesus monkeys seven IV injections of manganese chloride at approximately 1-week intervals. We evaluated neurologic status by serial clinical examinations and performed a levodopa test if the animal developed features of basal ganglia dysfunction. After the animals were killed, we performed neuropa...

journal_title：Neurology

authors： Olanow CW,Good PF,Shinotoh H,Hewitt KA,Vingerhoets F,Snow BJ,Beal MF,Calne DB,Perl DP

更新日期：1996-02-01 00:00:00

abstract：:Spinal cord compression by extramedullary hemopoietic tissue is a rare complication of hemolytic anemias. This is the first report of this complication in hemolytic anemia caused by pyruvate-kinase deficiency. Indium scan, computed tomography (CT) scan, and myelography were helpful in diagnosis. Surgery and radiothera...

journal_title：Neurology

authors： Rutgers MJ,van der Lugt PJ,van Turnhout JM

更新日期：1979-04-01 00:00:00

abstract：OBJECTIVE:To estimate rate of progression from normal cognition or mild impairment to dementia, and to identify potential risk and protective factors for incident dementia, based on age at dementia onset in a prospective study of a population-based cohort (n = 1,982) aged 65 years and older. METHODS:Following the coho...

journal_title：Neurology

authors： Ganguli M,Lee CW,Snitz BE,Hughes TF,McDade E,Chang CC

更新日期：2015-01-06 00:00:00

abstract：:The goal of pharmacologic therapy for patients with epilepsy is to suppress seizures without side effects. There is growing interest in developing antiepileptogenic drugs capable of preventing the onset of seizures in patients at high risk and inducing a permanent remission of seizures in patients with epilepsy, i.e.,...

journal_title：Neurology

authors： Schachter SC

更新日期：2002-11-12 00:00:00

abstract：OBJECTIVE:To investigate the association between discordant β-amyloid (Aβ) PET and CSF biomarkers at baseline and the emergence of tau pathology 5 years later. METHODS:We included 730 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants without dementia (282 cognitively normal, 448 mild cognitive impairment...

journal_title：Neurology

authors： Reimand J,Collij L,Scheltens P,Bouwman F,Ossenkoppele R,Alzheimer's Disease Neuroimaging Initiative.

更新日期：2020-11-10 00:00:00

abstract：BACKGROUND:In patients with active epilepsy, adverse medication effects and severity of depression are correlated with health-related quality of life, but seizure frequency is not. We sought to examine if the same pattern exists in patients with psychogenic nonepileptic seizures (PNES). METHODS:We administered seizure...

journal_title：Neurology

authors： LaFrance WC Jr,Syc S

更新日期：2009-08-04 00:00:00

abstract：:Fourteen patients with Alzheimer's disease were evaluated by psychometric testing, fluorodeoxyglucose positron emission tomography (PET), and EEG. They were divided into two groups according to the EEG findings. Group A (seven patients) had normal alpha backgrounds and group B (seven patients) had decreased alpha back...

journal_title：Neurology

authors： Sheridan PH,Sato S,Foster N,Bruno G,Cox C,Fedio P,Chase TN

更新日期：1988-05-01 00:00:00

abstract：OBJECTIVE:To measure white matter (WM) and gray matter (GM) atrophy and lesion load in a large population of patients with multiple sclerosis (MS) using a fully automated, operator-independent, multiparametric segmentation method. METHODS:The study population consisted of 597 patients with MS and 104 control subjects....

journal_title：Neurology

authors： Tedeschi G,Lavorgna L,Russo P,Prinster A,Dinacci D,Savettieri G,Quattrone A,Livrea P,Messina C,Reggio A,Bresciamorra V,Orefice G,Paciello M,Brunetti A,Coniglio G,Bonavita S,Di Costanzo A,Bellacosa A,Valentino P,Quar

更新日期：2005-07-26 00:00:00

abstract：:The authors report a double-blind, placebo-controlled, crossover study of talampanel in 49 patients with refractory partial seizures. Three doses of talampanel were investigated based on differences in patients' concomitant antiepileptic drug usage. Talampanel showed efficacy in reducing seizure frequency (p = 0.001) ...

journal_title：Neurology

authors： Chappell AS,Sander JW,Brodie MJ,Chadwick D,Lledo A,Zhang D,Bjerke J,Kiesler GM,Arroyo S

更新日期：2002-06-11 00:00:00

abstract：:Treatment of functional symptoms has a long history, and interventions were often used in soldiers returning from battle. On the 75th anniversary of the end of the Second World War, I review the portrayal of neurology in documentary film. Two documentaries were released in 1946 and 1948 (Let There Be Light and Shades ...

journal_title：Neurology

authors： Wijdicks EFM

更新日期：2020-06-09 00:00:00

abstract：:Article abstract Depressive disorders (DDs) are the most common type of psychiatric co-morbidity in patients with epilepsy. They are more likely to occur in patients with partial seizure disorders of temporal and frontal lobe origin and are more frequent among patients with poorly controlled seizures. Despite their re...

journal_title：Neurology

authors： Kanner AM,Balabanov A

更新日期：2002-04-23 00:00:00

abstract：OBJECTIVE:SCN8A encodes the sodium channel voltage-gated α8-subunit (Nav1.6). SCN8A mutations have recently been associated with epilepsy and neurodevelopmental disorders. We aimed to delineate the phenotype associated with SCN8A mutations. METHODS:We used high-throughput sequence analysis of the SCN8A gene in 683 pat...

journal_title：Neurology

authors： Larsen J,Carvill GL,Gardella E,Kluger G,Schmiedel G,Barisic N,Depienne C,Brilstra E,Mang Y,Nielsen JE,Kirkpatrick M,Goudie D,Goldman R,Jähn JA,Jepsen B,Gill D,Döcker M,Biskup S,McMahon JM,Koeleman B,Harris M,Bra

更新日期：2015-02-03 00:00:00

abstract：:We report the vasocapacitance of the cerebral circulation, as determined by cerebral blood flow reactivity to induced hypercapnia using fluoromethane positron emission tomography, in 32 patients with unilateral anterior circulation transient ischemic attacks. A hemodynamic subset of eight patients, defined based on ex...

journal_title：Neurology

authors： Levine RL,Lagreze HL,Dobkin JA,Hanson JM,Satter MR,Rowe BR,Nickles RJ

更新日期：1989-01-01 00:00:00

abstract：:Two cohorts of 20 patients diagnosed with neoplastic meningitis (NM) with or without encephalopathy were matched with respect to age, sex, primary tumor, and performance status. Median survival was 10 weeks (range 6 to 20 weeks) in the cohort with NM-related encephalopathy compared to 24 weeks (range 8 to 40 weeks) in...

journal_title：Neurology

authors： Chamberlain MC,Tsao-Wei D,Groshen S

更新日期：2004-12-14 00:00:00

abstract：BACKGROUND:Pregnancy registries for women taking anticonvulsant drugs have been developed to determine more efficiently the fetal risks of each drug. A total of 722 drug-exposed pregnancies are needed to identify a sevenfold increase in the rate of occurrence of a specific abnormality, such as spina bifida, with a freq...

journal_title：Neurology

authors： Holmes LB,Baldwin EJ,Smith CR,Habecker E,Glassman L,Wong SL,Wyszynski DF

更新日期：2008-05-27 00:00:00

abstract：:In a 20-year-old patient with the classic form of Pelizaeus-Merzbacher disease, electroencephalograms during wakefulness were moderately diffusely abnormal, and an overnight polygraphic sleep recording showed distorted nonrapid eye movement sleep patterns without vertex sharp waves, K-complexes, spindles, or positive ...

journal_title：Neurology

authors： Wilkus RJ,Farrell DF

更新日期：1976-11-01 00:00:00

abstract：BACKGROUND:The probability of hearing loss during cerebellopontine angle (CPA) surgery can be reduced by using brainstem auditory evoked potential (BAEP) intraoperative monitoring (IOM). A wave V latency prolongation of 1.0 milliseconds or amplitude decrement of greater than 50% is arbitrarily considered the point when...

journal_title：Neurology

authors： James ML,Husain AM

更新日期：2005-11-22 00:00:00

abstract：:Antiepileptic drug use was documented before and after temporal lobectomy. Carbamazepine, phenytoin, and clobazam were the most commonly used drugs, both pre- and postoperatively. Preoperatively, polytherapy was used in 78% of patients; at 6 months follow-up, 47%; at 12 months, 18%; and at 24 months, 14%. Preoperative...

journal_title：Neurology

authors： Maher J,McLachlan RS

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:X-linked adrenoleukodystrophy (X-ALD) has variants with widely different outcomes, hampering clinical counseling and evaluation of therapies. OBJECTIVE:To evaluate the degree to which MRI patterns can predict lesion progression. METHODS:Two hundred six boys and men with cerebral X-ALD (median age 12.2 year...

journal_title：Neurology

authors： Loes DJ,Fatemi A,Melhem ER,Gupte N,Bezman L,Moser HW,Raymond GV

更新日期：2003-08-12 00:00:00

abstract：OBJECTIVE:To characterize the molecular basis of a novel fast-channel congenital myasthenic syndrome. METHODS:We used the candidate gene approach to identify the pathogenic mutation in the acetylcholine receptor (AChR) ε subunit, genetically engineered the mutant AChR into HEK cells, and evaluated the level of express...

journal_title：Neurology

authors： Shen XM,Brengman JM,Edvardson S,Sine SM,Engel AG

更新日期：2012-07-31 00:00:00

abstract：:The incidence of MS in the Orkney Islands has been updated from 1941 to September 21, 1983. Since 1965, MS incidence rates have fallen significantly when compared with those for 1941 to 1964. Alterations in age-specific prevalence, mean duration of illness, and mean age of the MS population are consistent with the dec...

journal_title：Neurology

authors： Cook SD,Cromarty JI,Tapp W,Poskanzer D,Walker JD,Dowling PC

更新日期：1985-04-01 00:00:00

abstract：OBJECTIVE:To test the hypothesis that, in the context of robotic therapy designed to enhance proprioceptive feedback via a Hebbian model, integrity of both somatosensory and motor systems would be important in understanding interparticipant differences in treatment-related motor gains. METHODS:In 30 patients with chro...

journal_title：Neurology

authors： Ingemanson ML,Rowe JR,Chan V,Wolbrecht ET,Reinkensmeyer DJ,Cramer SC

更新日期：2019-03-05 00:00:00

abstract：:Pramipexole is a new, selective, nonergoline dopamine agonist that acts on D2 and preferentially on D3 dopamine receptors. Phase II and III clinical trials have shown this drug to be useful in treating both early and advanced Parkinson's disease (PD) patients. A double-blind, randomized, multicenter study was performe...

journal_title：Neurology

authors： Guttman M

更新日期：1997-10-01 00:00:00

abstract：:Orthostatic hypotension is a fall in blood pressure on standing that causes symptoms of dizziness, visual changes, and discomfort in the head and neck. The goal of treatment is the improvement of the patient's functional capacity, rather than a target blood pressure. For treatment to be successful, it must be individu...

journal_title：Neurology

authors： Robertson D,Davis TL

更新日期：1995-04-01 00:00:00

abstract：BACKGROUND:After Pokémon viewing triggered an epidemic of seizures in Japan, many efforts have been made to design safety guidelines and systems to protect subjects with photosensitivity. The authors developed a new method based upon nonlinear diffusion techniques capable of filtering the epileptogenic content of a vid...

journal_title：Neurology

authors： Parra J,Kalitzin SN,Stroink H,Dekker E,de Wit C,Lopes da Silva FH

更新日期：2005-03-08 00:00:00

abstract：OBJECTIVE:To describe four patients with temporal lobe epilepsy with limbic encephalitis unrelated to neoplasm. METHODS:The authors performed a retrospective evaluation of patient data obtained during presurgical evaluation, with additional CSF analyses, serum analyses, and histopathologic investigations. RESULTS:The...

journal_title：Neurology

authors： Bien CG,Schulze-Bonhage A,Deckert M,Urbach H,Helmstaedter C,Grunwald T,Schaller C,Elger CE

更新日期：2000-12-26 00:00:00

abstract：OBJECTIVES:To compare the degrees to which 8 domains of health are affected across types of cerebrovascular events and to identify factors associated with domain scores in different event types. METHODS:This was an observational cohort study of 2,181 patients with ischemic stroke, intracerebral hemorrhage (ICH), subar...

journal_title：Neurology

authors： Katzan IL,Schuster A,Newey C,Uchino K,Lapin B

更新日期：2018-12-04 00:00:00

abstract：:Thirty-one (23%) of 137 patients treated for leptomeningeal metastases (LM) achieved a sustained off-therapy response of at least 6 months' duration following treatment by a standard protocol. Of the 31 patients, equal distribution was found among various tumors: lymphoma, 13/44 (29%); breast carcinoma, 10/51 (20%); a...

journal_title：Neurology

authors： Siegal T,Lossos A,Pfeffer MR

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:To incorporate standardized documentation into an epilepsy clinic and to use these standardized data to compare patients' perception of epilepsy diagnosis to provider documentation. METHODS:Using quality improvement methodology, we implemented interventions to increase documentation of epilepsy diagnosis, se...

journal_title：Neurology

authors： Jones FJS,Smith JR,Ayub N,Herman ST,Buchhalter JR,Fureman BE,Cash SS,Hoch DB,Moura LMVR

更新日期：2020-07-14 00:00:00

abstract：OBJECTIVE:To determine the diagnostic accuracy and prognostic value of ¹⁸FDG-PET in a recent series of patients operated for intractable partial epilepsy associated with histologically proven Taylor-type focal cortical dysplasia (TTFCD) and negative MRI. METHODS:Of 23 consecutive patients (12 male, 7-38 years old) wit...

journal_title：Neurology

authors： Chassoux F,Rodrigo S,Semah F,Beuvon F,Landre E,Devaux B,Turak B,Mellerio C,Meder JF,Roux FX,Daumas-Duport C,Merlet P,Dulac O,Chiron C

更新日期：2010-12-14 00:00:00