Limbic encephalitis not associated with neoplasm as a cause of temporal lobe epilepsy.

Abstract:

OBJECTIVE:To describe four patients with temporal lobe epilepsy with limbic encephalitis unrelated to neoplasm. METHODS:The authors performed a retrospective evaluation of patient data obtained during presurgical evaluation, with additional CSF analyses, serum analyses, and histopathologic investigations. RESULTS:The patients shared the following clinical features: onset of the disease in young adulthood with subacute onset or exacerbation of frequent intractable temporal lobe seizures, verbal and visual memory deficits, and affective abnormalities. MRI showed variably extended areas of increased T2 signal in limbic structures and adjacent areas. In the histopathologic investigation, chronic inflammation was observed without evidence of a viral origin. There was no evidence of an underlying malignancy. CONCLUSIONS:Nonparaneoplastic limbic encephalitis should be included in the differential diagnosis of adult patients with temporal lobe epilepsy.

journal_name

Neurology

journal_title

Neurology

authors

Bien CG,Schulze-Bonhage A,Deckert M,Urbach H,Helmstaedter C,Grunwald T,Schaller C,Elger CE

doi

10.1212/wnl.55.12.1823

subject

Has Abstract

pub_date

2000-12-26 00:00:00

pages

1823-8

issue

12

eissn

0028-3878

issn

1526-632X

journal_volume

55

pub_type

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