The predictive value of gray matter atrophy in clinically isolated syndromes.

abstract：OBJECTIVE:To distinguish, in patients with Korsakoff syndrome (KS), the structural brain abnormalities shared with alcoholic patients without KS (AL), from those specific to KS. METHODS:MRI data were collected in 11 alcoholic patients with KS, 34 alcoholic patients without KS, and 25 healthy control subjects (CS). Gra...

journal_title：Neurology

authors： Pitel AL,Chételat G,Le Berre AP,Desgranges B,Eustache F,Beaunieux H

更新日期：2012-04-24 00:00:00

abstract：:A man with onset of obsessive-compulsive disorder (OCD) at age 62 had a large right posterior frontal infarct and occlusion of the ipsilateral internal carotid artery. We review additional cases from the literature with obsessive or compulsive behaviors and structural lesions. OCD may have a structural correlate, and ...

journal_title：Neurology

authors： Swoboda KJ,Jenike MA

更新日期：1995-12-01 00:00:00

abstract：BACKGROUND:Neurofibrillary tangles (NFTs), composed of hyperphosphorylated tau proteins, are one of the pathologic hallmarks of Alzheimer disease (AD). We aimed to determine whether patterns of gray matter atrophy from antemortem MRI correlate with Braak staging of NFT pathology. METHODS:Eighty-three subjects with Bra...

journal_title：Neurology

authors： Whitwell JL,Josephs KA,Murray ME,Kantarci K,Przybelski SA,Weigand SD,Vemuri P,Senjem ML,Parisi JE,Knopman DS,Boeve BF,Petersen RC,Dickson DW,Jack CR Jr

更新日期：2008-09-02 00:00:00

abstract：:Thirteen patients presented with brief, repetitive, stereotyped transient ischemic attacks, large artery atherostenoses or occlusions with impaired collateral flow to a cortical perfusion borderzone, and orthostatic hypotension (OH). OH was caused by diabetes mellitus, aging, and treatments for ischemic heart disease ...

journal_title：Neurology

authors： Dobkin BH

更新日期：1989-01-01 00:00:00

abstract：:Dapsone produces a potentially reversible toxic neuropathy, with its primary effect on the soma and axons of motor neurons as opposed to myelin. There is very little evidence to suggest involvement of sensory axons in most cases; if present, it would appear minimal. A "dying back" of motor axons is postulated to produ...

journal_title：Neurology

authors： Gutmann L,Martin JD,Welton W

更新日期：1976-06-01 00:00:00

abstract：:We used proton magnetic resonance spectroscopy (1H MRS) to investigate the temporal lobes of 25 patients with temporal lobe epilepsy. Spectra were obtained from 2 x 2 x 2 cm cubes in the medial region of the temporal lobe, and were analyzed on the basis of signals from N-acetylaspartate (NAA), creatine + phosphocreati...

journal_title：Neurology

authors： Connelly A,Jackson GD,Duncan JS,King MD,Gadian DG

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:In this study, we compared a cognition-specific computer-based cognitive training program with a motion-controlled computer sports game that is not cognition-specific for their ability to enhance cognitive performance in various cognitive domains in patients with Parkinson disease (PD). METHODS:Patients with...

journal_title：Neurology

authors： Zimmermann R,Gschwandtner U,Benz N,Hatz F,Schindler C,Taub E,Fuhr P

更新日期：2014-04-08 00:00:00

abstract：:The authors compared the transcranial color-coded duplex pattern of the middle cerebral arteries (MCAs) before and after IV and combined IV-intra-arterial (IV-IA) thrombolysis in consecutive first-ever stroke patients. Patients receiving combined IV-IA thrombolysis showed greater improvement in flow signal and higher ...

journal_title：Neurology

authors： Perren F,Loulidi J,Graves R,Yilmaz H,Rüfenacht D,Landis T,Sztajzel R

更新日期：2006-07-25 00:00:00

abstract：:Spinocerebellar ataxia type 6 (SCA6) is a newly classified autosomal-dominant cerebellar ataxia (ADCA) associated with CAG repeat expansion. We screened 111 patients with cerebellar ataxia for the SCA6 mutation. Of these, 35 patients were found to have expanded CAG repeats in the SCA6 gene, indicating that second to S...

journal_title：Neurology

authors： Matsumura R,Futamura N,Fujimoto Y,Yanagimoto S,Horikawa H,Suzumura A,Takayanagi T

更新日期：1997-11-01 00:00:00

abstract：:Three children with cerebral oligodendrogliomas causing partial complex or generalized seizures presented with completely normal neurologic examinations. CT showed low-density, nonenhancing surface lesions. Although these CT features are usually associated with infarcts or cysts, neoplasm was suspected because of irre...

journal_title：Neurology

authors： Varma RR,Crumrine PK,Bergman I,Latchaw RE,Price RA,Vries J,Painter MJ

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:It has been suggested that anemia may be a risk factor for dementia, for restless legs syndrome, and for Parkinson disease (PD). Thus, we investigated the association of anemia with the subsequent risk of PD using a case-control study design. METHODS:We used the medical records-linkage system of the Rocheste...

journal_title：Neurology

authors： Savica R,Grossardt BR,Carlin JM,Icen M,Bower JH,Ahlskog JE,Maraganore DM,Steensma DP,Rocca WA

更新日期：2009-10-27 00:00:00

abstract：:Magnetization transfer imaging (MTI) is a magnetic resonance imaging (MRI) technique that is now used in multiple sclerosis (MS) studies, and is thought to have a higher pathological specificity than conventional T2-weighted imaging. This review outlines the correlations between magnetization transfer (MT) metrics and...

journal_title：Neurology

authors： Rovaris M,Horsfield MA,Filippi M

更新日期：1999-01-01 00:00:00

abstract：OBJECTIVE:Hospital readmission is an important quality improvement measure that has not been well-studied in pediatric neurology. We examined predictors of 7-day and 30-day readmissions for pediatric patients hospitalized with a neurologic diagnosis. METHODS:This was a retrospective study of hospital readmission rates...

journal_title：Neurology

authors： Hong A,Shah Y,Singh K,Karkare S,Kothare S

更新日期：2019-04-16 00:00:00

abstract：OBJECTIVE:To evaluate the potential efficacy of immediate-release methylphenidate (MPH) for treating cognitive deficits in epilepsy. METHODS:This was a double-blind, randomized, single-dose, 3-period crossover study in patients with epilepsy and chronic cognitive complaints comparing the effects of placebo and MPH 10 ...

journal_title：Neurology

authors： Adams J,Alipio-Jocson V,Inoyama K,Bartlett V,Sandhu S,Oso J,Barry JJ,Loring DW,Meador K

更新日期：2017-01-31 00:00:00

abstract：:We evaluated the therapeutic efficacy and toxicity of high-dose monotherapy, using carbamazepine or phenytoin, in patients with previously uncontrolled seizures. Treatment with a single drug was equal to or better than polypharmacy, but only a few patients became free of seizures. Toxicity was mild and associated with...

journal_title：Neurology

authors： Lesser RP,Pippenger CE,Lüders H,Dinner DS

更新日期：1984-06-01 00:00:00

abstract：OBJECTIVE:To determine the diagnostic value of high-resolution ultrasound (HRUS) for detection of chronic inflammatory demyelinating polyneuropathy (CIDP), Lewis-Sumner syndrome (LSS), and multifocal motor neuropathy (MMN). METHODS:Between January 2013 and January 2015, we enrolled 75 consecutive treatment-naive patie...

journal_title：Neurology

authors： Goedee HS,van der Pol WL,van Asseldonk JH,Franssen H,Notermans NC,Vrancken AJ,van Es MA,Nikolakopoulos S,Visser LH,van den Berg LH

更新日期：2017-01-10 00:00:00

abstract：BACKGROUND:Cervical artery dissection is often attributed to an underlying arteriopathy related to a generalized extracellular matrix defect. OBJECTIVE:The authors compared the hemodynamic and morphologic properties of the carotid artery, as assessed noninvasively by ultrasonography, in patients with spontaneous inter...

journal_title：Neurology

authors： Guillon B,Tzourio C,Biousse V,Adraï V,Bousser MG,Touboul PJ

更新日期：2000-09-12 00:00:00

abstract：OBJECTIVE:To report eight cases of sensory Guillain-Barré syndrome (GBS). BACKGROUND:The concept of sensory equivalent to ascending paralysis of GBS was raised in 1958, and the diagnostic criteria for a sensory loss and areflexia variant of GBS were proposed in 1981. However, clinical cases meeting these criteria have...

journal_title：Neurology

authors： Oh SJ,LaGanke C,Claussen GC

更新日期：2001-01-09 00:00:00

abstract：:We identified seven patients with refractory partial epilepsy and sleep apnea. Treatment of the sleep apnea with nasal continuous positive airway pressure (CPAP), protriptyline, trazodone, acetazolamide, or tracheostomy reduced seizure frequency and severity in six patients. Success with CPAP depended largely on compl...

journal_title：Neurology

authors： Devinsky O,Ehrenberg B,Barthlen GM,Abramson HS,Luciano D

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:To estimate the prevalence of childhood ataxia resulting from both genetic and acquired causes. METHODS:A systematic review was conducted following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) statement. Five databases were searched for articles reporting a frequency measur...

journal_title：Neurology

authors： Musselman KE,Stoyanov CT,Marasigan R,Jenkins ME,Konczak J,Morton SM,Bastian AJ

更新日期：2014-01-07 00:00:00

abstract：OBJECTIVE:(1)H-MRS studies have shown abnormalities in brain levels of myo-inositol (mI) and N-acetyl aspartate (NAA) in AD, but the relation of these abnormalities with dementia severity was not examined. The authors sought to determine whether altered brain levels of mI and other metabolites occur in mild AD and whet...

journal_title：Neurology

authors： Huang W,Alexander GE,Chang L,Shetty HU,Krasuski JS,Rapoport SI,Schapiro MB

更新日期：2001-08-28 00:00:00

abstract：OBJECTIVE:To study the prognostic significance of multiple novel biomarkers in combination after ischemic stroke. METHODS:We derived data from the China Antihypertensive Trial in Acute Ischemic Stroke, and 12 informative biomarkers were measured. The primary outcome was the combination of death and major disability (m...

journal_title：Neurology

authors： Zhong C,Zhu Z,Wang A,Xu T,Bu X,Peng H,Yang J,Han L,Chen J,Xu T,Peng Y,Wang J,Li Q,Ju Z,Geng D,He J,Zhang Y

更新日期：2019-01-22 00:00:00

abstract：:We studied acetaminophen sulfation, plasma sulfate levels, and the activity of sulfotransferase in blood platelets in patients with Parkinson's disease, Huntington's disease, and in controls and did not find any abnormality in the patient groups, independent of the use of medication. ...

journal_title：Neurology

authors： Roos RA,Steenvoorden JM,Mulder GJ,Van Kempen GM

更新日期：1993-07-01 00:00:00

abstract：:Information about 255 children and adults with Pompe disease was gathered through a questionnaire. Disease severity was associated with disease duration and not with age; an early manifestation of the disease implied earlier wheelchair or ventilator dependency. The patient group under age 15 included a subgroup with a...

journal_title：Neurology

authors： Hagemans ML,Winkel LP,Hop WC,Reuser AJ,Van Doorn PA,Van der Ploeg AT

更新日期：2005-06-28 00:00:00

abstract：OBJECTIVE:To identify phenotypic features of febrile seizures that can be used to reduce heterogeneity and thereby increase power in linkage analysis. BACKGROUND:Despite exciting discoveries in several rare pedigrees, the genetic basis of common febrile seizures remains a mystery. The major drawback of studying common...

journal_title：Neurology

authors： Pal DK,Kugler SL,Mandelbaum DE,Durner M

更新日期：2003-02-11 00:00:00

abstract：:Four patients with a clinical syndrome closely resembling amyotrophic lateral sclerosis recovered completely, without treatment, 5 to 12 months after onset. Electrodiagnostic tests revealed acute and chronic denervation, with normal motor and sensory nerve conduction studies. The CSF was normal, and tests for paraprot...

journal_title：Neurology

authors： Tucker T,Layzer RB,Miller RG,Chad D

更新日期：1991-10-01 00:00:00

abstract：OBJECTIVE:Recent studies have suggested modifications of serotonin cerebral metabolism and of 5-HT(1A) receptors density in Alzheimer disease (AD). This study aims at exploring hippocampus 5-HT(1A) receptor density in patients at the amnesic mild cognitive impairment (aMCI) and mild AD dementia stages. METHODS:With us...

journal_title：Neurology

authors： Truchot L,Costes SN,Zimmer L,Laurent B,Le Bars D,Thomas-Antérion C,Croisile B,Mercier B,Hermier M,Vighetto A,Krolak-Salmon P

更新日期：2007-09-04 00:00:00

abstract：OBJECTIVE:To determine the minimum incidence and minimum prevalence rates of small-fiber neuropathy (SFN) in a well-defined region in the southern part of the Netherlands. METHODS:In this cross-sectional study with retrospective data collection, we used data of patients diagnosed with pure SFN at our Small Fiber Neuro...

journal_title：Neurology

authors： Peters MJ,Bakkers M,Merkies IS,Hoeijmakers JG,van Raak EP,Faber CG

更新日期：2013-10-08 00:00:00

abstract：:Although psychological distress and cognitive dysfunction are well documented in adults with multiple sclerosis (MS), they are poorly understood in children with the disease. Psychosocial difficulty experienced by children and adolescents with MS involves factors common to all chronic illnesses in children, as well as...

journal_title：Neurology

authors： MacAllister WS,Boyd JR,Holland NJ,Milazzo MC,Krupp LB,International Pediatric MS Study Group.

更新日期：2007-04-17 00:00:00

abstract：BACKGROUND:The epsilon 4 allele of the APOE gene (APOE) is more frequent in patients with AD than in the general population, but studies are inconclusive as to whether it affects rate of progression or survival. Because survival in AD is generally longer in women than in men, the authors investigated whether APOE affec...

journal_title：Neurology

authors： Dal Forno G,Carson KA,Brookmeyer R,Troncoso J,Kawas CH,Brandt J

更新日期：2002-04-09 00:00:00