Abstract:
:We evaluated the therapeutic efficacy and toxicity of high-dose monotherapy, using carbamazepine or phenytoin, in patients with previously uncontrolled seizures. Treatment with a single drug was equal to or better than polypharmacy, but only a few patients became free of seizures. Toxicity was mild and associated with higher total plasma levels after polypharmacy. Free fractions ranged from 0.14 to 0.30 for carbamazepine and from 0.60 to 0.13 for phenytoin. Toxicity was associated with free phenytoin levels above 3 micrograms/ml; there was no clear relationship between free carbamazepine level and toxicity.
journal_name
Neurologyjournal_title
Neurologyauthors
Lesser RP,Pippenger CE,Lüders H,Dinner DSdoi
10.1212/wnl.34.6.707subject
Has Abstractpub_date
1984-06-01 00:00:00pages
707-11issue
6eissn
0028-3878issn
1526-632Xjournal_volume
34pub_type
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