Abstract:
OBJECTIVE:To demonstrate whether the cerebral hemispheres (language dominant versus nondominant) affect immune function differentially in humans by delineating the effects of resections for epilepsy surgery on T-cell indices. BACKGROUND:Cerebral lateralization has been postulated to affect immunomodulation. Differential effects of left versus right cerebral lesions on T-cell numbers and responsiveness have been demonstrated in animals, but the effects in humans are unclear. METHODS:Pre- and postoperative changes in T-cell indices were examined in relation to side of language dominance in patients undergoing epilepsy surgery. RESULTS:Absolute lymphocyte count, total T cells (CD3+), helper T cells (CD3+4+), cytotoxic/suppressor cells (CD3+8+), and total suppressor cells (CD8+) were reduced after language-dominant resections, but were increased after nondominant resections. CONCLUSIONS:Although the mechanisms are not fully elucidated, the results demonstrate differential immunologic responses in humans to focal cerebral lesions as a function of cerebral lateralization.
journal_name
Neurologyjournal_title
Neurologyauthors
Meador KJ,De Lecuona JM,Helman SW,Loring DWdoi
10.1212/wnl.52.6.1183subject
Has Abstractpub_date
1999-04-12 00:00:00pages
1183-7issue
6eissn
0028-3878issn
1526-632Xjournal_volume
52pub_type
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