Distinctive pathologic findings in proximal diabetic neuropathy (diabetic amyotrophy).

abstract：:A patient with clinical and radiographic findings initially suggesting a neoplasm was diagnosed as having Hodgkin disease. Computerized axial tomography demonstrated profound diffuse decreased density similar to that seen in cases of cerebral edema or leukomalacia. Cerebral angiography showed blood vessels with a bead...

journal_title：Neurology

authors： Rajjoub RK,Wood JH,Ommaya AK

更新日期：1977-06-01 00:00:00

abstract：:We studied the effects of botulinum toxin A in 12 patients with spasticity and in eight patients with rigidity. The study design was a double-blind, placebo-controlled crossover trial with botulinum toxin A versus saline. Using the Ashworth Scale for spasticity and the Unified Parkinson's Disease Rating Scale for rigi...

journal_title：Neurology

authors： Grazko MA,Polo KB,Jabbari B

更新日期：1995-04-01 00:00:00

abstract：:A physically and intellectually normally developed boy had a resection of a lumbar myelomeningocele shortly after birth and a shunt was inserted for hydrocephalus. He died at age 12 years after a traffic accident. Autopsy disclosed a hyperplasia of the cerebellar vermis. An abnormal median-sagittal triangular fiber tr...

journal_title：Neurology

authors： Friede RL,Briner J

更新日期：1978-12-01 00:00:00

abstract：OBJECTIVES:Using high-resolution structural MRI, we endeavored to study the relationships among APOE ε4, hippocampal subfield and stratal anatomy, and episodic memory. METHODS:Using a cross-sectional design, we studied 11 patients with Alzheimer disease dementia, 14 patients with amnestic mild cognitive impairment, an...

journal_title：Neurology

authors： Kerchner GA,Berdnik D,Shen JC,Bernstein JD,Fenesy MC,Deutsch GK,Wyss-Coray T,Rutt BK

更新日期：2014-02-25 00:00:00

abstract：:Gilles de la Tourette's syndrome (TS) is a familial disorder that is often exacerbated by stress or fatigue. Here we present a family of a TS proband that has several members with obsessive-compulsive symptoms, a bleeding disorder, and an unusual sensitivity to heat. The proband, who is affected by all of these traits...

journal_title：Neurology

authors： Lombroso PJ,Mack G,Scahill L,King RA,Leckman JF

更新日期：1991-12-01 00:00:00

abstract：:Adult-onset dystonia-parkinsonism is a syndrome in search of a pathology. We therefore reviewed the literature on dystonic manifestations in autopsy-proven cases of multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and idiopathic Parkinson's disease (PD). Only 6 of 140 autopsy reports of MSA remarke...

journal_title：Neurology

authors： Rivest J,Quinn N,Marsden CD

更新日期：1990-10-01 00:00:00

abstract：:In 21 normal subjects, far-field somatosensory potentials were recorded from the scalp after stimulation of the tibial nerve at the ankle (tibial SEP). With the use of a knee reference contralateral to the side of stimulation, the tibial SEP consisted of three major positive peaks, P17, P24, and P31, and three additio...

journal_title：Neurology

authors： Yamada T,Machida M,Kimura J

更新日期：1982-10-01 00:00:00

abstract：OBJECTIVE:To discuss the indications and timing for resective surgery in patients with Sturge-Weber syndrome (SWS) and medication-resistant epilepsy. BACKGROUND:SWS that causes epilepsy severe enough to merit surgery is rare. Because of the variable natural history of the disease, it is difficult to establish clear-cu...

journal_title：Neurology

authors： Arzimanoglou AA,Andermann F,Aicardi J,Sainte-Rose C,Beaulieu MA,Villemure JG,Olivier A,Rasmussen T

更新日期：2000-11-28 00:00:00

abstract：:Although Parkinson's disease has a definite neurologic basis, patients and relatives experience a multitude of stresses, only partly related to motor symptoms. Subjective and behavioral problems may be regarded as secondary disease symptoms. In an integrated approach, patients and relatives receive psychological couns...

journal_title：Neurology

authors： Ellgring H,Seiler S,Perleth B,Frings W,Gasser T,Oertel W

更新日期：1993-12-01 00:00:00

abstract：:The authors analyzed the association of L-carnitine treatment with hepatic survival in 92 patients with severe, symptomatic, valproate-induced hepatotoxicity. Forty-eight percent of the 42 patients treated with L-carnitine survived, but only 10% of the 50 patients treated solely with aggressive supportive care survive...

journal_title：Neurology

authors： Bohan TP,Helton E,McDonald I,König S,Gazitt S,Sugimoto T,Scheffner D,Cusmano L,Li S,Koch G

更新日期：2001-05-22 00:00:00

abstract：OBJECTIVE:Diagnostic criteria from 2002 classify transverse myelitis (TM) as idiopathic or disease associated but predate the discovery of aquaporin-4 (AQP4)-immunoglobulin G (IgG) and myelin oligodendrocyte glycoprotein (MOG)-IgG, which associate with TM. Prior incidence estimates of idiopathic TM (ITM) range from 1 t...

journal_title：Neurology

authors： Sechi E,Shosha E,Williams JP,Pittock SJ,Weinshenker BG,Keegan BM,Zalewski NL,Lopez-Chiriboga AS,Jitprapaikulsan J,Flanagan EP

更新日期：2019-07-23 00:00:00

abstract：:We gave three adult rhesus monkeys seven IV injections of manganese chloride at approximately 1-week intervals. We evaluated neurologic status by serial clinical examinations and performed a levodopa test if the animal developed features of basal ganglia dysfunction. After the animals were killed, we performed neuropa...

journal_title：Neurology

authors： Olanow CW,Good PF,Shinotoh H,Hewitt KA,Vingerhoets F,Snow BJ,Beal MF,Calne DB,Perl DP

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:Small uncontrolled series suggest that treatment of obstructive sleep apnea (OSA) in patients with epilepsy may improve seizure control. Prior to conducting a definitive randomized controlled trial, we addressed critical design issues in a pilot study. METHODS:We identified a cohort of adult patients with me...

journal_title：Neurology

authors： Malow BA,Foldvary-Schaefer N,Vaughn BV,Selwa LM,Chervin RD,Weatherwax KJ,Wang L,Song Y

更新日期：2008-08-19 00:00:00

abstract：OBJECTIVE:To use the Unified Batten Disease Rating Scale (UBDRS) to measure the rate of decline in physical and functional capability domains in patients with juvenile neuronal ceroid lipofuscinosis (JNCL) or Batten disease, a neurodegenerative lysosomal storage disorder. We have evaluated the UBDRS in subjects with JN...

journal_title：Neurology

authors： Kwon JM,Adams H,Rothberg PG,Augustine EF,Marshall FJ,Deblieck EA,Vierhile A,Beck CA,Newhouse NJ,Cialone J,Levy E,Ramirez-Montealegre D,Dure LS,Rose KR,Mink JW

更新日期：2011-11-15 00:00:00

abstract：:We studied a family with an extrapyramidal disorder characterized by childhood onset of lower-limb and axial dystonia, followed by parkinsonism. Dramatic response to levodopa therapy and minimal progression in adult life was seen. The family included five generations of affected members of both sexes in an autosomal d...

journal_title：Neurology

authors： Nygaard TG,Duvoisin RC

更新日期：1986-11-01 00:00:00

abstract：OBJECTIVES:To evaluate basal ganglia changes along the amyotrophic lateral sclerosis (ALS)-ALS-frontotemporal dementia (FTD) continuum using multiple, complementary imaging techniques. METHODS:Sixty-seven C9orf72-negative patients with ALS and 39 healthy controls were included in a cross-sectional quantitative MRI stu...

journal_title：Neurology

authors： Machts J,Loewe K,Kaufmann J,Jakubiczka S,Abdulla S,Petri S,Dengler R,Heinze HJ,Vielhaber S,Schoenfeld MA,Bede P

更新日期：2015-10-13 00:00:00

abstract：:We evaluated the therapeutic efficacy of gamma aminobutyric acid (GABA) system stimulation in four patients with classical Huntington's disease and one with the hypokinetic-rigid form. Orally administered THIP (4,5,6,7-tetrahydroisoxazolo-[5,4,-c] pyridin-3-ol), a novel GABA receptor agonist, failed to improve motor o...

journal_title：Neurology

authors： Foster NL,Chase TN,Denaro A,Hare TA,Tamminga CA

更新日期：1983-05-01 00:00:00

abstract：OBJECTIVE:To demonstrate that progress has been made in unifying brain death determination guidelines in the last decade by directly comparing the policies of the US News and World Report's top 50 ranked neurologic institutions from 2006 and 2015. METHODS:We solicited official hospital guidelines in 2015 from these to...

journal_title：Neurology

authors： Wang HH,Varelas PN,Henderson GV,Wijdicks EF,Greer DM

更新日期：2017-02-07 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) is a neuroactive cytokine found in Schwann cells, which appears to be released in response to nerve injury. The ALS CNTF Treatment Study (ACTS) clinical trial was a phase II-III randomized, placebo-controlled, double-blind study designed to evaluate the safety, tolerability, and effi...

journal_title：Neurology

authors：

更新日期：1996-05-01 00:00:00

abstract：:We prospectively evaluated the relationship between a common psychological stressor and relapses in multiple sclerosis (MS) in a group of 32 MS patients exposed to the threat of missile attacks during the Persian Gulf War of 1991. The number of relapses during the war and the following 2 months was significantly lower...

journal_title：Neurology

authors： Nisipeanu P,Korczyn AD

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:In multifocal motor neuropathy (MMN), high dose of IV immunoglobulin (IVIg) is the only established treatment. Subcutaneous self-infusion with immunoglobulin G (IgG) (SCIG) increases patient autonomy and treatment flexibility, and might be associated with fewer side effects due to lower peak IgG levels. In a...

journal_title：Neurology

authors： Harbo T,Andersen H,Jakobsen J

更新日期：2010-10-12 00:00:00

abstract：BACKGROUND:Saccades are essential for optimal visual function. Chiari type II malformation (CII) is a congenital anomaly of the cerebellum and brainstem, associated with spina bifida. OBJECTIVE:To investigate the effects of CII on saccades and correlate saccadic parameters with brain MRI measurements. METHODS:Saccade...

journal_title：Neurology

authors： Salman MS,Sharpe JA,Eizenman M,Lillakas L,To T,Westall C,Steinbach MJ,Dennis M

更新日期：2005-06-28 00:00:00

abstract：:An allele (263bp) of the nonamyloid component of plaques (NACP)-Repl polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease (HD)...

journal_title：Neurology

authors： Tan EK,Matsuura T,Nagamitsu S,Khajavi M,Jankovic J,Ashizawa T

更新日期：2000-03-14 00:00:00

abstract：OBJECTIVES:To investigate clinical, imaging, and pathologic associations of the cingulate island sign (CIS) in dementia with Lewy bodies (DLB). METHODS:We retrospectively identified and compared patients with a clinical diagnosis of DLB (n=39); patients with Alzheimer disease (AD) matched by age, sex, and education (n...

journal_title：Neurology

authors： Graff-Radford J,Murray ME,Lowe VJ,Boeve BF,Ferman TJ,Przybelski SA,Lesnick TG,Senjem ML,Gunter JL,Smith GE,Knopman DS,Jack CR Jr,Dickson DW,Petersen RC,Kantarci K

更新日期：2014-08-26 00:00:00

abstract：OBJECTIVE:To assess the clinical implications and the pathophysiologic determinants of interictal bitemporal hypometabolism (BTH) in temporal lobe epilepsy (TLE) not associated with bilateral MRI abnormalities or intracranial space-occupying lesions. METHODS:The authors compared the clinical, interictal, and ictal EEG...

journal_title：Neurology

authors： Koutroumanidis M,Hennessy MJ,Seed PT,Elwes RD,Jarosz J,Morris RG,Maisey MN,Binnie CD,Polkey CE

更新日期：2000-05-09 00:00:00

abstract：OBJECTIVE:This study prospectively examined the relationships among late night salivary cortisol (NSC) levels and depressive symptoms, memory performance, and hippocampal volumes in patients with medically intractable temporal lobe epilepsy (TLE) and the potential mediating effects of cortisol in the relationships betw...

journal_title：Neurology

authors： Busch RM,Frazier T,Chapin JS,Hamrahian AH,Diehl B,Alexopoulos A,Unnwongse K,Naugle RI,Kubu CS,Tesar GE,Najm IM

更新日期：2012-04-03 00:00:00

abstract：OBJECTIVE:Alzheimer disease (AD) risk factors are present throughout the lifespan. This randomized controlled trial evaluated the effectiveness of various online education strategies concerning AD risk reduction and brain health in younger populations. METHOD:High school and college students were recruited via social ...

journal_title：Neurology

authors： Saif N,Niotis K,Dominguez M,Hodes JF,Woodbury M,Amini Y,Sadek G,Scheyer O,Caesar E,Hristov H,Knowlton N,Lee P,McInnis M,Isaacson RS

更新日期：2020-10-20 00:00:00

abstract：OBJECTIVE:To investigate whether cognitive function is related to incidence of stroke. METHODS:A population-based cohort of 1551 subjects with no clinical history or signs of stroke, age 75 years and over at baseline, were followed up for 3 years. Individuals with a first-ever stroke event that was recorded in the Sto...

journal_title：Neurology

authors： Zhu L,Fratiglioni L,Guo Z,Winblad B,Viitanen M

更新日期：2000-06-13 00:00:00

abstract：OBJECTIVE:To test the hypothesis that US neurologists were experiencing significant challenges with lack of personal protective equipment (PPE), rapid changes in practice, and varying institutional protocols, we conducted this survey study. The current coronavirus disease of 2019 (COVID-19) pandemic has caused widespre...

journal_title：Neurology

authors： Sharma A,Maxwell CR,Farmer J,Greene-Chandos D,LaFaver K,Benameur K

更新日期：2020-08-04 00:00:00

abstract：:We administered 3 commonly employed tests of mental status (the Information-Memory-Concentration test [IMC], the Mini-Mental State Examination [MMSE], and the Dementia Rating Scale [DRS]) to 92 patients with probable dementia of the Alzheimer type. The 3 tests were readministered to 55 of the patients (2-year subgroup...

journal_title：Neurology

authors： Salmon DP,Thal LJ,Butters N,Heindel WC

更新日期：1990-08-01 00:00:00