Saccades in children with spina bifida and Chiari type II malformation.

abstract：:Tolcapone is a potent, reversible inhibitor of catechol O-methyltransferase (COMT) intended for use as an adjunct to levodopa therapy for Parkinson's disease (PD). Findings from the first pharmacokinetics/pharmacodynamics and tolerability studies of tolcapone in volunteers are reviewed. Following linear and dose-propo...

journal_title：Neurology

authors： Jorga KM

更新日期：1998-05-01 00:00:00

abstract：:In a series of 100 patients exhibiting clinical and molecular features of facioscapulohumeral muscular dystrophy (FSHMD), five patients had conduction defects or arrhythmia in the absence of cardiovascular risk factors--namely, intraventricular conduction delay and supraventricular arrhythmia induced by electrophysiol...

journal_title：Neurology

authors： Laforêt P,de Toma C,Eymard B,Becane HM,Jeanpierre M,Fardeau M,Duboc D

更新日期：1998-11-01 00:00:00

abstract：:Acid protease activity was increased in skeletal muscle of patients with ALS. The highest levels of activity were found in individuals with the clinically and histologically most affected muscle. High levels of proteolytic activity correlated with the extent of muscle atrophy, the presence of target fibers and the ove...

journal_title：Neurology

authors： Antel JP,Chelmicka-Schorr E,Sportiello M,Stefansson K,Wollmann RL,Arnason BG

更新日期：1982-08-01 00:00:00

abstract：:The authors retrospectively reviewed the efficacy of mycophenolate mofetil (MMF; mean dose, 2 g/day given for an average of 14 months) in 21 patients with immune demyelinating polyneuropathy. There were no significant differences in the median strength, sensory, or Rankin scores before and after treatment. In patients...

journal_title：Neurology

authors： Gorson KC,Amato AA,Ropper AH

更新日期：2004-08-24 00:00:00

abstract：BACKGROUND:Impairment in the central dopaminergic system has been consistently suggested as an etiologic factor in restless legs syndrome (RLS). OBJECTIVE:To investigate a possible role for the MAOA and MAOB genes in RLS using a population-based association study. METHODS:In addition to a dinucleotide repeat located ...

journal_title：Neurology

authors： Desautels A,Turecki G,Montplaisir J,Brisebois K,Sequeira A,Adam B,Rouleau GA

更新日期：2002-07-23 00:00:00

abstract：BACKGROUND:Although gray matter (GM) atrophy is recognized as a common feature of multiple sclerosis (MS), conflicting results have been obtained in patients with clinically isolated syndromes (CIS). Methodologic and clinical constraints may take account for literature discrepancies. METHODS:A total of 105 patients pr...

journal_title：Neurology

authors： Calabrese M,Rinaldi F,Mattisi I,Bernardi V,Favaretto A,Perini P,Gallo P

更新日期：2011-07-19 00:00:00

abstract：:A 16-year-old male with a 9-year history of spontaneously arrested hydrocephalus was noted to have hydrosyringomyelia and increased intracranial pressure shortly after sustaining minor head trauma. His symptoms resolved completely following ventriculoperitoneal shunt replacement. Hydrosyringomyelia may occur in the se...

journal_title：Neurology

authors： Olson DM,Milstein JM

更新日期：1988-04-01 00:00:00

abstract：OBJECTIVE:To determine whether changes in brain biometals in Alzheimer disease (AD) and in normal brain tissue are tandemly associated with amyloid beta-peptide (Abeta) burden and dementia severity. METHODS:The authors measured zinc, copper, iron, manganese, and aluminum and Abeta levels in postmortem neocortical tiss...

journal_title：Neurology

authors： Religa D,Strozyk D,Cherny RA,Volitakis I,Haroutunian V,Winblad B,Naslund J,Bush AI

更新日期：2006-07-11 00:00:00

abstract：:Mapping eloquent language cortex in presurgical patients typically is accomplished using highly invasive direct cortical stimulation techniques. Functional imaging during language activation using positron emission tomography (PET) is a promising, noninvasive alternative that requires validation. In seven patients und...

journal_title：Neurology

authors： Bookheimer SY,Zeffiro TA,Blaxton T,Malow BA,Gaillard WD,Sato S,Kufta C,Fedio P,Theodore WH

更新日期：1997-04-01 00:00:00

abstract：:We followed 419 patients with a first, unprovoked, primarily or secondarily generalized tonic-clonic seizure, randomized to immediate antiepileptic treatment or to treatment only in the event of seizure recurrence. The probability of achieving a 2-year remission was 72 vs 57% at 3 months, 84 to 79% at 3 years, and 85 ...

journal_title：Neurology

authors： Leone MA,Solari A,Beghi E,FIRST Group.

更新日期：2006-12-26 00:00:00

abstract：OBJECTIVES:To examine whether preadmission use of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) influenced 30-day stroke mortality. METHODS:We conducted a nationwide population-based cohort study. Using medical databases, we identified all first-time stroke hospitalizations in Denmark between 2004 and 2012 ...

journal_title：Neurology

authors： Schmidt M,Hováth-Puhó E,Christiansen CF,Petersen KL,Bøtker HE,Sørensen HT

更新日期：2014-11-25 00:00:00

abstract：:A 32-year-old patient with seizures experienced decreased right-ear hearing during electrocortical stimulation mapping of the left lateral superior temporal gyrus. Audiometric testing under headphones confirmed a reversible, moderate unilateral hearing loss. Under binaural listening conditions, auditory comprehension ...

journal_title：Neurology

authors： Sinha SR,Crone NE,Fotta R,Lenz F,Boatman DF

更新日期：2005-01-25 00:00:00

abstract：:The childhood type fo dermatomyositis, which occurs in children and young adults, shows a specific constellation of pathologic changes in muscle. Capillary necrosis leads to capillary loss, generally starting on the periphery of muscle fascicles. Electron microscopy discloses undulating tubules in endothelial cells, l...

journal_title：Neurology

authors： Carpenter S,Karpati G,Rothman S,Watters G

更新日期：1976-10-01 00:00:00

abstract：OBJECTIVE:To evaluate levels of neurofilament light (NFL) and glial fibrillary acidic protein (GFAP) in CSF from patients with multiple sclerosis (MS) in relation to clinical progress of the disease. METHODS:CSF levels of NFL and GFAP were determined by sensitive ELISAs in 99 patients with different subtypes of MS, cl...

journal_title：Neurology

authors： Norgren N,Sundström P,Svenningsson A,Rosengren L,Stigbrand T,Gunnarsson M

更新日期：2004-11-09 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of remote nonpainful electrical upper arm skin stimulation in reducing migraine attack pain. METHODS:This is a prospective, double-blinded, randomized, crossover, sham-controlled trial. Migraineurs applied skin electrodes to the upper arm soon after attack onset for 20 minutes, at va...

journal_title：Neurology

authors： Yarnitsky D,Volokh L,Ironi A,Weller B,Shor M,Shifrin A,Granovsky Y

更新日期：2017-03-28 00:00:00

abstract：:An allele (263bp) of the nonamyloid component of plaques (NACP)-Repl polymorphism has shown association with sporadic PD in a German population. The authors studied this polymorphism in 100 American PD patients and 100 healthy controls. The authors also studied 46 essential tremor (ET) and 55 Huntington's disease (HD)...

journal_title：Neurology

authors： Tan EK,Matsuura T,Nagamitsu S,Khajavi M,Jankovic J,Ashizawa T

更新日期：2000-03-14 00:00:00

abstract：OBJECTIVE:To determine the surgical outcome and factors of predictive value in patients undergoing reoperation for intractable partial epilepsy. METHODS:The authors retrospectively studied the operative outcome in 64 consecutive patients who underwent reoperation for intractable partial epilepsy. Demographic data, res...

journal_title：Neurology

authors： Siegel AM,Cascino GD,Meyer FB,McClelland RL,So EL,Marsh WR,Scheithauer BW,Sharbrough FW

更新日期：2004-12-28 00:00:00

abstract：OBJECTIVES:Determine the frequency of and the predictive factors for abnormal ocular fundus findings among emergency department (ED) headache patients. METHODS:Cross-sectional study of prospectively enrolled adult patients presenting to our ED with a chief complaint of headache. Ocular fundus photographs were obtained...

journal_title：Neurology

authors： Thulasi P,Fraser CL,Biousse V,Wright DW,Newman NJ,Bruce BB

更新日期：2013-01-29 00:00:00

abstract：OBJECTIVE:The NIH Stroke Scale (NIHSS) may not appropriately assess the spectrum of posterior circulation (PC)-related neurologic deficits. We determined the cutoff baseline NIHSS score that predicts independent daily life activity during the chronic stage in anterior circulation (AC) vs PC ischemic strokes. METHODS:A...

journal_title：Neurology

authors： Sato S,Toyoda K,Uehara T,Toratani N,Yokota C,Moriwaki H,Naritomi H,Minematsu K

更新日期：2008-06-10 00:00:00

abstract：:Epilepsy surgery is a well-established treatment for certain types of intractable epilepsy. While there is a relatively high number of epilepsy surgery centers in Canada and the United States, the same cannot be said about many other parts of the world, such as South America. Although there are notable exceptions, suc...

journal_title：Neurology

authors： Steven DA,Vasquez CM,Delgado JC,Zapata-Luyo W,Becerra A,Barreto E,Arango MF,Burneo JG

更新日期：2018-08-21 00:00:00

abstract：OBJECTIVE:To evaluate the safety, tolerability, and efficacy of glatiramer acetate (GA) 40 mg daily vs the approved 20-mg formulation in relapsing-remitting multiple sclerosis. METHODS:Eligibility criteria included clinically definite multiple sclerosis, Expanded Disability Status Scale score 0 to 5.0, no previous use...

journal_title：Neurology

authors： Cohen JA,Rovaris M,Goodman AD,Ladkani D,Wynn D,Filippi M,9006 Study Group.

更新日期：2007-03-20 00:00:00

abstract：:The authors report a case of hereditary multiple exostoses (HME) with neurologic complications, and review the literature. A 23-year-old man exhibited a worsening spastic paraparesis with sphincter dysfunction. The cranial nerves and the exteroceptive and deep sensations were apparently undamaged. The family history, ...

journal_title：Neurology

authors： Ferrari G,Taddei L,Vivenza C,Rossi G

更新日期：1979-07-01 00:00:00

abstract：:Sensory disturbance in the unilateral hand and ipsilateral mouth region, the cheiro-oral syndrome, may be due to cortical, thalamic, or brainstem lesions. We report five patients with this syndrome due to infarction at the border of the posterior limb of the internal capsule and the corona radiata. The sensory fibers ...

journal_title：Neurology

authors： Isono O,Kawamura M,Shiota J,Araki S,Hirayama K

更新日期：1993-01-01 00:00:00

abstract：:We tested serum specimens from patients with HAM/TSP and asymptomatic HTLV-I carriers from endemic areas of Japan, Jamaica, Colombia, and Chile for neutralizing antibodies against HTLV-I. The data suggest a trend for neutralizing activity to be found more frequently in the sera from HAM/TSP patients than in sera from ...

journal_title：Neurology

authors： Minagawa H,Yoshida T,Itoyama Y,Mora CA,Albert P,Mori R

更新日期：1992-11-01 00:00:00

abstract：:In the coterminous United States, MS mortality rates demonstrate a north-south gradient, which is confirmed by more sophisticated--and more expensive--prevalence studies. Mortality rates from idiopathic Parkinson's disease show a similar north-south gradient, and they correlate significantly with the MS mortality and ...

journal_title：Neurology

authors： Lux WE,Kurtzke JF

更新日期：1987-03-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between baseline hypertension and severity of white matter hyperintensities (WMH) at 4-year follow-up in a sample of subjects aged 59 to 71 years old at entry. METHODS:Subjects were participants in the Epidemiology of Vascular Ageing study, a longitudinal study on vascular agi...

journal_title：Neurology

authors： Dufouil C,de Kersaint-Gilly A,Besançon V,Levy C,Auffray E,Brunnereau L,Alpérovitch A,Tzourio C

更新日期：2001-04-10 00:00:00

abstract：:Systematic screening of many compounds in animal models led to identification of the established antiepileptic drugs (AEDs). By contrast, the newer AEDs were specifically designed to enhance an inhibitory process or to inhibit a specific excitatory pathway. However, it was later discovered that some of the designed dr...

journal_title：Neurology

authors： Moshé SL

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To assess the impact of intracranial arterial stenosis on the progression from mild cognitive impairment (MCI) to Alzheimer disease (AD). METHODS:A total of 423 participants with MCI were included and evaluated with clinical and neuropsychological examinations annually for 4 years. The incidence of dementia ...

journal_title：Neurology

authors： Zhu J,Wang Y,Li J,Deng J,Zhou H

更新日期：2014-03-11 00:00:00

abstract：:The authors investigated whether the lack of effect of tirilazad on clinical outcome in patients with acute ischemic stroke is explained by failure of tirilazad to reduce infarct volume. Overall, tirilazad had no significant effect on infarct volume. In the subgroups of male patients and of those with a cortical infar...

journal_title：Neurology

authors： van der Worp HB,Kappelle LJ,Algra A,Bär PR,Orgogozo JM,Ringelstein EB,Bath PM,van Gijn J,TESS Investigators.,TESS II Investigators.

更新日期：2002-01-08 00:00:00

abstract：OBJECTIVE:To summarize current and emerging imaging techniques that can be used to assess neuroprotection and repair in multiple sclerosis (MS), and to provide a consensus opinion on the potential utility of each technique in clinical trial settings. METHODS:Clinicians and scientists with expertise in the use of MRI i...

journal_title：Neurology

authors： Oh J,Ontaneda D,Azevedo C,Klawiter EC,Absinta M,Arnold DL,Bakshi R,Calabresi PA,Crainiceanu C,Dewey B,Freeman L,Gauthier S,Henry R,Inglese M,Kolind S,Li DKB,Mainero C,Menon RS,Nair G,Narayanan S,Nelson F,Pelleti

更新日期：2019-03-12 00:00:00