The childhood type of dermatomyositis.

Abstract:

:The childhood type fo dermatomyositis, which occurs in children and young adults, shows a specific constellation of pathologic changes in muscle. Capillary necrosis leads to capillary loss, generally starting on the periphery of muscle fascicles. Electron microscopy discloses undulating tubules in endothelial cells, lymphocytes, pericytes, and pseudosatellite cells. The muscle fiber damage is coextensive with capillary damage and probably results from progressive ischemia. The muscle cells, before atrophying, show mitochondrial elongation, Z disk streaming, focal myofibrillary loss, and occassionally selective thick filament loss. Muscle cell necrosis is rare and limited to infarctlike lesions. Inflammatory infiltrates, if present, occur only in connective tissue septa. The cause of the capillary damage has not been determined.

journal_name

Neurology

journal_title

Neurology

authors

Carpenter S,Karpati G,Rothman S,Watters G

doi

10.1212/wnl.26.10.952

subject

Has Abstract

pub_date

1976-10-01 00:00:00

pages

952-62

issue

10

eissn

0028-3878

issn

1526-632X

journal_volume

26

pub_type

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