Abstract:
:The childhood type fo dermatomyositis, which occurs in children and young adults, shows a specific constellation of pathologic changes in muscle. Capillary necrosis leads to capillary loss, generally starting on the periphery of muscle fascicles. Electron microscopy discloses undulating tubules in endothelial cells, lymphocytes, pericytes, and pseudosatellite cells. The muscle fiber damage is coextensive with capillary damage and probably results from progressive ischemia. The muscle cells, before atrophying, show mitochondrial elongation, Z disk streaming, focal myofibrillary loss, and occassionally selective thick filament loss. Muscle cell necrosis is rare and limited to infarctlike lesions. Inflammatory infiltrates, if present, occur only in connective tissue septa. The cause of the capillary damage has not been determined.
journal_name
Neurologyjournal_title
Neurologyauthors
Carpenter S,Karpati G,Rothman S,Watters Gdoi
10.1212/wnl.26.10.952subject
Has Abstractpub_date
1976-10-01 00:00:00pages
952-62issue
10eissn
0028-3878issn
1526-632Xjournal_volume
26pub_type
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