Abstract:
:The authors investigated whether the lack of effect of tirilazad on clinical outcome in patients with acute ischemic stroke is explained by failure of tirilazad to reduce infarct volume. Overall, tirilazad had no significant effect on infarct volume. In the subgroups of male patients and of those with a cortical infarct, tirilazad significantly reduced infarct volume. These effects were reduced to nonsignificant trends after adjustment for imbalances in baseline characteristics. In conclusion, early treatment of patients with tirilazad has no effect on infarct volume.
journal_name
Neurologyjournal_title
Neurologyauthors
van der Worp HB,Kappelle LJ,Algra A,Bär PR,Orgogozo JM,Ringelstein EB,Bath PM,van Gijn J,TESS Investigators.,TESS II Investigators.doi
10.1212/wnl.58.1.133subject
Has Abstractpub_date
2002-01-08 00:00:00pages
133-5issue
1eissn
0028-3878issn
1526-632Xjournal_volume
58pub_type
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