Neutralizing antibodies against HTLV-I in HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients and asymptomatic carriers.

abstract：BACKGROUND:Extrapyramidal signs (EPS) are common in Alzheimer disease (AD) and increase in prevalence as AD advances. The neuropathologic substrate responsible for EPS in AD remains to be fully characterized. METHODS:Subjects had a clinical diagnosis of AD confirmed by neuropathologic examination. EPS during life were...

journal_title：Neurology

authors： Burns JM,Galvin JE,Roe CM,Morris JC,McKeel DW

更新日期：2005-04-26 00:00:00

abstract：OBJECTIVE:To evaluate the production rate of CSF in patients with differing disease states. METHODS:The authors measured the production rate of CSF in three groups of patients: five patients with PD below age 60 (aged 51 +/- 4 years, mean +/- SD), nine with PD over age 60 (aged 69 +/- 6 years, mean +/- SD), and seven ...

journal_title：Neurology

authors： Silverberg GD,Heit G,Huhn S,Jaffe RA,Chang SD,Bronte-Stewart H,Rubenstein E,Possin K,Saul TA

更新日期：2001-11-27 00:00:00

abstract：:The concept of earlier diagnosis of amyotrophic lateral sclerosis (ALS) requires in-depth investigation of its benefits and consequences. First, how good must a treatment be before ALS is determined to be a treatable condition? Analogy with cancer therapy suggests that a good quality of life after treatment is an esse...

journal_title：Neurology

authors： Brooks BR

更新日期：1999-01-01 00:00:00

abstract：:A number of unresolved issues complicate the effective management of patients with Parkinson's disease (PD). Chief among these is the role of neuroprotective versus symptomatic pharmacologic interventions. Until the etiology of PD is further defined, consensus on appropriate management of this illness is unlikely. Cli...

journal_title：Neurology

authors： Stern MB

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Cerebral infarctions are common in older persons but their relationship with dementia and cognitive function remains controversial. METHODS:Participants were 164 older Catholic nuns, priests, and brothers who underwent annual clinical evaluation and brain autopsy at death. The authors quantified number and ...

journal_title：Neurology

authors： Schneider JA,Wilson RS,Cochran EJ,Bienias JL,Arnold SE,Evans DA,Bennett DA

更新日期：2003-04-08 00:00:00

abstract：:Spontaneous arm levitation (SAL) is well-recognized in cortical-basal ganglionic degeneration, but not in other neurodegenerative diseases. We report six cases of progressive supranuclear palsy (PSP) with SAL. Pathologic examination in four revealed the classic features of PSP with additional areas of focal cortical d...

journal_title：Neurology

authors： Barclay CL,Bergeron C,Lang AE

更新日期：1999-03-10 00:00:00

abstract：OBJECTIVE:Causes of benign positional vertigo (BPV) are mostly unknown. The aim of this study was to elucidate an association of osteoporosis with idiopathic BPV. METHODS:Two hundred nine consecutive patients with a confirmed diagnosis of idiopathic BPV underwent bone mineral densitometry of anterior-posterior lumbar ...

journal_title：Neurology

authors： Jeong SH,Choi SH,Kim JY,Koo JW,Kim HJ,Kim JS

更新日期：2009-03-24 00:00:00

abstract：:Seven hours after 39 migraineurs and 37 controls consumed an amino acid drink that contained or omitted l-tryptophan (thereby reducing brain serotonin synthesis), motion sickness was provoked by the visual illusion of movement. Tryptophan depletion boosted dizziness, nausea, and the illusion of movement in controls to...

journal_title：Neurology

authors： Drummond PD

更新日期：2005-08-23 00:00:00

abstract：BACKGROUND:Congenital muscular dystrophies (CMD) with reduced glycosylation of alpha-dystroglycan (alpha-DG) are a heterogeneous group of conditions associated with mutations in six genes encoding proven or putative glycosyltransferases. OBJECTIVES:The aim of the study was to establish the prevalence of mutations in t...

journal_title：Neurology

authors： Mercuri E,Messina S,Bruno C,Mora M,Pegoraro E,Comi GP,D'Amico A,Aiello C,Biancheri R,Berardinelli A,Boffi P,Cassandrini D,Laverda A,Moggio M,Morandi L,Moroni I,Pane M,Pezzani R,Pichiecchio A,Pini A,Minetti C,Mon

更新日期：2009-05-26 00:00:00

abstract：:The childhood type fo dermatomyositis, which occurs in children and young adults, shows a specific constellation of pathologic changes in muscle. Capillary necrosis leads to capillary loss, generally starting on the periphery of muscle fascicles. Electron microscopy discloses undulating tubules in endothelial cells, l...

journal_title：Neurology

authors： Carpenter S,Karpati G,Rothman S,Watters G

更新日期：1976-10-01 00:00:00

abstract：:We have performed positron emission tomography (PET) with 2-deoxy-2[18F]fluoro-D-glucose (FDG) in eight infants and children (aged 18 days to 5 years) with medically refractory epilepsy of neonatal onset. It was hypothesized that in at least some of these infants a surgical approach (focal resection, cerebral hemisphe...

journal_title：Neurology

authors： Chugani HT,Shewmon DA,Peacock WJ,Shields WD,Mazziotta JC,Phelps ME

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVE:To assess whether the association between reperfusion and improved clinical outcomes after stroke differs depending on the site of the arterial occlusive lesion (AOL). METHODS:We pooled data from Solitaire With the Intention for Thrombectomy (SWIFT), Solitaire FR Thrombectomy for Acute Revascularisation (STA...

journal_title：Neurology

authors： Lemmens R,Hamilton SA,Liebeskind DS,Tomsick TA,Demchuk AM,Nogueira RG,Marks MP,Jahan R,Gralla J,Yoo AJ,Yeatts SD,Palesch YY,Saver JL,Pereira VM,Broderick JP,Albers GW,Lansberg MG,DEFUSE 2, IMS III, STAR, and SWIFT trial

更新日期：2016-02-23 00:00:00

abstract：:Zinc is essential for normal embryogenesis and may have particular importance for closure of the human neural tube. Compared to 258 controls, we found increased zinc content in umbilical cord serum in eight of nine newborn anencephalics (p less than 0.02) and three infants with spina bifida (p less than 0.001). Increa...

journal_title：Neurology

authors： Zimmerman AW

更新日期：1984-04-01 00:00:00

abstract：OBJECTIVE:To identify regional metabolic brain networks related specifically to the presence of tremor in PD. BACKGROUND:The pathophysiology of parkinsonian tremor is unknown. Because tremor in PD occurs mainly in repose, we used resting state PET with 18F-fluorodeoxyglucose (FDG) to identify specific metabolic brain ...

journal_title：Neurology

authors： Antonini A,Moeller JR,Nakamura T,Spetsieris P,Dhawan V,Eidelberg D

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:To determine whether the incidence and clinical features of pediatric multiple sclerosis (MS) and other forms of pediatric acquired demyelinating syndromes (ADS) vary by race/ethnicity in a population-based cohort. METHODS:We used a combination of electronic database searches followed by complete medical rec...

journal_title：Neurology

authors： Langer-Gould A,Zhang JL,Chung J,Yeung Y,Waubant E,Yao J

更新日期：2011-09-20 00:00:00

abstract：OBJECTIVE:The purpose of this study was to develop an algorithm incorporating MRI metrics to classify patients with mild traumatic brain injury (mTBI) and controls. METHODS:This was an institutional review board-approved, Health Insurance Portability and Accountability Act-compliant prospective study. We recruited pat...

journal_title：Neurology

authors： Lui YW,Xue Y,Kenul D,Ge Y,Grossman RI,Wang Y

更新日期：2014-09-30 00:00:00

abstract：OBJECTIVE:To cross-sectionally compare the regional white matter fractional anisotropy (FA) of cognitively normal (CN) older individuals and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD), separately focusing on the normal-appearing white matter (NAWM) and white matter hyperintensities (WMH), ...

journal_title：Neurology

authors： Lee DY,Fletcher E,Martinez O,Ortega M,Zozulya N,Kim J,Tran J,Buonocore M,Carmichael O,DeCarli C

更新日期：2009-11-24 00:00:00

abstract：OBJECTIVE:We developed the Recurrence and Recovery Questionnaire (RRQ) by converting the Pediatric Stroke Outcome Measure (PSOM) to a questionnaire for telephone interview and sought to validate the RRQ in a large cohort. METHOD:We analyzed parents' RRQ responses and same-day PSOM assessments for 232 children who had ...

journal_title：Neurology

authors： Lo WD,Ichord RN,Dowling MM,Rafay M,Templeton J,Halperin A,Smith SE,Licht DJ,Moharir M,Askalan R,Deveber G,International Pediatric Stroke Study (IPSS) Investigators.

更新日期：2012-08-28 00:00:00

abstract：OBJECTIVE:The pedunculopontine nucleus region (PPNR) is being investigated as a target for deep brain stimulation (DBS) in Parkinson disease (PD), particularly for gait and postural impairment. A greater understanding of how PPNR activities and oscillations are modulated with voluntary movements is crucial to the devel...

journal_title：Neurology

authors： Tsang EW,Hamani C,Moro E,Mazzella F,Poon YY,Lozano AM,Chen R

更新日期：2010-09-14 00:00:00

abstract：:This single case report describes a large (giant) left internal carotid aneurysm that showed a very marked decrease in the size of its lumen on reevaluation 5 days after the initial arteriogram. A review of the literature found only 5 cases of spontaneous thrombosis documented by arteriography and only one involved a ...

journal_title：Neurology

authors： Carlson DH,Thomson D

更新日期：1976-04-01 00:00:00

abstract：OBJECTIVE:To distinguish, in patients with Korsakoff syndrome (KS), the structural brain abnormalities shared with alcoholic patients without KS (AL), from those specific to KS. METHODS:MRI data were collected in 11 alcoholic patients with KS, 34 alcoholic patients without KS, and 25 healthy control subjects (CS). Gra...

journal_title：Neurology

authors： Pitel AL,Chételat G,Le Berre AP,Desgranges B,Eustache F,Beaunieux H

更新日期：2012-04-24 00:00:00

abstract：:Acid protease activity was increased in skeletal muscle of patients with ALS. The highest levels of activity were found in individuals with the clinically and histologically most affected muscle. High levels of proteolytic activity correlated with the extent of muscle atrophy, the presence of target fibers and the ove...

journal_title：Neurology

authors： Antel JP,Chelmicka-Schorr E,Sportiello M,Stefansson K,Wollmann RL,Arnason BG

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Resistance to insulin-mediated glucose uptake by peripheral tissues is a cardinal defect in type 2 diabetes mellitus. Insulin resistance is also common among nondiabetic individuals, and may be an important risk factor for stroke in both populations. The authors review the definition, epidemiolog...

journal_title：Neurology

authors： Kernan WN,Inzucchi SE,Viscoli CM,Brass LM,Bravata DM,Horwitz RI

更新日期：2002-09-24 00:00:00

abstract：:The authors examined the influence of APOE and human leukocyte antigen-DRB1-DQB1 polymorphisms on the course of multiple sclerosis in 871 patients, 773 with relapsing and 98 with primary progressive disease, and 348 control subjects. The risk of the primary progressive course was increased (odds ratio = 6.81, p = 0.00...

journal_title：Neurology

authors： Cocco E,Sotgiu A,Costa G,Murru MR,Mancosu C,Murru R,Lai M,Contu P,Marrosu MG

更新日期：2005-02-08 00:00:00

abstract：:We investigated potential risk factors for Alzheimer's disease (AD) in a clinicopathologic study of 407 patients with definite AD, 100 non-Alzheimer dementia patients, and 50 normal subjects. The AD patients had more first-degree relatives with dementia than the non-AD dementia group (odds ratio of 1.85, 95% confidenc...

journal_title：Neurology

authors： Mendez MF,Underwood KL,Zander BA,Mastri AR,Sung JH,Frey WH 2nd

更新日期：1992-04-01 00:00:00

abstract：:There is now increasing use of dopamine agonists as effective early monotherapy in the treatment of Parkinson's disease (PD). Dopamine agonists can induce an antiparkinsonian effect through actions on either D(1)-like or D(2)-like dopamine receptors, and the multiple receptor subtypes present in the brain may provide ...

journal_title：Neurology

authors： Jenner P

更新日期：2002-02-26 00:00:00

abstract：OBJECTIVE:To study the clinical and radiologic spectrum and genotype-phenotype correlation of 4H (hypomyelination, hypodontia, hypogonadotropic hypogonadism) leukodystrophy caused by mutations in POLR3A or POLR3B. METHODS:We performed a multinational cross-sectional observational study of the clinical, radiologic, and...

journal_title：Neurology

authors： Wolf NI,Vanderver A,van Spaendonk RM,Schiffmann R,Brais B,Bugiani M,Sistermans E,Catsman-Berrevoets C,Kros JM,Pinto PS,Pohl D,Tirupathi S,Strømme P,de Grauw T,Fribourg S,Demos M,Pizzino A,Naidu S,Guerrero K,van der

更新日期：2014-11-18 00:00:00

abstract：BACKGROUND:Impairment in the central dopaminergic system has been consistently suggested as an etiologic factor in restless legs syndrome (RLS). OBJECTIVE:To investigate a possible role for the MAOA and MAOB genes in RLS using a population-based association study. METHODS:In addition to a dinucleotide repeat located ...

journal_title：Neurology

authors： Desautels A,Turecki G,Montplaisir J,Brisebois K,Sequeira A,Adam B,Rouleau GA

更新日期：2002-07-23 00:00:00

abstract：:We studied the effects of bromocriptine on periodic limb movements in sleep (PLMS) of narcoleptic patients. Bromocriptine significantly reduced the number and index of PLMS without improving the nocturnal sleep disruption in that disorder. These results support the hypothesis that dopaminergic mechanisms are involved ...

journal_title：Neurology

authors： Boivin DB,Lorrain D,Montplaisir J

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:To determine the risk, predictors, and prognosis of independence loss and institutionalization in patients with early Parkinson disease (PD). METHODS:We conducted a prospective population-based 5-year longitudinal study following 189 patients with incident PD and 174 controls matched for age, sex, and comorb...

journal_title：Neurology

authors： Bjornestad A,Tysnes OB,Larsen JP,Alves G

更新日期：2016-10-11 00:00:00