Abstract:
OBJECTIVE:The purpose of this study was to develop an algorithm incorporating MRI metrics to classify patients with mild traumatic brain injury (mTBI) and controls. METHODS:This was an institutional review board-approved, Health Insurance Portability and Accountability Act-compliant prospective study. We recruited patients with mTBI and healthy controls through the emergency department and general population. We acquired data on a 3.0T Siemens Trio magnet including conventional brain imaging, resting-state fMRI, diffusion-weighted imaging, and magnetic field correlation (MFC), and performed multifeature analysis using the following MRI metrics: mean kurtosis (MK) of thalamus, MFC of thalamus and frontal white matter, thalamocortical resting-state networks, and 5 regional gray matter and white matter volumes including the anterior cingulum and left frontal and temporal poles. Feature selection was performed using minimal-redundancy maximal-relevance. We used classifiers including support vector machine, naive Bayesian, Bayesian network, radial basis network, and multilayer perceptron to test maximal accuracy. RESULTS:We studied 24 patients with mTBI and 26 controls. Best single-feature classification uses thalamic MK yielding 74% accuracy. Multifeature analysis yields 80% accuracy using the full feature set, and up to 86% accuracy using minimal-redundancy maximal-relevance feature selection (MK thalamus, right anterior cingulate volume, thalamic thickness, thalamocortical resting-state network, thalamic microscopic MFC, and sex). CONCLUSION:Multifeature analysis using diffusion-weighted imaging, MFC, fMRI, and volumetrics may aid in the classification of patients with mTBI compared with controls based on optimal feature selection and classification methods. CLASSIFICATION OF EVIDENCE:This study provides Class III evidence that classification algorithms using multiple MRI features accurately identifies patients with mTBI as defined by American Congress of Rehabilitation Medicine criteria compared with healthy controls.
journal_name
Neurologyjournal_title
Neurologyauthors
Lui YW,Xue Y,Kenul D,Ge Y,Grossman RI,Wang Ydoi
10.1212/WNL.0000000000000834subject
Has Abstractpub_date
2014-09-30 00:00:00pages
1235-40issue
14eissn
0028-3878issn
1526-632Xpii
WNL.0000000000000834journal_volume
83pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract:OBJECTIVE:To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD). METHODS:Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI. RESUL...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000247052.18422.e5
更新日期:2006-12-12 00:00:00
abstract:OBJECTIVE:To evaluate differences in cerebrovascular reactivity (CVR) to mild hypercapnia in obese/overweight individuals with and without insulin resistance (IR) compared to comparable lean controls. METHODS:A total of 60 cognitively normal participants (20 lean controls and 24 obese/overweight individuals with and 1...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004110
更新日期:2017-07-18 00:00:00
abstract::Ullrich disease is a form of congenital muscular dystrophy characterized clinically by generalized muscle weakness, contractures of the proximal joints, and hyperflexibility of the distal joints from birth or early infancy. Recently, mutations of the collagen VI gene have been associated with Ullrich disease. The auth...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.59.6.920
更新日期:2002-09-24 00:00:00
abstract::We established the frequency of Horner's syndrome (HS) in 248 elective patients after coronary artery bypass surgery. Patients were evaluated neurologically pre- and post-operatively and 6 months after surgery. Nineteen patients (7.7%) developed unilateral HS postoperatively, 12 involving the left eye. The finding per...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.1.181
更新日期:1996-01-01 00:00:00
abstract::It is not known whether the antiepileptic drug (AED) levetiracetam can be used safely in human pregnancy. As part of a study to determine the risks of major congenital malformations (MCMs) for infants exposed to AEDs in utero, we identified all cases exposed to levetiracetam. Three of 117 exposed pregnancies had an MC...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000244491.48937.55
更新日期:2006-11-28 00:00:00
abstract:BACKGROUND:Expert knowledge may compensate for age-related declines in basic cognitive and sensory-motor abilities in some skill domains. We investigated the influence of age and aviation expertise (indexed by Federal Aviation Administration pilot ratings) on longitudinal flight simulator performance. METHODS:Over a 3...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000255943.10045.c0
更新日期:2007-02-27 00:00:00
abstract::Recently published reports have suggested that multiple sclerosis (MS) may be associated with human retrovirus infection. Indeed, an autonomously proliferating T-cell clone was isolated from the CSF of an MS patient, an observation interpreted as indicating an infection with human T lymphotropic virus I (HTLV I). In v...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.1.28
更新日期:1988-01-01 00:00:00
abstract:OBJECTIVE:To make evidence-based treatment recommendations for patients with Parkinson disease (PD) with dementia, depression, and psychosis based on these questions: 1) What tools are effective to screen for depression, psychosis, and dementia in PD? 2) What are effective treatments for depression and psychosis in PD?...
journal_title:Neurology
pub_type: 杂志文章,实务指引
doi:10.1212/01.wnl.0000215428.46057.3d
更新日期:2006-04-11 00:00:00
abstract::Thyrotropin-releasing hormone (TRH) exerts many effects upon spinal cord function in animals, and may also play a role in human spinal cord function. We have used the technique of quantitative autoradiography to anatomically localize specific receptors for TRH within human spinal cord. Highest concentrations of TRH re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.3.328
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and efficacy of 60 Hz deep brain stimulation (DBS) of the globus pallidus internus (GPi) in 15 consecutive patients with primary dystonia. METHODS:We conducted a retrospective analysis of clinic charts relative to 15 consecutive patients with medically refractory primary dystonia who u...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000267430.95106.ff
更新日期:2007-08-14 00:00:00
abstract:OBJECTIVE:To evaluate the usefulness of ocular motor information in the early diagnosis of corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP). METHODS:Seven PSP patients, six CBD patients, and three atypical CBD patients were followed longitudinally with repeated electrooculographic (EOG) recordi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.5.1029
更新日期:2000-03-14 00:00:00
abstract:OBJECTIVE:Cell-based therapies are being investigated as an adjunct to IV thrombolysis or mechanical thrombectomy in ischemic stroke. This review summarizes the potential applications as well as challenges of intravascular cell delivery in ischemic stroke. METHOD:We conducted a search of Medline as well as the clinica...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e31826959d2
更新日期:2012-09-25 00:00:00
abstract:BACKGROUND:Several studies indicate semantic fluency more sensitively discriminates patients with Alzheimer disease (AD) from normal elderly persons, with disproportionate impairment of semantic over phonemic fluency. OBJECTIVE:To determine the ability of abbreviated fluency measures in the clinic setting (1-minute le...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.62.4.556
更新日期:2004-02-24 00:00:00
abstract::Radiation rhombencephalopathy and radiation myelopathy may occur in patients months or years after radiotherapy for malignancy of the head and neck. We obtained multimodal evoked potentials longitudinally in 26 patients with proven nasopharyngeal carcinoma. Recordings were made before radiotherapy and at 1 week, 3 mon...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.2.521
更新日期:1996-08-01 00:00:00
abstract::Lymphocytic meningoradiculitis (Bannwarth's syndrome) is a radicular neuralgia associated with a chronic lymphocytic pleocytosis in cerebrospinal fluid and frequently with unilateral or bilateral peripheral facial weakness. Most reported cases have occurred during the summer among adults living in central Europe. Lymp...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.11.1476
更新日期:1983-11-01 00:00:00
abstract:OBJECTIVES:Despite many neuropsychological studies to differentiate subcortical vascular dementia (SVaD) from Alzheimer disease (AD), previous studies did not eliminate confounding effects of mixed Alzheimer and vascular pathology. We aimed to investigate neuropsychological differences between patients with Pittsburgh ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182815485
更新日期:2013-02-05 00:00:00
abstract::We performed a multicenter prospective study on the incidence and prognosis of Guillain-Barré syndrome (GBS) in the Emilia-Romagna region (3,909,512 inhabitants), Italy, over a 2-year period (1992-1993). The case finding method was based on a surveillance system including neurologic departments, all private and public...
journal_title:Neurology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:To assess the available evidence for the diagnostic accuracy of CSF testing for protein 14-3-3 in patients with suspected sporadic Creutzfeldt-Jakob disease (sCJD). METHODS:The authors performed a systematic review of the available literature from 1995 to January 1, 2011, to identify articles involving patie...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31826d5fc3
更新日期:2012-10-02 00:00:00
abstract::Nodoparanodopathy is a recent concept in the field of peripheral neuropathy, corresponding to peripheral nerve disorders stemming from an autoimmune attack directed and limited to the nodal region. This concept was identified using modern techniques of electrophysiology, immunology, and pathology (including electron m...
journal_title:Neurology
pub_type: 历史文章,杂志文章
doi:10.1212/WNL.0000000000008399
更新日期:2019-10-29 00:00:00
abstract::A 12-year-old girl developed simple partial motor and sensory seizures due to a right perirolandic astrocytoma. Subdural EEG recording and functional stimulation disclosed close correlation between EEG-clinical manifestations of focal seizures and functional responses to cortical stimulation. This case supports the id...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.3.642
更新日期:1992-03-01 00:00:00
abstract::Gamma hydroxybutyrate was administered to adult cats by intravenous infusion at varying dosages while an electroencephalogram (EEG) was recorded from electrodes placed stereotactically in the right and left hippocampus and thalamic intralaminar nucleus and from cortical electrodes. Blood cerebrospinal fluid samples we...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.1.51
更新日期:1976-01-01 00:00:00
abstract::The endogenous auditory P300 event-related potential (P3) has been used to differentiate functional and organic cognitive disorders in adults. We found that children with organic cognitive impairments (as determined by the Halstead-Reitan [HR] test) had greater P3 latencies than children with normal HR evaluations. Th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.3.323
更新日期:1985-03-01 00:00:00
abstract:OBJECTIVE:To compare the proportion of APOE ε4 genotype carriers in aphasic vs amnestic variants of Alzheimer disease (AD). METHOD:The proportion of APOE ε4 carriers was compared among the following 3 groups: (1) 42 patients with primary progressive aphasia (PPA) and AD pathology (PPA/AD) enrolled in the Northwestern ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008666
更新日期:2020-02-11 00:00:00
abstract::Idiopathic trigeminal sensory neuropathy is a benign disorder. We report two patients with transient MRI abnormalities, suggesting transient inflammation of the trigeminal nerve caused temporary facial sensory symptoms. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.5.1455
更新日期:1996-05-01 00:00:00
abstract::In patients with spatial neglect, contralesional reflexive saccades toward suddenly appearing targets show direction-specific deficits. We examined whether these deficits also occur during free exploration of space. Neglect patients' voluntary eye movements showed reduced amplitudes for saccades in all directions but ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.2.515
更新日期:2000-01-25 00:00:00
abstract:OBJECTIVES:To evaluate the effect of intensive care unit continuous EEG (cEEG) monitoring on inpatient mortality, hospital charges, and length of stay. METHODS:A retrospective cross-sectional study was conducted using the Nationwide Inpatient Sample, a dataset representing 20% of inpatient discharges in nonfederal US ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000436948.93399.2a
更新日期:2013-12-03 00:00:00
abstract::Using data from the compulsory Medical Birth Registry of Norway, the authors investigated the effect of maternal multiple sclerosis (MS) on pregnancy, delivery, and birth outcome in 649 births by MS mothers and 2.1 million control births. The mothers with MS had a higher proportion of neonates small for gestational ag...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000188898.02018.95
更新日期:2005-12-27 00:00:00
abstract::Machado-Joseph disease is a dominantly inherited, multisystem, degenerative disorder that lacks a proven genetic marker. Peripheral nerve conduction-refractory period, sensory evoked potentials, and quantified oculomotor recordings were studied in nine patients affected with this disease to look for a potential physio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.1.112
更新日期:1987-01-01 00:00:00
abstract::A patient presented with bilateral brachial plexus neuropathy which 2 weeks later evolved into a polyneuropathy involving all four extremities. On further investigation, the patient was found to have systemic lupus erythematosus. Treatment with steroids was accompanied by complete resolution of the neurologic findings...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.29.12.1633-a
更新日期:1979-12-01 00:00:00
abstract:BACKGROUND:Paroxysmal nonkinesigenic dyskinesia (PNKD) is a rare disorder characterized by episodic hyperkinetic movement attacks. We have recently identified mutations in the MR-1 gene causing familial PNKD. METHODS:We reviewed the clinical features of 14 kindreds with familial dyskinesia that was not clearly induced...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000262029.91552.e0
更新日期:2007-05-22 00:00:00