当前位置： SCI文献检索 > NEUROLOGY期刊下所有文献 > Diagnostic utility of abbreviated fluency measures in Alzheimer disease and vascular dementia.

Diagnostic utility of abbreviated fluency measures in Alzheimer disease and vascular dementia.

Abstract：

BACKGROUND:Several studies indicate semantic fluency more sensitively discriminates patients with Alzheimer disease (AD) from normal elderly persons, with disproportionate impairment of semantic over phonemic fluency. OBJECTIVE:To determine the ability of abbreviated fluency measures in the clinic setting (1-minute letter F and animal fluency tests) to detect AD, and to assess whether difference scores between these measures discriminate patients with AD and vascular dementia (VaD) from normal elderly persons. METHODS:The authors studied patients with AD (n = 98) meeting National Institute of Neurological Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria, VaD patients (n = 18) meeting National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche et l'Enseignement en Neurosciences criteria, cognitively impaired but not demented patients (CIND; n = 25), vascular CIND patients (VCIND; n = 24), and normal control subjects (NCs; n = 46). RESULTS:Analysis of covariance controlling for age, education, and overall impairment indicated all groups generated fewer animal names compared with NCs, whereas only VaD patients generated fewer letter F words compared with NCs. On standardized scores, patients with AD and CIND, unlike those with VCIND and VaD, scored significantly worse on the animal fluency test than on the letter F fluency test. The animal fluency test was superior in discriminating all patient groups from NCs. Positive likelihood ratios (PLRs) revealed animal fluency scores <15 were 20 times more likely in a patient with AD than in an NC (sensitivity = 0.88; specificity = 0.96). Letter F scores <4 discriminated VaD from AD patients (PLR = 4.0; sensitivity = 0.44; specificity = 0.90). Difference scores <0 (i.e., fewer animal than letter F words) discriminated patients with VCIND from those with CIND (PLR = 2.5; sensitivity = 0.32; specificity = 1.00). CONCLUSIONS:A 1-minute semantic fluency test can assist in early detection of dementia in the memory clinic setting.

journal_name

Neurology

journal_title

Neurology

authors

Canning SJ,Leach L,Stuss D,Ngo L,Black SE

doi

10.1212/wnl.62.4.556

subject

Has Abstract

pub_date

2004-02-24 00:00:00

pages

556-62

issue

eissn

0028-3878

issn

1526-632X

journal_volume

pub_type

杂志文章

在线工具

Diagnostic utility of abbreviated fluency measures in Alzheimer disease and vascular dementia.