Abstract:
:We investigated the association of PD with a recently reported I93M mutation of the ubiquitin carboxy-terminal hydrolase L1 (UCH-L1) gene, and with a new and common polymorphic variant S18Y of the same gene. We did not identify the I93M mutation in any of 139 unrelated PD cases or 113 controls. However, S18Y polymorphism carriers had significantly lower risk of PD (odds ratio = 0.53; p = 0.03), and the risk reduction was greater for younger onset cases.
journal_name
Neurologyjournal_title
Neurologyauthors
Maraganore DM,Farrer MJ,Hardy JA,Lincoln SJ,McDonnell SK,Rocca WAdoi
10.1212/wnl.53.8.1858subject
Has Abstractpub_date
1999-11-10 00:00:00pages
1858-60issue
8eissn
0028-3878issn
1526-632Xjournal_volume
53pub_type
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