Abstract:
OBJECTIVE:To examine the relationships between age at onset and duration of seizure disorder with severity of hippocampal sclerosis (HS) and cognitive functioning in patients with HS and unilateral temporal lobe epilepsy. METHODS:Twenty-six subjects had left temporal lobe seizure onset; 20 had right temporal onset. Measures were age at seizure onset, duration of seizure disorder divided by age (seizure duration), history of febrile convulsion (FC), ratio of the smaller hippocampal volume to the larger (HF) as determined by volumetric MRI, and pathologic HS grade. RESULTS:Results showed that pathologic HS grade and HF were positively related to seizure duration, and negatively related to seizure onset. When subjects were divided into onset prior to age 10 versus later, subjects with earlier onset had higher mean pathologic HS grade and smaller (more asymmetric) mean HF. When subjects were divided into seizure duration <0.5 (i.e., less than half current lifetime) vs greater, subjects with seizure duration > or =0.5 had higher mean pathologic HS grade and lower mean HF. There was also evidence for earlier age at seizure onset and longer seizure duration being associated with worse performance on neuropsychological measures. FC was not related to either seizure duration or age at seizure onset, but patients with a history of FC showed higher pathologic HS grade and lower HF. A history of FC was not related to cognitive functioning. CONCLUSIONS:Unilateral HS patients with earlier seizure onset and longer duration of epilepsy have more severe HS and greater hippocampal volume asymmetry. This suggests that HS may be a progressive disorder with risk for cognitive dysfunction.
journal_name
Neurologyjournal_title
Neurologyauthors
Fuerst D,Shah J,Kupsky WJ,Johnson R,Shah A,Hayman-Abello B,Ergh T,Poore Q,Canady A,Watson Cdoi
10.1212/wnl.57.2.184subject
Has Abstractpub_date
2001-07-24 00:00:00pages
184-8issue
2eissn
0028-3878issn
1526-632Xjournal_volume
57pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Thyrotropin-releasing hormone (TRH) exerts many effects upon spinal cord function in animals, and may also play a role in human spinal cord function. We have used the technique of quantitative autoradiography to anatomically localize specific receptors for TRH within human spinal cord. Highest concentrations of TRH re...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.3.328
更新日期:1985-03-01 00:00:00
abstract::Serum from 35 cases of naturally occurring acquired canine myasthenia gravis (MG) were assayed for patterns of autoantibody specificities against canine acetylcholine receptor (AChR) using monoclonal antibodies (mAbs) and antiserum against defined regions of the AChR as competitive inhibitors of autoantibody binding. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.9.1417
更新日期:1988-09-01 00:00:00
abstract::In 64 patients with Parkinson's disease (PD), the basal level of prolactin (PRL) was normal. Bromocriptine (BCT) caused a significant suppression of PRL in all parkinsonian patients and controls. When given after BCT treatment, thyrotropin-releasing hormone (TRH) induced a significantly lower PRL rise in recent-onset ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.3.393
更新日期:1986-03-01 00:00:00
abstract:OBJECTIVE:Functional or psychogenic movement disorders (FMD) present a diagnostic challenge. To diagnose FMD, clinicians must have experience with signs typical of FMD and distinguishing features from other hyperkinetic disorders. The aim of this study was to clarify the decision-making process of expert clinicians whi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003479
更新日期:2017-01-10 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy and safety of eptinezumab, a humanized anti-calcitonin gene-related peptide monoclonal antibody, in the preventive treatment of chronic migraine (CM). METHODS:The Prevention of Migraine via Intravenous ALD403 Safety and Efficacy-2 (PROMISE-2) study was a phase 3, multicenter, randomi...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000009169
更新日期:2020-03-31 00:00:00
abstract:OBJECTIVE:To evaluate possible abnormal increase in thalamic glutamate/glutamine levels for restless legs syndrome (RLS) indicating increased glutamatergic activity producing arousal that at night disrupts and shortens sleep. METHODS:(1)H MRS of the right thalamus was performed using a 1.5 T GE MRI scanner and the PRO...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318294b3f6
更新日期:2013-05-28 00:00:00
abstract:OBJECTIVE:To make evidence-based treatment recommendations for patients with Parkinson disease (PD) with dementia, depression, and psychosis based on these questions: 1) What tools are effective to screen for depression, psychosis, and dementia in PD? 2) What are effective treatments for depression and psychosis in PD?...
journal_title:Neurology
pub_type: 杂志文章,实务指引
doi:10.1212/01.wnl.0000215428.46057.3d
更新日期:2006-04-11 00:00:00
abstract::Of 58 consecutive patients with spontaneous CSF leaks, nine exhibited features of connective tissue disorder. One had Marfan's syndrome. Five additional patients had hyperflexible joints, of whom four had arachnodactyly, four were tall and slender, two had hyperextensible skin, and one had a strong family history of a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.5.814
更新日期:2002-03-12 00:00:00
abstract:OBJECTIVE:Since Alzheimer disease (AD) is a slowly progressive disorder and its pathologic features are likely to be present for many years before symptoms become manifest, we investigated whether microstructural white matter changes similar to those identified in patients with AD can be detected in cognitively normal ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182661f4d
更新日期:2012-08-21 00:00:00
abstract:BACKGROUND:Imaging determinations of the spatial extent of diffuse low-grade gliomas (DLGGs) are of paramount importance in evaluating the risk-to-benefit ratio of surgical resection. However, it is not clear how accurately preoperative conventional MRI can delineate DLGGs. METHODS:We report a retrospective histologic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181e04264
更新日期:2010-05-25 00:00:00
abstract:BACKGROUND:Krabbe disease (globoid cell leukodystrophy [GLD]) is an autosomal recessive lysosomal disorder affecting the central and peripheral nervous system. The authors performed MRS to characterize metabolic alterations and their regional variation in brain tissue in GLD in vivo. METHODS:Abnormalities of cerebral ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000049469.29011.e9
更新日期:2003-03-11 00:00:00
abstract:OBJECTIVE:To determine whether brain function is altered in cognitively normal individuals at high risk for AD several years before the typical age at onset for this illness. BACKGROUND:Neuropathologic alterations in AD precede cognitive impairment by several years. It is unknown whether functional alterations in neur...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.7.1391
更新日期:1999-10-22 00:00:00
abstract::Several controlled-release carbidopa/levodopa preparations have been formulated to achieve a more stable and extended antiparkinsonian action. The most effective is Sinemet CR (Sinemet CR4), with an erodible polymer matrix that retards release of levodopa. In 19 parkinsonians with prominent dose-by-dose fluctuations, ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract:OBJECTIVE:To correlate muscle biopsy findings with prebiopsy and postbiopsy clinical course and response to therapy in polymyositis (PM) and sporadic inclusion body myositis (IBM). BACKGROUND:Existence of pure PM has recently been questioned; subsequently, the definition and criteria for diagnosing PM were debated. M...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000277527.69388.fe
更新日期:2008-02-05 00:00:00
abstract:OBJECTIVE:To characterize a kindred with a distinctive autosomal dominant neuromuscular disorder. BACKGROUND:The authors studied a large Italian family affected by a progressive neuromyopathy. Ten individuals over three generations were affected. The disease was characterized by onset from the late teens to early 50s ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.4.830
更新日期:1999-09-11 00:00:00
abstract::A 12-year-old girl who had zoster ophthalmicus 10 months earlier presented with hemiparesis and corresponding basal ganglionic infarction related to middle cerebral artery branch thrombosis ipsilateral to the zoster. Hematologic evaluation disclosed protein C deficiency. This represents the first zoster-associated str...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.53.5.1128
更新日期:1999-09-22 00:00:00
abstract::In thymomas associated with myasthenia gravis (MG), the authors found that perivascular infiltrates of memory lymphocytes and mature dendritic cells (DCs) were more frequent in patients with early improvement after thymectomy than in patients without response to thymectomy. Although these findings may be limited to pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000174560.35190.84
更新日期:2005-09-13 00:00:00
abstract::We report a Japanese boy with muscular dystrophy whose clinical symptoms were intermediate between those usually considered typical of Duchenne and Becker muscular dystrophies. The patient had a large inframe deletion extending from exons 3 to 41 of the dystrophin gene, which would be expected to cause the production ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.9.1648
更新日期:1994-09-01 00:00:00
abstract:OBJECTIVE:To describe a new familial association of late-onset dementia, patchy leukoencephalopathy, intracerebral hemorrhages, bilateral occipital calcifications (BOC), and external carotid artery dysplasia (ECAD). METHODS:At age 62, the proband, who was of Spanish descent, had left temporal hemorrhage in a backgroun...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.11.1661
更新日期:2000-12-12 00:00:00
abstract::Erythrocyte calcium transport as a function of free [Ca++] was examined using inside-out vesicles from eight pairs of patients with Duchenne dystrophy and age- and sex-matched controls. The Km for Ca++ of the transport protein and the Vmax were higher in the Duchenne vesicles in seven of the eight pairs. The mean Km a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.11.1236
更新日期:1980-11-01 00:00:00
abstract::Thyrotropin-releasing hormone has been reported to increase strength in patients with amyotrophic lateral sclerosis (ALS). DN-1417 is an analog of thyrotropin-releasing hormone, which has less endocrinologic activity, but more anterior horn cell stimulating effect (with no "autorefractory state"). However, 2 mg DN-141...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.4.715
更新日期:1987-04-01 00:00:00
abstract:OBJECTIVE:Paroxysmal kinesigenic dyskinesia (PKD) is a rare disorder characterized by recurrent attacks of hyperkinetic movements. PKD can be isolated or associated with benign infantile seizures as part of the infantile convulsions with choreoathetosis (ICCA) syndrome. Mutations in the PRRT2 gene were recently identif...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31825f06c3
更新日期:2012-07-10 00:00:00
abstract:BACKGROUND:In the late 19th century, a man with a psychogenic movement disorder was evaluated by many of the Philadelphia neurologists associated with Silas Weir Mitchell. In 1885, prior to the development of movie cameras or projectors, the patient was photographed by pioneering photographer Eadweard Muybridge, in col...
journal_title:Neurology
pub_type: 历史文章,杂志文章
doi:10.1212/WNL.0000000000001192
更新日期:2015-01-27 00:00:00
abstract:OBJECTIVES:To correlate the two types of early ischemic change on noncontrast CT (NCCT) (parenchymal hypoattenuation [PH] and isolated focal swelling [IFS]) with concurrent assessment of cerebral perfusion and to compare their rates of progression to infarction. METHODS:We assessed cortical regions on NCCT for early i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000256366.86353.ff
更新日期:2007-03-06 00:00:00
abstract::A two-octapeptide repeat deletion of the prion protein gene has been recently observed in a patient with a 2-year history of dementia and a clinical diagnosis of possible Creutzfeldt-Jakob disease (CJD). The authors report a similar deletion in a patient with a definitive diagnosis of CJD. Since the two-repeat deletio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000035533.86833.28
更新日期:2002-11-26 00:00:00
abstract::The efficacy and safety of donepezil as a treatment for patients with mild to moderate Alzheimer's disease (AD) was investigated in a multicenter, double-blind study. Patients were randomly assigned to treatment with placebo (n = 162), 5 mg/d donepezil (n = 154), or 10 mg/d donepezil (n = 157) for 24 weeks followed by...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.50.1.136
更新日期:1998-01-01 00:00:00
abstract::Between 1982 and 1989, 197 patients with Parkinson's disease were treated with selegiline and levodopa for at least 0.3 years. Two groups of patients were included: a group of 65 patients (stage 2 or 3 on the Hoehn and Yahr Scale) who recently had been started on levodopa and were not experiencing response fluctuation...
journal_title:Neurology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::We treated 64 emergency room patients with a primary vascular headache with dihydroergotamine (DHE), meperidine, or butorphanol. Post-treatment pain scores were lowest in the DHE group (p less than 0.01). Eight of 21 patients receiving DHE had greater than 90% reduction in pain compared with three of 19 patients recei...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.39.4.590
更新日期:1989-04-01 00:00:00
abstract::Moderate hypothermia (33 degrees C) was induced for 7 and 3 days, respectively, in two patients with multiple sclerosis. In both patients, striking improvement of clinical signs persisted throughout the period of cooling, indicating the potential for sustained reversal of the neurologic deficit. Hypothermia may aid ma...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.3.302
更新日期:1977-03-01 00:00:00
abstract::Recent genetic studies show that the apolipoprotein E epsilon 4 allele (ApoE-epsilon 4) is a risk factor for Alzheimer's disease (AD). If ApoE-epsilon 4 individuals develop AD as they get older, we would expect a decrease in ApoE-epsilon 4 allele frequency with increasing age. We found a marked decline in ApoE-epsilon...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.8.1513
更新日期:1994-08-01 00:00:00