Abstract:
OBJECTIVE:Migrainous infarction is considered a rare complication of migraine. Although several studies reported silent brain lesions on neuroimaging in patients with migraine with aura, knowledge about lesion patterns in acute migrainous infarction is scarce. We investigated clinical and MRI characteristics in a series of patients with migraine-associated acute cerebral ischemia. METHODS:Seventeen patients among 8,137 stroke patients over an 11-year period were included. All had undergone a dedicated stroke workup including diffusion-weighted imaging (DWI) and a detailed assessment of clinical features and of vascular risk factors. RESULTS:The majority of patients presented with prolonged aura symptoms (visual aura 82.3%, sensory dysfunction 41.2%, and aphasia 5.9%; median NIH Stroke Scale score 2). Presentation at hospital was significantly delayed after symptom onset (mean 33 hours). A total of 70.6% had acute ischemic lesions in the posterior circulation; the middle cerebral artery territory was affected in 29.4%. Small lesions were present in 64.7%; multiple lesions were found in 41.2%. No overlapping ischemic lesions of different vascular territories were found. The prevalence of a patent foramen ovale was high (64.7%). CONCLUSIONS:This study supports previous observations that migrainous infarction mostly occurs in the posterior circulation, and in younger women with a history of migraine with aura. Acute ischemic lesions were often multiple and located in distinct arterial territories. As there were no overlapping ischemic lesions, hemodynamic compromise during the development of migraine is unlikely the cause of infarction. Differentiation between migrainous infarction and prolonged migraine aura is difficult and associated with delayed admission of patients.
journal_name
Neurologyjournal_title
Neurologyauthors
Wolf ME,Szabo K,Griebe M,Förster A,Gass A,Hennerici MG,Kern Rdoi
10.1212/WNL.0b013e31821d74d5subject
Has Abstractpub_date
2011-05-31 00:00:00pages
1911-7issue
22eissn
0028-3878issn
1526-632Xpii
76/22/1911journal_volume
76pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::A median safinamide (SAF) dose of 70 mg/day (range 40 to 90 mg/day) increased the percentage of parkinsonian patients improving their motor scores by > or =30% from baseline (responders) after 3 months from 21.4% (placebo) to 37.5% (p < 0.05, calculated by logistic regression analysis). In a subgroup of 101 patients u...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/01.wnl.0000134672.44217.f7
更新日期:2004-08-24 00:00:00
abstract:OBJECTIVE:Hospital readmission is an important quality improvement measure that has not been well-studied in pediatric neurology. We examined predictors of 7-day and 30-day readmissions for pediatric patients hospitalized with a neurologic diagnosis. METHODS:This was a retrospective study of hospital readmission rates...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007280
更新日期:2019-04-16 00:00:00
abstract::In a prospective cohort of 124 encephalopathic term infants, six infants had an acute focal stroke. All six encephalopathic patients with strokes presented with seizures. Neurodevelopmental outcome at 30 months was abnormal in all six patients and significantly worse when compared with the entire cohort overall. These...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000129909.77753.c4
更新日期:2004-06-08 00:00:00
abstract::The authors studied immunoglobulin G (IgG) Fc receptor (FcgammaR) IIA, IIIA, and IIIB polymorphisms in 62 patients with Guillain-Barré syndrome (GBS) and in 89 healthy controls. The FcgammaR genotypes and allele frequencies did not differ significantly between the patients with GBS and the controls. Patients homozygou...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.5.705
更新日期:2000-09-12 00:00:00
abstract::High plasma levels of 3-O-methyldopa (OMD) were found in parkinsonian patients chronically treated with levodopa, particularly in those with on-off phenomenon. However, no relation could be established between circulating levels of the levodopa metabolite and the presence of motor response fluctuations at any stage of...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.5.856
更新日期:1987-05-01 00:00:00
abstract::The motor effects of direct agonists which act selectively on certain dopamine receptors were studied in monkeys rendered hemiparkinsonian by unilateral intracarotid injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The D-2 dopamine agonist, LY 171555, but not the D-1 agonist, SKF 38393, reduced parkin...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.10.1592
更新日期:1987-10-01 00:00:00
abstract:OBJECTIVE:Using interictal alpha-[11C]methyl-l-tryptophan ([11C]AMT) PET scan, the authors have undertaken a quantitative analysis of all tubers visible on MRI or 2-deoxy-2-[18F]fluoro-d-glucose ([18F]FDG) PET, to determine the relationship between [11C]AMT uptake and epileptic activity on EEG. BACKGROUND:Tuberous scl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.10.1976
更新日期:2000-05-23 00:00:00
abstract:OBJECTIVE:To determine whether immunoglobulin G (IgG) from patients with Lambert-Eaton myasthenic syndrome (LEMS) decreases action potential–evoked synaptic vesicle exocytosis,and whether the effect is mediated by P/Q-type voltage-gated calcium channels (VGCCs). METHODS:IgG was obtained from 4 patients with LEMS (3 ma...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001225
更新日期:2015-02-10 00:00:00
abstract:OBJECTIVE:We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS). METHODS:Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31829c5ed5
更新日期:2013-07-23 00:00:00
abstract::IV immunoglobulin therapy can lead to vascular events through increased serum viscosity and possibly other mechanisms. The authors describe the successful use of tissue plasminogen activator in three of four patients who developed cerebral and peripheral arterial thrombosis after treatment with IV immunoglobulin. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000068334.04500.08
更新日期:2003-06-10 00:00:00
abstract:OBJECTIVE:The objective of the present work is to examine images of the brain dissection by Flemish-born anatomist Andreas Vesalius (1514-1564) as originally represented in the Fabrica (1543), and later copied without Vesalius' permission by Spanish anatomist Juan Valverde de Hamusco (c1525-c1587) in Historia de la com...
journal_title:Neurology
pub_type: 传,历史文章,杂志文章
doi:10.1212/WNL.0b013e31828407dc
更新日期:2013-02-26 00:00:00
abstract::In two patients, a sensory neuronopathy was the initial presentation of Sjögren's syndrome. There was no systemic or peripheral nerve vasculitis. Immunochemical studies failed to demonstrate specific antibodies against the nervous system. These features suggest that the damage to the sensory neurons might not be media...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.10.1637
更新日期:1988-10-01 00:00:00
abstract::The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.7.972
更新日期:2001-04-10 00:00:00
abstract::An HIV-1-infected patient with progressive multifocal leukoencephalopathy presented clinical deterioration and contrast-enhancing lesions on brain nuclear MR after the initiation of highly active antiretroviral therapy (HAART). Brain biopsy identified an inflammatory reaction compatible with immune reconstitution infl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000242728.26433.12
更新日期:2006-11-14 00:00:00
abstract:OBJECTIVE:To characterize the nature and degree of cognitive morbidity in patients with chronic temporal lobe epilepsy compared with healthy control subjects, determine the association between the duration of epilepsy and cognitive morbidity, and ascertain whether there are factors that moderate the association between...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000125186.04867.34
更新日期:2004-05-25 00:00:00
abstract::We evaluated the neuroprotective effect of MK-801, a noncompetitive, selective N-methyl-D-aspartate receptor antagonist, in a neonatal hypoxic-ischemic animal model. Seven-day-old rats underwent bilateral ligation of the carotid arteries followed by exposure to an 8% oxygen atmosphere for 1 hr. We sacrificed the anima...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.5.713
更新日期:1989-05-01 00:00:00
abstract:OBJECTIVE:This prospective, randomized, controlled study was designed to investigate the safety, feasibility, and preliminary efficacy of long-term CSF drainage via a low-flow ventriculoperitoneal shunt in subjects suffering from AD. METHODS:Twenty-nine subjects selected for probable AD (National Institute of Neurolog...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/01.wnl.0000031794.42077.a1
更新日期:2002-10-22 00:00:00
abstract:OBJECTIVE:This study aims to evaluate protective effects of brief repetitive bilateral arm ischemic preconditioning (BAIPC) on stroke recurrence in patients with symptomatic atherosclerotic intracranial arterial stenosis (IAS). METHODS:A total of 68 consecutive cases with symptomatic IAS, diagnosed by imaging, were en...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0b013e318271f76a
更新日期:2012-10-30 00:00:00
abstract:OBJECTIVE:Glucocerebrosidase (GBA) gene mutations represent a strong risk factor for Parkinson disease (PD). PD penetrance in GBA mutation carriers, which represents a key issue for genetic counseling, especially for relatives of patients with Gaucher disease (GD), is unknown. Our objective was to estimate PD penetranc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318245f476
更新日期:2012-02-07 00:00:00
abstract:BACKGROUND:After Pokémon viewing triggered an epidemic of seizures in Japan, many efforts have been made to design safety guidelines and systems to protect subjects with photosensitivity. The authors developed a new method based upon nonlinear diffusion techniques capable of filtering the epileptogenic content of a vid...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000152875.67527.61
更新日期:2005-03-08 00:00:00
abstract:OBJECTIVES:To correlate the two types of early ischemic change on noncontrast CT (NCCT) (parenchymal hypoattenuation [PH] and isolated focal swelling [IFS]) with concurrent assessment of cerebral perfusion and to compare their rates of progression to infarction. METHODS:We assessed cortical regions on NCCT for early i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000256366.86353.ff
更新日期:2007-03-06 00:00:00
abstract::Eighty-one percent (47/58) of private-sector neurologists in Colorado responded to a mail survey of practice patterns. We evaluated patient load, degree of principal versus consultative care, and use of neurodiagnostic tests. Broad areas of neurologic education that were perceived to have been lacking during residency...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.2.287
更新日期:1987-02-01 00:00:00
abstract:OBJECTIVE:To compare the prognostic accuracy of various acute stroke prognostic scales using a large, independent, clinical trials dataset. METHODS:We directly compared 8 stroke prognostic scales, chosen based on focused literature review (Acute Stroke Registry and Analysis of Lausanne [ASTRAL]; iSCORE; iSCORE-revised...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004332
更新日期:2017-09-05 00:00:00
abstract::We sought to determine whether geriatric patients with late-life-onset major depression have more subcortical hyperintensities on MRI and greater cognitive impairment than age-matched geriatric patients with early-life-onset major depression, suggesting that subcortical disease may be etiologic in late-life depression...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.6.1567
更新日期:1996-06-01 00:00:00
abstract:OBJECTIVE:To determine whether hippocampal neurons and choroidal epithelial cells demonstrate a mitochondrial enzyme deficiency in AD more frequently than in normal aging. BACKGROUND:High levels of mutant mitochondrial DNA (mtDNA) cause a deficiency in cytochrome c oxidase (COX) (complex IV activity) because three of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.2.260
更新日期:2001-07-24 00:00:00
abstract::Acid protease activity was increased in skeletal muscle of patients with ALS. The highest levels of activity were found in individuals with the clinically and histologically most affected muscle. High levels of proteolytic activity correlated with the extent of muscle atrophy, the presence of target fibers and the ove...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.8.901
更新日期:1982-08-01 00:00:00
abstract:OBJECTIVE:To test the diagnostic accuracy of the horizontal head impulse test (h-HIT) of vestibulo-ocular reflex (VOR) function in distinguishing acute peripheral vestibulopathy (APV) from stroke. Most patients with acute vertigo, nausea/vomiting, and unsteady gait have benign APV (vestibular neuritis or labyrinthitis)...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000314685.01433.0d
更新日期:2008-06-10 00:00:00
abstract::Research and development of the adenosine A2A receptor selective antagonist KW6002 have focused on developing a novel nondopaminergic therapy for Parkinson's disease (PD). Salient pharmacologic features of KW6002 were investigated in several animal models of PD. In rodent and primate models, KW6002 provides symptomati...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000095219.22086.31
更新日期:2003-12-09 00:00:00
abstract::Previous brain infarctions seen on CT are common in the absence of history of stroke. Eleven percent of patients (135/1,203) without stroke history had ischemic lesions on their first CT, unrelated to the presenting stroke. Stroke Data Bank files were reviewed to determine whether the occurrence, location, and CT char...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.11.1674
更新日期:1988-11-01 00:00:00
abstract:OBJECTIVE:To investigate whether tactile extinction alters the cortical somatosensory activations induced by hand vibration. BACKGROUND:Tactile extinction occurs mainly after right-brain lesions and consists of the inability to perceive a contralesional cutaneous stimulation when a similar stimulus is applied to the m...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.3.571
更新日期:1999-02-01 00:00:00