Abstract:
:An HIV-1-infected patient with progressive multifocal leukoencephalopathy presented clinical deterioration and contrast-enhancing lesions on brain nuclear MR after the initiation of highly active antiretroviral therapy (HAART). Brain biopsy identified an inflammatory reaction compatible with immune reconstitution inflammatory syndrome. Treatment with corticosteroids and transient suppression of HAART led to marked neurologic improvement.
journal_name
Neurologyjournal_title
Neurologyauthors
Martinez JV,Mazziotti JV,Efron ED,Bonardo P,Jordan R,Sevlever G,Martinez M,Verbanaz SC,Salazar ZS,Pardal MF,Reisin Rdoi
10.1212/01.wnl.0000242728.26433.12subject
Has Abstractpub_date
2006-11-14 00:00:00pages
1692-4issue
9eissn
0028-3878issn
1526-632Xpii
67/9/1692journal_volume
67pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Current medical educational theory encourages the development of competency-based curricula. The Accreditation Council for Graduate Medical Education's 6 core competencies for resident education (medical knowledge, patient care, professionalism, interpersonal and communication skills, practice-based learning, and syst...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000646
更新日期:2014-07-29 00:00:00
abstract::Migraine does not increase the risk for complications of pregnancy for the mother or for the fetus: the incidences of toxemia, miscarriages, abnormal labour, congenital anomalies, and stillbirths are comparable to those of the general population. Several retrospective studies have shown a tendency for migraine to impr...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::Between the years 1964 and 1973, 225 patients with transient ischemic attacks (TIAs) due primarily to atherosclerosis were evaluated and treated. They have now been followed for from 3 to 14 years (average 5.5 years). As of 1976, 82 of the 225 patients were dead, 21 from cerebral infarction, 52 from heart disease and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.8.746
更新日期:1978-08-01 00:00:00
abstract::Of 101 patients with benign intracranial hypertension not related to vasculitis, neck stiffness occurred in 31, tinnitus in 27, distal extremity paresthesias in 22, joint pains in 13, low back pain in 5, and gait "ataxia" in 4. Symptoms resolved promptly upon lowering the intracranial pressure by lumbar puncture, and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.9.1461
更新日期:1988-09-01 00:00:00
abstract::In a series of 100 patients exhibiting clinical and molecular features of facioscapulohumeral muscular dystrophy (FSHMD), five patients had conduction defects or arrhythmia in the absence of cardiovascular risk factors--namely, intraventricular conduction delay and supraventricular arrhythmia induced by electrophysiol...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.51.5.1454
更新日期:1998-11-01 00:00:00
abstract:OBJECTIVE:Current prehospital scales used to detect large vessel occlusion reveal very low endovascular thrombectomy (EVT) rates among selected patients. We developed a novel prehospital scale, the Madrid-Direct Referral to Endovascular Center (M-DIRECT), to identify EVT candidates for direct transfer to EVT-capable ce...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008998
更新日期:2020-02-25 00:00:00
abstract::Migraine and the MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes) syndrome have some clinical features in common. First, cerebral infarctions, most often in the posterior cerebral regions, which are a main symptom of MELAS, may complicate migraine. Second, migrainous headache w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.6.1735
更新日期:1996-06-01 00:00:00
abstract::Since a parental sex effect has been reported in Huntington's disease, we looked to see whether a similar effect is apparent in adult (autosomal dominant) familial ALS. We analyzed the data for 145 patients, with an onset age range of 20 to 68 years and a known affected parent (AP), from 52 families described in the l...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.41.8.1292
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVE:To address the role of cell death regulatory genes of the bcl-2 and caspase families in the neuropathology of human epilepsy using tissue extracted from patients undergoing temporal lobectomy for intractable seizures. METHODS:Using Western blotting and immunohistochemistry, the authors investigated the expre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.2.250
更新日期:2000-07-25 00:00:00
abstract:OBJECTIVE:Chronic inflammatory demyelinating polyneuropathy (CIDP) is characterized by immune-mediated peripheral demyelination. Although corticosteroid, IV immunoglobulin (IVIg) and plasma exchange have been established as the most effective therapeutics, subpopulations of patients show little or no response to either...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181bd1139
更新日期:2009-10-27 00:00:00
abstract:OBJECTIVE:To assess dyskinesia frequency in a population-based cohort of patients with Parkinson disease (PD). Dyskinesia complicates levodopa treatment and affects quality of life. METHODS:Utilizing the 1991-2010 population-based, parkinsonism-incident cohort of Olmsted County, MN (n = 669), accessed via the Rocheste...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006643
更新日期:2018-12-11 00:00:00
abstract:OBJECTIVE:Spontaneous spinal CSF leaks are an important cause of new-onset headaches. Such leaks are reported to be particularly common at the cervico-thoracic junction. The authors undertook a study to determine the significance of these cervico-thoracic CSF leaks. METHODS:The patient population consisted of a consec...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001697
更新日期:2015-06-16 00:00:00
abstract::We report 9 patients with an isolated infarct of the anterior part of the rostral cerebellum, ie, the territory of the lateral branch of the superior cerebellar artery. Clinicoanatomic correlations are based on CT, MRI, or both in 8 patients and on pathologic data in the ninth. The main clinical features were ipsilate...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.2_part_1.253
更新日期:1991-02-01 00:00:00
abstract::A marked decrease in the amplitude of the evoked thenar compound muscle action potential followed brief exercise at room temperature in two patients with paramyotonia congenita. This decline was more rapid and pronounced in our patient with coexistent thyrotoxicosis. The prolonged recovery period in paramyotonia conge...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.1.130
更新日期:1986-01-01 00:00:00
abstract::Mutations in DJ-1 are a cause of autosomal recessive parkinsonism. Polymorphism of genes implicated in hereditary forms of parkinsonism may be a predisposing factor in sporadic Parkinson's disease (PD). The authors analyzed whether a polymorphism (g.168_185del) within exon 1 of DJ-1 contributes to the risk of sporadic...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000083992.28066.7e
更新日期:2003-10-14 00:00:00
abstract::Valproic acid (VPA) has been postulated to exert its anticonvulsant effects by interaction with the postsynaptic GABA receptor. To test that hypothesis, we applied VPA in clinically appropriate concentrations to cortical neurons in dissociated cell culture. VPA did not enhance the postsynaptic effect of GABA, but did ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.2.259
更新日期:1986-02-01 00:00:00
abstract::Cholinergic neurons in the nucleus ambiguus (NA) were counted in autopsy tissue obtained from five patients with multiple system atrophy (MSA), four patients with PD, and five controls. The number of neurons in the dorsal NA was not significantly different among the three groups. Neurons in the ventrolateral portion o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000042087.07133.87
更新日期:2003-01-14 00:00:00
abstract::Charcot-Marie-Tooth disease type 1A (CMT1A) and hereditary neuropathy with liability to pressure palsies (HNPP) are inherited peripheral neuropathies. In most cases these disorders are caused by either the duplication (in CMT1A) or the deletion (in HNPP) of a 1.5-megabase DNA fragment on chromosome 17p11.2, which cont...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.3.760
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:There is evidence that angiotensin-converting enzyme inhibitors (ACEIs) reduce the risk of stroke. However, it is unclear whether ACEI use before stroke provides a vasoprotective effect resulting in less severe stroke. METHODS:We ascertained all strokes occurring in a defined population in Melbourne, Austra...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000261914.18101.60
更新日期:2007-05-15 00:00:00
abstract::A patient who abused multiple drugs developed a rapidly progressive mononeuropathy multiplex, which appeared to respond to corticosteroid therapy with partial resolution. Intravenous methamphetamine had been used almost exclusively from the fourth month prior to the onset of symptoms. Biopsy material revealed a necrot...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.6.570
更新日期:1975-06-01 00:00:00
abstract:OBJECTIVE:To ascertain the prevalence and determinants of neuropathy in patients with Parkinson disease (PD), in particular, the roles of vitamin B12 and levodopa exposure. METHODS:We performed a cross-sectional study of 37 patients with PD and 37 age- and gender-matched controls, using a sensitive and validated neuro...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31823a0ee4
更新日期:2011-11-29 00:00:00
abstract::We retrospectively examined the clinical courses of 20 children with severe near-drowning and divided their outcomes into 3 groups: normal (4), persistent vegetative state (9), and dead (7). We reviewed serial blood glucose levels and cerebral blood flow measured by stable xenon computed tomography within the 1st 48 h...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.5.820
更新日期:1990-05-01 00:00:00
abstract::A comprehensive sequence analysis of 29 exons that code for the functional domains of LRRK2 in 160 nondominant Parkinson disease (PD) patients was performed. Novel variant screening in a further 470 sporadic PD patients and 630 controls revealed two novel variants (R1067Q and IVS33 + 6 T>A), which are likely to be pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000180517.70572.37
更新日期:2005-10-25 00:00:00
abstract::A number of high-quality studies have recently been published that examine the association between neuropathic pain and health-related quality of life (HRQoL). The current review identified 52 such studies in patients with six neuropathic pain conditions associated with lesions of either the peripheral (postsurgical n...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/01.wnl.0000259085.61898.9e
更新日期:2007-04-10 00:00:00
abstract::Mammalian spinal neurons grown in tissue culture were used to study the effects of the four convulsants-penicillin, pentylenetetrazol, picrotoxin, and bicuculline-on these neurons' responses to amino acids. Bath application of all four convulsants produced paroxysmal depolarizing events in the neurons; iontophoresis o...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.4.325
更新日期:1978-04-01 00:00:00
abstract::The authors describe a case of neurologic involvement in mild hyperphenylalaninemia (HPA), not due to tetrahydrobiopterin (BH(4)) deficiency, with low levels of monoamine neurotransmitter metabolites in CSF. The combined BH(4)-Phe loading test suggested a BH(4) response, confirmed by clinical improvement after BH(4) t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.5.908
更新日期:2001-09-11 00:00:00
abstract::The authors investigated whether repetitive transcranial magnetic stimulation (rTMS) at 1 Hz (12 minutes; 90% of motor threshold) to the primary motor cortex (M1) leads to changes in diffusion-weighted imaging (DWI). After the rTMS train, there was a temporary small restriction in diffusion within the targeted left M1...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000058903.15205.46
更新日期:2003-05-13 00:00:00
abstract:OBJECTIVE:To learn to which portions of a line normal subjects would attend when watching this line actually moving or when perceiving movement even in the absence of actual movement, an illusory movement. METHODS:Twenty normal subjects watched a computer monitor on which either lines or dots moved to the right or lef...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000120546.14213.c7
更新日期:2004-04-27 00:00:00
abstract::Many studies have demonstrated that dipyridamole is not purely an antiplatelet agent but also exerts its antithrombotic properties through the vessel wall. Using a laboratory model in which bovine endothelial cells are seeded to form a subendothelial matrix (SEM), investigators have shown that dipyridamole enhances th...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.suppl_2.s20
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To investigate the relationship between markers of vitamin B(12) status and brain volume loss per year over a 5-year period in an elderly population. METHODS:A prospective study of 107 community-dwelling volunteers aged 61 to 87 years without cognitive impairment at enrollment. Volunteers were assessed year...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000325581.26991.f2
更新日期:2008-09-09 00:00:00