Abstract:
OBJECTIVE:We assessed whether clinical and imaging features of subjects with apraxia of speech (AOS) more severe than aphasia (dominant AOS) are more similar to agrammatic primary progressive aphasia (agPPA) or to primary progressive AOS (PPAOS). METHODS:Sixty-seven subjects (PPAOS = 18, dominant AOS = 10, agPPA = 9, age-matched controls = 30) who all had volumetric MRI, diffusion tensor imaging, F18-fluorodeoxyglucose and C11-labeled Pittsburgh compound B (PiB)-PET scanning, as well as neurologic and speech and language assessments, were included in this case-control study. AOS was classified as either type 1, predominated by sound distortions and distorted sound substitutions, or type 2, predominated by syllabically segmented prosodic speech patterns. RESULTS:The dominant AOS subjects most often had AOS type 2, similar to PPAOS. In contrast, agPPA subjects most often had type 1 (p = 0.01). Both dominant AOS and PPAOS showed focal imaging abnormalities in premotor cortex, whereas agPPA showed widespread involvement affecting premotor, prefrontal, temporal and parietal lobes, caudate, and insula. Only the dominant AOS and PPAOS groups showed midbrain atrophy compared with controls. No differences were observed in PiB binding across all 3 groups, with the majority being PiB negative. CONCLUSION:These results suggest that dominant AOS is more similar to PPAOS than agPPA, with dominant AOS and PPAOS exhibiting a clinically distinguishable subtype of progressive AOS compared with agPPA.
journal_name
Neurologyjournal_title
Neurologyauthors
Josephs KA,Duffy JR,Strand EA,Machulda MM,Senjem ML,Lowe VJ,Jack CR Jr,Whitwell JLdoi
10.1212/WNL.0b013e31829c5ed5subject
Has Abstractpub_date
2013-07-23 00:00:00pages
337-45issue
4eissn
0028-3878issn
1526-632Xpii
WNL.0b013e31829c5ed5journal_volume
81pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Behavioral testing following division of the corpus callosum has shown that the anterior commissure can transfer information related to visual tasks interhemispherically in nonhuman primates but not in humans. We have found that the ratio of anterior commissure cross-sectional area to total neocortical commissural are...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.11.1513
更新日期:1986-11-01 00:00:00
abstract::We performed an open-label study testing the effects of GM1 ganglioside on 10 Parkinson's disease (PD) patients. Patients received 1,000 mg of GM1 by IV infusion after the last of three baseline functional assessments. Patients then self-administered GM1 at a dose of 200 mg/d, by subcutaneous injection, for 18 weeks. ...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.45.6.1149
更新日期:1995-06-01 00:00:00
abstract::An improved agarose gel electrophoretic technique was used to fractionate serum and cerebrospinal fluid (CSF) proteins in patients with presenile dementia. The CSF electrophoretic patterns demonstrated three abnormal bands in the gamma-globulin region in five out of eight of these patients. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.8.882
更新日期:1980-08-01 00:00:00
abstract:OBJECTIVE:To report the incidence of prion disease in the United States. METHODS:Prion disease decedents were retrospectively identified from the US national multiple cause-of-death data for 2003-2015 and matched with decedents in the National Prion Disease Pathology Surveillance Center (NPDPSC) database through compa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008680
更新日期:2020-01-14 00:00:00
abstract::The authors correlated neurologic features of rostral lateral pontine infarct (rLPI) with lesion location on MRI. rLPI is a motor-sensory stroke presenting as crural monoparesis or crural dominant hemiparesis and segmental superficial or deep sensory disturbances. The dorsolateral pontine base causes crural paresis wi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000072323.19180.b7
更新日期:2003-07-08 00:00:00
abstract:OBJECTIVES:1) To reassess the prevalence of migraine in the United States; 2) to assess patterns of migraine treatment in the population; and 3) to contrast current patterns of preventive treatment use with recommendations for use from an expert headache panel. METHODS:A validated self-administered headache questionna...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000252808.97649.21
更新日期:2007-01-30 00:00:00
abstract::In 21 normal subjects, far-field somatosensory potentials were recorded from the scalp after stimulation of the tibial nerve at the ankle (tibial SEP). With the use of a knee reference contralateral to the side of stimulation, the tibial SEP consisted of three major positive peaks, P17, P24, and P31, and three additio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.32.10.1151
更新日期:1982-10-01 00:00:00
abstract:OBJECTIVE:To explore the association between postmenopausal hormone therapy (HT) and Alzheimer disease (AD). METHODS:Twenty-year follow-up data from the Kuopio Osteoporosis Risk Factor and Prevention study cohort were used. Self-administered questionnaires were sent to all women aged 47-56 years, residing in Kuopio Pr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003696
更新日期:2017-03-14 00:00:00
abstract::Delusions and other manifestations of psychotic behavior are common side effects in Parkinson's disease (PD) patients chronically treated with dopaminergic drugs. Clozapine, a dibenzodiazepine derivative, is an antipsychotic drug largely devoid of extrapyramidal side effects. We evaluated the effects of low doses of c...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.45.3.432
更新日期:1995-03-01 00:00:00
abstract::The frequency of recurrent cerebral ischemia and death was determined prospectively in 36 patients who presented with ischemic stroke and had atrial fibrillation. Patients were followed an average of 2.3 months (range, 3 weeks to 9 months). The recurrence rate for cerebral ischemia was 33%, and the mortality rate was ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.10.1285
更新日期:1984-10-01 00:00:00
abstract:BACKGROUND:Subjective memory deficit (SMD) is one of few potential presenting symptoms for people with early cognitive impairment. However, associations with underlying brain changes are unclear. METHODS:In a community sample of 1,779 people without dementia, and with neuroimaging (MRI) data, associations were investi...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/01.wnl.0000310982.99438.54
更新日期:2008-04-29 00:00:00
abstract:OBJECTIVES:The objective of this study was to clarify the characteristic brain MRI findings for genetically diagnosed CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy). METHODS:Seven patients with CARASIL carrying HTRA1 mutations (representing 6 Japanese families) we...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001803
更新日期:2015-08-04 00:00:00
abstract:BACKGROUND:Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare multisystem disorder associated with plasma cell dyscrasia. There is increasing evidence that high-dose chemotherapy with autologous peripheral blood stem cell transplantation (Auto-PBSCT) is an efficacious t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000323811.42080.a4
更新日期:2008-11-18 00:00:00
abstract::Visual hallucinations (VHs) occur frequently in Parkinson's disease (PD). VHs occur more frequently in elderly patients with longer duration of illness, cognitive impairment, and sleep disturbances. The relationship between the use of antiparkinsonian drugs and VHs is complicated, but most drugs used to treat parkinso...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.63.8_suppl_3.s28
更新日期:2004-10-26 00:00:00
abstract::Call-Fleming syndrome is a reversible segmental vasoconstriction of cerebral arteries manifested by a "thunderclap" headache and focal neurologic symptoms. Although of unknown etiology, it has been reported in association with vasoactive sympathomimetic drugs. The authors report Call-Fleming syndrome in two patients w...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000223648.76430.27
更新日期:2006-07-11 00:00:00
abstract::To test the safety and efficacy of recombinant human insulin-like growth factor-I (rhIGF-I) in ALS, 183 patients from eight European centers were randomized to receive double-blind placebo (n = 59) or rhIGF-I 0.1 mg/kg/day (n = 124) subcutaneously for 9 months. At study completion, the primary efficacy outcome measure...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1212/wnl.51.2.583
更新日期:1998-08-01 00:00:00
abstract::A patient with thymoma-associated neuromyotonia and voltage-gated potassium channel (Kv1.2 and Kv1.6) antibodies by immunoprecipitation and rat brain immunolabeling was treated successfully with immunoadsorption and cyclophosphamide. Curiously, glutamic acid decarboxylase antibodies, absent at onset, appeared later. S...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000156945.39471.2C
更新日期:2005-04-12 00:00:00
abstract::An HIV-1-infected patient with progressive multifocal leukoencephalopathy presented clinical deterioration and contrast-enhancing lesions on brain nuclear MR after the initiation of highly active antiretroviral therapy (HAART). Brain biopsy identified an inflammatory reaction compatible with immune reconstitution infl...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000242728.26433.12
更新日期:2006-11-14 00:00:00
abstract:BACKGROUND:We evaluated the clinicoradiologic characteristics of patients with branch occlusive disease (BOD)-type intracranial atherosclerotic stroke (ICAS) compared with those of patients with non-BOD-type ICAS or with small artery disease (SAD). METHODS:We analyzed 201 consecutive patients with acute infarcts withi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31824c4699
更新日期:2012-03-20 00:00:00
abstract:OBJECTIVE:To use a historical placebo control design to determine whether lithium carbonate slows progression of amyotrophic lateral sclerosis (ALS). METHODS:A phase II trial was conducted at 10 sites in the Western ALS Study Group using similar dosages (300-450 mg/day), target blood levels (0.3-0.8 mEq/L), outcome me...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0b013e31822dc7a5
更新日期:2011-09-06 00:00:00
abstract:OBJECTIVE:Frontotemporal lobar degeneration (FTLD) encompasses a variety of clinicopathologic entities. The antemortem prediction of the underlying pathologic lesions is reputed to be difficult. This study sought to characterize correlations between 1) the different clinical variants of primary progressive language and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181c7198e
更新日期:2010-01-05 00:00:00
abstract::There are multiple difficulties in evaluating new treatments for multiple sclerosis (MS). The clinical diagnosis is imprecise, and the correlation between lesion and clinical dysfunction is incomplete. The neurologic evaluation is complex and lacks full precision. The course of MS is complex and has limited predictabi...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.30.7_part_2.8
更新日期:1980-07-01 00:00:00
abstract::We found an antinuclear antibody highly restricted to nuclei of neurons in two patients with subacute sensory neuronopathy complicating oat cell carcinoma of the lung. Serum was tested by indirect immunofluorescence and immunoperoxidase staining. At low concentrations of antibody, only the nuclei of the neurons were s...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.4.538
更新日期:1985-04-01 00:00:00
abstract:OBJECTIVES:Abnormal high cerebral iron deposition may be implicated in chronic neurologic disorders, including multiple sclerosis (MS). R2* relaxometry has been recently validated in a postmortem study to indicate brain iron accumulation in a quantitative manner. We used this technique to assess brain iron levels in di...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318236ef0e
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:This study assessed the strength of military-related concussion-, psychological-, and behavioral-related measures to predict neurobehavioral symptom (NBS) reporting in order to help clarify the extent to which persistent NBS reflect lingering effects of concussion vs other psychological/behavioral factors amo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006034
更新日期:2018-08-21 00:00:00
abstract:OBJECTIVE:The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) study is the first stroke prevention trial to include protocol-driven intensive management of multiple risk factors. In this prespecified analysis, we aimed to investigate the relationship betwee...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000003534
更新日期:2017-01-24 00:00:00
abstract::We describe a case of Burkitt's cell acute lymphoblastic leukemia presenting with the bilateral numb chin syndrome as the initial symptom of the disease. Postmortem study of the trigeminal nerve showed heavy infiltrations of leukemic cells and destruction of axon and myelin by leukemic cells in the mandibular nerve. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.3.453
更新日期:1991-03-01 00:00:00
abstract:BACKGROUND:Extrapyramidal signs (EPS) are common in Alzheimer disease (AD) and increase in prevalence as AD advances. The neuropathologic substrate responsible for EPS in AD remains to be fully characterized. METHODS:Subjects had a clinical diagnosis of AD confirmed by neuropathologic examination. EPS during life were...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000158423.05224.7F
更新日期:2005-04-26 00:00:00
abstract:OBJECTIVE:To investigate whether patients with moyamoya angiopathy without obvious retinal pathologies such as retinal infarctions or the congenital morning glory anomaly may have subtle subclinical retinal changes. METHODS:In this cross-sectional study, spectral domain optical coherence tomography was used to analyze...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001832
更新日期:2015-08-11 00:00:00
abstract::Cognitive decline is recognized as a prevalent and debilitating symptom of multiple sclerosis (MS), especially deficits in episodic memory and processing speed. The field aims to (1) incorporate cognitive assessment into standard clinical care and clinical trials, (2) utilize state-of-the-art neuroimaging to more thor...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0000000000004977
更新日期:2018-02-06 00:00:00