Problems in evaluating new treatments for multiple sclerosis.

abstract：:In multifocal motor neuropathy (MMN), little is known of the long-term effect of human immunoglobulin (HIG) infusions as a maintenance therapy. We report a patient who improved after an initial HIG infusion of 2 g/kg and continued to improve both clinically and electrophysiologically during maintenance HIG treatment c...

journal_title：Neurology

authors： Van den Berg LH,Franssen H,Wokke JH

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:To assess the medial plantar nerve action potential (NAP) and skin biopsy in the evaluation of suspected distal sensory neuropathies (SN) with normal routine nerve conduction studies (NCS). METHODS:A total of 110 consecutive patients with suspected distal SN and normal routine NCS underwent medial plantar NA...

journal_title：Neurology

authors： Herrmann DN,Ferguson ML,Pannoni V,Barbano RL,Stanton M,Logigian EL

更新日期：2004-09-14 00:00:00

abstract：OBJECTIVE:To explore sensitivity of optical coherence tomography (OCT) in detecting prior unilateral optic neuritis. METHODS:This is a retrospective, observational clinical study of all patients who presented from January 1, 2014, to January 6, 2017, with unilateral optic neuritis and OCT available at least 3 months a...

journal_title：Neurology

authors： Xu SC,Kardon RH,Leavitt JA,Flanagan EP,Pittock SJ,Chen JJ

更新日期：2019-02-05 00:00:00

abstract：:Eighty-eight multiple sclerosis case-friend pairs were interviewed by telephone to elicit information about early-life exposures. Available mothers were also interviewed. Risk factors included childhood diseases, exposures to animals, and residence. We found a positive association between MS and having measles at a la...

journal_title：Neurology

authors： Sullivan CB,Visscher BR,Detels R

更新日期：1984-09-01 00:00:00

abstract：:Presenilin (PSEN)1 mutations are responsible for many cases of autosomal dominant Alzheimer disease (AD), although the clinical spectrum has not been fully defined. The authors describe two members of a kindred with a novel PSEN1 mutation (R278I) presenting with language impairment and relative preservation of memory....

journal_title：Neurology

authors： Godbolt AK,Beck JA,Collinge J,Garrard P,Warren JD,Fox NC,Rossor MN

更新日期：2004-11-09 00:00:00

abstract：:Hemorrhage complicating acute carbon monoxide poisoning is usually confined to the basal ganglia. The authors report three people with acute carbon monoxide poisoning manifesting selective or prominent white matter involvement complicated by hemorrhagic infarction on CT and MRI in one and by subcortical T2*-weighted M...

journal_title：Neurology

authors： Finelli PF,DiMario FJ Jr

更新日期：2004-09-28 00:00:00

abstract：OBJECTIVE:To investigate the role of multiple distributed brain networks, including the default mode, fronto-temporo-parietal, and cingulo-opercular networks, which mediate domain-general and task-specific processes during speech production after aphasic stroke. METHODS:We conducted an observational functional MRI stu...

journal_title：Neurology

authors： Geranmayeh F,Leech R,Wise RJS

更新日期：2016-04-05 00:00:00

abstract：:A 12-year-old girl developed simple partial motor and sensory seizures due to a right perirolandic astrocytoma. Subdural EEG recording and functional stimulation disclosed close correlation between EEG-clinical manifestations of focal seizures and functional responses to cortical stimulation. This case supports the id...

journal_title：Neurology

authors： Arroyo S,Krauss GL,Lesser RP,Gordon B,Hart J Jr,Carson BS,Uematsu S

更新日期：1992-03-01 00:00:00

abstract：:Two patients with acute onset of profound weakness and loss of muscle bulk during a critical illness had unusual histopathological changes of type II myofibers. Both patients had respiratory failure and prolonged neuromuscular blockade. High-dose steroids were used in only one case and atracurium in the other. Muscle ...

journal_title：Neurology

authors： Gutmann L,Blumenthal D,Gutmann L,Schochet SS

更新日期：1996-03-01 00:00:00

abstract：:One hundred and eight patients with independent, multifocal, spike discharges in the EEG were studied. The abnormality occurred at all ages but was more frequent between 4 and 7 years. The basic EEG activity in wake tracing was invariably slow for the age of the patient. The majority of the patients with independent m...

journal_title：Neurology

authors： Noriega-Sanchez A,Markand ON

更新日期：1976-07-01 00:00:00

abstract：:The administration of lecithin has failed to improve memory in aged or demented individuals. We studied the effect of lecithin on another cholinergic function, REM sleep latency. Intravenous doses of physostigmine shortened the latency to the first REM sleep period, but oral lecithin did not. In contrast to physostigm...

journal_title：Neurology

authors： Kapen S,Fleming PD,Drachman DA

更新日期：1986-08-01 00:00:00

abstract：OBJECTIVE:To perform a psychometric evaluation of the inflammatory neuropathy cause and treatment (INCAT) sensory sumscore (ISS) in sensory-motor immune-mediated polyneuropathies. This new sensory scale was evaluated to strive for uniformity in assessing sensory deficit in these disorders. METHODS:The ISS comprises vi...

journal_title：Neurology

authors： Merkies IS,Schmitz PI,van der Meché FG,van Doorn PA

更新日期：2000-02-22 00:00:00

abstract：OBJECTIVE:To investigate the prevalence, predictors, and clinical relevance of cortical superficial siderosis (cSS) progression in cerebral amyloid angiopathy (CAA). METHODS:Consecutive patients with symptomatic CAA meeting Boston criteria in a prospective cohort underwent baseline and follow-up MRI within 1 year. cSS...

journal_title：Neurology

authors： Pongpitakmetha T,Fotiadis P,Pasi M,Boulouis G,Xiong L,Warren AD,Schwab KM,Rosand J,Gurol ME,Greenberg SM,Viswanathan A,Charidimou A

更新日期：2020-04-28 00:00:00

abstract：:We present an 11-year-old girl in whom high field strength MRI performed 2 1/2 years and 6 months before her death showed prominent hypointensity in the globus pallidus and substantia nigra consistent with iron deposition. This finding suggested Hallervorden-Spatz disease, which was confirmed at autopsy. ...

journal_title：Neurology

authors： Schaffert DA,Johnsen SD,Johnson PC,Drayer BP

更新日期：1989-03-01 00:00:00

abstract：OBJECTIVE:To assess the contribution of microstructural normal-appearing white matter (NAWM) damage to social cognition impairment, specifically in the theory of mind (ToM), in multiple sclerosis (MS). METHODS:We enrolled consecutively 60 patients with MS and 60 healthy controls (HC) matched on age, sex, and education...

journal_title：Neurology

authors： Batista S,Alves C,d'Almeida OC,Afonso A,Félix-Morais R,Pereira J,Macário C,Sousa L,Castelo-Branco M,Santana I,Cunha L

更新日期：2017-07-04 00:00:00

abstract：BACKGROUND:Two recent studies suggest that the risk of ALS is increased among Gulf War veterans. It is not known whether military service outside of the Gulf War is associated with increased risk of ALS. METHODS:The authors prospectively assessed the relation between service in the military and ALS mortality among par...

journal_title：Neurology

authors： Weisskopf MG,O'Reilly EJ,McCullough ML,Calle EE,Thun MJ,Cudkowicz M,Ascherio A

更新日期：2005-01-11 00:00:00

abstract：OBJECTIVE:To investigate the etiology of aseptic meningitis and encephalitis in an adult population using modern microbiologic methods. METHODS:Consecutive patients (ages > or =16) with aseptic meningitis or encephalitis treated in Turku University Hospital, Finland, during 1999 to 2003 were included in the study. Mic...

journal_title：Neurology

authors： Kupila L,Vuorinen T,Vainionpää R,Hukkanen V,Marttila RJ,Kotilainen P

更新日期：2006-01-10 00:00:00

abstract：OBJECTIVE:To determine the cumulative incidence of epilepsy in a population-based cohort of patients with multiple sclerosis (MS) and to investigate the association between epilepsy and clinical features of MS. METHODS:All available patients in the Swedish MS register (n = 14,545) and 3 age- and sex-matched controls p...

journal_title：Neurology

authors： Burman J,Zelano J

更新日期：2017-12-12 00:00:00

abstract：:Six neonates with prolonged, intractable seizures were treated with valproic acid (VPA). Each patient had received maximum doses of phenobarbital (greater than 40 micrograms/ml), and five patients received at least two additional anticonvulsants, without success. Seizure activity was controlled in five of six (83%) ca...

journal_title：Neurology

authors： Gal P,Oles KS,Gilman JT,Weaver R

更新日期：1988-03-01 00:00:00

abstract：OBJECTIVE:To describe the diagnosis and management of a 49-year-old woman with multiple sclerosis (MS) developing a progressive hemiparesis and expanding MRI lesion suspicious of progressive multifocal leukoencephalopathy (PML) 19 months after starting natalizumab. RESULTS:Polyomavirus JC (JCV)-specific qPCR in CSF wa...

journal_title：Neurology

authors： Kuhle J,Gosert R,Bühler R,Derfuss T,Sutter R,Yaldizli O,Radue EW,Ryschkewitsch C,Major EO,Kappos L,Frank S,Hirsch HH

更新日期：2011-12-06 00:00:00

abstract：:Fourteen patients with Alzheimer's disease were evaluated by psychometric testing, fluorodeoxyglucose positron emission tomography (PET), and EEG. They were divided into two groups according to the EEG findings. Group A (seven patients) had normal alpha backgrounds and group B (seven patients) had decreased alpha back...

journal_title：Neurology

authors： Sheridan PH,Sato S,Foster N,Bruno G,Cox C,Fedio P,Chase TN

更新日期：1988-05-01 00:00:00

abstract：:We reviewed the historical features, preoperative diagnostic evaluation, operative procedure, and surgical outcome in 16 patients with refractory frontal lobe epilepsy. Clinical expression of the epilepsy varied widely, particularly with respect to seizure characteristics, although high monthly seizure frequency and a...

journal_title：Neurology

authors： Laskowitz DT,Sperling MR,French JA,O'Connor MJ

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVES:Compensatory processes involving the recruitment of additional cerebral areas can limit cognitive impairment caused by brain damage as revealed by fMRI. Multiple sclerosis (MS) is characterized by frequent cognitive deficiencies and diffuse brain damage. Understanding the missing or disturbed processes resul...

journal_title：Neurology

authors： Bonnet MC,Allard M,Dilharreguy B,Deloire M,Petry KG,Brochet B

更新日期：2010-10-05 00:00:00

abstract：:We present a method for graphically reporting the results of brainstem auditory evoked response examinations on the basis of multiple parameters. The method is based on a transform that normalizes the many latency and amplitude measures obtained from the averaged evoked responses of normal subjects tested under standa...

journal_title：Neurology

authors： Lolas F,Hoeppner TJ,Morrell F

更新日期：1979-02-01 00:00:00

abstract：BACKGROUND:Although phenylketonuria is a treatable disease, patients with late or nonoptimal phenylalanine-restricted diet may experience brain damage. The authors used tridimensional MRI and a voxelwise analysis method to investigate possible volume changes in the brain parenchyma of patients with phenylketonuria. ME...

journal_title：Neurology

authors： Pérez-Dueñas B,Pujol J,Soriano-Mas C,Ortiz H,Artuch R,Vilaseca MA,Campistol J

更新日期：2006-04-11 00:00:00

abstract：:Despite strong evidence of the importance of hereditary factors in the etiology of Tourette's syndrome (TS), research findings have consistently pointed to a role of environmental influences. A recent line of research has suggested that tic disorders and associated behavioral disturbances, such as obsessive-compulsive...

journal_title：Neurology

authors： Kurlan R

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:To identify phenotypic features of febrile seizures that can be used to reduce heterogeneity and thereby increase power in linkage analysis. BACKGROUND:Despite exciting discoveries in several rare pedigrees, the genetic basis of common febrile seizures remains a mystery. The major drawback of studying common...

journal_title：Neurology

authors： Pal DK,Kugler SL,Mandelbaum DE,Durner M

更新日期：2003-02-11 00:00:00

abstract：OBJECTIVE:The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, and no information about preoperative cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. METHODS:To resolve this is...

journal_title：Neurology

authors： Robert GH,Le Jeune F,Lozachmeur C,Drapier S,Dondaine T,Péron J,Houvenaghel JF,Travers D,Sauleau P,Millet B,Vérin M,Drapier D

更新日期：2014-10-28 00:00:00

abstract：:Kuru plaques are the pathologic hallmark in Gerstmann-Sträussler syndrome (GSS). To demonstrate that prion protein (PrP) is a component of kuru plaque cores, we fractionated and sequenced kuru plaque core derived peptides, following digestion with Achromobacter lyticus protease I. We identified 3 PrP-derived peptides ...

journal_title：Neurology

authors： Kitamoto T,Yamaguchi K,Doh-ura K,Tateishi J

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Antiretroviral therapy has improved survival for HIV-1-infected individuals. The neuroepidemiologic implications of HIV-1 in an aging population are not well known, particularly the prevalence of HIV-associated dementia (HAD). METHODS:The authors report a baseline cross-sectional analysis of 202 HIV-1-serop...

journal_title：Neurology

authors： Valcour V,Shikuma C,Shiramizu B,Watters M,Poff P,Selnes O,Holck P,Grove J,Sacktor N

更新日期：2004-09-14 00:00:00