Abstract:
OBJECTIVE:The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, and no information about preoperative cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. METHODS:To resolve this issue, we set out to identify preoperative metabolic patterns and sociodemographic and clinical factors associated with increased apathy after STN-DBS. Forty-four patients with Parkinson disease were enrolled in this study. They all underwent STN-DBS. Metabolic activity was assessed with F-18 fluorodeoxyglucose PET 3 months before surgery. Apathy was assessed on the Apathy Evaluation Scale 3 months before and after STN-DBS. We controlled for preoperative age, levodopa therapy, and overall cognitive functions. RESULTS:Increased apathy after STN-DBS was significantly associated with reduced preoperative metabolism within the right ventral striatum. None of the sociodemographic and clinical variables tested were associated with apathy after STN-DBS. CONCLUSIONS:Preoperative PET, but not sociodemographic or clinical factors, is associated with apathy after STN-DBS.
journal_name
Neurologyjournal_title
Neurologyauthors
Robert GH,Le Jeune F,Lozachmeur C,Drapier S,Dondaine T,Péron J,Houvenaghel JF,Travers D,Sauleau P,Millet B,Vérin M,Drapier Ddoi
10.1212/WNL.0000000000000941subject
Has Abstractpub_date
2014-10-28 00:00:00pages
1620-6issue
18eissn
0028-3878issn
1526-632Xpii
WNL.0000000000000941journal_volume
83pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::The association of APOE genotypes with cerebral microbleeds (CMBs) was examined on the basis of the location of CMBs in 414 patients who were admitted primarily because of stroke. With respect to possession of the epsilon2 or epsilon4 allele, the adjusted odds ratio was 1.94 (1.05 to 3.58) for lobar CMBs but 1.21 (0.6...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000183311.48144.7f
更新日期:2005-11-08 00:00:00
abstract::Unusual late-onset complications of brain irradiation, characterized by reversible neurologic focal signs, seizures, and MRI alterations, have recently been reported and classified as stroke-like migraine attacks after radiation therapy (SMART)(1) and peri-ictal pseudoprogression (PIPG).(2.) ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a43b1f
更新日期:2013-09-10 00:00:00
abstract::Cerebral amyloid angiopathy is a common cause of spontaneous lobar hemorrhage in elderly patients. We discuss seven patients with amyloid angiopathy presenting without major lobar hemorrhage. The patients' presentations fell into two groups: recurrent transient neurologic symptoms and rapidly progressive dementia. The...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.10.2073
更新日期:1993-10-01 00:00:00
abstract:OBJECTIVE:To evaluate whether subthalamic nucleus (STN) stimulation has an effect on the orthostatic regulation of patients with Parkinson disease (PD), we studied cardiovascular regulation during on and off phases of STN stimulation. METHODS:We examined 14 patients with PD (mean age 58.1 +/- 5.8 years, 4 women, 10 me...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000244416.30605.f1
更新日期:2006-11-28 00:00:00
abstract:OBJECTIVE:To determine if migraine with aura is associated with neuroinflammation, which has been suggested by preclinical models of cortical spreading depression (CSD) as well as imaging of human pain conditions. METHODS:Thirteen migraineurs with aura and 16 healthy controls received integrated PET/MRI brain scans wi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007371
更新日期:2019-04-23 00:00:00
abstract::Delusions and other manifestations of psychotic behavior are common side effects in Parkinson's disease (PD) patients chronically treated with dopaminergic drugs. Clozapine, a dibenzodiazepine derivative, is an antipsychotic drug largely devoid of extrapyramidal side effects. We evaluated the effects of low doses of c...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.45.3.432
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Several studies indicate semantic fluency more sensitively discriminates patients with Alzheimer disease (AD) from normal elderly persons, with disproportionate impairment of semantic over phonemic fluency. OBJECTIVE:To determine the ability of abbreviated fluency measures in the clinic setting (1-minute le...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.62.4.556
更新日期:2004-02-24 00:00:00
abstract:OBJECTIVE:The Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) study is the first stroke prevention trial to include protocol-driven intensive management of multiple risk factors. In this prespecified analysis, we aimed to investigate the relationship betwee...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000003534
更新日期:2017-01-24 00:00:00
abstract::We investigated 26 right-handed patients who had aphasia caused by a single infarct in the territory of the left middle cerebral artery (MCA) with cranial CT, positron emission tomography, and a standard language test battery including the Token test. The patients represented an unselected sample of various infarct lo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.8.1083
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND:Silent infarcts are commonly discovered on cranial MRI in the elderly. OBJECTIVE:To examine the association between risk of stroke and presence of silent infarcts, alone and in combination with other stroke risk factors. METHODS:Participants (3,324) in the Cardiovascular Health Study (CHS) without a histor...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.7.1222
更新日期:2001-10-09 00:00:00
abstract::Sensorimotor polyneuropathy developed in two workers who had been exposed to ethylene oxide gas repeatedly for several months. Sural nerve biopsies revealed axonal degeneration with mild changes of the myelin sheath. Unmyelinated fibers were also involved. Muscle biopsies showed typical denervation atrophy. Symptoms i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.3.377
更新日期:1983-03-01 00:00:00
abstract:BACKGROUND:The epsilon 4 allele of the APOE gene (APOE) is more frequent in patients with AD than in the general population, but studies are inconclusive as to whether it affects rate of progression or survival. Because survival in AD is generally longer in women than in men, the authors investigated whether APOE affec...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.7.1045
更新日期:2002-04-09 00:00:00
abstract::The authors evaluated how history of concussion affects symptom reporting prior to and after sustaining a concussion. At baseline, athletes with a positive concussion history reported more current symptomatology than athletes who had never been concussed. At 2 hours postinjury, concussed athletes with a history of pre...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000142088.32204.82
更新日期:2004-10-26 00:00:00
abstract:OBJECTIVES:To correlate the two types of early ischemic change on noncontrast CT (NCCT) (parenchymal hypoattenuation [PH] and isolated focal swelling [IFS]) with concurrent assessment of cerebral perfusion and to compare their rates of progression to infarction. METHODS:We assessed cortical regions on NCCT for early i...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000256366.86353.ff
更新日期:2007-03-06 00:00:00
abstract::A 35-year-old woman had cardiac arrest requiring treatment with a left ventricular assist device. After regaining consciousness, examination revealed upbeating nystagmus, otherwise normal bulbar function, left arm dysmetria, and numbness periorally and in areas she described as "a turtleneck of numbness with a T-shirt...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000436939.70528.03
更新日期:2013-12-03 00:00:00
abstract:OBJECTIVES:To investigate the role of beta oscillations in urinary voiding and their association with lower urinary tract symptoms in Parkinson disease (PD). METHODS:We used surgically implanted deep brain stimulation electrodes to record local field potential signals from the subthalamic nucleus (STN) and globus pall...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005355
更新日期:2018-04-24 00:00:00
abstract:OBJECTIVE:To compare nondemented patients with Parkinson's disease (PD) with and without REM sleep behavior disorder (RBD) to healthy controls on quantitative EEG characteristics for both wakefulness and REM sleep. METHODS:Fifteen patients with PD (7 patients with polysomnographic-confirmed RBD [PD-RBD] and 8 patients...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000106460.34682.e9
更新日期:2004-02-10 00:00:00
abstract::The authors describe the outcome of five patients with a cardiac thrombus selected among 183 patients with stroke (2.7 %) who were given IV tissue plasminogen activator (tPA). No early systemic or cerebral embolism occurred. Two patients made a complete recovery at 3 months. Two patients had a moderate outcome. One pa...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.11.2122
更新日期:2001-12-11 00:00:00
abstract::A veterinarian contracted rabies in the course of laboratory work with homogenates of rabid goat brain. Epidemiologic study determined a respiratory mode of transmission. After a fulminant encephalitic illness, formed rabies virions were identified in the synaptic zones of the olfactory glomeruli. Identification, isol...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.27.1.67
更新日期:1977-01-01 00:00:00
abstract::Previous research has shown that the Mini-Mental State Examination (MMS) is biased as a measure of cognitive impairment in minority and low-education patients. The purpose of this study was to (1) develop a statistical correction for effects of age and education and (2) test the efficacy of the statistically adjusted ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.46.3.700
更新日期:1996-03-01 00:00:00
abstract::A physically and intellectually normally developed boy had a resection of a lumbar myelomeningocele shortly after birth and a shunt was inserted for hydrocephalus. He died at age 12 years after a traffic accident. Autopsy disclosed a hyperplasia of the cerebellar vermis. An abnormal median-sagittal triangular fiber tr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.12.1302
更新日期:1978-12-01 00:00:00
abstract::Clinical, electrodiagnostic, and pathologic studies indicate that the Guillain-Barre syndromes (GBSs) include both primary demyelinating and primary axonal forms. The axonal forms are usually thought to have a poorer prognosis, with less chance for rapid or complete recovery. In northern China, epidemics of one axonal...
journal_title:Neurology
pub_type: 评论,杂志文章
doi:10.1212/wnl.48.3.695
更新日期:1997-03-01 00:00:00
abstract::The authors describe diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) changes in the hippocampus within 48 hours of acute symptomatic seizures or status epilepticus in 12 patients. DWI showed increased signal and a decreased apparent diffusion coefficient (ADC) in all patients, with correspon...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/01.wnl.0000218207.18707.f4
更新日期:2006-06-13 00:00:00
abstract::The authors examined the neural function of a postmeningitic deaf-blind patient who regained his hearing with a multichannel cochlear implant. Auditory stimuli activated the temporal cortices of both sides in a manner similar to that of controls, reflecting the successful recruitment of the auditory cortex after impla...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000234141.72891.13
更新日期:2006-09-12 00:00:00
abstract:OBJECTIVE:To determine age- and sex-specific AD prevalence rates for whites using each of four severity-based definitions of a case: a person diagnosed as having at least questionable AD, one diagnosed as having at least mild AD, one diagnosed as having moderate or severe AD, and one diagnosed as having severe AD. MET...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.2.198
更新日期:2000-07-25 00:00:00
abstract:BACKGROUND:Hereditary spastic paraplegia (HSP) are classified clinically as pure when progressive spasticity occurs in isolation or complicated when other neurologic abnormalities are present. At least 22 genetic loci have been linked to HSP, 8 of which are autosomal recessive (ARHSP). HSP complicated with the presence...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000208501.52849.dd
更新日期:2006-04-25 00:00:00
abstract:OBJECTIVE:To define the natural history of the C9orf72 amyotrophic lateral sclerosis (C9ALS) patient population, develop disease biomarkers, and characterize patient pathologies. METHODS:We prospectively collected clinical and demographic data from 116 symptomatic C9ALS and 12 non-amyotrophic lateral sclerosis (ALS) f...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008359
更新日期:2019-10-22 00:00:00
abstract::This study concerns the expression of Met-enkephalin (MEnk) in the striatum and the external segment of the globus pallidus proper (GPe) in normal controls, idiopathic Parkinson's disease (PD), and striatonigral degeneration (SND). For this purpose, we developed a sensitive immunoperoxidase technique to visualize MEnk...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.7.1051
更新日期:1990-07-01 00:00:00
abstract::Creatine monohydrate has been shown to increase strength in studies of young healthy subjects and in a few studies with patients. Creatine monohydrate (10 g daily for 5 days to 5 g daily for 5 days) was administered to patients with neuromuscular disease in a pilot study (Study 1; n = 81), followed by a single-blinded...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.52.4.854
更新日期:1999-03-10 00:00:00
abstract::Coma is rare in temporal arteritis (TA). We describe a patient with TA who suddenly developed coma with a triphasic EEG pattern that resolved after initiation of steroid treatment. Although the arterial lesions in TA are segmental in nature, TA may present with signs of diffuse neurologic deficit; early treatment can ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.2.439
更新日期:1992-02-01 00:00:00