Preoperative factors of apathy in subthalamic stimulated Parkinson disease: a PET study.

Abstract:

OBJECTIVE:The current literature provides discrepant results regarding preoperative sociodemographic and clinical factors, and no information about preoperative cerebral metabolic patterns associated with apathy after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson disease. METHODS:To resolve this issue, we set out to identify preoperative metabolic patterns and sociodemographic and clinical factors associated with increased apathy after STN-DBS. Forty-four patients with Parkinson disease were enrolled in this study. They all underwent STN-DBS. Metabolic activity was assessed with F-18 fluorodeoxyglucose PET 3 months before surgery. Apathy was assessed on the Apathy Evaluation Scale 3 months before and after STN-DBS. We controlled for preoperative age, levodopa therapy, and overall cognitive functions. RESULTS:Increased apathy after STN-DBS was significantly associated with reduced preoperative metabolism within the right ventral striatum. None of the sociodemographic and clinical variables tested were associated with apathy after STN-DBS. CONCLUSIONS:Preoperative PET, but not sociodemographic or clinical factors, is associated with apathy after STN-DBS.

journal_name

Neurology

journal_title

Neurology

authors

Robert GH,Le Jeune F,Lozachmeur C,Drapier S,Dondaine T,Péron J,Houvenaghel JF,Travers D,Sauleau P,Millet B,Vérin M,Drapier D

doi

10.1212/WNL.0000000000000941

subject

Has Abstract

pub_date

2014-10-28 00:00:00

pages

1620-6

issue

18

eissn

0028-3878

issn

1526-632X

pii

WNL.0000000000000941

journal_volume

83

pub_type

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