Abstract:
:We investigated 26 right-handed patients who had aphasia caused by a single infarct in the territory of the left middle cerebral artery (MCA) with cranial CT, positron emission tomography, and a standard language test battery including the Token test. The patients represented an unselected sample of various infarct locations within the left MCA territory and showed a wide range of aphasia types and severity. Stepwise regression analysis revealed that Token test performance mainly depended on parietotemporal metabolism, irrespective of infarct location. Frontal and basal ganglia metabolism did not contribute significantly to Token test performance. These results suggest that disturbance of language comprehension is due to parietotemporal cortical dysfunction in all types of left MCA infarction. Infarcts restricted to basal ganglia or the anterior part of the MCA territory apparently do not disturb language comprehension directly, but via their remote effects on parietotemporal metabolism.
journal_name
Neurologyjournal_title
Neurologyauthors
Karbe H,Herholz K,Szelies B,Pawlik G,Wienhard K,Heiss WDdoi
10.1212/wnl.39.8.1083subject
Has Abstractpub_date
1989-08-01 00:00:00pages
1083-8issue
8eissn
0028-3878issn
1526-632Xjournal_volume
39pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::This study concerns the expression of Met-enkephalin (MEnk) in the striatum and the external segment of the globus pallidus proper (GPe) in normal controls, idiopathic Parkinson's disease (PD), and striatonigral degeneration (SND). For this purpose, we developed a sensitive immunoperoxidase technique to visualize MEnk...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.40.7.1051
更新日期:1990-07-01 00:00:00
abstract::Fourteen patients with Alzheimer's disease were evaluated by psychometric testing, fluorodeoxyglucose positron emission tomography (PET), and EEG. They were divided into two groups according to the EEG findings. Group A (seven patients) had normal alpha backgrounds and group B (seven patients) had decreased alpha back...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.5.747
更新日期:1988-05-01 00:00:00
abstract::Two hypertensive men presented clinically with small, largely unilateral hematomas of the pons and midbrain demonstrated by computerized tomography. Clinical manifestations included "ocular bobbing," complex forms of ophthalmoplegia, Cheyne-Stokes respiration, and pyramidal tract signs. The "typical" sings of massive ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.30.6.652
更新日期:1980-06-01 00:00:00
abstract::We investigated blood-brain barrier (BBB) function in relation to Alzheimer's disease (AD) and vascular dementia (VAD) in the very elderly. Sixty-five 85-year-old persons from a population-based sample were followed for 3 years; 29 were demented at age 85 (13 with AD, 14 with VAD, and 2 with other dementias), 7 develo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.4.966
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVE:To analyze differences in functional brain images collected in patients with type 2 and type 1 narcolepsy compared to normal controls and the relationship among brain images, objective neuropsychologic tests, and sleep findings. METHODS:Data collection included comprehensive clinical investigation, study of ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005346
更新日期:2018-04-24 00:00:00
abstract::About 9% of patients presenting to a Huntington disease (HD) clinic for evaluation of possible HD lacked a family history of the disorder. HD was the final diagnosis in 53 to 83% of these patients. As a group, HD-affected individuals without a family history of HD were older and had fewer CAG repeats than the average ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.47.6.1578
更新日期:1996-12-01 00:00:00
abstract::Outcome after carpal tunnel surgery was studied retrospectively in 32 patients with peripheral neuropathy and carpal tunnel syndrome. Nocturnal paresthesias were almost universally relieved, followed in order of responsiveness by pain, numbness, and weakness. Twenty-five of 28 patients said they would have the surgery...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.4.1159
更新日期:1997-10-01 00:00:00
abstract:OBJECTIVE:To identify independent predictors of clinical or cerebral lesion progression in a large sample of adult patients with moyamoya angiopathy (MMA) prior to decisions regarding revascularization surgery. METHODS:Ninety participants (median age, 37.5 years) were assessed at baseline and followed for a median tim...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007819
更新日期:2019-07-23 00:00:00
abstract::The authors report three patients with acute, chronic, and recurrent neuropathy associated with varicella zoster virus (VZV) infection but without zoster rash. CSF of all three patients contained VZV immunoglobulin G antibody, but not herpes simplex virus. In two patients, serum/CSF ratios of VZV immunoglobulin G were...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.2.351
更新日期:2001-07-24 00:00:00
abstract:OBJECTIVE:To determine whether metformin is associated with a lower incidence of dementia than sulfonylureas. METHODS:This was a retrospective cohort study of US veterans ≥65 years of age with type 2 diabetes who were new users of metformin or a sulfonylurea and had no dementia. Follow-up began after 2 years of therap...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004586
更新日期:2017-10-31 00:00:00
abstract:OBJECTIVE:This study was conducted to determine the relationship of frontal lobe cortical thickness and basal ganglia volumes to measures of cognition in adults with sickle cell anemia (SCA). METHODS:Participants included 120 adults with SCA with no history of neurologic dysfunction and 33 healthy controls (HCs). Part...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000000188
更新日期:2014-03-11 00:00:00
abstract:OBJECTIVE:To determine whether the cytokine tumor necrosis factor alpha (TNF-alpha) acts as a pain mediator in neuropathic pain in humans. BACKGROUND:In animal models, inflammatory cytokines such as TNF-alpha have been shown to facilitate neuropathic pain. METHODS:The expression of TNF-alpha was analyzed immunohistoc...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.10.1371
更新日期:2001-05-22 00:00:00
abstract::Weight loss is common in Alzheimer's disease (AD), but its pathogenesis is poorly understood. It is unclear whether an elevated daily energy expenditure contributes to the weight loss. We tested the hypothesis that daily energy expenditure is higher in AD patients compared to healthy elderly. Thirty AD (73 +/- 8 years...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.4.997
更新日期:1997-04-01 00:00:00
abstract::The authors studied the tolerability of subcutaneous interferon beta-1a (IFNbeta-1a) in 51 patients with early-onset multiple sclerosis. The most frequent systemic adverse effects were flu-like symptoms in 65%. Laboratory abnormalities included asymptomatic leukopenia (27%) and elevated hepatic transaminases (35%). Tr...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000153570.33845.6A
更新日期:2005-03-08 00:00:00
abstract::A patient with classic (type A) Niemann-Pick disease had the usual clinical signs of failure to thrive, hepatosplenomegaly, and intellectual deterioration in the first year of life. In addition, there was striking hypotonia, areflexia, and abnormal nerve conduction velocities. Pathologically, the Schwann cells were fi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.2.107
更新日期:1975-02-01 00:00:00
abstract:BACKGROUND:Semiology is very useful in the diagnosis and classification of seizures. Some clinical signs occur primarily with specific localization-related epilepsies. OBJECTIVE:To evaluate postictal nose-rubbing as a potential diagnostic sign and a potential lateralizing or localizing indicator. METHODS:We reviewed ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.4.743
更新日期:1999-03-10 00:00:00
abstract::As the substantia nigra degenerates in Parkinson's disease (PD), the nigrostriatal pathway is disrupted, reducing striatal dopamine and producing PD symptoms. Although dopamine does not readily cross the blood-brain barrier, its precursor, levodopa, does. Levodopa is absorbed in the small bowel and is rapidly cataboli...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.50.6_suppl_6.s11
更新日期:1998-06-01 00:00:00
abstract:OBJECTIVE:Alzheimer disease (AD) risk factors are present throughout the lifespan. This randomized controlled trial evaluated the effectiveness of various online education strategies concerning AD risk reduction and brain health in younger populations. METHOD:High school and college students were recruited via social ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000009859
更新日期:2020-10-20 00:00:00
abstract::Retarded mental and motor development was observed during the first year of life of a full-term female who had been delivered with difficulty. Generalized psychomotor seizures and dysplastic "acromegalic" facial changes began to develop when she was 8 years old, and generalized amyotrophy developed over the next sever...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.9.869
更新日期:1976-09-01 00:00:00
abstract::A 57-year-old chronically immunosuppressed woman with systemic lupus erythematosus developed fulminant meningoencephalitis due to Acanthamoeba castellanii. Amebic trophozoites were also found in the lungs, suggesting a primary pulmonary focus of infection. This case illustrates that Acanthamoeba can cause a fulminant,...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.2.174
更新日期:1981-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the associations of mild behavioral impairment (MBI) with cognitive deficits and patterns of gray matter changes in Parkinson disease (PD). METHODS:Sixty patients with PD without dementia and 29 healthy controls underwent a cognitive neuropsychological evaluation and structural MRI scan. MBI was ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000007968
更新日期:2019-08-20 00:00:00
abstract::Juvenile-onset dystonia that improves after levodopa may occur in both dopa-responsive dystonia (DRD) and juvenile parkinsonism (JP), clinically similar conditions with different prognoses and management goals. The authors show normal striatal uptake of the dopamine transporter ligand FP-CIT with SPECT in a clinically...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.56.2.266
更新日期:2001-01-23 00:00:00
abstract::The pathologic substrate of essential tremor (ET) remains unknown. The authors studied 10 patients with ET and 10 volunteers using a multislice MR spectroscopy imaging sequence. Left and right cerebellar hemisphere NAA/CR and NAA/Cho ratios were significantly smaller in the ET patients than healthy subjects. The autho...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000065885.15875.0d
更新日期:2003-04-22 00:00:00
abstract:OBJECTIVE:To compare nonadherence to statins in older black and white adults following an ischemic stroke. METHODS:We studied black and white adults ≥66 years of age with Medicare fee-for-service insurance coverage hospitalized for ischemic stroke from 2007 to 2012 who filled a statin prescription within 30 days follo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000003910
更新日期:2017-05-09 00:00:00
abstract::A two-octapeptide repeat deletion of the prion protein gene has been recently observed in a patient with a 2-year history of dementia and a clinical diagnosis of possible Creutzfeldt-Jakob disease (CJD). The authors report a similar deletion in a patient with a definitive diagnosis of CJD. Since the two-repeat deletio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000035533.86833.28
更新日期:2002-11-26 00:00:00
abstract:OBJECTIVE:We sought to determine the association of dietary factors and risk of cognitive decline in a population at high risk of cardiovascular disease. METHODS:Baseline dietary intake and measures of the Mini-Mental State Examination were recorded in 27,860 men and women who were enrolled in 2 international parallel...
journal_title:Neurology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1212/WNL.0000000000001638
更新日期:2015-06-02 00:00:00
abstract:OBJECTIVE:To determine whether cardiac magnetic resonance imaging (CMR) could be useful in identifying previously undiagnosed cardiomyopathies in a cohort of patients with ischemic stroke who underwent standard etiologic investigation and to describe the type and frequency of these cardiomyopathies. METHODS:We perform...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000008698
更新日期:2020-01-07 00:00:00
abstract::A 30-year-old woman was thought to have Friedreich's disease because of progressive ataxia, dysarthria, and titubation from age 3 years. Her diet was normal, and there were neither symptoms nor laboratory evidence of liver disease or fat malabsorption. Serum vitamin E content and the ratio of serum vitamin E to total ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.1.68
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:Previous work has suggested that functional reorganization of cortical motor areas might have a role in limiting the motor deficits in patients with MS. OBJECTIVE:To test whether movement-associated cortical changes in MS might extend beyond the "classic" motor areas and involve sites for multimodal integra...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.58.6.866
更新日期:2002-03-26 00:00:00
abstract::Restless legs syndrome (RLS) is a common neurologic disorder that affects 5 to 10% of the population and increases in prevalence with aging. The clinical hallmarks of RLS include dysesthesias or paresthesias in the legs and sometimes the arms, occurring primarily at rest, which are usually worse in the evening and are...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.58.suppl_1.s87
更新日期:2002-02-26 00:00:00