Abstract:
:Previous research has shown that the Mini-Mental State Examination (MMS) is biased as a measure of cognitive impairment in minority and low-education patients. The purpose of this study was to (1) develop a statistical correction for effects of age and education and (2) test the efficacy of the statistically adjusted MMS (MMSAdj) as a screening test for dementia using different ethnic groups and education levels. We used a population-base community survey sample (n=590) composed of 46.6% Hispanics and 53.4% non-Hispanics to derive the statistical correction, defined as:MMSAdj = Raw MMS - (0.471 X [Education-12]) + (0.131 X [Age-70]). Ethnicity and language of test administration were not significantly related to MMSAdj in the community survey sample, but the raw MMS was strongly influenced by these factors. We used an independent sample (n=2,983) of patients evaluated through the California Alzheimer's Disease Diagnostic and Treatment Centers to test the diagnostic accuracy of the MMS and the MMSAdj across low- and high-education groups and across whites, Hispanics, and blacks. Results showed greater stability of sensitivity and specificity across education levels and ethnic groups for the MMSAdj than for the raw MMS and suggest that the MMSAdj is a preferable measure of cognitive impairment for low- education and minority individuals.
journal_name
Neurologyjournal_title
Neurologyauthors
Mungas D,Marshall SC,Weldon M,Haan M,Reed BRdoi
10.1212/wnl.46.3.700subject
Has Abstractpub_date
1996-03-01 00:00:00pages
700-6issue
3eissn
0028-3878issn
1526-632Xjournal_volume
46pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Eighty-five healthy elderly subjects were prospectively evaluated for 3 years to determine motor differences between those who remain cognitively intact and those who developed cognitive impairment during prospective follow-up. The 18 subjects who developed cognitive impairment had slower finger tapping and took longe...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/wnl.50.5.1496
更新日期:1998-05-01 00:00:00
abstract::We report a patient with rostral hypothalamic damage that significantly disrupted temporal patterning of the sleep-wake cycle, body temperature, and cognitive and behavioral functioning. The findings suggest that the suprachiasmatic region of the hypothalamus is important for the circadian control of human behavior, a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.5.726
更新日期:1991-05-01 00:00:00
abstract::Neurologic disorders are among the most frequent causes of morbidity and mortality in the United States. Moreover, the current shortfall of neurologists is expected to worsen over the coming decade. As a consequence, many patients with neurologic disorders will be treated by physicians and primary care providers witho...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000006716
更新日期:2019-01-22 00:00:00
abstract:OBJECTIVE:Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which these genetic effects are consistent across different populations is unknown. METHODS:Investigators f...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318264e353
更新日期:2012-08-14 00:00:00
abstract:OBJECTIVE:To determine whether there are distinct thalamic regions statistically associated with either contraversive or ipsiversive disturbance of verticality perception measured by subjective visual vertical (SVV). METHODS:We used modern statistical lesion behavior mapping on a sample of 37 stroke patients with isol...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002238
更新日期:2016-01-12 00:00:00
abstract::We developed a scheme using routinely available data to estimate the risk of human immunodeficiency virus (HIV) dementia in HIV-infected persons over time. We performed a longitudinal review of medical records from more than 100 medical facilities in 11 U.S. cities. A total of 19,462 HIV-infected persons without histo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.2.392
更新日期:1998-02-01 00:00:00
abstract:OBJECTIVES:Many patients with traumatic brain injury (TBI) report chronic fatigue, and previous studies showed a potential relationship between sleepiness and fatigue in these patients. Our study first looked at the impact of objective and subjective sleepiness on fatigue in patients with TBI. We then investigated how ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000334753.49193.48
更新日期:2008-11-11 00:00:00
abstract:OBJECTIVES:The Stroke-Thrombolytic Predictive Instrument (Stroke-TPI) predicts the probability of good and bad outcomes with and without recombinant tissue plasminogen activator (rtPA). We sought to rebuild and externally validate a simpler Stroke-TPI to support implementation in routine clinical care. METHODS:Using t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001925
更新日期:2015-09-15 00:00:00
abstract::We compared MRI and CT in a study of 175 patients; 87 infarcts within a week, 40 from 1 to 40 weeks, 25 a year after onset, and 23 hemorrhages, 18 within 2 weeks and 5 in 4 to 8 weeks. Fifty-nine infarcts and eight hemorrhages had sequential scanning. MRI is more sensitive than CT in the early detection of cerebral in...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.37.10.1580
更新日期:1987-10-01 00:00:00
abstract::In patients with cranial dystonia, we compared the effects of central anticholinergic, peripheral anticholinergic, and placebo treatments in a double-blind crossover study. One of the nine patients who completed the study improved markedly with central anticholinergic therapy. The three treatments were indistinguishab...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.34.2.215
更新日期:1984-02-01 00:00:00
abstract::We studied the effect of CSF drainage on cerebral blood flow (CBF) in normal pressure hydrocephalus (NPH) and non-NPH dementia using the 133Xenon inhalation technique. Dementia patients had lower CBF than matched elderly normals. Flow values for NPH and non-NPH patients did not differ before or after CSF drainage. CBF...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.1.96
更新日期:1984-01-01 00:00:00
abstract::Progressive thoracic myelopathy occurred in a patient with AIDS. Concurrent opportunistic infections included disseminated systemic cytomegalovirus, aspergillosis, and cutaneous herpes simplex virus (HSV). At autopsy, immune stains indicated that the myelopathy was caused by HSV type 2 infection of the spinal cord. ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.7.1071
更新日期:1985-07-01 00:00:00
abstract::A 59-year-old woman with levodopa-responsive parkinsonism complicated by motor fluctuations and generalized levodopa dyskinesia underwent bilateral subthalamic deep brain stimulation (STN DBS) 7 years after symptom onset. DBS improved levodopa-responsive upper extremity bradykinesia but aggravated speech, swallowing, ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000073986.74883.36
更新日期:2003-07-22 00:00:00
abstract:BACKGROUND:Semiology is very useful in the diagnosis and classification of seizures. Some clinical signs occur primarily with specific localization-related epilepsies. OBJECTIVE:To evaluate postictal nose-rubbing as a potential diagnostic sign and a potential lateralizing or localizing indicator. METHODS:We reviewed ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.4.743
更新日期:1999-03-10 00:00:00
abstract::The unique case of a baritone with a spinal dural arteriovenous fistula (SDAVF) causing recurrent, acute paraplegia during singing is described. This case underscores the presence of impaired venous drainage in these lesions and the high level of clinical suspicion required for their diagnosis in patients with any mye...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.58.8.1279
更新日期:2002-04-23 00:00:00
abstract::Among 50 patients with phenytoin intoxication, 14 had seizures during the episode. Seizures in 9 of these 14 patients probably resulted from poor seizure control despite high phenytoin levels, but in 5 cases, attacks were attributed to phenytoin toxicity. The only factor that seemed to correlate with seizures was a se...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.12.1769
更新日期:1985-12-01 00:00:00
abstract:OBJECTIVES:We hypothesized that integrated motor-visual functions measured by manipulative manual dexterity are affected by white matter lesion (WML) burden as measured on cranial MRI across relevant brain regions in subjects at risk of preclinical occult vascular disease. METHODS:A real-time cross-sectional study of ...
journal_title:Neurology
pub_type: 杂志文章,随机对照试验
doi:10.1212/WNL.0000000000001557
更新日期:2015-05-12 00:00:00
abstract:OBJECTIVE:To determine possible effects of prolonged marijuana use on the cerebrovascular system during a month of monitored abstinence and to assess how the intensity of current use might have influenced cerebrovascular perfusion in these marijuana users. METHOD:The authors recorded blood flow velocity in the anterio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.WNL.0000150882.69371.DD
更新日期:2005-02-08 00:00:00
abstract:OBJECTIVE:To provide a comprehensive understanding of APOE ε4 effects across the lifespan on the 3 main neuroimaging biomarkers. METHODS:Two hundred seven community-dwelling, cognitively normal APOE ε4 carriers and noncarriers aged 20-87 years were involved in this study. They underwent structural MRI, fluorodeoxygluc...
journal_title:Neurology
pub_type: 临床试验,杂志文章
doi:10.1212/WNL.0000000000003234
更新日期:2016-10-18 00:00:00
abstract:OBJECTIVE:In this study, we compared a cognition-specific computer-based cognitive training program with a motion-controlled computer sports game that is not cognition-specific for their ability to enhance cognitive performance in various cognitive domains in patients with Parkinson disease (PD). METHODS:Patients with...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000287
更新日期:2014-04-08 00:00:00
abstract::Serum ratios of monoclonal immunoglobulin (Ig) to total protein, monoclonal immunoglobulin to albumin, CSF/serum Ig-albumin index, and CSF to serum monoclonal immunoglobulin were obtained in 21 patients with multiple myeloma and 2 with Waldenström's macroglobulinemia. Twelve patients (3 with CNS complications) showed ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.11.1411
更新日期:1983-11-01 00:00:00
abstract:BACKGROUND:Cervical artery dissection is often attributed to an underlying arteriopathy related to a generalized extracellular matrix defect. OBJECTIVE:The authors compared the hemodynamic and morphologic properties of the carotid artery, as assessed noninvasively by ultrasonography, in patients with spontaneous inter...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.5.663
更新日期:2000-09-12 00:00:00
abstract::The intensive study of seizures via serial 24-hour EEG-video monitoring has allowed enhanced observation of sleep patterns among epilepsy patients and has revealed that disturbed rest is common in this population. Previous work has shown that sleep deprivation of any type can exacerbate seizure activity, leading to sp...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:
更新日期:2000-01-01 00:00:00
abstract::To assess the role of current weekly alcohol consumption as a risk factor for cerebral infarction, we administered a pretested questionnaire to 205 middle-aged and elderly acute ischemic stroke patients and 410 outpatient controls matched by age, sex, race, and method of hospital payment. The frequency of hypertension...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.39.3.339
更新日期:1989-03-01 00:00:00
abstract:OBJECTIVES:Despite many neuropsychological studies to differentiate subcortical vascular dementia (SVaD) from Alzheimer disease (AD), previous studies did not eliminate confounding effects of mixed Alzheimer and vascular pathology. We aimed to investigate neuropsychological differences between patients with Pittsburgh ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182815485
更新日期:2013-02-05 00:00:00
abstract:OBJECTIVES:1) To reassess the prevalence of migraine in the United States; 2) to assess patterns of migraine treatment in the population; and 3) to contrast current patterns of preventive treatment use with recommendations for use from an expert headache panel. METHODS:A validated self-administered headache questionna...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000252808.97649.21
更新日期:2007-01-30 00:00:00
abstract:OBJECTIVE:To assess the impact of intracranial arterial stenosis on the progression from mild cognitive impairment (MCI) to Alzheimer disease (AD). METHODS:A total of 423 participants with MCI were included and evaluated with clinical and neuropsychological examinations annually for 4 years. The incidence of dementia ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000000185
更新日期:2014-03-11 00:00:00
abstract::We tested the efficacy of coenzyme Q10 (ubidecarenone, CoQ10) therapy in patients with Kearns-Sayre syndrome and other mitochondrial myopathies with chronic progressive external ophthalmoplegia (CPEO). We treated seven patients for 1 year with daily oral administration of 120 mg of CoQ10. Throughout the treatment most...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.6.892
更新日期:1988-06-01 00:00:00
abstract::Guillain-Barré syndrome (GBS) appeared in four patients 1 to 2 weeks after epidural anesthesia. In all patients, clinical diagnosis was confirmed by CSF findings and nerve conduction velocity studies. Although epidural anesthesia has not been listed as an antecedent event in GBS, evidence for the relationship has been...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.35.10.1473
更新日期:1985-10-01 00:00:00
abstract:OBJECTIVE:It is uncertain whether patients with cardioembolic stroke and without a guidance-based indication for statin therapy should be administered a statin for prevention of subsequent vascular events. This study was performed to determine whether the statin therapy is beneficial in preventing major vascular events...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000009397
更新日期:2020-05-12 00:00:00