Adverse effects of subthalamic nucleus DBS in a patient with multiple system atrophy.

Abstract:

:A 59-year-old woman with levodopa-responsive parkinsonism complicated by motor fluctuations and generalized levodopa dyskinesia underwent bilateral subthalamic deep brain stimulation (STN DBS) 7 years after symptom onset. DBS improved levodopa-responsive upper extremity bradykinesia but aggravated speech, swallowing, and gait. Motor fluctuations were not improved and levodopa dose remained unchanged. Pulse generators were turned off. Clinical features and brain MRI in this case were indicative of multiple system atrophy (MSA). STN DBS is not recommended for patients with MSA.

journal_name

Neurology

journal_title

Neurology

authors

Tarsy D,Apetauerova D,Ryan P,Norregaard T

doi

10.1212/01.wnl.0000073986.74883.36

subject

Has Abstract

pub_date

2003-07-22 00:00:00

pages

247-9

issue

2

eissn

0028-3878

issn

1526-632X

journal_volume

61

pub_type

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