Incidence of seizures with phenytoin toxicity.

Abstract:

:Among 50 patients with phenytoin intoxication, 14 had seizures during the episode. Seizures in 9 of these 14 patients probably resulted from poor seizure control despite high phenytoin levels, but in 5 cases, attacks were attributed to phenytoin toxicity. The only factor that seemed to correlate with seizures was a serum phenytoin level over 30 micrograms/ml. No demographic, metabolic, neuropsychiatric, or therapeutic variables were predictive; nor were any other symptoms of toxicity particularly likely to be found in association with seizures. Seizures are an occasional manifestation of phenytoin toxicity, particularly when levels are high.

journal_name

Neurology

journal_title

Neurology

authors

Stilman N,Masdeu JC

doi

10.1212/wnl.35.12.1769

subject

Has Abstract

pub_date

1985-12-01 00:00:00

pages

1769-72

issue

12

eissn

0028-3878

issn

1526-632X

journal_volume

35

pub_type

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