Incidence of seizures with phenytoin toxicity.


:Among 50 patients with phenytoin intoxication, 14 had seizures during the episode. Seizures in 9 of these 14 patients probably resulted from poor seizure control despite high phenytoin levels, but in 5 cases, attacks were attributed to phenytoin toxicity. The only factor that seemed to correlate with seizures was a serum phenytoin level over 30 micrograms/ml. No demographic, metabolic, neuropsychiatric, or therapeutic variables were predictive; nor were any other symptoms of toxicity particularly likely to be found in association with seizures. Seizures are an occasional manifestation of phenytoin toxicity, particularly when levels are high.






Stilman N,Masdeu JC




Has Abstract


1985-12-01 00:00:00












  • Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment.

    abstract:OBJECTIVE:Recent studies have suggested modifications of serotonin cerebral metabolism and of 5-HT(1A) receptors density in Alzheimer disease (AD). This study aims at exploring hippocampus 5-HT(1A) receptor density in patients at the amnesic mild cognitive impairment (aMCI) and mild AD dementia stages. METHODS:With us...


    pub_type: 杂志文章


    authors: Truchot L,Costes SN,Zimmer L,Laurent B,Le Bars D,Thomas-Antérion C,Croisile B,Mercier B,Hermier M,Vighetto A,Krolak-Salmon P

    更新日期:2007-09-04 00:00:00

  • Association between waking EEG slowing and REM sleep behavior disorder in PD without dementia.

    abstract:OBJECTIVE:To compare nondemented patients with Parkinson's disease (PD) with and without REM sleep behavior disorder (RBD) to healthy controls on quantitative EEG characteristics for both wakefulness and REM sleep. METHODS:Fifteen patients with PD (7 patients with polysomnographic-confirmed RBD [PD-RBD] and 8 patients...


    pub_type: 杂志文章


    authors: Gagnon JF,Fantini ML,Bédard MA,Petit D,Carrier J,Rompré S,Décary A,Panisset M,Montplaisir J

    更新日期:2004-02-10 00:00:00

  • Pilot trial of IOM duty hour recommendations in neurology residency programs: unintended consequences.

    abstract:OBJECTIVE:To study the potential effect of the 2008 Institute of Medicine (IOM) work duty hour (WDH) recommendations on neurology residency programs. METHODS:This study evaluated resident sleepiness, personal study hours, quality of life, and satisfaction and faculty satisfaction during a control month using the Accre...


    pub_type: 杂志文章


    authors: Schuh LA,Khan MA,Harle H,Southerland AM,Hicks WJ,Falchook A,Schultz L,Finney GR

    更新日期:2011-08-30 00:00:00

  • Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism.

    abstract::The association of the STH gene polymorphism with Alzheimer disease (AD) is debated. In the analysis of two genetically and diagnostically distinct groups of Alzheimer patients from the USA and Italy, the authors did not find an association with the STH polymorphism. However, the APOE-4-associated risk of AD greatly i...


    pub_type: 杂志文章


    authors: Seripa D,Matera MG,D'Andrea RP,Gravina C,Masullo C,Daniele A,Bizzarro A,Rinaldi M,Antuono P,Wekstein DR,Dal Forno G,Fazio VM

    更新日期:2004-05-11 00:00:00

  • Droxidopa for neurogenic orthostatic hypotension: a randomized, placebo-controlled, phase 3 trial.

    abstract:OBJECTIVE:To determine whether droxidopa, an oral norepinephrine precursor, improves symptomatic neurogenic orthostatic hypotension (nOH). METHODS:Patients with symptomatic nOH due to Parkinson disease, multiple system atrophy, pure autonomic failure, or nondiabetic autonomic neuropathy underwent open-label droxidopa ...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kaufmann H,Freeman R,Biaggioni I,Low P,Pedder S,Hewitt LA,Mauney J,Feirtag M,Mathias CJ,NOH301 Investigators.

    更新日期:2014-07-22 00:00:00

  • Striatocapsular infarction: large infarcts in the lenticulostriate arterial territory.

    abstract::A specific form of deep cerebral hemisphere infarction was identified in 11 of 1,600 stroke register patients. Despite the CT finding of a deep striatocapsular lesion, these patients showed evidence of both cortical and capsular abnormalities. Angiography showed significant proximal carotid artery lesions as well as e...


    pub_type: 杂志文章


    authors: Bladin PF,Berkovic SF

    更新日期:1984-11-01 00:00:00

  • Mononeuropathy multiplex as a complication of amphetamine angiitis.

    abstract::A patient who abused multiple drugs developed a rapidly progressive mononeuropathy multiplex, which appeared to respond to corticosteroid therapy with partial resolution. Intravenous methamphetamine had been used almost exclusively from the fourth month prior to the onset of symptoms. Biopsy material revealed a necrot...


    pub_type: 杂志文章


    authors: Stafford CR,Bogdanoff BM,Green L,Spector HB

    更新日期:1975-06-01 00:00:00

  • New NBIA subtype: genetic, clinical, pathologic, and radiographic features of MPAN.

    abstract:OBJECTIVE:To assess the frequency of mutations in C19orf12 in the greater neurodegeneration with brain iron accumulation (NBIA) population and further characterize the associated phenotype. METHODS:Samples from 161 individuals with idiopathic NBIA were screened, and C19orf12 mutations were identified in 23 subjects. D...


    pub_type: 杂志文章


    authors: Hogarth P,Gregory A,Kruer MC,Sanford L,Wagoner W,Natowicz MR,Egel RT,Subramony SH,Goldman JG,Berry-Kravis E,Foulds NC,Hammans SR,Desguerre I,Rodriguez D,Wilson C,Diedrich A,Green S,Tran H,Reese L,Woltjer RL,Hayfli

    更新日期:2013-01-15 00:00:00

  • Striatal D2 receptors in symptomatic and asymptomatic carriers of dopa-responsive dystonia measured with [11C]-raclopride and positron-emission tomography.

    abstract::We tested the hypothesis that asymptomatic carriers of dopa-responsive dystonia (DRD) have increased dopamine D2 receptors in the striatum that protect them from the clinical manifestations of dopaminergic deficiency. We examined striatal D2-receptor binding in (1) symptomatic subjects (treated and untreated) and (2) ...


    pub_type: 杂志文章


    authors: Kishore A,Nygaard TG,de la Fuente-Fernandez R,Naini AB,Schulzer M,Mak E,Ruth TJ,Calne DB,Snow BJ,Stoessl AJ

    更新日期:1998-04-01 00:00:00

  • Norming plans for the NIH Toolbox.

    abstract:OBJECTIVE:The NIH Toolbox for Assessment of Neurological and Behavioral Function (NIH Toolbox) is a comprehensive battery of brief assessment tools. The purpose of this article is to describe plans to establish normative reference values for the NIH Toolbox measures. METHODS:A large sample will be obtained from the US...


    pub_type: 杂志文章


    authors: Beaumont JL,Havlik R,Cook KF,Hays RD,Wallner-Allen K,Korper SP,Lai JS,Nord C,Zill N,Choi S,Yost KJ,Ustsinovich V,Brouwers P,Hoffman HJ,Gershon R

    更新日期:2013-03-12 00:00:00

  • Head trauma preceding PD: a case-control study.

    abstract:OBJECTIVE:To investigate the association of PD with preceding head trauma using a case-control study design. METHODS:The medical records-linkage system of the Rochester Epidemiology Project was used to identify 196 subjects who developed PD in Olmsted County, MN, from 1976 through 1995. Each incident case was matched ...


    pub_type: 杂志文章,评审


    authors: Bower JH,Maraganore DM,Peterson BJ,McDonnell SK,Ahlskog JE,Rocca WA

    更新日期:2003-05-27 00:00:00

  • Transcranial Doppler in brain death.

    abstract::Transcranial Doppler examinations (TCD) of 24 brain-dead adult patients demonstrated persistent movement of blood within the middle cerebral arteries in 21. The characteristic pattern of Doppler shift frequencies, seen in 14, was a sharply contoured, brief anterograde systolic envelope with reversed diastolic flow. Fi...


    pub_type: 杂志文章


    authors: Ropper AH,Kehne SM,Wechsler L

    更新日期:1987-11-01 00:00:00

  • Delayed psychosis after right temporoparietal stroke or trauma: relation to epilepsy.

    abstract::We observed acute onset of delayed psychosis in 8 patients 1 month to 11 years after right temporoparietooccipital (TPO) stroke or trauma. The psychotic disorder included hallucinations and, in some patients delusions and agitation. All patients had spatioconstructional difficulties. None had an earlier psychiatric di...


    pub_type: 杂志文章


    authors: Levine DN,Finklestein S

    更新日期:1982-03-01 00:00:00

  • A PET study of photophobia during spontaneous migraine attacks.

    abstract:BACKGROUND:Photophobia is an abnormal sensitivity to light experienced by migraineurs during attacks. The pathophysiology of photophobia is poorly understood. Nevertheless, 2 facts appear to have a link with photophobia: visual cortex hyperexcitability on the one hand and interactions between visual pathway and trigemi...


    pub_type: 杂志文章


    authors: Denuelle M,Boulloche N,Payoux P,Fabre N,Trotter Y,Géraud G

    更新日期:2011-01-18 00:00:00

  • Neuronal hyperexcitability in stroke-like episodes of MELAS syndrome.

    abstract:BACKGROUND:The pathogenesis of stroke-like episodes in patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) remains unknown. METHODS:Fourteen stroke-like episodes in six patients with MELAS were studied using clinical, neuroradiologic, and electrophysiologic approaches...


    pub_type: 杂志文章


    authors: Iizuka T,Sakai F,Suzuki N,Hata T,Tsukahara S,Fukuda M,Takiyama Y

    更新日期:2002-09-24 00:00:00

  • The nigrostriatal dopaminergic system in familial early onset parkinsonism with parkin mutations.

    abstract::Nigrostriatal dopaminergic function and cerebral energy metabolism were measured with PET in two brothers with early-onset parkinsonism caused by mutation of the parkin gene. Energy metabolism did not differ, but the nigrostriatal dopaminergic pattern was clearly different than that of sporadic PD. Thus parkinsonism i...


    pub_type: 杂志文章


    authors: Portman AT,Giladi N,Leenders KL,Maguire P,Veenma-van der Duin L,Swart J,Pruim J,Simon ES,Hassin-Baer S,Korczyn AD

    更新日期:2001-06-26 00:00:00

  • A novel locus for hereditary spastic paraplegia with thin corpus callosum and epilepsy.

    abstract:BACKGROUND:Hereditary spastic paraplegia (HSP) are classified clinically as pure when progressive spasticity occurs in isolation or complicated when other neurologic abnormalities are present. At least 22 genetic loci have been linked to HSP, 8 of which are autosomal recessive (ARHSP). HSP complicated with the presence...


    pub_type: 杂志文章


    authors: Al-Yahyaee S,Al-Gazali LI,De Jonghe P,Al-Barwany H,Al-Kindi M,De Vriendt E,Chand P,Koul R,Jacob PC,Gururaj A,Sztriha L,Parrado A,Van Broeckhoven C,Bayoumi RA

    更新日期:2006-04-25 00:00:00

  • Development and initial validation of a screening tool for Parkinson disease surgical candidates.

    abstract::As there is currently no standardized assessment tool for evaluating Parkinson disease (PD) patients for deep brain stimulation (DBS), the authors developed the Florida Surgical Questionnaire for Parkinson Disease (FLASQ-PD). Part I of the study was a retrospective analysis of 174 patients presenting for a surgical sc...


    pub_type: 杂志文章,多中心研究


    authors: Okun MS,Fernandez HH,Pedraza O,Misra M,Lyons KE,Pahwa R,Tarsy D,Scollins L,Corapi K,Friehs GM,Grace J,Romrell J,Foote KD

    更新日期:2004-07-13 00:00:00

  • A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group.

    abstract::The efficacy and safety of donepezil as a treatment for patients with mild to moderate Alzheimer's disease (AD) was investigated in a multicenter, double-blind study. Patients were randomly assigned to treatment with placebo (n = 162), 5 mg/d donepezil (n = 154), or 10 mg/d donepezil (n = 157) for 24 weeks followed by...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Rogers SL,Farlow MR,Doody RS,Mohs R,Friedhoff LT

    更新日期:1998-01-01 00:00:00

  • Fetal akinesia deformation sequence (Pena-Shokeir phenotype) associated with acquired intrauterine brain damage.

    abstract::An infant with Pena-Shokeir phenotype was born to a cocaine-using mother. The pathologic findings included polyhydramnios, facial anomalies, arthrogryposis, camptodactyly, pulmonary hypoplasia, and tetralogy of Fallot. The neuropathologic findings were diffuse brainstem and spinal cord neuronal degeneration and focal ...


    pub_type: 杂志文章


    authors: Lavi E,Montone KT,Rorke LB,Kliman HJ

    更新日期:1991-09-01 00:00:00

  • Subacute sclerosing panencephalitis: clinical and immunologic study of 23 patients.

    abstract::Lymphocyte subpopulations ("active' T cells, total T cells, and B cells), leukocyte migration, lymphocyte transformation, complements (CH50, C3, and C4), and immune complexes in serum and cerebrospinal fluid were studied in 23 patients with subacute sclerosing panencephalitis. The percentage of active T cells was norm...


    pub_type: 杂志文章


    authors: Derakhshan I,Massoud A,Foroozanfar N,Nikbin B,Lotfi J,Shakib N,Ala F

    更新日期:1981-02-01 00:00:00

  • Infantile spasms: outcome and prognostic factors of cryptogenic and symptomatic groups.

    abstract::We reviewed the outcome (developmental, neurologic, and seizure) and prognostic factors of 57 cases of infantile spasms (17 cryptogenic, 40 symptomatic). The mean developmental score of the cryptogenic group (71.2 +/- 24.2) was significantly higher than that of the symptomatic group (48.4 +/- 24.5), as assessed by the...


    pub_type: 杂志文章


    authors: Koo B,Hwang PA,Logan WJ

    更新日期:1993-11-01 00:00:00

  • Phenobarbital and phenytoin in neonatal seizures: metabolism and tissue distribution.

    abstract::Loading doses of 15 to 20 mg per kilogram of both phenobarbital and phenytoin, administered intravenously, are necessary in the newborn to achieve rapid therapeutic plasma anticonvulsant levels. Maintenance doses of 3 to 4 mg per kilogram of both agents will maintain therapeutic levels. Phenytoin is, however, not pred...


    pub_type: 杂志文章


    authors: Painter MJ,Pippenger C,Wasterlain C,Barmada M,Pitlick W,Carter G,Abern S

    更新日期:1981-09-01 00:00:00

  • Neurologic complications of influenza A(H1N1)pdm09: surveillance in 6 pediatric hospitals.

    abstract:OBJECTIVE:We sought to determine the range and extent of neurologic complications due to pandemic influenza A (H1N1) 2009 infection (pH1N1'09) in children hospitalized with influenza. METHODS:Active hospital-based surveillance in 6 Australian tertiary pediatric referral centers between June 1 and September 30, 2009, f...


    pub_type: 杂志文章,多中心研究


    authors: Khandaker G,Zurynski Y,Buttery J,Marshall H,Richmond PC,Dale RC,Royle J,Gold M,Snelling T,Whitehead B,Jones C,Heron L,McCaskill M,Macartney K,Elliott EJ,Booy R

    更新日期:2012-10-02 00:00:00

  • Immunocytochemical analysis of the cellular infiltrate in brain lesions in subacute sclerosing panencephalitis.

    abstract::We studied lymphocyte subsets and major histocompatibility complex (MHC) class II antigens in frozen brain tissues from three patients with subacute sclerosing panencephalitis (SSPE) using immunocytochemical techniques. Perivascular cuffs consisted predominantly of T cells and MHC class II-positive cells. In the paren...


    pub_type: 杂志文章


    authors: Nagano I,Nakamura S,Yoshioka M,Kogure K

    更新日期:1991-10-01 00:00:00

  • Diagnosis and misdiagnosis of adult neuronal ceroid lipofuscinosis (Kufs disease).

    abstract:OBJECTIVE:To critically re-evaluate cases diagnosed as adult neuronal ceroid lipofuscinosis (ANCL) in order to aid clinicopathologic diagnosis as a route to further gene discovery. METHODS:Through establishment of an international consortium we pooled 47 unsolved cases regarded by referring centers as ANCL. Clinical a...


    pub_type: 杂志文章


    authors: Berkovic SF,Staropoli JF,Carpenter S,Oliver KL,Kmoch S,Anderson GW,Damiano JA,Hildebrand MS,Sims KB,Cotman SL,Bahlo M,Smith KR,Cadieux-Dion M,Cossette P,Jedličková I,Přistoupilová A,Mole SE,ANCL Gene Discovery Consortiu

    更新日期:2016-08-09 00:00:00

  • Regional cortical thinning in preclinical Huntington disease and its relationship to cognition.

    abstract::The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occu...


    pub_type: 杂志文章


    authors: Rosas HD,Hevelone ND,Zaleta AK,Greve DN,Salat DH,Fischl B

    更新日期:2005-09-13 00:00:00

  • Depression in patients with early versus late onset of Parkinson's disease.

    abstract::We examined correlates of depression in patients whose onset of Parkinson's disease (PD) began before age 55 (early-onset group) compared with patients whose onset was after age 55 (late-onset group). The early-onset group showed a significantly higher frequency of depression than the late-onset group. When both group...


    pub_type: 杂志文章


    authors: Starkstein SE,Berthier ML,Bolduc PL,Preziosi TJ,Robinson RG

    更新日期:1989-11-01 00:00:00

  • Cerebral small-vessel disease and progression of brain atrophy: the SMART-MR study.

    abstract:OBJECTIVES:To investigate whether severity and progression of periventricular and deep white matter lesions (WML) and lacunar infarcts were associated with progression of brain atrophy. METHODS:Within the SMART-MR study, a prospective cohort on MRI changes in patients with symptomatic atherosclerotic disease, 565 pati...


    pub_type: 杂志文章


    authors: Kloppenborg RP,Nederkoorn PJ,Grool AM,Vincken KL,Mali WP,Vermeulen M,van der Graaf Y,Geerlings MI,SMART Study Group.

    更新日期:2012-11-13 00:00:00

  • Aquaporin-4 and MOG autoantibody discovery in idiopathic transverse myelitis epidemiology.

    abstract:OBJECTIVE:Diagnostic criteria from 2002 classify transverse myelitis (TM) as idiopathic or disease associated but predate the discovery of aquaporin-4 (AQP4)-immunoglobulin G (IgG) and myelin oligodendrocyte glycoprotein (MOG)-IgG, which associate with TM. Prior incidence estimates of idiopathic TM (ITM) range from 1 t...


    pub_type: 杂志文章


    authors: Sechi E,Shosha E,Williams JP,Pittock SJ,Weinshenker BG,Keegan BM,Zalewski NL,Lopez-Chiriboga AS,Jitprapaikulsan J,Flanagan EP

    更新日期:2019-07-23 00:00:00