Differences in cognitive impairment of relapsing remitting, secondary, and primary progressive MS.

abstract：:We report the clinical and pathologic features of a patient with peripheral neuropathy that was the first clinical expression of cholesterol emboli syndrome (CES). Biopsy of skeletal muscle and peripheral nerve revealed cholesterol clefts in lumens of small arteries, necrotizing arteritis, and severe degeneration of p...

journal_title：Neurology

authors： Bendixen BH,Younger DS,Hair LS,Gutierrez C,Meyers ML,Homma S,Jaffe IA

更新日期：1992-02-01 00:00:00

abstract：:We report the treatment of four patients with inclusion-body myositis (IBM) and severe slowly progressive weakness using high-dose intravenous immunoglobulin (IVIg). After two monthly infusions, the strength of the proximal and less atrophic muscle groups improved or normalized in three of the four patients. The impro...

journal_title：Neurology

authors： Soueidan SA,Dalakas MC

更新日期：1993-05-01 00:00:00

abstract：:We report two conjugal cases of amyotrophic lateral sclerosis (ALS) occurring between 1977 and 1991 in southern France (Languedoc-Roussillon). Although conjugal ALS may occur by chance, the description of two cases in the same area points to a role of environmental or genetic factors in the etiology of the disease. ...

journal_title：Neurology

authors： Camu W,Cadilhac J,Billiard M

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between visual hallucinations in Parkinson disease (PD) and levels of γ-aminobutyric acid (GABA) in the primary visual cortex. METHODS:We utilized magnetic resonance spectroscopy to investigate occipital GABA levels in 36 participants with PD, 19 with and 17 without complex vi...

journal_title：Neurology

authors： Firbank MJ,Parikh J,Murphy N,Killen A,Allan CL,Collerton D,Blamire AM,Taylor JP

更新日期：2018-08-14 00:00:00

abstract：:Estrogen have been reported in animal studies to both enhance and block central dopaminergic activity and in one clinical report to improve tardive dyskinesia. In the present study estrogen (Premarin, 2.5 mg per day) administration caused varying degrees of improvement in less than one-third of 21 patients with chorea...

journal_title：Neurology

authors： Koller WC,Barr A,Biary N

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVE:To characterize the prevalence and prognostic significance of major driver molecular alterations in adult midline diffuse gliomas (MLG). METHODS:Adults with histologically proven MLG diagnosed between 1996 and 2017 were identified from our tumor bank, systematically reviewed, and reclassified according to WH...

journal_title：Neurology

authors： Picca A,Berzero G,Bielle F,Touat M,Savatovsky J,Polivka M,Trisolini E,Meunier S,Schmitt Y,Idbaih A,Hoang-Xuan K,Delattre JY,Mokhtari K,Di Stefano AL,Sanson M

更新日期：2018-06-05 00:00:00

abstract：INTRODUCTION:As clinical trials move toward earlier intervention, we sought to redefine the β-amyloid (Aβ)-PET threshold based on the lowest point in a baseline distribution that robustly predicts future Aβ accumulation and cognitive decline in 3 independent samples of clinically normal individuals. METHODS:Sequential...

journal_title：Neurology

authors： Farrell ME,Jiang S,Schultz AP,Properzi MJ,Price JC,Becker JA,Jacobs HIL,Hanseeuw BJ,Rentz DM,Villemagne VL,Papp KV,Mormino EC,Betensky RA,Johnson KA,Sperling RA,Buckley RF,Alzheimer's Disease Neuroimaging Initiative and t

更新日期：2021-01-26 00:00:00

abstract：OBJECTIVE:To assess the effect of usage of three different versions of Creutzfeldt-Jakob disease (CJD) diagnostic criteria on estimates of CJD incidence. METHODS:A total of 428 patients referred for suspected sporadic CJD between 1991 and 1997 were classified according to different criteria to be compared after analys...

journal_title：Neurology

authors： Brandel JP,Delasnerie-Lauprêtre N,Laplanche JL,Hauw JJ,Alpérovitch A

更新日期：2000-03-14 00:00:00

abstract：:Extracranial and intracranial angioplasty and stenting of the cerebral vessels are being performed more frequently. One clinical trial demonstrated equivalent outcomes between extracranial carotid angioplasty and carotid endarterectomy, but the results in both groups were suboptimal. Concerns remain about the iatrogen...

journal_title：Neurology

authors： Chaturvedi S,Fessler R

更新日期：2002-09-10 00:00:00

abstract：OBJECTIVE:To determine serial MRI and CT abnormalities around calcified cysts due to cysticercosis in previously treated patients during periods of seizure activity. BACKGROUND:Some patients with calcified lesions due to cysticercosis have seizures. How and why seizures occur in this setting are unknown. METHODS:Thre...

journal_title：Neurology

authors： Nash TE,Patronas NJ

更新日期：1999-09-11 00:00:00

abstract：:Cisternography and ventriculography were performed in five normal anesthetized dogs to study the dynamics of tracer dispersal. Indium 111-diethylenetriaminepentaacetic acid was injected into lateral ventricles, cisterna magna, thoracic subarachnoid space, and lumbar sac. The patterns of dispersal from each injection s...

journal_title：Neurology

authors： Schossberger PF,Touya JJ

更新日期：1976-03-01 00:00:00

abstract：:The authors conducted a randomized, double-blind, placebo-controlled, twofold crossover study in 16 patients with MS who presented with severe spasticity to investigate safety, tolerability, and efficacy of oral Delta(9)-Tetrahydrocannabinol (THC) and Cannabis sativa plant extract. Both drugs were safe, but adverse ev...

journal_title：Neurology

authors： Killestein J,Hoogervorst EL,Reif M,Kalkers NF,Van Loenen AC,Staats PG,Gorter RW,Uitdehaag BM,Polman CH

更新日期：2002-05-14 00:00:00

abstract：OBJECTIVE:To determine the risk of seizure recurrence after a first seizure due to neurocysticercosis (NC) and to evaluate risk factors for seizure recurrence, including the influence of antihelminthic treatment. METHODS:The authors prospectively followed 77 patients with a first seizure and active or transitional NC ...

journal_title：Neurology

authors： Carpio A,Hauser WA

更新日期：2002-12-10 00:00:00

abstract：:Regional cerebral glucose metabolism was studied in 16 patients with idiopathic torticollis, using positron emission tomography. Analysis of subcortical regions revealed no consistent focal abnormality of cerebral metabolic rate for glucose, but there was a bilateral breakdown of the normal relationships between the t...

journal_title：Neurology

authors： Stoessl AJ,Martin WR,Clark C,Adam MJ,Ammann W,Beckman JH,Bergstrom M,Harrop R,Rogers JG,Ruth TJ

更新日期：1986-05-01 00:00:00

abstract：:Some epilepsy patients quickly develop resistance to antiepileptic drugs (AEDs). We report a case of a patient with refractory epilepsy with daily seizures who initially responded to levetiracetam daily therapy, but then returned to baseline seizure frequency. However, when levetiracetam was given once weekly, the pat...

journal_title：Neurology

authors： Friedman D,French JA

更新日期：2006-02-28 00:00:00

abstract：:We used a nested polymerase chain reaction assay to quantitate the number of viral copies in cells of CSF of eight patients with herpes simplex virus encephalitis (HSVE). The viral load was monitored in serial CSF samples during the course of disease and correlated to clinical symptoms, radiologic manifestations, effi...

journal_title：Neurology

authors： Wildemann B,Ehrhart K,Storch-Hagenlocher B,Meyding-Lamadé U,Steinvorth S,Hacke W,Haas J

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:To apply the ATN scheme to memory clinic patients, to assess whether it discriminates patient populations with specific features. METHODS:We included 305 memory clinic patients (33% subjective cognitive decline [SCD]: 60 ± 9 years, 61% M; 19% mild cognitive impairment [MCI]: 68 ± 9 years, 68% M; 48% dementia...

journal_title：Neurology

authors： Altomare D,de Wilde A,Ossenkoppele R,Pelkmans W,Bouwman F,Groot C,van Maurik I,Zwan M,Yaqub M,Barkhof F,van Berckel BN,Teunissen CE,Frisoni GB,Scheltens P,van der Flier WM

更新日期：2019-10-22 00:00:00

abstract：OBJECTIVE:To evaluate the effectiveness of yoga as an adjuvant to conventional medical management on clinical outcomes in patients with migraine. METHODS:CONTAIN was a prospective, randomized, open-label superiority trial with blinded endpoint assessment carried out at a single tertiary care academic hospital in New D...

journal_title：Neurology

authors： Kumar A,Bhatia R,Sharma G,Dhanlika D,Vishnubhatla S,Singh RK,Dash D,Tripathi M,Srivastava MVP

更新日期：2020-05-26 00:00:00

abstract：OBJECTIVE:To determine the minimum incidence and minimum prevalence rates of small-fiber neuropathy (SFN) in a well-defined region in the southern part of the Netherlands. METHODS:In this cross-sectional study with retrospective data collection, we used data of patients diagnosed with pure SFN at our Small Fiber Neuro...

journal_title：Neurology

authors： Peters MJ,Bakkers M,Merkies IS,Hoeijmakers JG,van Raak EP,Faber CG

更新日期：2013-10-08 00:00:00

abstract：OBJECTIVE:To assess the clinical relevance of a positive voltage-gated potassium channel (VGKC) test in patients lacking antibodies to LGI1 and Caspr2. METHODS:VGKC-positive patients were tested for LGI1 and Caspr2 antibodies. Patients lacking both antibodies were matched (1:2) to VGKC-negative patients. Clinical and ...

journal_title：Neurology

authors： van Sonderen A,Schreurs MW,de Bruijn MA,Boukhrissi S,Nagtzaam MM,Hulsenboom ES,Enting RH,Thijs RD,Wirtz PW,Sillevis Smitt PA,Titulaer MJ

更新日期：2016-05-03 00:00:00

abstract：OBJECTIVE:To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP). BACKGROUND:LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases, especially AD. METHOD:The authors evaluated the brains of 72 consecutive cases of pathologically conf...

journal_title：Neurology

authors： Tsuboi Y,Ahlskog JE,Apaydin H,Parisi JE,Dickson DW

更新日期：2001-11-13 00:00:00

abstract：OBJECTIVE:We performed propensity score (PS) models to compare the outcome of patients with myasthenia gravis (MG) submitted to 2 different surgical approaches: extended transsternal (T-3b) or thoracoscopic extended thymectomy (VATET). METHODS:Patients' clinical data were retrieved from the MG database of the C. Besta...

journal_title：Neurology

authors： Brenna G,Antozzi C,Montomoli C,Baggi F,Mantegazza R,INCB-MG Group.

更新日期：2017-07-11 00:00:00

abstract：:This update to the American Academy of Neurology's 1998 position statement endeavors to provide guidance for the consistent ethical conduct and review of neurologic research involving human participants. It does so by outlining a widely used ethical framework of 7 principles derived from the foundational documents of ...

journal_title：Neurology

authors： Tolchin B,Conwit R,Epstein LG,Russell JA,Ethics, Law, and Humanities Committee, a joint committee of the American Academy of Neurology, American Neurological Association, and Child Neurology Society.

更新日期：2020-04-14 00:00:00

abstract：:Two hypertensive men presented clinically with small, largely unilateral hematomas of the pons and midbrain demonstrated by computerized tomography. Clinical manifestations included "ocular bobbing," complex forms of ophthalmoplegia, Cheyne-Stokes respiration, and pyramidal tract signs. The "typical" sings of massive ...

journal_title：Neurology

authors： Kase CS,Maulsby GO,Mohr JP

更新日期：1980-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to apply the HIV-associated neurocognitive disorders (HAND) criteria for diagnosing HAND in HIV-infected adults, in a cohort of HIV-infected youth to thus establish whether this system is able to detect a spectrum of neurocognitive disorders (ND) in HIV-infected youth. METHODS:We us...

journal_title：Neurology

authors： Hoare J,Phillips N,Joska JA,Paul R,Donald KA,Stein DJ,Thomas KG

更新日期：2016-07-05 00:00:00

abstract：:The prevalence of spontaneous lingual-facial-buccal movements was determined in 661 patients between the ages of 50 and 79 without neuroleptic exposure or known CNS disease. The prevalence was 0.8% between ages 50 and 59, 6% between ages 60 and 69, and 7.8% between ages 70 and 79. ...

journal_title：Neurology

authors： Klawans HL,Barr A

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to identify risk factors for rupture of unruptured cerebral aneurysms (UCAs) in elderly Japanese patients aged 70 years or older. METHODS:The participants included all patients 70 years of age or older in 3 prospective studies in Japan (the Unruptured Cerebral Aneurysm Study of Jap...

journal_title：Neurology

authors： Hishikawa T,Date I,Tokunaga K,Tominari S,Nozaki K,Shiokawa Y,Houkin K,Murayama Y,Ishibashi T,Takao H,Kimura T,Nakayama T,Morita A,For UCAS Japan and UCAS II Investigators.

更新日期：2015-11-24 00:00:00

abstract：OBJECTIVE:To perform a single-center pilot investigation of early hematoma removal in patients with intracerebral hemorrhage (ICH). BACKGROUND:Considerable debate remains regarding the utility of surgical clot evacuation for ICH. METHODS:This was a prospective trial of open craniotomy within 12 hours of ICH symptom o...

journal_title：Neurology

authors： Morgenstern LB,Frankowski RF,Shedden P,Pasteur W,Grotta JC

更新日期：1998-11-01 00:00:00

abstract：BACKGROUND:Patients with carnitine palmitoyltransferase II (CPT II) deficiency often experience muscle pain and myoglobinuria during prolonged exercise because of impaired oxidation of long-chain fatty acids. OBJECTIVE:To investigate whether IV or oral glucose can improve exercise tolerance in CPT II deficiency. METH...

journal_title：Neurology

authors： Ørngreen MC,Olsen DB,Vissing J

更新日期：2002-10-08 00:00:00

abstract：OBJECTIVE:To determine whether droxidopa, an oral norepinephrine precursor, improves symptomatic neurogenic orthostatic hypotension (nOH). METHODS:Patients with symptomatic nOH due to Parkinson disease, multiple system atrophy, pure autonomic failure, or nondiabetic autonomic neuropathy underwent open-label droxidopa ...

journal_title：Neurology

authors： Kaufmann H,Freeman R,Biaggioni I,Low P,Pedder S,Hewitt LA,Mauney J,Feirtag M,Mathias CJ,NOH301 Investigators.

更新日期：2014-07-22 00:00:00