Abstract:
:Estrogen have been reported in animal studies to both enhance and block central dopaminergic activity and in one clinical report to improve tardive dyskinesia. In the present study estrogen (Premarin, 2.5 mg per day) administration caused varying degrees of improvement in less than one-third of 21 patients with chorea due to Huntington's disease and tardive dyskinesia and had no effect in eight patients with dystonia. Estrogens appear to have an antidopaminergic effect in humans but poses only limited efficacy in the treatment of dyskinetic disorders.
journal_name
Neurologyjournal_title
Neurologyauthors
Koller WC,Barr A,Biary Ndoi
10.1212/wnl.32.5.547subject
Has Abstractpub_date
1982-05-01 00:00:00pages
547-9issue
5eissn
0028-3878issn
1526-632Xjournal_volume
32pub_type
临床试验,杂志文章,随机对照试验相关文献
NEUROLOGY文献大全abstract::Cross-sectional studies have not adequately resolved the question of whether subjects infected with HIV-1 may suffer cognitive decline during the early, asymptomatic stages of the infection. We studied longitudinally 238 asymptomatic healthy HIV-1-infected homosexual/bisexual men (CDC groups 2 and 3) and 170 uninfecte...
journal_title:Neurology
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1212/wnl.40.2.204
更新日期:1990-02-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to assess the prevalence of and to identify epidemiologic, genetic, electrophysiologic, and neuroanatomic risk factors for autism spectrum disorders (ASD) in a cohort of patients with tuberous sclerosis complex (TSC). METHODS:A total of 103 patients with TSC were evaluated for A...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182104347
更新日期:2011-03-15 00:00:00
abstract:OBJECTIVE:Frontotemporal lobar degeneration (FTLD) encompasses a variety of clinicopathologic entities. The antemortem prediction of the underlying pathologic lesions is reputed to be difficult. This study sought to characterize correlations between 1) the different clinical variants of primary progressive language and...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181c7198e
更新日期:2010-01-05 00:00:00
abstract::We examined serum-mediated cytotoxicity on cultured rat oligodendrocytes, using serum from patients with acute or chronic progressive multiple sclerosis and normal controls. We found heat-labile serum factors in serum from MS and also in controls. The cytotoxic effects of MS and normal sera were not restored by adding...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.2.276
更新日期:1986-02-01 00:00:00
abstract::Although psychological distress and cognitive dysfunction are well documented in adults with multiple sclerosis (MS), they are poorly understood in children with the disease. Psychosocial difficulty experienced by children and adolescents with MS involves factors common to all chronic illnesses in children, as well as...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000259420.54635.63
更新日期:2007-04-17 00:00:00
abstract:OBJECTIVE:To examine whether late-life exposure to PM2.5 (particulate matter with aerodynamic diameters <2.5-µm) contributes to progressive brain atrophy predictive of Alzheimer's disease (AD) using a community-dwelling cohort of women (aged 70-89) with up to two brain MRI scans (MRI-1: 2005-6; MRI-2: 2010-11). METHOD...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011149
更新日期:2020-11-18 00:00:00
abstract::No uniformly accepted hypothesis explains the genesis and rupture of intracranial aneurysms. We followed 5,184 men and women prospectively for 26 years; 36 cases of aneurysmal subarachnoid hemorrhage (SAH) accounted for 62% of all intracranial hemorrhages. Blood pressure before SAH was higher in these patients than in...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.34.7.847
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:Metals are suspected of being involved in the pathogenesis of various neurologic diseases. We previously found a complex imbalance in serum chemical elements and oxidative status in patients with clinically definite multiple sclerosis (CDMS). OBJECTIVE:To understand whether this imbalance affects people wit...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e31820af7de
更新日期:2011-02-08 00:00:00
abstract::The authors studied immunoglobulin G (IgG) Fc receptor (FcgammaR) IIA, IIIA, and IIIB polymorphisms in 62 patients with Guillain-Barré syndrome (GBS) and in 89 healthy controls. The FcgammaR genotypes and allele frequencies did not differ significantly between the patients with GBS and the controls. Patients homozygou...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.5.705
更新日期:2000-09-12 00:00:00
abstract::Between the years 1964 and 1973, 225 patients with transient ischemic attacks (TIAs) due primarily to atherosclerosis were evaluated and treated. They have now been followed for from 3 to 14 years (average 5.5 years). As of 1976, 82 of the 225 patients were dead, 21 from cerebral infarction, 52 from heart disease and ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.28.8.746
更新日期:1978-08-01 00:00:00
abstract::One hundred and eight patients with independent, multifocal, spike discharges in the EEG were studied. The abnormality occurred at all ages but was more frequent between 4 and 7 years. The basic EEG activity in wake tracing was invariably slow for the age of the patient. The majority of the patients with independent m...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.7.667
更新日期:1976-07-01 00:00:00
abstract::Isovaleric acidemia (IVA) is an inborn error of leucine metabolism, resulting in an accumulation of isovaleric acid in the body fluids. The neuropathologic findings in an 11-day-old infant with IVA consisted of diffuse cerebral edema, massive cerebellar hemorrhage, upward transtentorial herniation, and focal degenerat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.6.746
更新日期:1981-06-01 00:00:00
abstract::We report the cases of three siblings homozygous for a mutated transthyretin (TTR) gene that causes type I familial amyloidotic polyneuropathy (FAP), in whom we made the diagnosis by identifying both the mutated TTR gene and a variant TTR in their sera. Their serum levels for the variant TTR are twice those of patient...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.10.2045
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:To assess the effects of the modified amino acid acetyl-dl-leucine (AL) on cerebellar ataxia, eye movements, and quality of life of patients with Niemann-Pick type C (NP-C) disease. METHODS:Twelve patients with NP-C disease were treated with AL 3 g/d for 1 week and then with 5 g/d for 3 weeks with a subseque...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000002041
更新日期:2015-10-20 00:00:00
abstract:OBJECTIVE:To examine the association between body mass index (BMI) and the risk of Parkinson disease (PD). METHODS:Study cohorts included 22,367 Finnish men and 23,439 women 25 to 59 years of age without a history of PD at baseline. Hazards ratios (HRs) of incident PD were estimated for different levels of BMI. RESUL...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000247052.18422.e5
更新日期:2006-12-12 00:00:00
abstract::Outcome after carpal tunnel surgery was studied retrospectively in 32 patients with peripheral neuropathy and carpal tunnel syndrome. Nocturnal paresthesias were almost universally relieved, followed in order of responsiveness by pain, numbness, and weakness. Twenty-five of 28 patients said they would have the surgery...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.49.4.1159
更新日期:1997-10-01 00:00:00
abstract::In 10 patients with chronic autonomic failure, the sympathetic perivascular nerve plexuses from quadriceps muscle biopsies were studied by catecholamine fluorescence and electronmicroscopy. There was almost complete absence of catecholamine fluorescence and fewer than normal numbers of small granular (noradrenergic) v...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.12.1501
更新日期:1981-12-01 00:00:00
abstract:OBJECTIVE:To assess survival and functional outcome in patients endotracheally intubated after ischemic stroke (IS) or spontaneous intracerebral hemorrhage (ICH). BACKGROUND:Endotracheal intubation is both a necessary life support intervention and a measure of severity in IS or ICH. Knowledge of associated clinical va...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.52.7.1374
更新日期:1999-04-22 00:00:00
abstract:BACKGROUND:Among patients with a patent foramen ovale (PFO) and a prior cryptogenic ischemic stroke or TIA, the absolute and relative risk of recurrent events is unclear. METHODS:We conducted a systematic review and meta-analysis of clinical studies in any language published up to February 2008. We included studies re...
journal_title:Neurology
pub_type: 杂志文章,meta分析,评审
doi:10.1212/WNL.0b013e3181aa2a19
更新日期:2009-07-14 00:00:00
abstract:OBJECTIVE:To determine the frequency of Lewy bodies (LB) in progressive supranuclear palsy (PSP). BACKGROUND:LB are characteristic of PD, but are also found in normal controls and in other neurodegenerative diseases, especially AD. METHOD:The authors evaluated the brains of 72 consecutive cases of pathologically conf...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.57.9.1675
更新日期:2001-11-13 00:00:00
abstract:OBJECTIVE:To investigate brain amyloid pathology in a dementia-risk population defined as cardiovascular risk factors, aging, and dementia risk (CAIDE) score of at least 6 but with normal cognition and to examine associations between brain amyloid load and cognitive performance and vascular risk factors. METHODS:A sub...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004827
更新日期:2018-01-16 00:00:00
abstract::Some epilepsy patients quickly develop resistance to antiepileptic drugs (AEDs). We report a case of a patient with refractory epilepsy with daily seizures who initially responded to levetiracetam daily therapy, but then returned to baseline seizure frequency. However, when levetiracetam was given once weekly, the pat...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000198500.84481.da
更新日期:2006-02-28 00:00:00
abstract::We studied clinical characteristics and coexisting causes of stroke in 305 patients admitted to a population-based primary care center with an initial ischemic stroke and a potential cardiac source of embolism (PCSE). Using systematic standardized cardiac, arterial, and cerebral investigations and the logistics of the...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.6.855
更新日期:1991-06-01 00:00:00
abstract:BACKGROUND:Cervical artery dissection is often attributed to an underlying arteriopathy related to a generalized extracellular matrix defect. OBJECTIVE:The authors compared the hemodynamic and morphologic properties of the carotid artery, as assessed noninvasively by ultrasonography, in patients with spontaneous inter...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.5.663
更新日期:2000-09-12 00:00:00
abstract::Co-morbid conditions frequently occur in childhood epilepsy and may significantly affect epilepsy and its treatment. Similarly, epilepsy and antiepileptic drugs (AEDs) may affect these associated conditions. Co-morbidities that have a significant association with childhood epilepsy include attention-deficit/hyperactiv...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.62.5_suppl_2.s17
更新日期:2004-03-09 00:00:00
abstract::In the past, stereotactic surgery was a regular treatment for prominent unilateral tremor in Parkinson's disease (PD), but follow-up studies were usually short-term and always unblinded. We examined 17 PD patients in long-term follow-up (mean, 10.9 years after surgery) and used videotapes and the Unified Parkinson's D...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.42.7.1311
更新日期:1992-07-01 00:00:00
abstract:OBJECTIVE:To determine whether the Alzheimer's disease dementia conversion-related pattern (ADCRP) on [18F]FDG PET can serve as a valid predictor for the development of Alzheimer's disease dementia, the individual expression of the ADCRP (subject score) and its prognostic value were examined in subjects with mild cogni...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000011521
更新日期:2021-01-06 00:00:00
abstract:PURPOSE:To assess the extent of demyelination in cervical spondylotic myelopathy (CSM) using myelin water imaging (MWI) and electrophysiologic techniques. METHODS:Somatosensory evoked potentials (SSEPs) and MWI were acquired in 14 patients with CSM and 18 age-matched healthy controls. MWI was performed on a 3.0T whole...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004197
更新日期:2017-08-08 00:00:00
abstract:OBJECTIVES:Deep brain stimulation of the internal pallidum (GPi-DBS) is an established therapeutic option in treatment-refractory dystonia, and the identification of factors predicting surgical outcome is needed to optimize patient selection. METHODS:In this retrospective multicenter study, GPi-DBS outcome of 8 patien...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000001312
更新日期:2015-03-03 00:00:00
abstract::Since the emergence of the specialty, neurologists have worked with a rather restricted list of relatively inexpensive pharmacologic agents. This is rapidly changing with the development of new agents for the treatment of migraine, multiple sclerosis, Parkinson's disease, Alzheimer's disease, and epilepsy, accelerated...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.45.3.569
更新日期:1995-03-01 00:00:00