Abstract:
:Isovaleric acidemia (IVA) is an inborn error of leucine metabolism, resulting in an accumulation of isovaleric acid in the body fluids. The neuropathologic findings in an 11-day-old infant with IVA consisted of diffuse cerebral edema, massive cerebellar hemorrhage, upward transtentorial herniation, and focal degeneration of clusters of glial cells in white and gray matter. Although abnormal myelination has been described in different aminoacidopathies, the above findings have not been reported previously in IVA.
journal_name
Neurologyjournal_title
Neurologyauthors
Fischer AQ,Challa VR,Burton BK,McLean WTdoi
10.1212/wnl.31.6.746subject
Has Abstractpub_date
1981-06-01 00:00:00pages
746-8issue
6eissn
0028-3878issn
1526-632Xjournal_volume
31pub_type
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