Abstract:
OBJECTIVE:Given the limited information on cognitive function before Parkinson disease (PD) clinical onset in the general population, we sought to assess prodromal PD (pPD) probability and relate it to detailed cognitive performance in a community cohort. METHODS:In a population-based cohort of 1,629 dementia-free and PD-free participants ≥65 years of age in Greece, we assessed probability of pPD according to the International Parkinson and Movement Disorder Society's criteria. Clinical cognitive diagnoses (cognitively unimpaired, mild cognitive impairment [MCI], dementia) considering neuropsychological testing and functional status were assigned in consensus conferences. Cognitive performance in 5 cognitive domains was assessed by a detailed neuropsychological battery and summarized in the form of z scores. We investigated associations between pPD probability (and its individual constituents) and cognitive outcomes. RESULTS:The median probability of pPD was 1.81% (0.2%-96.7%). Participants with MCI had higher probability of pPD compared to those with normal cognition (p < 0.001). Higher probability of pPD was related to lower performance in all cognitive domains (memory, language, executive, attention, and visuospatial function) (p < 0.001). Lower cognitive performance was further associated with certain nonmotor markers of pPD, such as daytime somnolence, depression, urinary dysfunction, constipation, and subthreshold parkinsonism (p < 0.001). CONCLUSIONS:Higher probability of pPD was associated with lower cognitive performance in all domains and higher probability of MCI. This may reflect a widespread pathologic process although future studies are warranted to infer causality. These results suggest to clinicians that they should assess cognition early, and to researchers that they should further look into the possible mechanisms that may underlie this observation.
journal_name
Neurologyjournal_title
Neurologyauthors
Bougea A,Maraki MI,Yannakoulia M,Stamelou M,Xiromerisiou G,Kosmidis MH,Ntanasi E,Dardiotis E,Hadjigeorgiou GM,Sakka P,Anastasiou CA,Stefanis L,Scarmeas Ndoi
10.1212/WNL.0000000000007453subject
Has Abstractpub_date
2019-05-07 00:00:00pages
e2261-e2272issue
19eissn
0028-3878issn
1526-632Xpii
WNL.0000000000007453journal_volume
92pub_type
杂志文章相关文献
NEUROLOGY文献大全abstract::Restless legs syndrome (RLS) is a common neurologic disorder that affects 5 to 10% of the population and increases in prevalence with aging. The clinical hallmarks of RLS include dysesthesias or paresthesias in the legs and sometimes the arms, occurring primarily at rest, which are usually worse in the evening and are...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.58.suppl_1.s87
更新日期:2002-02-26 00:00:00
abstract::Combined infusion of high doses of lidocaine and thiopental in a comatose patient induced major latency and amplitude BAEP changes, which progressed to complete BAEP abolition. Responses returned to normal after drugs were discontinued. EEGs during the episodes showed long-lasting periods of activity suppression, but ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.38.9.1487
更新日期:1988-09-01 00:00:00
abstract:OBJECTIVE:To determine the role of weight loss in the treatment of idiopathic intracranial hypertension (IIH) in obese women. METHODS:Chart review of 250 patients with suspected IIH revealed 58 women who met our criteria, did not undergo early surgical intervention, and had adequate documentation of visual status, pap...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.50.4.1094
更新日期:1998-04-01 00:00:00
abstract:OBJECTIVES:To evaluate the frequency, clinical and etiologic features, and short- and long-term outcomes of early recurrent TIA. METHODS:This prospective observational cohort study enrolled all consecutive patients with TIA referred to our emergency department and diagnosed by a vascular neurologist. Expedited assessm...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000010317
更新日期:2020-09-22 00:00:00
abstract::Previous reports and the Physicians' Desk Reference caution against the use of levodopa in Parkinson's disease (PD) patients with melanoma. A critical review of the literature reveals only anecdotal evidence to support a link between levodopa and melanoma. In fact, levodopa has an antitumor effect on melanoma. We repo...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/wnl.43.4.674
更新日期:1993-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the risk of relapses during pregnancy and in the first 3 months after delivery in 2 successive pregnancies in a cohort of French and Italian women with multiple sclerosis (MS). METHODS:A total of 93 women were included if they had had 2 pregnancies followed prospectively after MS onset between Ja...
journal_title:Neurology
pub_type: 杂志文章,多中心研究
doi:10.1212/WNL.0000000000003036
更新日期:2016-09-27 00:00:00
abstract:BACKGROUND:Curative therapy for childhood cancer has dramatically improved over past decades. Therapeutic radiation has been instrumental in this success. Unfortunately, irradiation is associated with untoward effects, including stroke and other cerebrovascular disease (CVD). The Children's Oncology Group (COG) has dev...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/WNL.0b013e3181c17ea8
更新日期:2009-12-01 00:00:00
abstract::A 25-year-old man with the skin lesions of malignant atrophic papulosis had clinical and electrodiagnostic evidence of a multifocal asymmetric myelomalacia or polyradiculopathy in association with elevated CSF protein and hypoglycorrhachia. Autopsy findings included widespread infarctions and necrosis of brain, brains...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.7.936
更新日期:1983-07-01 00:00:00
abstract:OBJECTIVE:To determine the efficacy of acetyl-l-carnitine (ALCAR) on the rate of decline in early-onset AD patients. METHODS:A 1-year, multicenter, double-blind, placebo-controlled, randomized trial was conducted. Subjects were 45 to 65 years old, with a diagnosis of probable AD according to National Institute of Neur...
journal_title:Neurology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1212/wnl.55.6.805
更新日期:2000-09-26 00:00:00
abstract:BACKGROUND:Computerized ambulatory monitoring provides real-time assessments of clinical outcomes in natural contexts, and it has been increasingly applied in recent years to investigate symptom expression in a wide range of disorders. The purpose of this study was to examine the feasibility and validity of this data c...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3181c0d466
更新日期:2009-11-10 00:00:00
abstract::One hundred and eight patients with independent, multifocal, spike discharges in the EEG were studied. The abnormality occurred at all ages but was more frequent between 4 and 7 years. The basic EEG activity in wake tracing was invariably slow for the age of the patient. The majority of the patients with independent m...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.26.7.667
更新日期:1976-07-01 00:00:00
abstract::Since the first development of diagnostic criteria for multiple sclerosis (MS), there have been regular revisions of disease definitions and diagnostic thresholds aimed at improving specificity while maintaining sensitivity. The central requirements for diagnosis of MS are dissemination in space (DIS) and disseminatio...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e318277d144
更新日期:2012-12-04 00:00:00
abstract:OBJECTIVES:To investigate whether severity and progression of periventricular and deep white matter lesions (WML) and lacunar infarcts were associated with progression of brain atrophy. METHODS:Within the SMART-MR study, a prospective cohort on MRI changes in patients with symptomatic atherosclerotic disease, 565 pati...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182749f02
更新日期:2012-11-13 00:00:00
abstract:OBJECTIVE:The aims of this study were to examine executive dysfunction using an antisaccade (AS) task in normal elderly (NE) and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD) as well as to evaluate the relationship between AS performance and cortical thinning within AD-associated regions. ME...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0b013e3182a6cbfe
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To investigate residual function of the motor cortex corresponding to the hand of the amputated arm (MCamp). METHODS:Focal transcranial magnetic stimulation (TMS) of MCamp was performed in 10 patients 22 to 52 years after arm amputation to inhibit tonic muscle contraction in the intact hand ipsilateral to co...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.54.4.984
更新日期:2000-02-22 00:00:00
abstract::Evidence suggests that untreated obstructive sleep apnea (OSA) can lead to hypertension, cardiovascular disease, and stroke. Conversely, the systemic effects of a wide variety of critical illnesses can lead to CNS dysfunction, which can precipitate respiratory failure. Reported is a patient in whom an acute encephalop...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/01.wnl.0000064166.82077.eb
更新日期:2003-05-27 00:00:00
abstract::IgM anti-GM1 antibodies are associated with motor neuropathy syndromes, including multifocal motor neuropathy (MMN). We compared the ability of serum IgM from patients with multifocal motor neuropathy to bind to GM1 ganglioside alone and to GM1 as a component of a lipid mixture that also contained galactocerebroside a...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.48.4.1104
更新日期:1997-04-01 00:00:00
abstract::Using an antibody against choline acetyltransferase (ChAT), mesencephalic cholinergic cell nuclei were studied in autopsy material from 3 cases of progressive supranuclear palsy (PSP) and 4 controls. ChAT-immunoreactive neurons were quantified in sections that spanned the rostrocaudal extent of each nucleus. In PSP, t...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.41.1.25
更新日期:1991-01-01 00:00:00
abstract::Ischemic stroke subtype distribution was compared between Mexican Americans (MAs) and non-Hispanic whites (NHWs) in a community-based stroke surveillance study in Nueces County, TX. There was no difference in the distribution of stroke subtype by ethnicity (p = 0.19). There was a similar proportion of small-vessel and...
journal_title:Neurology
pub_type: 杂志文章,评审
doi:10.1212/01.wnl.0000133212.99040.07
更新日期:2004-08-10 00:00:00
abstract::To assess reversibility of focal cerebral ischemia, we performed a neurologic and pathologic study of 27 monkeys subjected to temporary middle cerebral artery occlusion. An implanted snare ligature occluded the artery in awake monkeys for 30 minutes, 4 hours, 8 hours, 16 hours, 24 hours, or permanently. Serial neurolo...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.31.10.1295
更新日期:1981-10-01 00:00:00
abstract:OBJECTIVE:To determine age- and sex-specific AD prevalence rates for whites using each of four severity-based definitions of a case: a person diagnosed as having at least questionable AD, one diagnosed as having at least mild AD, one diagnosed as having moderate or severe AD, and one diagnosed as having severe AD. MET...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.55.2.198
更新日期:2000-07-25 00:00:00
abstract::To evaluate the potential for clinical application, the reputed protective action of barbiturates in cerebral ischemia was tested in a controlled study after segmental middle cerebral artery occlusion in primates. Surviving treated animals promptly recovered consciousness, locomotion, and feeding behavior despite pers...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.25.9.870
更新日期:1975-09-01 00:00:00
abstract::The association between multiple sclerosis (MS) and alleles of the HLA class II genes indicates that at least one MS susceptibility gene is linked to the HLA class II region. However, the actual locus responsible has not been precisely identified. The recent cloning of new genes involved in antigen processing that map...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.43.6.1192
更新日期:1993-06-01 00:00:00
abstract:OBJECTIVE:To compare the accuracy of Alberta Stroke Program Early Computed Tomography Score (ASPECTS) and CT perfusion to detect established infarction in acute anterior circulation stroke. METHODS:We performed an observational study in 59 acute anterior circulation ischemic stroke patients who underwent brain noncont...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004028
更新日期:2017-06-13 00:00:00
abstract::We reviewed the clinical and electrophysiologic features of 36 patients with increased titers of IgM anti-GM1 antibodies. Mildly elevated titers of up to 3,200 were not associated with any particular clinical syndrome or disease. Clinically, 14 of 16 patients with highly elevated titers of 6,400 or higher had progress...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.44.7.1278
更新日期:1994-07-01 00:00:00
abstract:OBJECTIVE:To assess the contribution of microstructural normal-appearing white matter (NAWM) damage to social cognition impairment, specifically in the theory of mind (ToM), in multiple sclerosis (MS). METHODS:We enrolled consecutively 60 patients with MS and 60 healthy controls (HC) matched on age, sex, and education...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000004060
更新日期:2017-07-04 00:00:00
abstract::An autoimmune reaction to the endplate acetylcholine receptor (AChR) is thought to be responsible for the muscular weakness of myasthenia gravis (MG). However, the significance of antithymic antibodies and the thymic AChR-like protein is still uncertain. We transferred immunoglobulins (Igs) from patients with MG to mi...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.33.10.1356
更新日期:1983-10-01 00:00:00
abstract:OBJECTIVE:The natural history of succinic semialdehyde dehydrogenase (SSADH) deficiency in adulthood is unknown; we elucidate the clinical manifestations of the disease later in life. METHODS:A 63-year-old man with long-standing intellectual disability was diagnosed with SSADH deficiency following hospitalization for ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000001906
更新日期:2015-09-08 00:00:00
abstract:OBJECTIVE:To determine the rate of relapse occurrence during pregnancy and postpartum. METHODS:In a cross-sectional study using the national multiple sclerosis (MS) registry, pregnant women with relapsing MS were identified. Data on demographics, clinical characteristics, and disease-modifying therapies (DMTs), includ...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/WNL.0000000000005065
更新日期:2018-03-06 00:00:00
abstract::Migration from an area where MS is common to an area where it is rare (and vice versa) affects the risk of MS, provided migration occurs in childhood. A childhood infection might explain this effect. Therefore, the age pattern of infectious diseases in different regions was examined. A higher proportion of children sh...
journal_title:Neurology
pub_type: 杂志文章
doi:10.1212/wnl.36.10.1386
更新日期:1986-10-01 00:00:00