Abstract:
:To evaluate the potential for clinical application, the reputed protective action of barbiturates in cerebral ischemia was tested in a controlled study after segmental middle cerebral artery occlusion in primates. Surviving treated animals promptly recovered consciousness, locomotion, and feeding behavior despite persistent hemiplegia, while control animals ran an indolent course, with slow recovery of poor quality. Cerebral lesions in treated animals were confined to the deep hemispheric structures, while control specimens showed larger deep lesions confluent with extensive areas of cortical infarction. These results are less dramatic than those reported by others, but the protective effect observed in fields of collateral circulation deserves further exploration as an adjunct to medical and surgical management.
journal_name
Neurologyjournal_title
Neurologyauthors
Moseley JI,Laurent JP,Molinari GFdoi
10.1212/wnl.25.9.870subject
Has Abstractpub_date
1975-09-01 00:00:00pages
870-4issue
9eissn
0028-3878issn
1526-632Xjournal_volume
25pub_type
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